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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Influence of selective cerebral hypothermia on resting energy expenditure in patients in acute period of ischemic stroke
Rationale: Therapeutic hypothermia has a universally recognized neuroprotective potential, but clinical trials around the world are continuing to prove efficacy. To optimize nutritional support for patients with ischemic stroke who undergo selective cerebral hypothermia with systemic normothermia (SCH), we began the study.
Source: Clinical Nutrition - August 22, 2018 Category: Nutrition Authors: B.J. Torosyan, A.V. Butrov, O.A. Shevelev, D.V. Cheboxarov Source Type: research

Effect of hypothermia on interleukin-1 receptor antagonist pharmacodynamics in inflammatory-sensitized hypoxic-ischemic encephalopathy of term newborns
Hypothermia is increasingly tested in several neurological conditions, such as neonatal encephalopathy, stroke, traumatic brain injury, subarachnoid hemorrhage, spinal cord injury, and neurological outcomes of...
Source: Journal of Neuroinflammation - July 30, 2018 Category: Neurology Authors: Mathilde Chevin, Cl émence Guiraut and Guillaume Sébire Tags: Short report Source Type: research

Mild hypothermia inhibits the Notch 3 and Notch 4 activation and seizure after stroke in the rat model
This study further investigated the involvement of Notch 3 and 4 in post-stroke seizure and the effect of mild hypothermia on these two factors. A global cerebral ischemia (GCI) model was conducted in Sprague Dawley rats. Seizure activity was evaluated by the frequency of seizure attacks, seizure severity scores, and seizure discharges. Seizures were frequently occurred in the first and the second 24 h after GCI, however active whole-body cooling (mild hypothermia) and DAPT (Notch inhibitor) injection into the hippocampus, alone or in combination, alleviated seizure activity after GCI. Immunohistochemistry and Western bl...
Source: Pathology Research and Practice - July 10, 2018 Category: Pathology Source Type: research

Development of a core outcome set for trials on induction of labour (COSIOL): An international multi-stakeholder Delphi study.
CONCLUSION: Trials on induction of labour should include this core outcome set to standardise reporting. This article is protected by copyright. All rights reserved. PMID: 29981523 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 7, 2018 Category: OBGYN Authors: Dos Santos F, Drymiotou S, Antequera A, Mol BW, Gale C, Devane D, Van't Hooft J, Johnson MJ, Hogg M, Thangaratinam S Tags: BJOG Source Type: research

Mild hypothermia inhibits the Notch 3 and Notch 4 activation and seizure after stroke in the rat model
This study further investigated the involvement of Notch 3 and 4 in post-stroke seizure and the effect of mild hypothermia on these two factors. A global cerebral ischemia (GCI) model was conducted in Sprague Dawley rats. Seizure activity was evaluated by the frequency of seizure attacks, seizure severity scores, and seizure discharges. Seizures were frequently occurred in the first and the second 24 h after GCI, however active whole-body cooling (mild hypothermia) and DAPT (Notch inhibitor) injection into the hippocampus, alone or in combination, alleviated seizure activity after GCI. Immunohistochemistry and Western bl...
Source: Pathology Research and Practice - July 5, 2018 Category: Pathology Source Type: research

Effect of mild hypothermia on expression of inflammatory factors in surrounding tissue after minimally invasive hematoma evacuation in the treatment of hypertensive intracerebral hemorrhage.
Authors: Zhao J, Mao Q, Qian Z, Zhu J, Qu Z, Wang C Abstract Mild hypothermia combined with minimally invasive hematoma evacuation was evaluated in the treatment of hypertensive intracerebral hemorrhage to reduce inflammatory response of brain tissue around hematoma and ameliorate brain function, and to investigate its safety, effectiveness and feasibility. A total of 206 patients with acute spontaneous hypertensive intracerebral hemorrhage were collected clinically and randomly divided into minimally invasive hematoma evacuation group (group A) and mild hypothermia combined with minimally invasive hematoma evacuat...
Source: Experimental and Therapeutic Medicine - May 30, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

An amperometric glutamate biosensor for monitoring glutamate release from brain nerve terminals and in blood plasma.
Abstract An excess of the excitatory neurotransmitter, glutamate, in the synaptic cleft during hypoxia/ischemia provokes development of neurotoxicity and originates from the reversal of Na+-dependent glutamate transporters located in the plasma membrane of presynaptic brain nerve terminals. Here, we have optimized an electrochemical glutamate biosensor using glutamate oxidase and developed a biosensor-based methodological approach for analysis of rates of tonic, exocytotic and transporter-mediated glutamate release from isolated rat brain nerve terminals (synaptosomes). Changes in the extracellular glutamate conce...
Source: Analytica Chimica Acta - May 9, 2018 Category: Chemistry Authors: Borisova T, Kucherenko D, Soldatkin O, Kucherenko I, Pastukhov A, Nazarova A, Galkin M, Borysov A, Krisanova N, Soldatkin A, El Skaya A Tags: Anal Chim Acta Source Type: research

Mild focal hypothermia regulates the dynamic polarization of microglia after ischemic stroke in mice.
Conclusions Hypothermia is protective following ischemic stroke and can reduce brain tissue loss. Moreover, hypothermia shifts the polarization of microglia from the M1 to the M2 phenotype in the ischemic mice brain. This observed biological phenomenon may partially explain the protective effects seen due to hypothermia in acute ischemic stroke. PMID: 29619889 [PubMed - as supplied by publisher]
Source: Neurological Research - April 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Comparison of immediate extubation versus ultrafast tracking strategy in the management of off-pump coronary artery bypass surgery.
Conclusion: IE appears to be safe and effective in OPCAB patients without any major complications. It can be achieved after fulfilling traditional extubation criteria but is confined to highly selective group of patients. PMID: 29652272 [PubMed - in process]
Source: Annals of Cardiac Anaesthesia - April 1, 2018 Category: Anesthesiology Authors: Nagre AS, Jambures NP Tags: Ann Card Anaesth Source Type: research

Comparison of three haemodynamic monitoring methods in comatose post cardiac arrest patients.
CONCLUSION: We found low bias, but relatively wide limits of agreement in SV with PiCCO, FloTrac/Vigileo and TTE during TTM treatment. The methods are not interchangeable. Precision was not improved by transpulmonary thermodilution calibration during hypothermia. PMID: 29544369 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - March 20, 2018 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Safety and Efficacy of Hypothermia (34 °C) after Hemicraniectomy for Malignant MCA Infarction.
CONCLUSION: This study suggests that hypothermia after hemicraniectomy is a viable option when the progression of patients with malignant MCA infarction indicate poor prognosis. PMID: 29526071 [PubMed]
Source: Journal of Korean Neurosurgical Society - March 13, 2018 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Management of concomitant metabolic encephalopathy and meningioma with vasogenic edema and impending herniation.
Conclusions: Management of concomitant metabolic encephalopathy and meningioma with vasogenic edema and impending herniation can be challenging. Correction of the encephalopathy is crucial to minimize perioperative morbidity and mortality. Awareness of metabolic causes of acute decompensation is critical for perioperative management, so a high index of clinical suspicion can make an important timely diagnosis for treatment initiation. Severely hypothyroid patients are sensitive to anesthetic agents and are at a high risk for perioperative complications. Prompt treatment prior to surgical intervention can help minimize peri...
Source: Surgical Neurology International - March 3, 2018 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia.
Authors: Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D Abstract Stroke is considered an underlying etiology of the development of seizures. Stroke leads to glucose and oxygen deficiency in neurons, resulting in brain dysfunction and injury. Mild hypothermia is a therapeutic strategy to inhibit stroke‑induced seizures, which may be associated with the regulation of energy metabolism of the brain. Mammalian target of rapamycin (mTOR) signaling and solute carrier family 2, facilitated glucose transporter member (GLUT)‑1 are critical for energy metabolism. Furthermore, mTOR overactivation and GLUT‑1 deficiency...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Magnesium as a Neuroprotective Agent: A Review of Its Use in the Fetus, Term Infant with Neonatal Encephalopathy, and the Adult Stroke Patient
This article explores the current status of magnesium being used as an adjunct to hypothermia in term neonatal encephalopathy (NE) against a background of its use in other populations. There is some evidence for magnesium sulfate as a neuroprotective agent, however animal studies of NE at term equivalent age have been confounded by concomitant hypothermia induced by magnesium itself. Nevertheless, the combination of magnesium and cooling has been shown to be more effective than either treatment alone in adult rodents. In the preterm baby, magnesium sulfate given antenatally in threatened preterm labor has demonstrated a si...
Source: Developmental Neuroscience - February 7, 2018 Category: Neuroscience Source Type: research

Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies
ABSTRACTPURPOSE OF REVIEWNeonatal encephalopathy is the most common condition in neonates encountered by child neurologists. The etiology is most often global hypoxia-ischemia due to failure of cerebral perfusion to the fetus caused by uterine, placental, or umbilical cord compromise prior to or during delivery. Other etiologies of neonatal encephalopathy include ischemic stroke and intracranial hemorrhage, infection, developmental anomalies, and inborn errors of metabolism.RECENT FINDINGSTherapeutic hypothermia is standard of care for the treatment of neonatal encephalopathy presumed to be caused by hypoxia-ischemia. The ...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2018 Category: Neurology Tags: Review Articles Source Type: research