Human Embryonic Stem Cells in the Treatment of Autism: A Case Series

Conclusion: The use of human embryonic stem cell therapy may be a safe and effective treatment for patients with autism spectrum disorder. Studies with larger sample sizes are needed to support the use of human embryonic stem cell therapy in this patient population. Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social disconnection, incomplete verbal and nonverbal communication, severely restricted interests, and display of stereotyped and repetitive obsessive behaviors.[1,2] The current diagnosis of ASD is based on the revised criteria in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).[3] According to the DSM-5, ASD is a single spectrum disorder that comprises three disorders previously described in the fourth edition of the DSM[4] —autism, Asperger’s disorder, and pervasive developmental disorder, not otherwise specified (PDD-NOS). Scientific evidence and clinical practice support that this single spectrum reflects the currently defined symptomatology, time-course, and response to treatment of the disorder.[5] Multiple factors contribute to the etiology of ASD, including genetic, environmental, immunodeficient, encephalitic, and viral factors.[1] Impairment of methylation and mutations in the mecp2 gene are found to be related to ADS. The genetic polymorphism of cytochrome P450 enzyme, particularly CYP27B1 gene, has also been associated with ASD. CYP27B1 gene is vital for the metabol...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Autism Behavioral and Cognitive Neurology Case Review Current Issue Neurologic Systems and Symptoms Pervasive Developmental Disorders brain related disorder hESC human embryonic stem cell neurodevelopmental disorder stem cell therapy Source Type: research