End-of-Life Healthcare Sessions at ASBH 2017

Conclusion: Patients with LEP had significant differences and disparities in end-of-life decision-making. Interventions to facilitate informed decision-making for those with LEP is a crucial component of care for this group. THU 1:30 pm:  “But She’ll Die if You Don’t!”: Understanding and Communicating Risks at the End of Life (Janet Malek) Clinicians sometimes decline to offer interventions even if their refusal will result in an earlier death for their patients. For example, a nephrologist may decide against initiating hemodialysis despite a patient’s rising creatinine levels if death is expected within weeks even with dialysis. Although clinicians can describe their reasons for not offering an intervention (often related to overall prognosis, suffering, and mental status) toward the end of life, their reasoning has not been explored in detail or described in a nuanced way. Anecdotal experience as well as published scholarship suggests that clinicians decline treatment if “the risks outweigh the benefits.” This facile explanation does not adequately address concerns of a family member who wants to give their loved one every possible chance, arguing, “But she’ll die if you don’t! What do we have to lose?” In an attempt to bridge this impasse often encountered by clinical ethics consultants and critical care physicians, we conducted interviews with physicians (intensivists, oncologists, surgeons, and...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: Health Care syndicated Source Type: blogs

Related Links:

Authors: Xu W, Lou Y, Chen W, Kang Y Abstract Effective cancer therapy usually requires the assistance of well-designed drug carriers. In order to increase the drug accumulation to tumor tissue as well as to reduce the side effects of drug carriers, the hybrid drug delivery system (DDS) was developed by integrating folic acid (FA) and a metal-organic framework (MOF). The anticancer drug doxorubicin (DOX) was preloaded into the MOF nanoparticles during the synthesis process of the MOF nanoparticles. After surface modification with FA, the resulting FA/MOF/DOX nanoparticles were capable of serving as a biocompatible ...
Source: Biomedizinische Technik/Biomedical Engineering - Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research
What are the latest strategies for fertility preservation in adolescent and young adult survivors of childhood cancer?Current Opinion in Urology
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Urology Journal Article Source Type: news
Publication date: Available online 12 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Alexandra Kollara, Premalatha Shathasivam, Soyeon Park, Maurice J. Ringuette, Theodore J. BrownAbstractStudies indicate androgens contribute to initiation or progression of epithelial ovarian cancer through poorly understood mechanisms. We provide evidence that the androgen receptor (AR) interacts in a ligand-independent manner with the putative armadillo repeat domain of ventricular zone expressed PH domain-containing 1 (VEPH1). This interaction was increased by mutation of the two nuclear receptor...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
This article reviews the major pathways by which adrenal steroids are converted to the potent male sex hormones, testosterone (T) and 5α-dihydrotestosterone (5α-DHT) and the discrete enzyme isoforms involved in castration resistant prostate cancer. Previous studies have mainly utilized radiotracers to investigate these pathways but have not used prevailing concentrations of precursors found in castrate male human serum. In addition, the full power of stable-isotope dilution liquid chromatography tandem mass spectrometry has not been applied routinely. Furthermore, it is clear that adaptive responses occur in th...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 12 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Laura Tatiana Pelegrina, Myriam LaconiAbstractOvarian carcinoma is one of the most common cause of death by gynecologic cancer. Several epidemiological and in vitro studies have shown controversial data about progesterone effects in ovarian cancer. Progesterone can be converted in its active metabolite, allopregnanolone, its effects in ovarian cancer are still unknown. Previously, we demonstrated that allopregnanolone modifies ovarian morphophysiology, being able to alter critical process of tumor d...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 12 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Yucui Jiao, Chao Du, Lijun Zong, Xueying Guo, Yufeng Han, Xiaopan Zhang, Lin Li, Chengwu Zhang, Qiang Ju, Jinhua Liu, Hai-Dong Yu, Wei HuangAbstractA novel three-dimensional (3D) vertical-flow paper-based device (3VPD), integrated with a sandwich-type fluorescent immunoassay, was developed for multiplexed detection of cancer biomarkers simultaneously based on the principle of origami. The developed 3VPD, composed of a sample layer, a splitting layer, and a test layer, could be fabricated simply by wax-printing on paper at ...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
This article demonstrates the fabrication of versatile nanoformulation by conveniently wrapping the ultrasmall platinum nanoparticles-dispersed over the zinc metal-doped mesoporous silica-based nanocarriers (Zn-MSNs) for not only conveying the drug cargo efficiently but also facilitating the advanced abilities of deep tumor penetration through interacting with adherens junctions and aphotic (dark) synergistic therapeutic effects to combat cancer multidrug resistance.
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 13 October 2019Source: European UrologyAuthor(s): Bruce Montgomery, Stephen Plymate
Source: European Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn our study, the Met-allele was associated with higher stress levels. To the best of our knowledge, this is the first study investigating this area. The findings from this study should trigger more investigators to focus on the impact of stress, due to the potential effects of these genes, on medical students.
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
Publication date: Available online 12 October 2019Source: Social Science &MedicineAuthor(s): Kristin Bindley, Joanne Lewis, Joanne Travaglia, Michelle DiGiacomoAbstractAn emphasis on individual intervention and psychological complexity has characterised research on bereavement following an experience of life-limiting illness. Exploration of “structural vulnerability” as a positionality produced by social and structural inequity could provide insights into areas of practice and policy in need of development. This scoping review sought to summarise published research on experiences of social and structural in...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
More News: Alzheimer's | Babies | Babies Heart Conditions | Belgium Health | Blogging | Brain | Brain Cancers | Canada Health | Cancer | Cancer & Oncology | Cardiology | Cervical Cancer | Chemotherapy | Child Development | Children | Chronic Obstructive Pulmonary | Conferences | Dementia | Depression | Dialysis | Disability | Education | Edwards Syndrome | Emergency Medicine | Genetics | Health Management | Heart | Heart Disease | Heart Failure | Hemodialysis | History of Medicine | Insurance | Intensive Care | International Medicine & Public Health | Legislation | Medical Ethics | Medical Homes | Men | Netherlands Health | Neurology | Neurosurgery | Nurses | Nursing | Nutrition | Oral Cancer | Palliative | Palliative Care | Parenteral Nutrition | Pediatrics | Perinatology & Neonatology | Pneumonia | Politics | Pregnancy | Primary Care | Psychiatry | Psychology | Reproduction Medicine | Study | Suicide | Switzerland Health | Tax | Teaching | Transitional Cell Carcinoma | Universities & Medical Training | Urology & Nephrology | USA Health | Workshops