CNS Summit 2018 Abstract Supplement Digital Edition
Click the cover below to access the CNS Summit 2018 Abstract Supplement digital edition! The post CNS Summit 2018 Abstract Supplement Digital Edition appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 30, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Digital Editions Source Type: research

CNS Summit 2018 Abstracts of Poster Presentations
A message from the editor: Dear Colleagues: Welcome to the annual CNS Summit Abstracts of Poster Presentations supplement to Innovations in Clinical Neuroscience. We are pleased to provide you with this reference guide to some of the innovative research that is being presented during CNS Summit 2018. The supplement is also available online by visiting […] The post CNS Summit 2018 Abstracts of Poster Presentations appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 30, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Supplements clinical trials CNS Summit Source Type: research

Mobile Technology
A model for researchers to engage in suicide prevention Presenters: Hendry P,1 Armstrong K,2 Barag J,2 Fowler C,3 Gutierrez N,4, Harkavy-Friedman J,5 Perez E,3 Saillard J,6 Vanover K,6 and Kramer L7 Affiliations: 1Mental Health America, Alexandria, Virginia; 2Premier Research, Durham, North Carolina; 3Otsuka, Princeton, New Jersey; 4Woodland Research Northwest, Rogers, Arkansas; 5American Foundation for Suicide […] The post Mobile Technology appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 27, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Investigative Drug Compounds/Therapies
*Differential treatment effects of TNX- 102 SL, a sublingual formulation of cyclobenzaprine, on dissociative symptoms of derealization and depersonalization in a military-related PTSD population: retrospective analysis of a double-blind randomized study** Presenters: Sullivan GM Affiliations: Tonix Pharmaceuticals, Inc Objective: Dissociative symptoms are associated with trauma disorders including posttraumatic stress disorder (PTSD). This is retrospective analysis […] The post Investigative Drug Compounds/Therapies appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Trial Protocol
Evaluation of collecting human emotions and if it could provide valuable evidence in clinical trials Presenters: Yamamoto R Affiliation: ERT Objective: The goal is to present a pilot project evaluating passively collected emotional data during clinical trials to determine its usefulness in supplementing traditional endpoint data. Design: The 11-person study combined the Columbia Suicide Severity […] The post Trial Protocol appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Rater Assessment And Training
Interrater reliability of the Protokinetics Movement Analysis Software and the Zeno Walkway during Four Step Square Test in individuals with Parkinson’s disease Presenters: Boddy A, Andrea C, Lomaglio M, Murphy J, and Perry L Affiliations: University of St. Augustine and S.T.A.R.S Rehab Objective: There is a growing interest in understanding postural instability in individuals with […] The post Rater Assessment And Training appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Placebo Response
Classical and quantum machine learning applied to predicting placebo response For clinical trials in bipolar disorder: recent results Presenters: Geraci J,1,2Wong B,1 Ziauddin J,1 Jain S,1,3 Leonczyk P,1 and Bishop KI4 Affiliations: 1NetraMark Corp, Toronto, Ontario, Canada; 2Department of Molecular Medicine, Queen’s University, Kingston, Ontario, Canada; 3University of Toronto, Toronto, Ontario, Canada; 4Global Pharma Consultancy, […] The post Placebo Response appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Early Indentification, Predictive Tools, And Imaging
Computerized gait analysis of dual tasks to improve eligibility and outcomes for Alzheimer’s disease clinical trials Presenters: Rosenfeld A, Tolea MI, and Galvin JE Affiliations: Comprehensive Center for Brain Health, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida Objective: Clinical trials in Alzheimer’s disease are expanding to test compounds in the […] The post Early Indentification, Predictive Tools, And Imaging appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Patient Recruitment
Impact and return on investment of patient recruitment campaign in a clinical trial of patients with opioid use disorder Presenters: Ramos J,1 Carter D,1 Romanello S,2 Miller M,3 and Martin W1 Affiliations: 1Alkermes, Inc.; 2PriMedia; 3StudyKIK Background: ALK6428-A302 was a Phase III clinical trial that evaluated the efficacy, safety, and tolerability of low doses of […] The post Patient Recruitment appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Patient Assessment
Do the symptoms that drive the CGI vary by geography? Presenter: Daniel DG and Kott A Affiliation: CRF Bracket Background/Objective: We have previously demonstrated regional differences in measurement of psychiatric symptoms. Global clinical trials in schizophrenia pool data using the Clinical Global Impression (CGI) to assess overall severity of illness. We hypothesized that the symptom […] The post Patient Assessment appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Digital Tools And Technology
Agile development of a prescription digital therapeutic for patients with schizophrenia Presenters: Campellone TR, Smayda KE, and Maricich YA Affiliations: Pear Therapeutics, Boston, Massachusetts Objective: With software-based “digital” therapeutic interventions, product development is agile and data-driven, allowing for continuous product refinement. Compared to existing models of therapeutic development, this approach allows for more rapid clinical […] The post Digital Tools And Technology appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - October 26, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

How exactly to Compose a Diagnostic Essay?
In conclusion may be the trickiest component of a diagnostic essay, and this could be because of enough time restriction. Here, you’ll want to take a few a breath that is deep come up with a strong declaration to get rid of your essay with. Then what you need to do is write it straight down, as well as your essay will be complete. Search for errors After you have completed your essay, it is crucial which you concentrate on finding and mistakes that are rectifying the essay. The key mistakes you’ll want to look for are – punctuation, subject-verb agreement and incorrect usage of tenses. As soon as you fi...
Source: Innovations in Clinical Neuroscience - September 22, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Online Writing Services Source Type: research

Wish to know ‘ Just How Long Have We ’ ve Been Dating? ’
Wish to know ‘Just https://brightbrides.net/ How Long Have We’ve Been Dating?’ A relationship that is strong partners to explore their union and comprehend their experiences and strive to make sure they are better. To achieve dating, reviewing the right times you have got invested together offers you a glimpse for the future. Thus, assessment should arrived at the eye of partners as critical to sustaining their union and get yourself ready for the near future. Couples should assess the following factors when time that is determining in their relationship: Mark Relationship Timeline Developing the schedul...
Source: Innovations in Clinical Neuroscience - September 21, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Brides Photos Gallery Source Type: research

Composing Cause and Effect Essay: Tricks And Tips
Writing English essays is a thing but, composing an underlying cause and effect essay is not so popular. Because entertaining it with ‘so’ as it may sound, your essay should answer why and follow. It really is a standard sort of essay which determines the basis associated with subject and its impacts on a group that is particular individual, or setting. While composing a reason and impact essay appears rather easy for a few, formulating and structuring the main points that you should add and stress on defines whether your essay is cut for the A+ grade or simply another essay that is mediocre. To assist you wi...
Source: Innovations in Clinical Neuroscience - September 21, 2018 Category: Neuroscience Authors: Chris Moccia Tags: High School Writing Services Source Type: research

Hello world
Welcome to wiki This is your first post. Edit or delete it, then start blogging!The post Hello world appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - September 21, 2018 Category: Neuroscience Authors: Chris Moccia Tags: General Source Type: research

The Neuroscience Report —Vol. 53 (August 14, 2018): Binge Eating Disorders
Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information.   This week’s topic: Binge Eating Disorder   5 Journal Articles Binge eating, trauma, and suicide attempt in community adults with major depressive disorder The relationship between body mass index, binge eating disorder, and suicidality Association...
Source: Innovations in Clinical Neuroscience - August 14, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Eating Disorders The Neuroscience Report binge eating disorder Dasotraline lisdexamfetamine dimesylate phentermine–topiramate Source Type: research

Editorial Message
VOL. 15, NO. 5–6 • MAY–JUNE 2018 INNOVATIONSCNS.COM … Read the original article. The post Editorial Message appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - July 2, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Development Of A Behavioral Health Stigma Measure And Application Of Machine Learning For Classification
Conclusion: This study illustrates the potential for applying machine learning to derive a data-driven understanding of the extent to which stigma is prevalent in society. It establishes a framework for the development of an index to track stigma over time and to assist healthcare decision-makers with improving the health of populations and the experience of care for patients. … Read the original article. The post Development Of A Behavioral Health Stigma Measure And Application Of Machine Learning For Classification appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - July 2, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Lessons To Be Learned: A Review Of Post-Suicide Malpractice Lawsuits
This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. Questions and answers are provided by PRMS, Inc. (www.prms. com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professional liability risk. The answers published in this column represent those of only one risk management consulting company. Other risk management consulting companies or insu...
Source: Innovations in Clinical Neuroscience - July 2, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Author Guidelines
Submission requirements for Innovations in Clinical Neuroscience (Online ISSN 2158-8341, Print ISSN 2158-8333) are in accordance with the International Committee of Medical Journal Editors (ICMJE).See Uniform Requirements for Manuscripts Submitted to Biomedical Journals. EDITORIAL PURPOSE … Read the original article. The post Author Guidelines appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - July 2, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

July-August 2018 Digital Edition
Click the cover below to access the July-August 2018 digital edition of Innovations in Clinical Neuroscience! The post July-August 2018 Digital Edition appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Digital Editions Source Type: research

Editorial Message and Issue Highlights –Vol. 15, No. 7–8, July-August 2018
Dear Colleagues: Welcome to the July–August 2018 issue of Innovations in Clinical Neuroscience (ICNS). We start this issue with a report by Brennan et al titled, “Implementation of the Electronic Columbia-Suicide Severity Rating Scale (eCSSRS) Across Four Phase IIIb Clinical Trials in HIV-infected Individuals (ARIA, STRIIVING, DAWNING and INSPIRING).” Here, researchers assessed site perspectives on implementation of the eC-SSRS, which was used in Phase IIIb studies of dolutegravir. Next, in a case report by Teo et al titled, “Atypical Neuroleptic Malignant Syndrome (NMS) Precipitated by Clozapine an...
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Current Issue Editor's Message: Issue Highlights Editorial Message Source Type: research

Worsening Choreoathetosis in Huntington ’s Disease with Fluoxetine, Lisdexamfetamine, and Melatonin: A Case Report
Conclusion Our case is the second to describe worsened choreoathetoid movements with fluoxetine and psychostimulants in HD, and the first with melatonin. These observations are objectified by our patient’s marked improvements in movement and handwriting assessments (Figure 1).   We calculated Naranjo adverse event scores of 5, 5, and 2 for fluoxetine, lisdexamfetamine, and melatonin, respectively, based on several years of this individual’s outpatient medical records and current available literature (Table 1). Due to physiological and biochemical changes associated with HD progression, these medications co...
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Case Report Current Issue Neurodegenerative Disease amphetamine antidepressant chorea dopamine Fluoxetine Huntington’s disease melatonin psychostimulant Source Type: research

Transition from Obsession to Delusion in Schizo-obsessive Disorder: A Case Report and Literature Overview
Conclusion We believe our diagnosis of schizo-obsessive disorder in the described patient is appropriate due to his symptoms of schizophrenia and OCD. The OCS at first seemed to have retarded the psychotic manifestation; however, the negative and cognitive symptoms of schizophrenia associated with OCS were prominent, and we believe this greatly contributed to the poor prognosis of our patient. The improvement of his OCS occurred with the emergence of an over-valued idea, corroborating the existence of a schizo-obsessive spectrum modulated by the presence and extent of phenomenological features related to insight. Therefore...
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Case Report Current Issue Neurodegenerative Disease Schizophrenia comorbidity insight obsessive compulsive disorder Source Type: research

Atypical Neuroleptic Malignant Syndrome Precipitated By Clozapine And Quetiapine Overdose: A Diagnostic Challenge
CONCLUSION In conclusion, NMS is a potentially life-threatening condition with variable clinical presentation. Clinicians should have a high index of suspicion for NMS in patients on antipsychotic medications. NMS can have atypical presentations especially when precipitated by SGAs, such as clozapine and quetiapine. A diagnosis of atypical NMS should be considered even in the absence of rigidity or other classical symptoms. Serum CK should routinely be checked and trended to facilitate diagnosis in these cases. Future research is needed to define and validate threshold scores for existing diagnostic criteria for NMS. REFER...
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Current Issue Neurodegenerative Disease Neurology Original Research antipsychotics clozapine creatine kinase diagnosis drug overdose neuroleptic malignant syndrome quetiapine Source Type: research

Ethical Reflections On Offering Patients Accelerated Resolution Therapy (ART)
In this study, almost 80 percent of the participants responded positively after an average of less than four treatment sessions. The symptoms remained alleviated after two months.[1] In a randomized, controlled trial by Kip et al,[2] 57 U.S. service members/veterans with combat-related PTSD were treated with either the ART-based psychotherapy or an attention control (AC) regimen. The ART was delivered in 3.7±1.1 sessions with a 94-percent completion rate. The investigators reported that mean reductions in symptoms of PTSD, depression, anxiety, and trauma-related guilt were significantly greater (p
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Commentary Current Issue Practice Management Accelerated resolution therapy art cognitive processing therapy CPT ethical principles informed consent patient autonomy posttraumatic stress disorder PTSD Source Type: research

Implementation of the Electronic Columbia-Suicide Severity Rating Scale (eC-SSRS ™) Across Four Phase IIIB Clinical Trials in HIV-Infected Individuals (ARIA, STRIIVING, DAWNING and INSPIRING)
Conclusion: Results of the eC-SSRS from ARIA and STRIIVING were consistent with the clinical data. The eC-SSRS identified previous unreported risk for suicidality and provided physicians opportunity for follow-up. Respondents felt the eC-SSRS helps them manage suicide risk, and they reported that its administration became easier with experience. Thus, the eC-SSRS is considered a useful tool in this setting. Keywords: dolutegravir, HIV-1, integrase inhibitor, eC-SSRS, suicide risk assessment Innov Clin Neurosci. 2018;15(7–8):15–19 Apart from human immunodeficiency virus (HIV) infection/acquired immunodeficiency ...
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Current Issue Original Research Suicidality dolutegravir eC-SSRS HIV-1 integrase inhibitor suicide risk assessment Source Type: research

Risk Management: Licensing Board Complaints: What You Need To Know
By Ann McNary, JD Ms. McNary is Senior Risk Manager at PRMS, Inc. in Arlington, Virginia. Funding: No funding was provided for the preparation of this article. Disclosures: The authors have no conflicts of interest relevant to the content of this article. Innov Clin Neurosci. 2018;15(7–8):35–37 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk man...
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Current Issue Risk Management Source Type: research

Letter to the Editor: Metabolic Changes in Patients with Schizophrenia Switched from Olanzapine to Asenaprine or Clozapine
Conclusion The relationships between the potency of 5-HT2C blockade and hypertriglyceridemia and the potency of M3 blockade and glucose intolerance were shown in clinical setting. Receptor-binging profiles might be useful to estimate metabolic effect of antipsychotics-treatment. References Meyer JM, Davis VG, Goff DC, et al. Change in metabolic syndrome parameters with antipsychotic treatment in the CATIE Schizophrenia Trial: prospective data from phase 1. Schizophr Res. 2008;101: 273–286. Salvi V, Mencacci C, Barone-Adesi F. H1-histamine receptor affinity predicts weight gain with antidepressants. Eur Neuropsychoph...
Source: Innovations in Clinical Neuroscience - July 1, 2018 Category: Neuroscience Authors: Chris Moccia Tags: Current Issue Letters to the Editor Asenaprine clozapine olanzapine schizophrenia Source Type: research

Journal Watch
Highlights of noteworthy, peer-reviewed, evidence-based articles on neuroscience … Read the original article. The post Journal Watch appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - June 30, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Combination Phentermine –Topiramate Extended Release For The Treatment Of Binge Eating Disorder: An Open- Label, Prospective Study
ABSTRACT … Read the original article. The post Combination Phentermine–Topiramate Extended Release For The Treatment Of Binge Eating Disorder: An Open- Label, Prospective Study appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - June 30, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

News And Trends
Exploring Neuroscience Research in the Media … Read the original article. The post News And Trends appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - June 30, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Calendar Of Events
Upcoming Events in Neuroscience Research for Healthcare Professionals … Read the original article. The post Calendar Of Events appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - June 30, 2018 Category: Neuroscience Tags: Adverse Events in Psychiatry Brief Report Source Type: research

Editorial Message and Issue Highlights –Vol. 15, No. 5–6, May-June 2018
Dear Colleagues: Welcome to the May–June 2018 issue of Innovations in Clinical Neuroscience (ICNS). We start the issue with a timely review article by Touma and Scarff titled, “Valbenazine and Deutetrabenazine for Tardive Dyskinesia (TD).” Here, the authors discuss the two drugs, which were recently approved by the United States Food and Drug Administration (FDA) for the treatment of TD. The authors describe the drugs’ unique mechanisms of action as well as the evidence supporting their efficacy, tolerability, dosing, drug interactions, and precautions. Next, in the article titled “Combinatio...
Source: Innovations in Clinical Neuroscience - May 2, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Editor's Message: Issue Highlights Editorial Message Source Type: research

Risk Management: Lessons to Be Learned: A Review of Post-suicide Malpractice Lawsuits
Conclusion There are important lessons to be learned from reviewing malpractice claims and understanding the types of allegations that are frequently asserted against clinicians. By taking these into consideration, clinicians might be able to correct potential problems in their own practices and thus improve patient care—which, of course, is always the very best risk management strategy. References O’Sullivan v Presbyterian Hosp. in City of N.Y. at Columbia Presbyt. Med. Ctr., 217 AD2d 98, 100 [1995] American Psychiatric Association. The Principles of Medical Ethics: With Annotations Especially Applicable to P...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Risk Management Source Type: research

Letter to the Editor: Effective Pain Control in Hutchinson-Gilford Progeria Syndrome
Discussion. Patients with HGPS frequently suffer from acute and chronic pain because of musculoskeletal abnormalities and unintentional injuries. These injuries occur because of bone deformities, malfunctioning joints, and gait problems.2 Opioid pain medications are frequently used to treat acute pain conditions and for palliative care management in these cases.4 Clinicians should be aware that, because of accelerated aging, individuals with HGPS differ in their response to specific opioid analgesics. The metabolism and the rate of elimination of opioids from the body could vary significantly in these patients. They might ...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Letters to the Editor Pain pain management Source Type: research

May-June 2018 Digital Edition
Click the cover below to access the May-June 2018 digital edition of Innovations in Clinical Neuroscience! The post May-June 2018 Digital Edition appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Digital Editions Source Type: research

Atrial Fibrillation and Injected Aripiprazole: A Case Report
Conclusion In summary, although it is not possible to exclude confounding factors, the timing and dose-dependent effect of aripiprazole administration in our patient suggests an association between an initial intramuscular injection of long-acting aripiprazole and new onset of AF. This observation calls for clinical vigilance, not only in patients with additional risk factors for stroke but also in younger patients who might have predisposing factors for arrhythmias. References CPS (Canadian Pharmacists Association). Available at: http://www.e-therapeutics.ca. Accessed January 1, 2017. Polcwiartek C, Sneider B, Graff C,...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adverse effects aripiprazole atrial fibrillation schizoaffective disorder Source Type: research

Development of a Behavioral Health Stigma Measure and Application of Machine Learning for Classification
Conclusion: This study illustrates the potential for applying machine learning to derive a data-driven understanding of the extent to which stigma is prevalent in society. It establishes a framework for the development of an index to track stigma over time and to assist healthcare decision-makers with improving the health of populations and the experience of care for patients. Mental illness constitutes 13 percent of the global burden of disease and is projected to be 15 percent by 2020.1 It affects a significant portion of the United States population. Nearly half of all Americans are estimated to meet the criteria for a ...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review Behavioral health decision tree machine learning social stigma stigma index Source Type: research

Delirium and Psychotic Symptoms Associated with Hyperglycemia in a Patient with Poorly controlled Type 2 Diabetes Mellitus
We present the case of an 80-year-old woman, single with no children, who lived alone, and, up until presentation, was able to perform activities of daily living self-sufficiently. She reported to have the support of friends and neighbors, and she lived in the small community of São Miguel Island, Azores, Portugal. She had completed two years of college before dropping out during her third year, and her last job was as an elder care-worker. She had no personal or family psychiatric antecedents and no history of alcohol or illicit drug addictions. The patient was diagnosed with DM2 two years previously and was treate...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue acute confusional state delirium diabetes hyperglycemia psychosis Source Type: research

Effects of Lisdexamfetamine Dimesylate on Functional Impairment Measured on the Sheehan Disability Scale in Adults With Moderate-to-severe Binge Eating Disorder: Results from Two Randomized, Placebo-controlled Trials
We describe the effects of LDX (50mg and 70mg) on the Sheehan Disability Scale (SDS; exploratory endpoint) from both studies. Design: The SDS was assessed at baseline, Week 6, and Week 12/early termination. Analyses included mixed-effects models for repeated measures for the examination of SDS total and domain score changes and a generalized estimating equation model to assess dichotomized remission status (remission [total score ?6] versus nonremission [total score>6]). Results: Least squares (95% confidence interval [CI]) mean treatment differences for SDS total score change from baseline at Week 12 were -2.80 (-3.98,...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Drug Development Original Research binge eating disorder disability functionality lisdexamfetamine dimesylate Sheehan Disability Scale Source Type: research

Combination Phentermine –Topiramate Extended Release for the Treatment of Binge Eating Disorder: An Open-Label, Prospective Study
Conclusion: Phentermine–topiramate could be helpful for weight loss and reduction of binge-eating symptoms in patients with obesity or overweight in addition to BED. Controlled studies are warranted. Binge-eating disorder (BED), an eating disorder recognized in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), is characterized by recurrent and distressing episodes of binge eating (eating an unusually large amount of food with a sense of loss of control over eating) without inappropriate compensatory weight-loss behaviors.1 Known as the most common eating disorder, BED is strongly assoc...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Drug Development Original Research binge eating obesity phentermine–topiramate Qsymia® weight loss Source Type: research

Valbenazine and Deutetrabenazine for Tardive Dyskinesia
The objective of this review is to discuss the efficacy, tolerability, dosing, drug interactions, and precautions for valbenazine and deutetrabenazine. Tardive dyskinesia (TD) is defined as involuntary athetoid or choreiform movements lasting at least a few weeks and generally involving the tongue, face, and/or extremities, which develops in association with a neuroleptic medication usage for at least a few months.1 TD occurs in 32.4 percent of patients who receive typical antipsychotics and in 13.1 percent of patients who receive atypical antipsychotics.2 The pathophysiology of antipsychotic-induced TD is attributed to pr...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review deutetrabenazine tardive dyskinesia Valbenazine Source Type: research

Latest e-Edition of ICNS
Click here to access the latest e-Edition PDFs can be downloaded and printed from the e-Editions. Click on the above issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window.  The post Latest e-Edition of ICNS appeared first on Innovations in Clinical Neuroscience. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools Current Issue Drug Development Patient Assessment Psychiatry Psychopharmacology Scales Schizophrenia Trial Methodology Source Type: research

Editorial Message and Issue Highlights –Vol. 15, No. 3–4, March-April 2018
This article is a must-read for everyone—clinicians, researchers, big pharma, and small biotechs alike. Next, in a review article titled, “Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury,” Borghol et al review the evidence on the efficacy of modafinil use in patients with fatigue or excessive daytime sleepiness (EDS) following traumatic brain injury (TBI). The authors conclude that while modafinil appears to have the potential to improve wakefulness in patients with TBI, randomized, controlled research is needed before a determination on modafinil’s use in this pat...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Editor's Message: Issue Highlights Source Type: research

Letters to the Editor
We reported a sporadic case of olanzapine-induced rapid-onset Type 2 diabetes with severe hyperglycemia.2 In our case, the patient was negative for anti-glutamic acid decarboxylase antibodies, and the discontinuation of olanzapine and careful insulin replacement regimen reversed diabetes. A common feature between these two cases is acute-onset severe hyperglycemia. The first presentation of diabetes associated with olanzapine might be diabetic ketoacidosis (DKA), requiring admission to an intensive care unit. Patients exposed to antipsychotics have approximately 10 times increased risk of DKA compared to the general popula...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Letters to the Editor Source Type: research

Neuroscience is the Next Oncology
by Michael D. Ehlers, MD, PhD Dr. Ehlers is with Biogen in Cambridge, Massachusetts. Innov Clin Neurosci. 2018;15(3–4):15–16 Funding: No funding was received for the preparation of this article. Disclosures: Dr. Ehlers is an employee and shareholder at Biogen Inc. in Cambridge, Massachusetts. Prominent and expensive failures in Alzheimer’s disease therapies have led to a contagious belief system in some parts of the biopharma industry that neuroscience is just too hard, too risky, and too uncertain. But, might this belief system itself be a residual bias of the past? Close inspection reveals all the signs...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Commentary Current Issue Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple scleros...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research