A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants

Conclusions: Our estimates corroborate reports from several recent epidemiological studies of associations between PBDE exposures and neurobehavioral outcomes, and they support the inclusion of BDE-209 in the persistent organic pollutant (POP) convention as well as the need for strategies to reduce exposures to PBDE mixtures, including maximum residue limits for PBDEs in food and measures for limiting the release of PBDEs from consumer waste. https://doi.org/10.1289/EHP826 Received: 18 July 2016 Revised: 06 May 2017 Accepted: 09 May 2017 Published: 23 August 2017 Address correspondence to A. Kortenkamp, Brunel University London, Halsbury Building, room 124, Kingston Ln., Uxbridge, Middlesex UB8 3PH, UK. Telephone: 0044-1895-266525. Email: andreas.kortenkamp@brunel.ac.uk Supplemental Material is available online (https://doi.org/10.1289/EHP826). M.F. co-owns Faust &Backhaus Environmental Consulting, an environmental consulting company. All other authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your access...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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We report the case of a patient referred to us after multiple unsuccessful paranasal sinus operations who presented with enophthalmos and a resultant migratory keratitis with a suspected diagnosis of silent sinus syndrome. Preservation of the orbit was no longer feasible. After five years without a definitive diagnosis, we ascertained that this was a case of IgG4-related disease. DISCUSSION: IgG4-related disease represents an important element in the differential diagnosis of chronic advanced diseases of the orbit and paranasal sinuses. The diagnosis should be considered in the case of unclear ...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
SummaryBackgroundPharmacological treatment options for adolescents with obesity are very limited. Glucagon ‐like‐peptide‐1 (GLP‐1) receptor agonist could be a treatment option for adolescent obesity.ObjectiveTo investigate the effect of exenatide extended release on body mass index (BMI) ‐SDS as primary outcome, and glucose metabolism, cardiometabolic risk factors, liver steatosis, and other BMI metrics as secondary outcomes, and its safety and tolerability in adolescents with obesity.MethodsSix ‐month, randomized, double‐blinded, parallel, placebo‐controlled clinical trial in patients (n = 44, 10‐18&thin...
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
While the unemployment rate remains low in central Arkansas, income growth in the region has lagged behind that of the rest of the United States, notes the Metroplan report “Metro Trends: Economic Review and Outlook.”
Source: Arkansas Business - Health Care - Category: American Health Source Type: news
Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB00126K, CommunicationHiromichi Egami, Satoshi Nakagawa, Yuki Katsura, Masakatsu Kanazawa, Shingo Nishiyama, Toshihiro Sakai, Yasushi Arano, Hideo Tsukada, Osamu Inoue, Kenichiro Todoroki, Yoshitaka Hamashima Dihydromethidine (DHM) labeled with 18F at the para position of the benzene ring was designed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS).... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research
In this study, yellowfin seabream (Acanthopagrus latus), a euryhaline marine teleost, was used to investigate immune responses of different tissues (gill, liver, and muscle) under hypoosmotic stress. Comparative transcriptomic and physiological analyses of three tissues were conducted after fish exposed to the fresh water (FW, salinity = 0 ppt), low-saline water (LW, salinity = 3 ppt), and brackish water (BW, salinity = 6 ppt) for 8 days. The results showed that hypoosmotic stress dramatically altered the gene expression of three tissues in yellowfin seabream; The investigation of differentially expressed...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 15 February 2020Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Manal Naciri, Yasmina El Aoufir, Hassane Lgaz, Fatima Lazrak, Ahmed Ghanimi, Abdallah Guenbour, ismat H. Ali, Mouloud El Moudane, Jamal Taoufik, Ill-Min ChungAbstractCarbon steel is a commonly used alloy in petroleum refining equipment. Nonetheless, its weak corrosion resistance is a perpetual problem for these industries. In the present study, we manifest the usefulness of a novel 1,2,4-triazole derivative, namely 5-hexylsulfanyl-1,2,4-triazole (HST) in inhibiting the carbon steel (CS) corr...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 15 February 2020Source: Toxicology ReportsAuthor(s): Hellen A. Oketch-Rabah, Amy L. Roe, Cynthia V. Rider, Herbert L. Bonkovsky, Gabriel I. Giancaspro, Victor Navarro, Mary F. Paine, Joseph M. Betz, Robin J. Marles, Steven Casper, Bill Gurley, Scott A. Jordan, Kan He, Mahendra P. Kapoor, Theertham P. Rao, Averell H. Sherker, Robert J. Fontana, Simona Rossi, Raj Vuppalanchi, Leonard B. SeeffABSTRACTAs part of the United States Pharmacopeia’s ongoing review of dietary supplement safety data, a new comprehensive systematic review on green tea extracts (GTE) has been completed. GTEs may...
Source: Toxicology Reports - Category: Toxicology Source Type: research
This study investigated the adsorption of the multicomponent VOCs in a homemade CAR waste-based activated carbon (CAR-AC). A fixed-bed experimental setup was used to explore the adsorption and desorption of single- and multi-component VOCs. Surface adsorption and diffusion molecular models with different defects were built to study the underlying adsorption and diffusion mechanisms of multicomponent VOCs on CAR-AC. The adsorption amount of ethyl acetate in CAR-AC from multicomponent VOCs was 3.04 and 5.91 times higher than those of acetone and acetaldehyde, respectively, and the interaction energy between ethyl acetate and...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: Available online 15 February 2020Source: Journal of Hazardous MaterialsAuthor(s): Lijin Huang, Rujia Shen, Ruiqi Liu, Qin ShuaiAbstractCovalent organic frameworks (COFs) have attracted tremendous attention due to their excellent performance in wastewater remediation, but their practical application still suffers from various challenges. The development of highly-efficient magnetic COFs along with fast adsorption kinetic and high adsorption capacity is very promising. To achieve the purpose, thiol-functionalized magnetic covalent organic frameworks (M-COF-SH) with abundant accessible chelating sites were d...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: Available online 15 February 2020Source: Journal of Hazardous MaterialsAuthor(s): Fisseha A Bezza, Shepherd M Tichapondwa, Evans MN ChirwaAbstractUniformly dispersed silver nanoparticles (AgNPs) with remarkable colloidal stability were synthesized using chemical reduction method in lipopeptide biosurfactant reverse micelles. Transmission Electron microscopy (TEM), Scanning electron microscopy (SEM) and UV–vis spectroscopy analysis exhibited monodisperse nanoparticles with spherical morphology of diameter of 21 ± 2. The lipopeptide stabilized AgNPs displayed remarkable antibacter...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
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