The Effects of Intelectin-1 on Antioxidant and Angiogenesis in HUVECs Exposed to Oxygen Glucose Deprivation

Conclusion: These results suggest intelectin-1 promotes angiogenesis, inhibits oxidative stress and reduces apoptosis by stimulating the Akt-eNOS signaling pathway in response to ischemia in vitro. Introduction Stroke is a main reason of human neurological disability, ischemic stroke (IS) accounts for almost 80–90% of all strokes. IS occurs after a cerebral blood flow disruption, leading to cellular death and tissue damage by restricting glucose and oxygen supplies (1). Ischemic vascular diseases cause substantial vascular valve and vascular endothelial cell injuries, eventually damaging the surrounding tissues (2, 3). Because of the complexity of acute IS pathophysiology, there are no effective methods and measures to treat acute IS. Previous research has focused on the neuronal and astrocytic damage following IS; however, as strokes also affect microvessels, vascular endothelial cell changes. Recent stroke research has paid great attention to the importance of neurovascular units (NVUs, is made up of neurons, endothelial cells, and astrocytes), because stroke affects neurons, astrocytes and microvessels at same time (4, 5). Within NVUs, endothelial cells are critical for the blood flow, oxygen and glucose delivery, and the regulation of cerebral microcirculation (6, 7). Vascular damage during ischemia often leads to disruption of the blood–brain barrier (BBB) and dysregulation of vascular tonus, eventually causing substantial cell death (8). Induct...
Source: Frontiers in Neurology - Category: Neurology Source Type: research