Latest e-Edition of ICNS
Click here to access the latest e-Edition PDFs can be downloaded and printed from the e-Editions. Click on the above issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.  The post Latest e-Edition of ICNS appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools Current Issue Drug Development Patient Assessment Psychiatry Psychopharmacology Scales Schizophrenia Trial Methodology Source Type: research

Editorial Message and Issue Highlights –Vol. 15, No. 3–4, March-April 2018
This article is a must-read for everyone—clinicians, researchers, big pharma, and small biotechs alike. Next, in a review article titled, “Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury,” Borghol et al review the evidence on the efficacy of modafinil use in patients with fatigue or excessive daytime sleepiness (EDS) following traumatic brain injury (TBI). The authors conclude that while modafinil appears to have the potential to improve wakefulness in patients with TBI, randomized, controlled research is needed before a determination on modafinil’s use in this pat...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Editor's Message: Issue Highlights Source Type: research

Letters to the Editor
We reported a sporadic case of olanzapine-induced rapid-onset Type 2 diabetes with severe hyperglycemia.2 In our case, the patient was negative for anti-glutamic acid decarboxylase antibodies, and the discontinuation of olanzapine and careful insulin replacement regimen reversed diabetes. A common feature between these two cases is acute-onset severe hyperglycemia. The first presentation of diabetes associated with olanzapine might be diabetic ketoacidosis (DKA), requiring admission to an intensive care unit. Patients exposed to antipsychotics have approximately 10 times increased risk of DKA compared to the general popula...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Letters to the Editor Source Type: research

Neuroscience is the Next Oncology
by Michael D. Ehlers, MD, PhD Dr. Ehlers is with Biogen in Cambridge, Massachusetts. Innov Clin Neurosci. 2018;15(3–4):15–16 Funding: No funding was received for the preparation of this article. Disclosures: Dr. Ehlers is an employee and shareholder at Biogen Inc. in Cambridge, Massachusetts. Prominent and expensive failures in Alzheimer’s disease therapies have led to a contagious belief system in some parts of the biopharma industry that neuroscience is just too hard, too risky, and too uncertain. But, might this belief system itself be a residual bias of the past? Close inspection reveals all the signs...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple scleros...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Effects of Statins and Cholesterol on Patient Aggression: Is There a Connection?
Conclusion. It is evident that psychiatric inpatients with lower total cholesterol levels are at an increased risk for loss of behavioral control. Keywords: Statins, cholesterol, aggression, agitation, violence, psychiatric inpatients Little data support or refute the claim that statins or low serum cholesterol increase a patient’s risk of aggression. Therefore, it is imperative that we, as healthcare professionals, contribute to best practices to ensure that we do not inadvertently worsen a patient’s preexisting psychiatric condition. Behavioral changes can be provoked by a variety of medications. Recent ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Retrospective Study aggression agitation cholesterol psychiatric inpatients Statins violence Source Type: research

Comorbid Insomnia and Psychiatric Disorders: An Update
This article reviews this relationship and provides recommendations for management. Keywords: Insomnia, sleep disorder, psychiatric disorder, depression, psychosis, schizophrenia, anxiety disorder Insomnia affects 25 million people in the United States annually and leads to an estimated $100 billion health care burden. Insomnia has also been shown to be a causal factor in other medical and psychiatric disorders, cognitive impairments, accidents, absenteeism, and reduced quality of life.1 The cost of not treating insomnia is more than the cost of treating insomnia.2 Insomnia as a symptom is seen in up to one third of the Un...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review anxiety disorder depression insomnia psychiatric disorder psychosis schizophrenia sleep disorder Source Type: research

Psychosis in a Child with Atypical Autism: A Case Report and a Brief Review of the Association of Psychosis and Autism
We present the case of a 12-year-old child with atypical autism who developed psychotic symptoms that led to a diagnostic dilemma. Proper exploration of early childhood history, prompt treatment with an antipsychotic medication, and social skill training led to resolution of psychotic symptoms and improvement in disruptive symptoms of autism. Keywords: Autism, psychosis, association, autism spectrum disorder, ASD Since the concept of psychosis by Blueler 1 and Kraeplin2 first emerged, autism spectrum disorder (ASD) was thought to be an early manifestation of psychosis or schizophrenia, and ASD in children was referred as &...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue ASD association autism autism spectrum disorder psychosis Source Type: research

Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder
Conclusion. The audio-digital recording method provides a useful second opinion that can affirm the need for a different treatment intervention in these anxious patients. A second live assessment would have required additional clinic time and added patient burden. The audio-digital recording method is less burdensome than live second opinion assessments and might have utility in both research and clinical practice settings. Keywords: Generalized anxiety disorder (GAD), anxiolytic medications, anxious symptoms, audio-digital recording, dual review, second opinions Anxiety symptoms are prevalent in most populations wher...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Original Research anxiolytic medications anxious symptoms audio-digital recording dual review Generalized anxiety disorder (GAD) second opinions Source Type: research

Hot Topics in Neuroscience: Is Electroconvulsive Therapy a Treatment for Depression Following Traumatic Brain Injury?
Conclusion TBI is a distinct and complex pathophysiological entity. Neurocognitive deficits and mood disorders are common sequelae of TBI. While nonmodifiable factors influence risk of developing post-TBI depression, there is also evidence that biological factors are involved. People who have suffered TBI are at increased risk for ictal events and cognitive impairment. ECT has been documented to successfully treat patients with post-TBI mood symptoms in only three published cases. While these vignettes suggest that ECT might be a safe and effective therapeutic option in treating individuals with post-TBI depression, more r...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Hot Topics in Neuroscience depression ECT Electroconvulsive therapy mood disorders TBI traumatic brain injury treatments Source Type: research

Risk Management: Prescribing Controlled Substances: Managing the Risks
Conclusion Using the three Cs of risk management strategies—collecting information, communicating, and carefully documenting—when prescribing controlled substances supports quality patient care and can decrease the risk of improper prescribing allegations. Appendix 1. Prescribing Controlled Substances: Informed Consent Some, but not all states have promulgated various requirements and recommendations for components of an informed consent discussion when prescribing controlled substances.  The following is a compilation of current individual state requirements and recommendations for informed consent. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Risk Management Source Type: research

Letter to the Editor: Discussing ANT1 role in Amyotrophic Lateral Sclerosis pathogenesis
Innov Clin Neurosci. 2018;15(3–4):11–14 Dear Editor: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a rapid progression, affecting motor neurons in the brain and spinal cord, ultimately leading to respiratory failure and death.1 ALS might present as sporadic (sALS) or familial (fALS), both of which are clinically indistinguishable.1 ALS etiology is still unknown, despite several studies evaluating the underlying mechanism of motor neuron degeneration (e.g., neuroinflammation, oxidative stress, mitochondrial dysfunction, axonal damage, and protein aggregation).1 Among such mechanisms, mi...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Letters to the Editor Source Type: research

“Vetting” Service Dogs and Emotional Support Animals
by Ann L. McNary, JD Ms. McNary is a Senior Risk Manager at PRMS, Inc. Innov Clin Neurosci. 2017;15(1–2):49–51 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professional liability risk. ...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Practice Management Risk Management emotional support animal service animal Source Type: research

Wants Talk Psychotherapy but Cannot Talk: EMDR for Post-stroke Depression with Expressive Aphasia
CONCLUSION This is the first reported case demonstrating that EMDR can be effective for depression, even in those with severe expressive aphasia. In our case, there was no reluctance to disclose information, simply a neurological inability to do so. Through preparation, patience, perseverance, and plasticity (clinician flexibility, though perhaps also neuroplasticity), the patient’s PSD gradually improved, and she was able to reinvent her life within her limitations. ACKNOWLEDGMENTS The authors gratefully acknowledge Eugene Schwartz, E.C. Hurley, and Mark Hubner for providing consultation during patient care. REFEREN...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Neurologic Systems and Symptoms Neurology Psychotherapy Stroke aphasia depression EMDR Source Type: research

Latest e-Edition of ICNS
Click here to access the latest e-edition PDFs can be downloaded and printed from the e-Editions. Click on the above issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.The post Latest e-Edition of ICNS appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools Current Issue Drug Development Patient Assessment Psychiatry Psychopharmacology Scales Schizophrenia Trial Methodology Source Type: research

Editorial Message and Issue Highlights – Vol. 15, No. 1 –2, January-February 2018
Dear Colleagues: Welcome to the January-February 2018 issue of Innovations in Clinical Neuroscience (ICNS). This is a milestone year for us as it marks the beginning of our 15th year of publication! We are pleased to continue serving you, our valued readers and colleagues, by providing peer-reviewed, evidence-based information on the latest innovations in both research and clinical practice in the field of neuroscience. We’d like to thank those dedicated readers who have been with us since 2004, the year we launched the journal, and to welcome new readers who are just discovering ICNS and what it has to offer. We&rsq...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Editor's Message: Issue Highlights Source Type: research

Pimavanserin: A Novel Drug Approved to Treat Parkinson ’s Disease Psychosis
Conclusion: Evidence suggests pimavanserin attenuates PDP symptoms with few adverse effects and little risk of worsening motor function. With limited treatment options for PDP, pimavanserin represents an important therapeutic innovation. KEYWORDS: Pimavanserin, ACP-103, Parkinson’s disease psychosis INTRODUCTION Parkinson’s disease (PD) is a prevalent disorder that affects approximately 40 to 1,000 persons/100,000, with increased occurrence in older individuals.[1] PD is characterized by progressive neurodegeneration that manifests in the early stages as mild cognitive impairment and moderate motor dysfunction,...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Movement Disorders Neurology Parkinson's disease Psychiatry Psychopharmacology psychosis Review Schizophrenia ACP-103 Parkinson’s disease psychosis Pimavanserin Source Type: research

Effectiveness of Electroconvulsive Therapy (ECT) in Parkinsonian Symptoms: A Case Series
We describe their treatment and review the current literature on the use of ECT among patients with PD. CASE SERIES All six patients in our retrospective chart review received bitemporal modified brief pulse ECT. Prior to ECT, the patients underwent pre-ECT evaluation, which involved hemogram analysis, renal and liver function tests, fasting blood glucose analysis, chest X-ray (posteroanterior view), and serum electrolyte analysis, all of which were within the normal range for all six patients, and none of the patients showed evidence of raised intracranial pressure on fundoscopy examination. All patients provided written ...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Case Review Current Issue Depression Devices ECT Mental Disorders Mood Disorders Movement Disorders Neurology Parkinson's disease Psychiatry Technology Electroconvulsive therapy parkinson’s disease Source Type: research

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
by Jessica Robinson-Papp, MD, MS; Mary Catherine George, MM, PhD; Alexandra Nmashie, MD; Donald Weisz, PhD; and David M. Simpson, MD Drs. Robinson-Papp, George, Nmashie and Simpson are with the Department of Neurology and Dr. Weisz is with the Department of Neurosurgery—all from the Icahn School of Medicine at Mount Sinai in New York, New York. Innov Clin Neurosci. 2017;15(1–2):28–32 FUNDING: This investigator-initiated project was supported by a grant from CSL Behring. The project was also supported by Grant Number #UL1TR000067 from the National Center for Advancing Translational Sciences (NCATS), a comp...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research

The Benefit of Mirtazapine in the Treatment of Progressive Multifocal Leukoencephalopathy in a Young HIV-positive Patient: A Case Report
We report a young HIV-positive patient who suffered from progressive multifocal leukoencephalopathy caused by the human John Cunningham virus and showed objective clinical improvement after adding mirtazapine to the treatment regimen, an observation that is supported by the emerging literature. KEYWORDS: Progressive multifocal leukoencephalopathy (PML), acquired immunodeficiency syndrome (AIDS), human immunodeficiency virus (HIV), mirtazapine, highly active antiretroviral therapy (HAART) INTRODUCTION Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the huma...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report CNS Infections Cognition Current Issue Neurologic Systems and Symptoms Primary Care Psychopharmacology acquired immunodeficiency syndrome (AIDS) highly active antiretroviral therapy (HAART) human immunodeficiency virus (HIV) Source Type: research

Cognitive Impairment Associated with Cancer: A Brief Review
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research

Letter to the Editor: Pneumocephalus: Is the needle size significant?
Discussion. Pneumocephalus is defined by two mechanisms: a ball-valve and an inverted bottle concept.1 The ball-valve type implies positive pressure events, such as coughing or valsalva maneuvers, that prevent air escape. Tension pneumocephalus is included in this mechanism, causing a parenchymal mass effect. The inverted bottle theory includes a negative intracranial pressure gradient following cerebrospinal fluid drainage, relieved by air influx. A small pneumocephalus is usually sealed by blood clots or granulation, allowing spontaneous reabsorption and resolution.[1] Otherwise, the lateral positioning of a patient duri...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools CNS Infections Current Issue Letters to the Editor Neurologic Systems and Symptoms Neurology Stroke Traumatic Brain Injury epidural needle size Pneumocephalus spinal tap Source Type: research

Vol. 51 (December 28, 2017): New Discoveries in Neurodegenerative Diseases
Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Discoveries in Neurodegenerative Diseases 5 Journal Articles Pathogenesis and progression of multiple sclerosis: the role of arachidonic acid-mediated neuroinflammation Down-regulation of MiR-9* in the peripheral leukocytes of Huntington’s disease patients The mirror neurons...
Source: Innovations in Clinical Neuroscience - December 25, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Neurodegenerative Disease The Neuroscience Report Source Type: research

Vol. 50 (December 20, 2017): Advances in Neuroscience
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Advances in Neuroscience 5 Journal Articles Closing the loop on impulsivity via nucleus accumbens delta-band activity in mice and man   Can surgical simulation be used to train detection and classification of neu...
Source: Innovations in Clinical Neuroscience - December 20, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: The Neuroscience Report Source Type: research

Vol. 49 (December 11, 2017): Neurological Disorders
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Neurological Disorders 5 Journal Articles Disease Modifying Treatments and Symptomatic Drugs for Cognitive Impairment in Multiple Sclerosis: Where Do We Stand? Inventory of Real World Data Sources in Parkinson’s...
Source: Innovations in Clinical Neuroscience - December 11, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: The Neuroscience Report neurological disorders Source Type: research

Hot Topics in Multiple Sclerosis
CLICK HERE TO ACCESS E-EDITION December 2017 Past Issues PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window. November 2017The post Hot Topics in Multiple Sclerosis appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - December 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Multiple Sclerosis Neurodegenerative Disease Neurology Special Issues Supplements Source Type: research

Vol. 48 (November 30, 2017): Multiple Sclerosis
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Multiple Sclerosis Journal Articles Primary Progressive Multiple Sclerosis: Putting Together the Puzzle The State of Multiple Sclerosis: Current Insight Into the Patient/Health Care Provider Relationship, Treatm...
Source: Innovations in Clinical Neuroscience - November 30, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Neurodegenerative Disease The Neuroscience Report multiple sclerosis Source Type: research

November –December: PANSS 30th Anniversary e-Edition
CLICK HERE TO ACCESS THE E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.The post November–December: PANSS 30th Anniversary e-Edition appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue antipsychotic drugs Positive and Negative Syndrome Scale (PANSS) schizophrenia Source Type: research

Precursors to the PANSS: The BPRS and its progenitors
Conclusion One definition of value is when a trademark is used as a generic; Kleenex and Jello come to mind. From that perspective, the BPRS became the name for numerous scales that went far beyond the original. Perhaps the distinction of the PANSS is that it changed the terrain by creating both a new name and a brand. With its remarkable utility in the development of new antipsychotic medications and other treatments in schizophrenia and psychotic disorders today, the PANSS will help to shape the future of assessment tools, and ultimately psychiatric research. References Kay SR, Fiszbein A, Opler LA. The positive an...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review 7-point Likert scale BPRS factor analysis of data PANSS psychometrics schizophrenia symptom assessment the Brief Psychiatric Rating Scale The Positive and Negative Syndrome Scale Source Type: research

A Developmental History of the Positive and Negative Syndrome Scale (PANSS)
Conclusion Since Moore’s initial efforts and discovery of five highly correlated syndromes, there have been different assessments created to evaluate symptom profiles, target populations, and drug efficacy. All of the scales discussed here strive to appropriately assess an individual’s symptoms and functioning. The advancements in assessments made by the discussed scientists, doctors, clinicians, and researchers discussed above paved the way for the future of understanding symptoms, treatment, and the overall state of knowledge for psychosis. Lorr contributed by stressing the importance of interrater reliabilit...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review Brief Psychiatric Rating Scale (BPRS) Inpatient Multidimensional Psychiatric Scale (IMPS) Multidimensional Scale for Rating Psychiatric Patients (MSRPP) Positive and Negative Syndrome Scale (PANSS) psychometrics psychosi Source Type: research

Using the Positive and Negative Syndrome Scale (PANSS) to Define Different Domains of Negative Symptoms: Prediction of Everyday Functioning by Impairments in Emotional Expression and Emotional Experience
In this study, as we did not use full information methods, we excluded cases that were missing information on any of the variables; the resulting sample size was 630 cases. We compared the demographic information for these cases to the 191 cases with at least one missing observation. There were no significant differences between the current sample and the previous sample. The PANSS reduced emotional experience factor and the PANSS reduced expression factor were significantly correlated with each other in this dataset (r=0.30, p
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Original Research factor analysis negative symptoms schizophrenia Source Type: research

Insight and Treatment Outcomes in Schizophrenia: Post-hoc Analysis of a Long-term, Double-blind Study Comparing Lurasidone and Quetiapine XR
Conclusion: In this post-hoc analysis, flexibly dosed lurasidone 40 to 160mg/d was found to be associated with significantly greater improvement in insight compared to flexibly dosed quetiapine XR 200 to 800mg/d over long-term treatment in patients with schizophrenia. Across treatment groups, improvement in insight and judgment was significantly associated with improvement in cognition, functional capacity, quality of well-being, and depressive symptoms over time. Keywords: Insight, schizophrenia, cognition, functional capacity, quality of well-being, depressive symptoms, lurasidone, quetiapine XR Innov Clin Neurosci. 2017...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Original Research cognition depressive symptoms functional capacity insight lurasidone quality of well-being quetiapine XR schizophrenia Source Type: research

Negative Symptom Dimensions of the Positive and Negative Syndrome Scale Across Geographical Regions: Implications for Social, Linguistic, and Cultural Consistency
Conclusion: These results suggest that the Positive and Negative Syndrome Scale negative symptom factor can be better represented by a two-factor model than by a single-factor model. Additionally, the results show significant differences in responses to items representing the Positive and Negative Syndrome Scale expressive factors, but not the experiential factors, across regions. This could be due to a lack of equivalence between the original and translated versions, cultural differences with the interpretation of items, dissimilarities in rater training, or diversity in the understanding of scoring anchors. Knowing which...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Original Research experiential deficits expressive deficits negative symptoms PANSS Positive and Negative Syndrome Scale schizophrenia Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

September –October 2017 e-Edition
CLICK HERE TO ACCESS THE E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.  The post September–October 2017 e-Edition appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - September 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Drug Development e-Edition Neurology Psychiatry Psychiatry and Neurology Trial Methodology central nervous system CNS ICNS Innovations in Clinical Neuroscience psychotherapy Source Type: research

A Case of Psychosis in a Patient with Secondary Adrenal Insufficiency: A Possible Etiological Role of a Hypocortisolemic-induced Increase in Proinflammatory Cytokines
We present a case of secondary adrenal insufficiency caused by a pituitary tumor. During the course of evaluation and treatment, the patient developed a psychotic episode. We will briefly review the condition of adrenal insufficiency and propose how hypocortisolemia can result in psychosis. Keywords: Psychosis, secondary adrenal insufficiency, hypocortisolemia, proinflammatory cytokines Innov Clin Neurosci. 2017;14(9–10):4–10 Incidentally found lesions of the pituitary gland, referred to as “pituitary incidentalomas,” are present in approximately 10 percent of individuals undergoing brain magnetic r...
Source: Innovations in Clinical Neuroscience - September 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue hypocortisolemia proinflammatory cytokines psychosis secondary adrenal insufficiency Source Type: research

An Open-Label Prophylaxis Study of Lithium Plus Extended-Release Carbamazepine (ERC-CBZ) Combination for Rapid Cycling Bipolar Disorder
by Sriram Ramaswamy, MD; David Driscoll, PhD; and Lynette M. Smith, PhD Dr. Ramaswamy is with the Department of Psychiatry, Creighton University School of Medicine, Omaha, Nebraska, and the VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska. Dr. Driscoll is with the VA Nebraska-Western Iowa Health Care System, Omaha, Nebraska. Dr. Smith is with the College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska. Funding/financial disclosures: This work was supported by an investigator-initiated grant from Shire Pharmaceuticals. Keywords: carbamazepine, lithium, rapid cycling, bipolar disorde...
Source: Innovations in Clinical Neuroscience - September 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Letters to the Editor bipolar disorder carbamazepine Lithium rapid cycling Source Type: research

Hot Topics in Neuroscience: Zika Microcephaly
Discussion Zika virus can be detected in almost all body fluids. Its various methods of transmission and sequelae have created global public health concerns. The virus can negatively affect neurologic outcomes of development at all stages of pregnancy; there is evidence to substantiate a significant association between zika infections during gestation and microcephaly.1–8 Despite the World Health Organization and CDC having developed guidelines for pregnant women, there is no proven link to fully verify the confirmed or potential neurological risks during a concurrent zika virus infection.7 It has recently been demon...
Source: Innovations in Clinical Neuroscience - September 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Hot Topics in Neuroscience microcephaly zika Source Type: research

Top 10 Myths about Telepsychiatry
This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professional liability risk. The answers published in this column represent those of only one risk management consulting company. Other risk management c...
Source: Innovations in Clinical Neuroscience - September 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Risk Management telepsychiatry Source Type: research

July –August e-edition
Click here to access e-Edition PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.  The post July–August e-edition appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Drug Development e-Edition Neurology Psychiatry Psychiatry and Neurology Trial Methodology central nervous system CNS ICNS Innovations in Clinical Neuroscience psychotherapy Source Type: research

Immersive Virtual Reality Therapy with Myoelectric Control for Treatment-resistant Phantom Limb Pain: Case Report
Conclusions: Currently available immersive virtual reality technology with myolectric and motion tracking control may represent a possible therapy option for treatment-resistant phantom limb pain. Keywords: virtual reality, phantom limb pain, rehabilitation, amputation, therapy, pain Innov Clin Neurosci. 2017;14(7–8):3–7 Phantom limb pain (PLP), the sensation of pain in an absent limb, is a frequent complication after amputation, with reported prevalence rates ranging from 40 to 85 percent.1,2 While the exact mechanism of PLP remains to be elucidated, peripheral and central neural factors are thought to contrib...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue amputation pain phantom limb pain rehabilitation therapy virtual reality Source Type: research

Methadone Treatment of Opiate Addiction: A Systematic Review of Comparative Studies
Conclusion and Recommendations More intervention-based clinical trials are needed to provide a strong alternative candidate therapy for management of opiate use disorder. Buprenorphine, although a promising candidate, should be researched more regarding treatment retention and patient satisfaction before any conclusions can be made regarding its standard use for opiate substitution maintenance treatment of pregnant patients with opiate use disorder. Heroin-assisted treatment still cannot be considered in opiate addicts refractory to MMT; more data should be collected regarding efficacy in larger participant populations un...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue General Review buphernorphin heroin methadone opiate opiate addiction treatment withdrawal Source Type: research

Narcolepsy in Adolescence — A Missed Diagnosis: A Case Report
We report a case of an adolescent male who presented with all four cardinal symptoms of narcolepsy and had been misdiagnosed with epilepsy, psychosis, and depression. We discuss various issues regarding narcolepsy in children and adolescents. Keywords: narcolepsy, adolescence, misdiagnosis Innov Clin Neurosci. 2017;14(9–10):20–23 Introduction Narcolepsy is an uncommon sleep cycle disorder characterized by the tetrad of chronic excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep paralysis.1 The cardinal symptom of paroxysmal sleep is seen in all patients, whereas other symptoms such as ...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adolescence misdiagnosis narcolepsy Source Type: research

Trazodone for Insomnia: A Systematic Review
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insom...
Source: Innovations in Clinical Neuroscience - July 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research

Editorial Message and Issue Highlights, May –June 2017
Dear Colleagues: Welcome to the May-June 2017 issue of Innovations in Clinical Neuroscience. We start the issue with the review article, “The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review,” by Spiegel et al. Here, the authors describe and discuss human studies that explore acute neural transmission processes of pain, pruritus, and nausea, including how cortical and subcortical networks are activated by these symptoms. Based on the discussed research, the authors then describe potential treatment options for patients w...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Editor's Message: Issue Highlights Amir H. Kalali Innovations in Clinical Neuroscience Source Type: research

The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review
This article reviews the acute neural transmission of pain, pruritus, and nausea symptoms, which can begin in the periphery and/or viscera. The subsequent multiple pathways in the central nervous system that become involved in the processing of these symptoms are also discussed. The authors describe human brain imaging studies that have revealed consistent cortical and subcortical networks  activated by these symptoms, including sensory, limbic, and associative regions. In particular, the authors discuss information revealed by the studies regarding the primary somatosensory cortex, secondary somatosensory cortex, ant...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Neurologic Systems and Symptoms Neurology Pain Review central processing nausea pruritus Source Type: research

Single Nucleotide Polymorphisms and the Central Nervous System: Potential Biomarkers in Identifying Suicide Risk
Conclusion Point of care testing (POC) with immediately available results becomes more important, especially in young adults in whom an escalation in the number and severity of self-destructive behaviors is increasingly associated with fatal outcomes. Other populations of concern would be the active duty military and veterans where suicides are also steadily rising and warrant close monitoring and predictive testing when available. At the very least, it behooves us as clinicians and scientists to further explore and clearly establish the relationship between SNPs and suicidal behaviors. Disclaimer The views expressed here ...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: biomarkers Current Issue Drug Development Genetics Psychiatry Review Suicidality CNS CYP2C19 CYP2D6 pharmacogenomics Single nucleotide polymorphism Single nucleotide polymorphisms SNP SNPs suicide risk Source Type: research

When the Opioid Medications Go Missing: Confidentiality and Safety in Adolescents
Conclusion Clinicians should be aware of state laws regarding consent for alcohol and substance use treatment for minors. While family participation is the ideal strategy for treatment, minors can invoke the right of confidentiality to bar clinicians from sharing information regarding substance use with their families. Clinicians should obtain appropriate consent for communications and maintain confidentiality when possible, but above all ensure the safety of the adolescent while providing optimal care. Advice from peers, hospital ethical committees, and/or attorneys is recommended in these situations. Acknowledgment The a...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Child Adol Mental Disorders Commentary Current Issue Ethics in Psychiatry Substance Use Disorders adolescents confidentiality diversion opioids safety Source Type: research

It ’s Time for Combination Therapies in Multiple Sclerosis
Conclusion In summary, MS?therapies that combine BBB-crossing molecules with peripherally acting MAbs should be a strategy of MS drug development. MS therapies that effectively limit or halt disease progression and improve overall treatment outcomes will need to address the disease mechanisms both inside and outside the CNS. It must also be recognized that the presence of lymphoid-follicle like structures are associated clinically with irreversible disability and, from a pathological perspective, show pronounced demyelination, microglial activation, and loss of neurites in the cerebral cortex.[14] Without addressing such f...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Drug Development Multiple Sclerosis Neurodegenerative Disease Neurology Neuromuscular Disease Psychopharmacology Update on Blood Brain Barrier combination therapies cyclophosphamide disability status laquin Source Type: research

What Can I Do About a Negative Online Review?
Conclusion While the vast majority of online reviews about healthcare professionals are positive, it can be very frustrating to see false, negative, and/or unfair comments posted about one’s professionalism and/or treatment practices or that of one’s clinic. Keep in mind that there are very few options in terms of response, and some responses, such as filing a lawsuit against the poster, will likely not benefit the healthcare professional, and will very likely generate more attention to the accusations in the post. References Attorney General Cuomo secures settlement with plastic surgery franchise that flooded...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Practice Management Risk Management clinician-patient interaction HIPAA online reviews patient relationship Source Type: research