Editor ’s Message: Issue Highlights, January–February 2017
Dear Colleagues: Welcome to the January–February 2017 issue of Innovations in Clinical Neuroscience. We start our 14th year of publication strong with an interesting and diverse issue we hope you enjoy as much as we did putting it together. In the review article by Dascal et al, “Virtual Reality and Medical Inpatients: A Systematic Review of Randomized, Controlled Trials,” the researchers evaluate the evidence supporting the use of virtual reality among patients in acute inpatient medical settings. The authors found that virtual reality in the medical setting has demonstrated some efficacy, but they concl...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Editor's Message: Issue Highlights Source Type: research

Behavioral and Stereological Analysis of the Effects of Intermittent Feeding Diet on the Orally Administrated MDMA ( “ecstasy”) in Mice
In this study, we investigated the behavioral and histological outcomes of the effect of intermittent feeding on the orally administered MDMA in mice. Methods—The animals (male albino mice) were divided into four groups: ad libitum (AL), intermittent feeding (IF) (food given every other day), and AL and IF control groups. After five weeks, AL and IF groups were given a single oral dose of 20 or 60mg/kg MDMA. Behavior was assessed with the elevated plus-maze and the open field tests. Each of the treatment groups were then divided in to two groups: AL-AL (AL diet throughout), AL-IF (IF after MDMA administration), IF-IF...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Current Issue Original Research Psychiatry Substance Use Disorders Elevated plus-maze hippocampus intermittent feeding MDMA neuronal numerical density open field Source Type: research

MicroRNAs as Biomarkers for Psychiatric Conditions: A Review of Current Research
Conclusion Neural miRNAs are responsive to environmental, synaptic, and pathological changes and are actively secreted by cells as exosomes from brain into blood. While serum miRs cannot cross the blood brain barrier (BBB), naturally occurring exosomes are capable of crossing the BBB. These exosomes bear cell-type specific surface markers. Using a neural-specific surface marker, neural-derived exosomes can be successfully isolated and can be used as diagnostic markers for many psychiatric conditions. For example, brain-derived exosomes are fused with neuron-specific RVG peptide (rabies virus glycoprotein, a peptide known t...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: biomarkers Bipolar Disorder Current Issue Depression Psychiatry Review Schizophrenia hippocampus messengerRNA (mRNA) MicroRNA (miR/miRNA) neurogenesis neuronal plasticity Source Type: research

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

Risk Management Issues When Taking Locum Tenens Assignments
by Charles D. Cash, JD, LLM Mr. Cash is Assistant Vice President of Risk Management at PRMS, Inc., Arlington, Virginia. Innov Clin Neurosci. 2017;14(1–2)60–62 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient ou...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Practice Management Psychiatry Risk Management liability Locum Tenens malpractice Source Type: research

Letters to the Editor: Discussing sexual health after traumatic brain injury: an unmet need!
In conclusion, taking into account the high prevalence of SD in men with TBI and its multifactorial etiology, we believe clinicians who treat patients with TBI should be properly trained in human sexuality in order to better meet the needs of these patients. Clinicians should be prepared to have frank, educated discussions on sexual functioning with all of their TBI patients so that they may provide valuable information to their patients on achieving healthy sexual functioning; this in turn will help their patients and their patients’ partners achieve a higher quality of life. References Bivona U, Antonucci G, Contr...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Behavioral and Cognitive Neurology Current Issue Evaluations Letters to the Editor Medical Issues Neurologic Systems and Symptoms Traumatic Brain Injury clinician-patient interaction sexual dysfunction TBI Source Type: research

The Neuroscience Report —Volume 47 (December 6, 2016): Psychology of Technology in Society
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Psychology of Technology in Society Journal Articles Virtual Detox: Inpatient Therapy for Internet Addicts The Effect of Distance on Moral Engagement: Event Related Potentials and Alpha Power are Sensitive to Perspective i...
Source: Innovations in Clinical Neuroscience - December 6, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Devices Psychology Technology The Neuroscience Report society Source Type: research

Editors Message and Issue Highlights: November –December 2016
Dear Colleagues: Welcome to the November–December 2016 issue of Innovations in Clinical Neuroscience. We begin this issue with a thoughtful review and commentary by Calabró et al titled, “The Right to Die in Chronic Disorders of Consciousness: Can We Avoid the Slippery Slope Argument?” Here the authors review current opinions and ethical issues concerning end-of-life decisions in patients with disorders of consciousness (DOCs) (i.e., vegetative state, minimally conscious state), including the impact misdiagnoses of DOCs may have on end-of-life decisions, the concept of “dignity” and &ld...
Source: Innovations in Clinical Neuroscience - December 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Editor's Message: Issue Highlights Source Type: research

Acute Hyperglycemia Associated with Psychotic Symptoms in a Patient with Type 1 Diabetes Mellitus: A Case Report
Conclusion Clinicians should consider inadequate glycemic control as a potential cause of acute-onset psychotic episodes in patients with diabetes. Our case highlights the importance of first stabilizing these patients’ glycemic levels before prescribing antipsychotics, especially atypical antipsychotics, which may exacerbate hyperglycemia and thus potentially worsen the psychosis. If other pathologies are ruled out and an association between hyperglycemia and psychotic symptoms is established, these patients may benefit from benzodiazepines, as these drugs will not exacerbate hyperglycemia and may help calm the pati...
Source: Innovations in Clinical Neuroscience - December 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Medical Issues Primary Care Psychiatry Schizophrenia Acute psychosis diabetes mellitus hyperglycemia organic psychosis Source Type: research

Complete Recovery from Cardiac Arrest Caused by Risperidone-induced Hypothermia
Conclusion Our patient presented to the ER in a state of cardiac arrest. We were able to successfully resuscitate her without complication. Based on her very low body temperature and the presence of J-waves on her ECG, we speculated that hypothermia was the cause of the cardiac arrest. The patient did not have any medical conditions known to cause hypothermia nor had she been subjected to unusually cold temperatures; however, she was taking risperidone, an antipsychotic known to cause hypothermia. Thus, we deduced that our patient’s hypothermia was caused by risperidone. After being stabilized, our patient was switch...
Source: Innovations in Clinical Neuroscience - December 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Medical Issues Psychiatry Schizophrenia Cardiac arrest hypothermia J-wave risperidone Source Type: research

Sympathetic Nerve Entrapment Point Injection as an Antireflux Procedure for Refractory Laryngopharyngeal Reflux: A First Case Report of Innovative Autonomic Regulation
Conclusion Hyperexcitability of T5 and T6 sympathetic preganglionic fibers appears to be the main etiology of LPR. SNEPI can reduce LES relaxation and improve blood flow to the mucosa, thereby increasing the stability of the vagus reflex and laryngopharyngeal mucosal defense factors. To the best of our knowledge, this case represents the first report of a patient with LPR refractory to PPIs who was successfully treated with SNEPI alone. SNEPI can be considered as an alternative to anti-reflux procedures. References 1. Vakil N, van Zanten SV, Kahrilas P, et al. Global Consensus Group. The Montreal definition and classificat...
Source: Innovations in Clinical Neuroscience - December 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Medical Issues Neurologic Systems and Symptoms Neurology antireflux procedure autonomic regulation laryngopharyngeal reflux refractory Sympathetic nerve entrapment point injection Source Type: research

Ransomware: Minimizing the Risks
by Justin Pope, JD Mr. Pope is Associate Risk Manager at PRMS, Inc. in Arlington, Virginia. Innov Clin Neurosci. 2016;13(11–12)37–40 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professi...
Source: Innovations in Clinical Neuroscience - December 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Digital Medicine Practice Management Risk Management Technology computer system data security EHR electronic health record hacker HIIPA malware ransomware Source Type: research

Differential Diagnoses: Encephalopathy or Psychosis?
by Malathi Latha Perugula, MD, and Steven Lippmann, MD The authors are from the Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, Kentucky. Innov Clin Neurosci. 2016;13(11–12):41–42 This column series compares neurological conditions that pose differential challenges in diagnoses. Funding: No funding was provided for the preparation of this article. Financial disclosures: The authors have no conflicts of interest relevant to the content of this article. Introduction Encephalopathy and psychosis are two separate mental states that are both characterized by ...
Source: Innovations in Clinical Neuroscience - December 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: CNS Infections Current Issue Differential Diagnoses Medical Issues Mental Disorders Neuro oncology Neurologic Systems and Symptoms Neurology Psychiatry Schizophrenia Substance Use Disorders encephalopathy psychosis Source Type: research

The Neuroscience Report —Volume 46 (November 11, 2016): Accessibility of Mental Healthcare
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information.   This week’s topic: Accessibility of Mental Healthcare Journal Articles Moving Out of the Office: Removing Barriers to Access to Psychiatrists Factors for Success in Mental Health Advocacy Acceptance of Insurance by Psychiatr...
Source: Innovations in Clinical Neuroscience - November 11, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Medical Issues Practice Management Primary Care Psychiatry Psychotherapy The Neuroscience Report access to mental healthcare physician shortage Source Type: research

Editor ’ s Message: September –October 2016 Issue Highlights
Dear Colleagues: Welcome to the September-October 2016 issue of Innovations in Clinical Neuroscience (ICNS). As the official journal of the CNS Summit, the International Society for CNS Drug Development (ISCDD), and the International Society for CNS Clinical Trials and Methodology (ISCTM), an important part of our editorial mission is to accelerate and enhance of the development of cheaper, more effective treatments for our patients through technology, collaboration, and innovation—not just in neuroscience but in all disciplines of medicine and among all involved entities, including clinicians, researchers, and membe...
Source: Innovations in Clinical Neuroscience - October 9, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Editor's Message: Issue Highlights Neurology Psychiatry Trial Methodology Amir H. Kalali CNS Summit Innovations in Clinical Neuroscience ISCDD ISCTM Source Type: research

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder
We report here an overview of the Depression Inventory Development initiative, including results of the third iteration of items assessing symptoms related to anhedonia, cognition, fatigue, general malaise, motivation, anxiety, negative thinking, pain and appetite. The strategies adopted from the Depression Inventory Development program, as an empirically driven and collaborative process for scale development, have provided the foundation to develop and validate measurement tools in other therapeutic areas as well. Introduction The Hamilton Depression Rating Scale (HAMD)[1] and Montgomery–Åsberg Depression Rati...
Source: Innovations in Clinical Neuroscience - October 9, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Depression Mood Disorders Patient Assessment Psychiatry Review Scales Trial Methodology depressive symptoms item response theory major depressive disorder rating scales Source Type: research

Eszopiclone-induced Parasomnia with Suicide Attempt: A Case Report
Conclusion The possibility for adverse effects, including life-threatening events, when taking eszopiclone should be considered by all prescribers. The pharmacological profile of eszopiclone suggests a potential for a greater risk of adverse events than with other benzodiazepine-like hypnotics such as zolpidem, which has a one-percent risk for sleep-related amnestic behaviors.[10] This risk increases further with concomitant administration of monoaminergic drugs like SSRIs. The risk for these behaviors among patients taking eszopiclone is yet to be quantified and presents an opportunity for future research endeavors. Regar...
Source: Innovations in Clinical Neuroscience - October 9, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Mood Disorders Psychiatry Psychopharmacology Sleep Disorders benzodiazepine-like drug reaction Eszopiclone hypnotic insomnia parasomnia sedative Source Type: research

Cariprazine for Schizophrenia and Bipolar Disorder
This article reviews mechanisms of action, efficacy, tolerability (including adverse effects), dosing, and contraindications of cariprazine. Introduction Schizophrenia is characterized by at least two of the following symptoms: delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, or negative symptoms.[1] Bipolar disorder consists of manic, hypomanic, or mixed episodes alternating with depressive episodes.[2] Because second-generation or atypical antipsychotics reduce both positive and negative symptoms of schizophrenia as well as manic and mixed episodes of bipolar disorder, they are recommen...
Source: Innovations in Clinical Neuroscience - October 8, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Bipolar Disorder Current Issue Mood Disorders Psychiatry Psychopharmacology Review Schizophrenia antipsychotic cariprazine mania mixed episode Source Type: research

Consent to Treatment of Minors, Revisited
by Ann McNary, JD Ms. McNary is Senior Risk Manager at PRMS, Inc. in Arlington, Virginia. Innov Clin Neurosci. 2016;13(9–10)53–55 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient outcomes and reduce professiona...
Source: Innovations in Clinical Neuroscience - October 8, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Child Adol Mental Disorders Current Issue Practice Management Psychiatry Psychology Psychotherapy Risk Management child and adolescent psychiatry consent of minor patient assent patient consent Source Type: research

The Neuroscience Report —Volume 45 (September 15, 2016): Schizophrenia
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Schizophrenia Journal Articles Brexpiprazole: A New Treatment Option for Schizophrenia Efficacy and Safety of Pharmacological and Psychological Interventions for the Treatment of Psychosis and Schizophrenia in Children, A...
Source: Innovations in Clinical Neuroscience - September 15, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Mental Disorders Psychiatry Schizophrenia The Neuroscience Report Source Type: research

Editor ’s Message—Issue Highlights, July–August 2016
Dear Colleagues: Welcome to the July–August 2016 issue of Innovations in Clinical Neuroscience. We start this issue with an interesting study by MacEwan et al titled, “Pharmaceutical Innovation in the Treatment of Schizophrenia and Mental Disorders Compared with Other Diseases.” Here, the authors assessed the level of private and public investment in research and development (R&D) of treatments for schizophrenia and other mental disorders and compared this to other diseases. They present their data on the economic burden and pharmaceutical innovation by disease area and compare the level of investment...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Editor's Message: Issue Highlights Neurology Psychiatry Amir Kalali Innovations in Clinical Neuroscience Source Type: research

Pharmaceutical Innovation in the Treatment of Schizophrenia and Mental Disorders Compared with Other Diseases
Conclusion: Despite the significant burden mental disorders impose on society, investment and pharmaceutical innovation in this disease area remains comparatively low. Policymakers should consider new strategies to stimulate public and private investment in the research and development of novel and effective therapies to treat schizophrenia and other mental disorders. Introduction Over the last two decades, there have been remarkable breakthroughs in healthcare. These breakthroughs include the development of novel pharmaceutical treatments that have significantly improved outcomes for patients suffering from various medica...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Bipolar Disorder Current Issue Drug Development Mental Disorders Mood Disorders Original Research Psychiatry Psychopharmacology disease burden expenditures major depressive disorder pharmaceutical innovation research and developmen Source Type: research

Brexpiprazole: A New Treatment Option for Schizophrenia
Conclusion Schizophrenia is a debilitating condition with significant morbidity and mortality. Many atypical antipsychotics improve functioning, but they carry risks for adverse effects. Brexpiprazole reduced symptoms of acute schizophrenia and prevented relapse with minimal adverse effects. It is an additional option for clinicians who treat patients with schizophrenia, and ongoing trials are assessing its efficacy as an adjunctive treatment for patients with posttraumatic stress disorder or behavioral disturbances associated with dementia. Disclaimer The views expressed in this article are those of the author and do not ...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Psychiatry Psychopharmacology Review Schizophrenia antipsychotic brexpiprazole Source Type: research

The Potential Role of T Helper Cell 22 and IL-22 in Immunopathogenesis of Multiple Sclerosis
Conclusion Recent evidence shows changes in frequency and function of Th22 and its cytokine IL-22 in patients with MS, which suggests a potential relationship between Th22 cells, IL-22 levels, and the development and disease course of MS and its response to treatment. How Th22 cells and IL-22 levels affect the disease course of MS requires further elucidation. Additional studies on the immunopathogenesis of MS, specifically the roles Th22 cells and IL-22 cytokines may play in disease progression, are warranted and may lead to the development of new therapeutic strategies for treating neuro-inflammatory diseases, such as MS...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Demyelinating Disease Genetics Multiple Sclerosis Neurology Review interleukin-22 T helper 22 Source Type: research

A Case of Treatment-resistant Depression and Body Dysmorphic Disorder: The Role of Electroconvulsive Therapy Revisited
Conclusion and Recommendations ECT has an important place in the management of treatment-resistant depression associated with BDD and, in select patients such as ours, may be effective for dysmorphic symptoms as well. It is currently not possible to identify such patients. However, BDD is said to be underestimated,21 and useful indications for ECT may emerge as the ascertainment of BDD in depressed populations becomes more refined. Previous studies establishing the efficacy of ECT in MDD may have unknowingly included and successfully treated a significant number of patients with BDD, given the elevated comorbidity of these...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue ECT Mood Disorders Neurology Psychiatry Suicidality BDD body dysmorphic disorder depression Electroconvulsive therapy suicide attempt treatment-resistant Source Type: research

Professional Liability for Forensic Activities: Liability Without a Treatment Relationship
by Donna Vanderpool, MBA, JD Ms. Vanderpool is Vice President of Risk Management at PRMS, Inc., Arlington, Virginia. Innov Clin Neurosci. 2016;13(7–8):41–44 This ongoing column is dedicated to providing information to our readers on managing legal risks associated with medical practice. We invite questions from our readers. The answers are provided by PRMS, Inc. (www.prms.com), a manager of medical professional liability insurance programs with services that include risk management consultation, education and onsite risk management audits, and other resources to healthcare providers to help improve patient out...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Evaluations Forensic Files Mental Disorders Practice Management Psychiatry Risk Management court of law expert testimony forensics liability psychiatric evaluation treatment relationship Source Type: research

Fahr ’ s Disease or Fahr ’ s Syndrome?
by Malathi Latha Perugula, MD, and Steven Lippmann, MD The authors are from the Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, Louisville, Kentucky. Innov Clin Neurosci. 2016;13(7–8):45–46 This column series compares neurological conditions that pose differential challenges in diagnoses. Funding: No funding was provided for the preparation of this article. Financial Disclosures: The authors have no conflicts of interest relevant to the content of this article. What’s Your Diagnosis? Fahr’s disease and Fahr’s syndrome are two conditions characte...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Dementia Differential Diagnoses Neurodegenerative Disease Neurology autosomal dominant trait autosomal recessive trait basal ganglia calcification Fahr's Syndrome Fahr’s disease Source Type: research

Criminal Behavior and Borderline Personality: Correlations among Four Measures
Innov Clin Neurosci. 2016;13(7–8):15–16 Dear Editor: Borderline personality disorder (BPD) is over-represented in prison populations, with 25 to 50 percent of incarcerated individuals suffering from this disorder.[1] As an empirical illustration of this association, Sansone et al[2] reported correlations of 0.32 and 0.47 between 27 criminal behaviors and two measures of BPD. Given these evolving associations between criminal behavior and BPD, no study to date has compared the strength of these associations among more than two assessment measures for BPD in a less criminally inclined sample (e.g., psychiatric in...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Letters to the Editor Personality Disorders Primary Care Psychiatry borderline personality disorder criminal behavior Source Type: research

Letter to the Editor: Gabapentin Abuse in a Patient with Comorbid Mood and Substance Use Disorders
Conclusion. Collectively, behavioral changes that include dose escalation and/or self-administration of gabapentin or withdrawal symptoms and/or indications of relapse into illicit drug use following the abrupt discontinuation of gabapentin are indicative of gabapentin misuse. Prescribing clinicians should take these factors into consideration when prescribing gabapentin and educate their patients about its risks. In particular, clinicians should closely monitor those patients with sigificant histories of comorbid mood and substance use disorders when prescribing gabapentin due to the increased risk of gabapentin’s m...
Source: Innovations in Clinical Neuroscience - August 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Bipolar Disorder Letters to the Editor Mental Disorders Mood Disorders Psychiatry Psychopharmacology Substance Use Disorders comorbidity gabapentin Source Type: research

The Neuroscience Report —Volume 44 (July 19, 2016): What ’ s Hot in Neuroimaging?
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: What’s Hot in Neuroimaging? Journal Articles How Can Neuroimaging Facilitate the Diagnosis and Stratification of Patients with Psychosis? Functional Neuroimaging of Traumatic Brain Injury: Advances and Clinical Utili...
Source: Innovations in Clinical Neuroscience - July 19, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Devices Drug Development EEG Genetics Neurology Psychiatry Technology The Neuroscience Report computed tomography electroencephalogram functional magnetic resonance imaging Magnetoencephalography neuroimaging P Source Type: research

The Neuroscience Report—Volume 44 (July 19, 2016): What’s Hot in Neuroimaging?
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: What’s Hot in Neuroimaging? Journal Articles How Can Neuroimaging Facilitate the Diagnosis and Stratification of Patients with Psychosis? Functional Neuroimaging of Traumatic Brain Injury: Advances and Clinical Utili...
Source: Innovations in Clinical Neuroscience - July 19, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Devices Drug Development EEG Genetics Neurology Psychiatry Technology The Neuroscience Report computed tomography electroencephalogram functional magnetic resonance imaging Magnetoencephalography neuroimaging P Source Type: research

The Neuroscience Report —Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Medical Marijuana in Neuroscience Journal Articles Systematic Review: Efficacy and Safety of Medical Marijuana in Selected Neurologic Disorders Medical Marijuana for Epilepsy? The Use of Medicinal Marijuana for Posttraumat...
Source: Innovations in Clinical Neuroscience - June 24, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Alzheimer's Disease Anxiety Disorders Dementia Epilepsy Neurodegenerative Disease Neurologic Systems and Symptoms Neurology Pain Psychiatry The Neuroscience Report Traumatic Brain Injury medical marijuana Source Type: research

The Neuroscience Report—Volume 43 (June 25, 2016): Medical Marijuana in Neuroscience
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Medical Marijuana in Neuroscience Journal Articles Systematic Review: Efficacy and Safety of Medical Marijuana in Selected Neurologic Disorders Medical Marijuana for Epilepsy? The Use of Medicinal Marijuana for Posttraumat...
Source: Innovations in Clinical Neuroscience - June 24, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Alzheimer's Disease Anxiety Disorders Dementia Epilepsy Neurodegenerative Disease Neurologic Systems and Symptoms Neurology Pain Psychiatry The Neuroscience Report Traumatic Brain Injury medical marijuana Source Type: research

The Neuroscience Report —Volume 42 (June 13, 2016): Neuroethics
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Neuroethics Journal Articles Neuroethics: A Modern Context for Ethics in Neuroscience Brain Matters: From Environmental Ethics to Environmental Neuroethics The Is and Ought of the Ethics of Neuroenhancement: Mind the ...
Source: Innovations in Clinical Neuroscience - June 13, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Ethics in Psychiatry Neurology The Neuroscience Report bioethics neuroethics neuroscience research Source Type: research

The Neuroscience Report—Volume 42 (June 13, 2016): Neuroethics
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Neuroethics Journal Articles Neuroethics: A Modern Context for Ethics in Neuroscience Brain Matters: From Environmental Ethics to Environmental Neuroethics The Is and Ought of the Ethics of Neuroenhancement: Mind the ...
Source: Innovations in Clinical Neuroscience - June 13, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Ethics in Psychiatry Neurology The Neuroscience Report bioethics neuroethics neuroscience research Source Type: research

Editor ’ s Message and May –June 2016 Issue Highlights
Dear Colleagues: Welcome to the May–June 2016 issue of Innovations in Clinical Neuroscience. I am pleased to start the issue with the first of a series of articles we’ll be publishing that will explore the emerging field of digital medicine and how innovative technology can improve patient outcomes in the field of neuroscience. I am honored to coauthor the series with Drs. Arshya Vahabzadeh and Ned Sahin from BrainPower, a company that develops brain science-driven software for wearables (e.g., Google Glass™) into neuro-assistive devices for the educational challenges of autism. In our first installment, ...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Editor's Message: Issue Highlights Neurology Psychiatry Amir H. Kalali Innovations in Clinical Neuroscience Source Type: research

Editor’s Message and May–June 2016 Issue Highlights
Dear Colleagues: Welcome to the May–June 2016 issue of Innovations in Clinical Neuroscience. I am pleased to start the issue with the first of a series of articles we’ll be publishing that will explore the emerging field of digital medicine and how innovative technology can improve patient outcomes in the field of neuroscience. I am honored to coauthor the series with Drs. Arshya Vahabzadeh and Ned Sahin from BrainPower, a company that develops brain science-driven software for wearables (e.g., Google Glass™) into neuro-assistive devices for the educational challenges of autism. In our first installment, ...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Editor's Message: Issue Highlights Neurology Psychiatry Amir H. Kalali Innovations in Clinical Neuroscience Source Type: research

Digital Suicide Prevention: Can Technology Become a Game-changer?
by Arshya Vahabzadeh, MD; Ned Sahin, PhD; and Amir Kalali, MD Dr. Vahabzadeh is Director of Digital Health, Brain Power, in Cambridge, Massachusetts; Instructor in Psychiatry, Harvard Medical School in Cambridge, Massachusetts; and Innovation Officer at Massachusetts General Hospital Psychiatry Academy in Boston, Massachusetts. Dr. Sahin is Chief Science Officer at Brain Power and Associate in Psychology at Harvard University in Cambridge, Massachusetts; and Dr. Kalali is Global Head of the Neuroscience Center of Excellence at Quintiles and Professor of Psychiatry at the University of California, San Diego, California. In...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Depression Digital Medicine Drug Development Mental Disorders Mood Disorders Psychiatry Suicidality Technology Trial Methodology big data data sharing machine learning medical devices medical technology suicidal Source Type: research

Physician Prescribing Practices of Vitamin D in a Psychiatric Hospital
This study and literature review will examine prescribing practices, prescriber rationale for use, and the impact of vitamin D levels on psychiatric disorders. Literature Review/ Introduction Vitamin D deficiency is a worldwide problem affecting as many as one billion people, and it is estimated that 20 to 100 percent of American, Canadian, and European elderly men and women are deficient.[8],[9] According to the Endocrine Society’s Clinical Practice Guideline on the Prevention of Vitamin D Deficiency in 2011, a serum vitamin D (25[OH]D) level of 21 to 29ng/mL (52.5–72.5nmol/L) is insufficient, and a level less...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Bipolar Disorder Current Issue Depression Medical Issues Mood Disorders Movement Disorders Multiple Sclerosis Neurodegenerative Disease Neuromuscular Disease Original Research Pr Source Type: research

Prolactin Levels After Switching to Paliperidone Palmitate in Patients with Schizophrenia
Conclusion: Switching from paliperidone-extended release or risperidone long-acting injectable to paliperidone palmitate did not result in any observed time-sequential changes in psychotic symptoms in study subjects, and prolactin levels decreased in male subjects switched from risperidone long-acting injectable. As measurement of paliperidone concentrations is limited in routine practice, a fluctuation range of prolactin levels may be a useful marker for confirmation of safety maintenance treatment with long-acting injectables in clinical settings. Introduction Schizophrenia is a chronic and recurrent psychiatric disorder...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Original Research Psychiatry Psychopharmacology Schizophrenia Paliperidone palmitate paliperidone-ER Prolactin risperidone long-acting injectable switching Source Type: research

The Standard for Clinicians ’ Interview in Psychiatry (SCIP): A Clinician-administered Tool with Categorical, Dimensional, and Numeric Output— Conceptual Development, Design, and Description of the SCIP
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research

The Standard for Clinicians’ Interview in Psychiatry (SCIP): A Clinician-administered Tool with Categorical, Dimensional, and Numeric Output— Conceptual Development, Design, and Description of the SCIP
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research

Remission of Psychosis in Treatment-resistant Schizophrenia Following a Seizure: A Case Report
Discussion Improvement in our patient’s mental state was very drastic and very closely temporally associated with the occurrence of the seizure. Clozapine-induced seizures are known to occur, as clozapine decreases the seizure threshold, and the cumulative one-year risk of seizure is about five percent.[4] In our patient, the dose of clozapine was high and there was no other comorbid medical or neurological condition that could explain the seizure, leading us to the conclusion that the seizure was caused by clozapine. ECT has been effective in improving patients on clozapine, and as ECT is based on the mechanism of s...
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue ECT Epilepsy Neurology Psychiatry Schizophrenia clozapine electroconvulsive therapy (ECT) seizure Treatment-resistant schizophrenia (TRS) Source Type: research

Exit Strategy: Planning for the Unexpected Closure of Your Practice
Conclusion Once drafted, your plan should be regularly updated to reflect changes in your practice and the practices of the colleagues who have agreed to assist in an emergency. Remember to include contact information for others who may be able to assist your family and/or staff, such as your malpractice carrier and your business attorney. The plan need not be complex, but it must be documented and readily available to anyone who may need to implement it. Your patients, your staff, and your family will thank you for it. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - June 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Practice Management Psychiatry Risk Management exit strategy office closing Source Type: research

The Neuroscience Report—Volume 41 (May 20, 2016): Human Brain vs. Artificial Intelligence
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Human Brain vs. Artificial Intelligence Journal Articles Consciousness: A Neural Capacity for Objectivity, Especially Pronounced in Humans Restructuring Consciousness—the Psychedelic State in Light of Integrated Information...
Source: Innovations in Clinical Neuroscience - May 20, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Cognition Drug Development Genetics Neurology Psychiatry The Neuroscience Report Trial Methodology Source Type: research

The Neuroscience Report—Volume 40 (May 6, 2016): Anti-addiction Medications
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Anti-addiction Medications Journal Articles Zonisamide, Topiramate, and Levetiracetam: Efficacy and Neuropsychological Effects in Alcohol Use Disorders Preliminary Evidence for Normalization of Risk Taking by Modafinil in Chronic...
Source: Innovations in Clinical Neuroscience - May 6, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Psychopharmacology Substance Use Disorders The Neuroscience Report Source Type: research

The Neuroscience Report—Volume 39 (April 11, 2016): Rapid-acting Antidepressants
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Rapid-acting Antidepressants Journal Articles Potential of Glutamate-Based Drug Discovery for Next Generation Antidepressants Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as The...
Source: Innovations in Clinical Neuroscience - April 11, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development Mood Disorders Psychiatry Psychopharmacology The Neuroscience Report glutamate Ketamine N-methyl-D-aspartate NMDA rapid acting antidepressant Source Type: research

March–April 2016—Volume 13, Issue 1–2
The March–April 2016 issue of Innovations in Clinical Neuroscience will be posted soon. Please check back! In the meantime, please enjoy these special supplements to the journal:   Hot Topics in Drug Development     Hot Topics in Pain Management     Current Trends in Epilepsy     CNS Summit 2015 Poster Abstracts     ISCTM March-April 2015 Supplement     Special Suicide Issue (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - April 3, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Source Type: research

Hot Topics in Drug Development
PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - April 3, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development Genetics Neurology Psychiatry Psychopharmacology Supplements Trial Methodology Source Type: research

Editor’s Message and Issue Highlights
Dear Colleagues: Welcome to the March–April 2016 issue of Innovations in Clinical Neuroscience (ICNS). Attitudes regarding marijuana use have changed dramatically over the past 50-plus years in the United States. According to data from the Pew Research Center, support for the legalization of marijuana has gone from 12 percent of the American population in favor of legalization in 1969 to 53 percent in 2015.[1] As of today, nearly half of American states allow the distribution and use of marijuana for medical purposes, 14 states have decriminalized marijuana use, and four states have passed measures to fully legalize ...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Editor's Message: Issue Highlights Neurology Psychiatry Psychopharmacology Trial Methodology Innovations in Clinical Neuroscience Source Type: research