Why Not Pot? A Review of the Brain-based Risks of Cannabis
Conclusion Evaluating the potential harms of a commonly used drug—especially a complex substance like marijuana—is a challenging but vital task. Fully informed awareness of both the potential and proven benefits and the potential and proven harms of marijuana are necessary in order to have rational discussions with patients, teens, and decision makers regarding marijuana use. Based on a review of the current literature, we suggest the mnemonic DDUMB (dependence, driving, underachievement, mental illness, and “bad to worse”) as a tool that captures several of the more well-supported, brain-based risk...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Behavioral and Cognitive Neurology Child Adol Mental Disorders Cognition Current Issue Medical Issues Neurologic Systems and Symptoms Psychiatry Psychopharmacology Review Substance Use Disorders Cannabis dependence drug-related har Source Type: research

Medical Marijuana for Epilepsy?
Conclusion For those whose seizures remain uncontrolled without alternative conventional interventions available, medical marijuana has received anecdotal support, but only on an empirical basis. Any clinical trial is appropriate only in selected refractory cases and only when strictly monitored by a physician. Being illegal in many jurisdictions remains a concern. There is a dearth of controlled scientific investigations reported on cannabidiol as an epilepsy control medication. Reportedly, there is no evidence for interactions between CBD and approved anticonvulsant drugs.13 The varied legal status of marijuana, unregula...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Behavioral and Cognitive Neurology Current Issue Drug Development Epilepsy Hot Topics in Neuroscience Medical Issues Neurologic Systems and Symptoms Substance Use Disorders Source Type: research

Inter-rater Reliability Assessment of ASPECT-R (A Study Pragmatic-Explanatory Characterization Tool-Rating)
Conclusion: The inter-rater reliability of the ASPECT-R total score was excellent, with excellent to good inter-rater reliability for most domains. The fair to poor inter-rater reliability for two domains may reflect a need for improved domain definition, anchoring, or training materials. ASPECT-R can be used to help understand the pragmatic-explanatory nature of completed or planned trials. Introduction Clinical trials have characteristics that are pragmatic (i.e., effectiveness studies asking whether an intervention works under usual or real-world conditions) and/or explanatory (i.e., asks whether an intervention works u...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Original Research Trial Methodology ASPECT-R explanatory Inter-rater reliability Intraclass correlation coefficient pragmatic real-world trial design Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and th...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Managing the Suicidal Patient in a Split-treatment Relationship
Conclusion The elements for increased liability risk are present in split treatment relationships, but each individual situation must be evaluated to understand its particular risk profile. The risk analysis must include the risks inherent in the treatment of the particular patient (What are this patient’s clinical needs?), coupled with an evaluation of the risks presented by the shared relationship (How does the split treatment complicate/increase problems in meeting the standard of care for this patient? Are there ways to manage those risks so that you are satisfied that patient care needs are being met?). Risk man...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Practice Management Risk Management Suicidality risk managmenet split treatment suicide Source Type: research

Hot Topics in Pain Management
CLICK HERE TO ACCESS E-EDITION PDFs can be downloaded and printed from the e-Editions. Click on the above issue issue, find the article, then click on the print command. For archived e-editions, click on the image above, then click on the folder icon at the top of the window. (Source: Innovations in Clinical Neuroscience)
Source: Innovations in Clinical Neuroscience - March 28, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Neurologic Systems and Symptoms Neurology Neuropathies Pain Patient Assessment Supplements Source Type: research

The Neuroscience Report—Volume 38 (March 22, 2016): Building Better Clinical Trials
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Building Better Clinical Trials Journal Articles ASPECT-R—A Tool to Rate the Pragmatic and Explanatory Characteristics of a Clinical Trial Design Data Quality Monitoring in Clinical Trials: Has It Been Worth It? An Evaluati...
Source: Innovations in Clinical Neuroscience - March 22, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development The Neuroscience Report Trial Methodology clinical trials FDA Source Type: research

The Neuroscience Report—Volume 37 (March 4, 2016): Motivational Interviewing
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Motivational Interviewing Journal Articles The Psychiatrist’s Guide to Motivational Interviewing Motivational Pharmacotherapy: Combining Motivational Interviewing and Antidepressant Therapy to Improve Treatment Adherence ...
Source: Innovations in Clinical Neuroscience - March 4, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Medical Issues Mental Disorders Primary Care Psychiatry Psychology Psychotherapy The Neuroscience Report change therapy motivational interviewing patient adherence Source Type: research

Editor’s Message and Issue Highlights, January–February 2016
Dear Colleagues: Welcome to the January–February 2016 issue of Innovations in Clinical Neuroscience. We start this issue with the article “Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study,” by Calabró et al. Here, the investigators evaluated the prevalence and causes of erectile dysfunction in a group of hospital inpatients suffering from neurologic disorders. The subjects were divided into two groups according to their lesion sites: G1 (lesions above the S2–S4 center) and G2 (lesions below the S2–S4 center). The authors found that e...
Source: Innovations in Clinical Neuroscience - February 23, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Editor's Message: Issue Highlights Neurology Psychiatry Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the ...
Source: Innovations in Clinical Neuroscience - February 22, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

The Neuroscience Report—Volume 36 (February 19, 2016): Heart Disease and Depression
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Heart Disease and Depression Journal articles High Sensitivity C Reactive Protein, Fibrinogen Levels, and the Onset of Major Depressive Disorder in Post-acute Coronary Syndrome The Impact of Pre-morbid and Post-morbid Depression ...
Source: Innovations in Clinical Neuroscience - February 19, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Depression Medical Issues Mood Disorders Primary Care Psychiatry The Neuroscience Report affective disorders cardiac disease cardiovascular disease heart attack heart disease major depressive disorder MDD Source Type: research

ASPECT-R—A Tool to Rate the Pragmatic and Explanatory Characteristics of a Clinical Trial Design
Conclusion: This new tool, ASPECT-R, should provide a reliable, objective way to rate studies along the explanatory-pragmatic spectrum that will better support trial design and facilitate interpretation of completed trials. The complete ASPECT-R tool and guide materials can be accessed online by clicking or visiting this link: http://innovationscns.com/aspect-r-tool-and-training-materials/. Introduction Clinical trial designs differ considerably with respect to whether they are conducted under highly controlled and defined conditions (explanatory) or more broadly reflect real world circumstances (pragmatic). These differen...
Source: Innovations in Clinical Neuroscience - February 16, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Brief Report Current Issue Drug Development Trial Methodology ASPECT-R explanatory pragmatic trial design Source Type: research

Data Quality Monitoring in Clinical Trials: Has It Been Worth It? An Evaluation and Prediction of the Future by All Stakeholders
by the CNS SUMMIT Data Quality Monitoring WORKGROUP CORE MEMBERS—David Daniel, MD; Amir Kalali, MD; Mark West; David Walling, PhD; Dana Hilt, MD; Nina Engelhardt, PhD; Larry Alphs, MD, PhD; Antony Loebel, MD; Kim Vanover, PhD; Sarah Atkinson, MD; Mark Opler, PhD, MPH; Gary Sachs, MD; Kari Nations, PhD; and Chris Brady, PsyD Dr. Daniel is with Bracket Global, Washington, DC; Dr. Kalali is with Quintiles, San Diego, California; Mr. West is with Innovum Technologies, Las Vegas, Nevada (Mr. West was with ePharma Solutions, Plymouth Meeting, Pennsylvania, during the preparation of this executive summary); Dr. Walling is w...
Source: Innovations in Clinical Neuroscience - February 16, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Executive Summary Proceedings Report Trial Methodology Clinical Trial Methodology clinical trials CNS data monitoring Data quality trial design Source Type: research

The Neuroscience Report—Volume 35 (February 12, 2016): Anxiety in Children and Teens
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Anxiety in Children and Teens  Journal Articles A Randomized Controlled Trial to Test the Effectiveness of an Immersive 3D Video Game for Anxiety Prevention among Adolescents Irritable Bowel Syndrome: Relationships with Abus...
Source: Innovations in Clinical Neuroscience - February 12, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Child Adol Mental Disorders Psychiatry The Neuroscience Report adolescents Children posttraumatic stress disorder PTSD teenagers Source Type: research

Quetiapine-induced Bradycardia and Hypotension in the Elderly—A Case Report
Conclusion We suggest that clinicians remain vigilent for signs or symptoms of adverse effects in their elderly patients who take SGAs. Elderly patients with histories of heart failure, myocardial infarction, and/or conduction abnormalities may be particularly vulnerable to cardiac abnormalities while on quetiapine, particularly at higher dosages, and thus should be continually and closely monitored for any symptoms of cardiac distress. References 1. Gareri P, De Fazio P, De Fazio S, et al. Adverse effects of atypical antipsychotics in the elderly: a review. Drugs Aging. 2006;23:937–956. 2. Nielsen J, Graff C, Kanter...
Source: Innovations in Clinical Neuroscience - February 10, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Behavioral and Cognitive Neurology Case Report Current Issue Dementia Medical Issues Neurodegenerative Disease Psychopharmacology Substance Use Disorders bradycardia hypotension quetiapine second generation antipsychotic Source Type: research

Amyotrophic Lateral Sclerosis with Frontotemporal Dementia in the Presence of C9orf72 Repeat Expansion—A Case Report
We report a case of a patient with autosomal dominant amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) in the presence of C9orf72 repeat expansion. We believe our case further supports the theory that the presence of C9orf72 repeat expansion in patients with a family history of amyotrophic lateral sclerosis and/or frontotemporal dementia significantly increases their risk of developing either or both diseases. The development of antisense oligonucleotides that might target GGGGCC RNA sequences theoretically may have a therapeutic role in mitigating the clinical expression of these illnesses. Introduction...
Source: Innovations in Clinical Neuroscience - February 10, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Behavioral and Cognitive Neurology Case Report Current Issue Dementia Genetics Neurodegenerative Disease Amyotrophic lateral sclerosis C9orf72 gene frontotemporal dementia GGGGCC repeat expansion neurodegenerative dementia Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based, Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the ...
Source: Innovations in Clinical Neuroscience - February 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

eTect Announces Initiation of a Clinical Study Using Its Novel Ingestion Event Monitoring System to Reliably Track Opioid Use for Pain Management
This study has been designed to evaluate use of the ID-Cap System in monitoring and improving medication adherence. Additional clinical validation studies in partnership with pharmaceutical companies, the NIH, and academic research organizations are planned for 2016. eTect’s technology enables an objective measurement of medication ingestion with real-time reporting of time-stamped dose ingestion events, ensuring that this important information is available to doctors who need it to provide the best care to their patients. The ID-Cap System allows a definitive understanding of medication-taking behavior that has the ...
Source: Innovations in Clinical Neuroscience - January 26, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: News Event Monitoring System ingestible tracking device opioids patient adherence patient compliance Source Type: research

The Neuroscience Report—Volume 34 (January 25, 2016): Patient Adherence
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Patient Adherence Journal Articles Nonadherence with Antipsychotic Medication in Schizophrenia: Challenges and Management Strategies There’s an App for That: A Guide for Healthcare Practitioners and Researchers on Smartphon...
Source: Innovations in Clinical Neuroscience - January 25, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Devices Drug Development Medical Issues Neurology Patient Assessment Practice Management Primary Care Psychiatry Psychopharmacology The Neuroscience Report Trial Methodology patient adherence patient compliance treatment adherenc Source Type: research

The Neuroscience Report—Volume 33 (January 11, 2016): Bipolar Disorder
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: Bipolar Disorder Journal Articles A Critical Appraisal of Neuroimaging Studies of Bipolar Disorder: Toward a New Conceptualization of Underlying Neural Circuitry and Roadmap for Future Research All the World’s a (...
Source: Innovations in Clinical Neuroscience - January 11, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Bipolar Disorder Cognition Mental Disorders Mood Disorders Patient Assessment Psychiatry Psychopharmacology Psychotherapy The Neuroscience Report This week's Neuroscience Report depression mania Source Type: research

The Neuroscience Report—Volume 32 (December 28, 2015): The Power of Placebo
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This week’s topic: The Power of Placebo Journal Articles Placebo Effects in Medicine Placebo and Nocebo Effects in the Neurological Practice Rethinking Psychopharmacotherapy: The Role of Treatment Context and Brain Plasticity in Antidepre...
Source: Innovations in Clinical Neuroscience - December 28, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Psychology Psychiatry Neurology Trial Methodology Psychopharmacology Drug Development The Neuroscience Report Psychotherapy clinical trials Placebo placebo effect placebo response nocebo effect clinical studies Source Type: research

The Neuroscience Report—Volume 31 (December 21, 2015): Hottest of the Hot in Neuroscience: 2015
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This weeks topics: 2015’s “Hottest of the Hot” in Neuroscience We’ve compiled a list of neuroscience topics that, in our opinion, comprises the “Hottest of the Hot” of 2015—these were the topi...
Source: Innovations in Clinical Neuroscience - December 23, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Psychiatry Neurology Primary Care Drug Development The Neuroscience Report Source Type: research

The Neuoroscience Report—Volume 30 (December 14, 2015): Memory
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Memory Journal Articles Time-based Loss in Visual Short-Term Memory is from Trace Decay, not Temporal Distinctiveness Does Stress Remove the HDAC Brakes for the Formation and Persistence of Long-term Memory? Workin...
Source: Innovations in Clinical Neuroscience - December 14, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Alzheimer's Disease Psychiatry Neurology Dementia The Neuroscience Report memory short term memory long term memory Source Type: research

Editor’s Message and Issue Highlights: November–December 2015
Dear Colleagues: Welcome to the November–December 2015 issue of Innovations in Clinical Neuroscience. First, I would like to call your attention to the accompanying supplement to this issue of the journal, a compendium of abstracts from the 2015 CNS Summit poster presentations. Each year, the CNS Summit brings together drug development leaders from pharma, research sites, and related service companies to address key issues in drug development—in a noncompetitive, interactive, collaborative environment. The poster presentations allow CNS Summit participants to share innovations in drug development research and t...
Source: Innovations in Clinical Neuroscience - December 2, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Editor's Message: Issue Highlights Source Type: research

Supplement to Nov-Dec 2015 Issue: Abstracts of Poster Presentations: CNS Summit 2015
This study compared the next-day residual effects of acute and steady-state nighttime doses of flibanserin (100mg/day and 200mg/day) on simulated driving performance and cognition in healthy female subjects. Objective: To test for negative effects on measures of next-day simulated driving performance and cognitive testing Methods: Healthy, premenopausal females (18–-50 years of age) were randomized to flibanserin (100mg or 200mg), zopiclone (7.5mg), or matching placebos the evening prior to testing in a double-blind, placebo-controlled, Latin-square design, with four-way, four-period crossover (n=83). Zopiclone was s...
Source: Innovations in Clinical Neuroscience - December 2, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Genetics Supplements Trial Methodology CNS Summit poster presentation abstracts Source Type: research

The Direct and Indirect Effects of Paliperidone Extended-release on Depressive Symptoms in Schizoaffective Disorder: A Path Analysis
Conclusion: Results of this analysis suggest that paliperidone’s effect on depressive symptoms in subjects with schizoaffective disorder participating in two six-week, randomized, placebo-controlled studies is mediated through indirect effects (e.g., positive and negative symptom changes) and a direct treatment effect. Introduction Patients with schizoaffective disorder (SCA) often experience complex symptomatology that is characterized by psychotic, depressive, and manic symptoms.[1–3] To manage these diverse symptom groupings, healthcare providers (HCPs) often use mood stabilizers and/or antidepressants in co...
Source: Innovations in Clinical Neuroscience - December 2, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Bipolar Disorder Current Issue Depression Mood Disorders Original Research Psychiatry Psychopharmacology Schizophrenia depressive symptoms direct effects paliperidone path analysis schizoaffective disorder Source Type: research

Sinus Node Dysfunction After Acute Lithium Treatment at Therapeutic Levels
Conclusion Our case strongly suggests that sinus node dysfunction of lithium can occur even with lithium levels in the therapeutic range and in short-term “acute” treatment. Therefore, patients receiving lithium therapy should have their pulse monitored regulatory for any rhythm abnormalities, and lithium should be discontinued if rhythm disturbances occur during treatment. Further, when prescribing lithium, clinicians should regularly monitor their patients’ ECG and serum lithium levels to prevent serious or fatal complications. Acknowledgment The authors would like to thank our colleagues throughout Kos...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Psychiatry Psychopharmacology Schizophrenia cardiac toxicity ECG Lithium sinus node dysfunction therapeutic level Source Type: research

Probable Nootropic-induced Psychiatric Adverse Effects: A Series of Four Cases
Conclusion Healthcare providers in general, and specifically those in the mental health and substance abuse fields, should keep in mind that nootropic use is an under recognized and evolving problem. Nootropic use should be considered in cases where there are sudden or unexplained exacerbations of psychiatric symptoms in patients who have been stable and medication adherent. It is also important to remember that most nootropics are not detected on standard drug toxicology screening tests. We have very little clinical information on how nootropics may interact with psychotropics (or other medications) and potentially cause ...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Series and Literature Review Current Issue Mental Disorders Psychiatry Psychopharmacology Substance Use Disorders Ampakines Armodafinil brain enhancer Cerebrolysin Citicoline cognitive enhancer homeopathic medicine natural r Source Type: research

Accountable Care Organizations and Professional Liability Risk
This article focuses on the impact an ACO may have on medical malpractice litigation. Issues related to forming an ACO or other integrative care model, and the significant associated risks to the entity (e.g., the Stark law, anti-kickback statute, and antitrust issues) are beyond the scope of this article. In some collaborative care models, the actual liability risks may not change Psychiatrists already can be held liable for the acts of other professionals. In a medical malpractice action, the plaintiff’s attorney has a professional obligation to pursue every possible defendant. This means that a psychiatrist who ha...
Source: Innovations in Clinical Neuroscience - December 1, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Practice Management Risk Management Accountable Care Organizations professional liability risk Source Type: research

The Neuroscience Report—Volume 29 (November 30, 2015): PTSD
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: PTSD Journal Articles Effects of Escitalopram on Autonomic Function in Posttraumatic Stress Disorder Among Veterans of Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Multimodal Approach to Identifying Mali...
Source: Innovations in Clinical Neuroscience - November 30, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Psychiatry The Neuroscience Report posttraumatic stress disorder PTSD Source Type: research

The Neuroscience Report—Volume 28 (November 16, 2015): Personalized Medicine
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Personalized Medicine Journal Articles Taking Personalized Medicine Seriously: Biomarker Approaches in Phase IIb/III Studies in Major Depression and Schizophrenia Towards a Phenome-wide Catalog of Human Clinical T...
Source: Innovations in Clinical Neuroscience - November 16, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development Genetics Medical Issues The Neuroscience Report biomarkers epigenetics personalized medicine RDoC Source Type: research

The Neuroscience Report—Volume 27 (November 9, 2015): Parkinson’s Disease
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Parkinson’s Disease Journal Articles Electroconvulsive Therapy Intervention for Parkinson’s Disease Temporal Fluctuations of Tremor Signals from Inertial Sensor: A Preliminary Study in Differentiating ...
Source: Innovations in Clinical Neuroscience - November 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Movement Disorders Neurologic Systems and Symptoms Neurology Parkinson's disease The Neuroscience Report parkinson’s disease Source Type: research

The Neuroscience Report—Volume 26 (October 26, 2015): Autism Spectrum Disorder
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Autism Spectrum Disorder Journal Articles Association Between Antidepressants Use During Pregnancy and Autistic Spectrum Disorders: A Meta-analysis Autism Spectrum Disorder Reclassified: A Second Look at the 1980s Utah...
Source: Innovations in Clinical Neuroscience - October 26, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Asperger's syndrome Autism Pervasive development disorder, NOS Pervasive Developmental Disorders Primary Care Psychiatry Psychotherapy The Neuroscience Report This week's Neuroscience Report autism spectrum disorder Autistic Source Type: research

The Neuroscience Report—Volume 25 (October 18, 2015): Duplicate Patients in Clinical Trials
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Duplicate Subjects in Clinical Trials Journal Articles CNS Sites Cooperate to Detect Duplicate Subjects with a Clinical Trial Subject Registry Failure Rate and “Professional Subjects” in Clinical Trials of ...
Source: Innovations in Clinical Neuroscience - October 20, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development The Neuroscience Report This week's Neuroscience Report Trial Methodology clinical trial dual enrollment duplicate patient duplicate subject patient recruitment Source Type: research

The Neuroscience Report—Volume 24 (October 12, 2015): Treatment Paradigm Shifts in CNS
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Treatment Paradigm Shifts in CNS Dr. Pani: “Medicine is dead. Biology is dead.” Dr. Tucson: “What’s alive?” Dr. Pani: “Information…DNA is Information…DNA teaches us tha...
Source: Innovations in Clinical Neuroscience - October 12, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development Genetics Neurology Psychiatry The Neuroscience Report This week's Neuroscience Report clinical trials CNS disruption paradigm shift Source Type: research

Editor’s Message and Issue Highlights, September–October 2015
Dear Colleagues: Welcome to the September–October 2015 issue of Innovations in Clinical Neuroscience. We start this issue with an intriguing review by Yarlagadda et al titled,“Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain.” Here the authors explore a possible link between in-utero exposure to a high maternal prolactin/dopamine ratio and subsequent development of autism spectrum disorder (ASD). The authors hypothesize that a comprehensive, biologically oriented approach to the use of psychotropics in the regulation of neurotransmission dur...
Source: Innovations in Clinical Neuroscience - October 10, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Editor's Message: Issue Highlights Amir H. Kalali Innovations in Clinical Neuroscience Source Type: research

Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain
Conclusion In summary, placenta being the most invasive tissue, to establish the hypothesized altered genetic transcription as the cause for complex phenotypic expressions in PDD, hormonal and environmental causes need to be ruled out. A pilot study to compare the ratios of prolactin/dopamine and oxytocin/GABA in gestational periods (20–40 weeks) as well as in the placenta would, in our opinion, provide valuable insights into the etiology of PDD. Alternative approaches may include the measurement of autoantibodies directed to the GABA-generating enzyme, glutamate decarboxylase 65 (GAD65), which have been detected in ...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Autism Behavioral and Cognitive Neurology Current Issue Mental Disorders Mood Disorders Pervasive Developmental Disorders Primary Care Psychiatry Psychopharmacology Review autism spectrum disorders (ASD) dopamine fetal brain gaba Source Type: research

The Effect of Carnitine Supplementation on Hyperammonemia and Carnitine Deficiency Treated with Valproic Acid in a Psychiatric Setting
Conclusion: In valproic acid-treated psychiatric patients,  carnitine supplementation resulted in overall improvement in mental status. Improvement of hyperammonemia and carnitine deficiency in this group may be related to mitochondrial function. Introduction Valproic acid (valproate, VPA) is a branched, medium-chain fatty acid agent having a broad-spectrum antiepileptic action. In the psychiatry clinical setting, VPA is frequently used for several psychiatric disorders as a mood stabilizer and combined with various types of antipsychotics.[1] Adverse reactions to VPA involve neurological, hematopoietic, hepatic, and ...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Bipolar Disorder Current Issue Epilepsy Mental Disorders Neurology Original Research Psychiatry Psychopharmacology Schizophrenia Traumatic Brain Injury carnitine deficiency hyperammonemia Levocarnitine psychiatric setting valpr Source Type: research

Electroconvulsive Therapy Intervention for Parkinson’s Disease
Conclusion: Motoric improvement induced by electroconvulsive therapy has been documented for decades in persons with Parkinson’s disease. Efficacy and safety are reported following electroconvulsive therapy in people with Parkinson’s disease who have sub-optimal response to medicines or experience the “on/off” phenomenon to L-dopa. Electroconvulsive therapy is an effective option for acute and maintenance treatment of Parkinson’s disease in select patients. Inability to predict how long the beneficial effects of ECT therapy will last in patients with Parkinson’s disease may be a reason w...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Devices ECT Movement Disorders Neurology Parkinson's disease Review Electroconvulsive therapy motor symptoms parkinson’s disease “on-off” phenomenon Source Type: research

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 R...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

Aripiprazole for Treatment of Apathy
Conclusion: Aripiprazole may be useful for treatment of apathy syndrome. Its role in treatment of apathy requires further investigation in clinical trials. Introduction Apathy is a profound loss of motivation not attributed to decreased level of consciousness, cognitive impairment, or emotional distress.[1] Apathy refers to a set of behavioral, emotional, and cognitive features such reduced interest and participation of activities of daily life. Another prime characteristic is lack of initiative or an absence of responsiveness to stimuli as demonstrated by a lack of self initiated action.[2] Apathy is highly prevalent in n...
Source: Innovations in Clinical Neuroscience - October 8, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Mood Disorders Psychiatry Psychopharmacology apathy aripiprazole depression Source Type: research

Letter to the editor: Resident and Patient Responses to the Institution of Required Narcotic Agreements in an Internal Medicine Outpatient Clinic
In this study, we examined whether a change in clinic policy from recommended narcotic agreements (Time-1) to required narcotic agreements (Time-2) would improve resident contracting and/or have any effect on patient behavior (as measured by provider requests for urine drug testing) in an internal medicine resident-provider outpatient clinic (30 providers). Participants consisted of 299 patients, 223 of whom provided data at Time-1 (during the period of recommended narcotic agreements) and 76 of whom entered the practice during Time-2 (after the initiation of required narcotic agreements). Of the 223 patients seen during t...
Source: Innovations in Clinical Neuroscience - October 8, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Letters to the Editor Original Research Primary Care Substance Use Disorders Adherence contract substance abuse Source Type: research

Letter to the editor: Healthcare Adherence Among Patients Who Report the Self-Sabotage of Their Own Medical Care
Dear Editor: Adherence to recommendations provided by healthcare professionals to patients is of keen importance to salutary outcomes. However, patients may, for a number of reasons, be nonadherent. Given that the area of medication adherence is well studied, patient rationales for nonadherence may include, but are not limited to, forgetfulness, concerning side effects, cost of treatment, the availability of insurance coverage, ambivalence about the necessity of treatment, concerns about the potential for addiction and withdrawal with medication, pharmacy access, and regimen complexity.[1,2] In addition, there may be psych...
Source: Innovations in Clinical Neuroscience - October 8, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Letters to the Editor Mental Disorders Primary Care Psychiatry Adherence mental illness Source Type: research

The Neuroscience Report—Vol. 23 (October 5, 2015): Traumatic Brain Injury
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Traumatic Brain Injury Journal Articles Altered Cognitive Control Activations after Moderate-to-Severe Traumatic Brain Injury and Their Relationship to Injury Severity and Everyday-Life Function Is Routine Repeated Hea...
Source: Innovations in Clinical Neuroscience - October 5, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Behavioral and Cognitive Neurology Epilepsy Headache Mood Disorders Neurologic Systems and Symptoms Patient Assessment Primary Care Psychiatry The Neuroscience Report Concussion TBI traumatic brain injury Source Type: research

The Neuroscience Report—Vol. 22 (September 28, 2015): Epigenetics
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Epigenetics Journal Articles Epigenetic Changes in the Developing Brain: Effects on Behavior Stress and the Dynamic Genome: Steroids, Epigenetics, and the Transposome Heading Off Depressive Illness Evolution and Progre...
Source: Innovations in Clinical Neuroscience - September 29, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Drug Development Genetics Neurology Psychiatry The Neuroscience Report DNA epigenetics genomics methylation Source Type: research

The Neuroscience Report—Vol. 21 (September 21, 2015): Emerging Trends in Neuroscience
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Emerging Trends in Neuroscience Journal Articles The Impact of Neuroscience on Society: Cognitive Enhancement in Neuropsychiatric Disorders and in Healthy People Efficacy of Transcranial Magnetic Stimulation (TMS) in t...
Source: Innovations in Clinical Neuroscience - September 22, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Cognition Devices Neurology Psychiatry Psychopharmacology The Neuroscience Report This week's Neuroscience Report artificial intelligence cognitive enhancement deep brain stimulation fMRI neurodevices neuroenhancement wearable ne Source Type: research

The Neuroscience Report—Vol. 20 (September 14, 2015): Pain
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Pain Journal Articles Chronic Pain Syndromes and Borderline Personality Why Psychotherapy Helps the Patient in Chronic Pain Herpes Zoster and Postherpetic Neuralgia: An Examination of Psychological Antecedents A Novel ...
Source: Innovations in Clinical Neuroscience - September 17, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Bipolar Disorder Headache Mental Disorders Mood Disorders Multiple Sclerosis Neurologic Systems and Symptoms Neurology Neuropathies Pain Personality Disorders Practice Management Psychiatry Schizophrenia Sleep Source Type: research

The Neuroscience Report—Vol. 19 (September 7, 2015): Children and Sleep
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Children and Sleep Journal Articles Novel Mechanisms, Treatments, and Outcome Measures in Childhood Sleep Sleepwalking and Sleep Terrors in Prepubertal Children: What Triggers Them? Insomnia and Attention Deficit Hyper...
Source: Innovations in Clinical Neuroscience - September 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Behavioral and Cognitive Neurology Child Adol Mental Disorders Cognition Sleep Disorders The Neuroscience Report adolescents and sleep children and sleep CNS Innovations in Clinical Neuroscience neuroscience of sleep Source Type: research

The Neuroscience Report—Vol. 18 (August 31, 2015): Death, Dying, and Grief
The latest in neuroscience—sorted and summarized for you Welcome to The Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. This Week’s Topic: Death, Dying, and Grief Journal Articles Near-Death Experiences and Psychotherapy “Helping the Angels:” A Review of Understanding and Helping Dying Children Physician Grief with Patient Death The Bereavemen...
Source: Innovations in Clinical Neuroscience - August 31, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Psychiatry Psychology The Neuroscience Report Source Type: research

The Neuroscience Report—Vol. 17 (August 24, 2015): Alzheimer’s Disease
The latest in neuroscience—sorted and summarized for you Welcome to the Neuroscience Report where each week we will highlight a specific topic in neuroscience and provide you with links to 5 journal articles, 5 news articles, and 5 wildcard picks. Brought to you by Innovations in Clinical Neuroscience—your source for peer-reviewed, evidence-based information. Volume 17 (August 24, 2015): Alzheimer’s Disease Journal Articles Informed Consent, Participation in Research, and the Alzheimer’s Patient Nonmedical Treatment of Patients with Dementia Deep Brain Stimulation: A Novel Strategy for ...
Source: Innovations in Clinical Neuroscience - August 24, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Alzheimer's Disease Cognition Devices Drug Development Ethics in Psychiatry Neurology Psychopharmacology The Neuroscience Report deep brain stimulation dementia Source Type: research