Query: stroke

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Stroke in a Feverish Patient with COVID-19 Infection and Unknown Endocarditis.
Authors: Mantero V, Rigamonti A, Basilico P, Sangalli D, Scaccabarozzi C, Salmaggi A PMID: 33029982 [PubMed]
Source: Journal of Clinical Neurology - October 10, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Ultra-Early Remote Intracranial Hemorrhage Complicating Intravenous Thrombolysis with Tenecteplase for Acute Ischemic Stroke.
Authors: Kargiotis O, Safouris A, Psychogios K, Chondrogianni M, Andrikopoulou A, Theodorou A, Magoufis G, Stamboulis E, Tsivgoulis G PMID: 33029978 [PubMed]
Source: Journal of Clinical Neurology - October 10, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Causes, Risk Factors, and Clinical Outcomes of Stroke in Korean Young Adults: Systemic Lupus Erythematosus is Associated with Unfavorable Outcomes.
CONCLUSIONS: Young adult IS patients in Korea exhibit low awareness and poor management of their risk factors. Although the short-term outcome was relatively favorable in those patients, having SLE was associated with unfavorable outcomes. More attention needs to be paid for improving awareness and controlling risk factors in this population. PMID: 33029967 [PubMed]
Source: Journal of Clinical Neurology - October 10, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Targeted Engagement of the Action Selection Network during Task-Oriented Arm Training after Stroke.
Abstract Action selection (AS), or selection of an action from a set of alternatives, is an important movement preparation process that engages a frontal-parietal network. The addition of AS demands to arm training after stroke could be used to engage this motor planning process and the neural network that supports it. The purpose of this case series is to describe the feasibility and outcomes associated with task-oriented arm training aimed at engaging the AS behavioral process and the related neural network in three individuals with chronic stroke. Three participants with mild to moderate motor deficits complete...
Source: Neural Plasticity - October 10, 2020 Category: Neurology Authors: Stewart JC, Handlery K, Baird JF, Blanck EL, Pathak G, Fritz SL Tags: Neural Plast Source Type: research

Differential Relationship between Microstructural Integrity in White Matter Tracts and Motor Recovery following Stroke Based on Brain-Derived Neurotrophic Factor Genotype.
Conclusions: The integrity of the intra- and interhemispheric connections might be related to different processes of motor recovery dependent on the BDNF genotype. Thus, the BDNF genotype may need to be considered as a factor influencing neuroplasticity and functional recovery in patients with stroke. This trial is registered with http://www.clinicaltrials.gov: NCT03647787. PMID: 33029116 [PubMed - in process]
Source: Neural Plasticity - October 10, 2020 Category: Neurology Authors: Park E, Lee J, Chang WH, Lee A, Hummel FC, Kim YH Tags: Neural Plast Source Type: research

Serum miRNA125a-5p, miR-125b-5p, and miR-433-5p as biomarkers to differentiate between posterior circulation stroke and peripheral vertigo
Acute vertigo is a common presentation of inner ear disease. However, it can also be caused by more serious conditions, especially posterior circulation stroke. Differentiating between these two conditions by ...
Source: BMC Neurology - October 10, 2020 Category: Neurology Authors: Naruchorn Kijpaisalratana, Pattaraporn Nimsamer, Ariya Khamwut, Sunchai Payungporn, Trairak Pisitkun, Aurauma Chutinet, Nattawan Utoomprurkporn, Stephen J. Kerr, Pakkawan Vongvasinkul and Nijasri C. Suwanwela Tags: Research article Source Type: research

Efficacy of Getong Tongluo Capsule ( 葛酮通络胶囊) for Convalescent-Phase of Ischemic Stroke and Primary Hypertension: A Multicenter, Randomized, Double-Blind, Controlled Trial
ConclusionGTC exhibited significant efficacy in improving patients ’ quality of life as well as neurological function and controlling hypertension. (Registration No. ChiCTR1800016667)
Source: Chinese Journal of Integrative Medicine - October 10, 2020 Category: Internal Medicine Source Type: research

Endovascular stroke treatment using balloon guide catheters may reduce penumbral tissue damage and improve long-term outcome
ConclusionsThe lowered MD index early after mechanical recanalization without BGC usage can be interpreted as microstructural ischemic damage of the salvaged penumbra. It was shown that achieving complete reperfusion in a setting of BGC usage with proximal flow arrest minimizes penumbral damage and improves long-term outcomes.Key Points• Microstructural ischemic damage can be reduced by using proximal flow arrest during endovascular treatment with balloon guide catheter.• Complete reperfusion in a setting of balloon guide catheter minimizes penumbral damage and improves long-term outcome.
Source: European Radiology - October 10, 2020 Category: Radiology Source Type: research

Correction to: Activation of Sigma-1 Receptor Enhanced Pericyte Survival Via the Interplay between Apoptosis and Autophagy: Implications for Blood –Brain Barrier Integrity in Stroke
In the original publication of this article, the representative western blot images of β-actin in Fig. 3e was presented repeatedly in Fig. 7b due to the same set of samples isolated from tissue of WT and σ-1R KO treated with pMCAO.
Source: Translational Stroke Research - October 10, 2020 Category: Neurology Source Type: research

Cerebral Herniation Secondary to Stroke-associated Hemorrhagic Transformation, Fulminant Cerebral Edema in Setting of COVID-19 Associated ARDS and Active Malignancy
We present the case of a very rapid neurologic and radiographic decline of a patient with an acute ischemic stroke who developed rapid fulminant cerebral edema leading to herniation in the setting of hypercarbic respiratory failure attributed to SARS-CoV-2 infection.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2020 Category: Neurology Authors: Katarina Dakay, Gurmeen Kaur, Stephan A. Mayer, Justin Santarelli, Chirag Gandhi, Fawaz Al-Mufti Tags: Case Report Source Type: research

Folic Acid Deficiency Enhances the Tyr705 and Ser727 Phosphorylation of Mitochondrial STAT3 in In Vivo and In Vitro Models of Ischemic Stroke
AbstractIschemic stroke remains one of the most common causes of death and disability worldwide. The stroke patients with an inadequate intake of folic acid tend to have increased brain injury and poorer prognosis. However, the precise mechanisms underlying the harmful effects of folic acid deficiency (FD) in ischemic stroke is still elusive. Here, we aimed to test the hypothesis that mitochondrial localized STAT3 (mitoSTAT3) expression may be involved in the process of neuronal damage induced by FD in in vivo and in vitro models of ischemic stroke. Our results exhibited that FD increased infarct size and aggravated the da...
Source: Translational Stroke Research - October 10, 2020 Category: Neurology Source Type: research

Reperfusion strategies in stroke due to isolated cervical internal carotid artery occlusion: systematic review and treatment comparison
ConclusionsOur systematic review highlights that, in acute ischemic stroke associated with isolated cervical ICA occlusion, bridging (IVT + EVT) might lead to higher rate of functional independence at follow-up, without increasing mortality. The low quality of available studies prevents from drawing firm conclusions, and randomized-controlled clinical trials are critically needed to define optimal treatment in this AIS subgroup.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

The influence of statin withdrawal and adherence on stroke outcomes
ConclusionThe suboptimal use of statins is associated with significantly worse clinical outcomes in stroke patients.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

Prediction of mTICI 3 recanalization and clinical outcomes in endovascular thrombectomy for acute ischemic stroke: a retrospective study in the Taiwan registry
ConclusionsPrediction of mTICI 3 recanalization and clinical outcomes offer valuable clinical information for treatment planning in EVT.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.
This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social d...
Source: The Journal of Alzheimers Association - October 9, 2020 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Accuracy and Implications of Hemorrhagic Stroke Recognition by Emergency Medical Services.
CONCLUSIONS: Among EMS-transported hemorrhagic stroke cases, stroke screen documentation was strongly associated with EMS stroke recognition, which was in turn associated with higher quality of EMS care and faster CT scans upon emergency department arrival. PMID: 33026277 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - October 9, 2020 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Acute ischemic stroke due to unruptured small aneurysm of internal carotid artery: A case report
Rationale: Intracranial small aneurysm is a rare cause of ischemic stroke, and been described only in sparse case reports. The exact pathophysiology, treatment strategies, and prognosis remain incompletely understood. Patient concerns: A 42-year-old man presented with an acute onset weakness of the right limbs. Diagnoses: Neuroimaging evaluation confirmed a diagnosis of acute ischemic stroke and left internal carotid artery (ICA) small aneurysm. Interventions: The patient underwent oral anti-platelet therapy (100 mg aspirin daily). Outcomes: The patient recovered to normal status within 4 weeks following an...
Source: Medicine - October 9, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Development and validation of a 2-year new-onset stroke risk prediction model for people over age 45 in China
Multiple factors, including increasing incidence, poor knowledge of stroke and lack of effective, noninvasive and convenient stroke risk prediction tools, make it more difficult for precautions against stroke in China. Effective prediction models for stroke may assist to establish better risk awareness and management, healthier lifestyle, and lower stroke incidence for people. The China Health and Retirement Longitudinal Survey was the development cohort. Logistic regression was applied to model's development, in which the candidate variables with statistically significant coefficient were included in the prediction model...
Source: Medicine - October 9, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Letter to the Editor regarding: Critical considerations for stroke management during COVID-19 pandemic by Inglis et al., Heart Lung Circ. 2020;29(9): 1263 –1267.
Source: Heart, Lung and Circulation - October 9, 2020 Category: Cardiology Authors: Skye Coote, Dominique A. Cadilhac, Elizabeth O ’Brien, Sandy Middleton, Acute Stroke Nurses Education Network (ASNEN) Steering Committee Tags: Letter to the Editor Source Type: research

Role of long noncoding RNA MEG3/miR-378/GRB2 axis in neuronal autophagy and neurological functional impairment in ischemic stroke Neurobiology
This study aims to investigate the regulatory mechanisms of the pathway consisting of MEG3 (maternally expressed gene 3), microRNA-378 (miR-378), and GRB2 (growth factor receptor-bound protein 2) in neuronal autophagy and neurological functional impairment in ischemic stroke. A mouse model of the middle cerebral artery occluded–induced ischemic stroke and an in vitro model of oxygen-glucose deprivation–induced neuronal injury were developed. To understand the role of the MEG3/miR-378/GRB2 axis in the neuronal regulation, the expression of proteins associated with autophagy in neurons was measured by Western blotting an...
Source: Journal of Biological Chemistry - October 9, 2020 Category: Chemistry Authors: Hong-Cheng Luo, Ting-Zhuang Yi, Fu-Gao Huang, Ying Wei, Xiao-Peng Luo, Qi-Sheng Luo Tags: Molecular Bases of Disease Source Type: research

Trends in prevalence of acute stroke impairments: A population-based cohort study using the South London Stroke Register
by Amanda Clery, Ajay Bhalla, Anthony G. Rudd, Charles D. A. Wolfe, Yanzhong Wang BackgroundAcute stroke impairments often result in poor long-term outcome for stroke survivors. The aim of this study was to estimate the trends over time in the prevalence of these acute stroke impairments. Methods and findingsAll first-ever stroke patients recorded in the South London Stroke Register (SLSR) between 2001 and 2018 were included in this cohort study. Multivariable Poisson regression models with robust error variance were used to estimate the adjusted prevalence of 8 acute impairments, across six 3-year time cohorts. Prevalence...
Source: PLoS Medicine - October 9, 2020 Category: Internal Medicine Authors: Amanda Clery Source Type: research

Clopidogrel increases risk of pneumonia compared with aspirin in acute ischemic minor stroke patients
AbstractAntiplatelet agents may increase the risk of infections via suppressing platelet-mediated immune response. Here we assessed the contribution of clopidogrel versus aspirin to the development of pneumonia during an acute ischemic stroke admission. A retrospective cohort study was conducted of acute ischemic stroke patients who were admitted to our hospital from 2015 to 2018. Included patients received uninterrupted clopidogrel or aspirin therapy and did not take other antiplatelet agents throughout their stay. The interest outcome was development of pneumonia after stroke. Conditional logistic regression model after ...
Source: Journal of Thrombosis and Thrombolysis - October 9, 2020 Category: Hematology Source Type: research

Stroke and Thromboprophylaxis in the era of COVID-19
In the rapidly evolving COVID-19 pandemic, many patients presenting with acute ischemic stroke may be potentially infected with the Severe Acute Respiratory Syndrome Coronavirus (SARS CoV-2) agent. As stroke patients are often unable to give an adequate history of preceding COVID-19 symptoms, all stroke patients in areas with high prevalence of community transmission should be considered potential cases. Observational studies have suggested an increased tendency for thrombotic events in patients infected with SARS CoV-2.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2020 Category: Neurology Authors: Alice Ma, Carlos S. Kase, Ashkan Shoamanesh, Mohamad Abdalkader, Aleksandra Pikula, Anvitha Sathya, Luciana Catanese, Alun T. Ellis, Thanh N. Nguyen Source Type: research

Intracranial Arterial Calcification Relates to Long-Term Risk of Recurrent Stroke and Post-stroke Mortality
Conclusions: IAC is a strong risk factor for recurrent stroke and post-stroke mortality. Among stroke subtypes, IAC relates to higher risk of stroke recurrence among patients with small-vessel disease, which indicates chronic calcification detected in large cerebral arteries may have potential effects on the cerebrovascular beds extending to small vessels.
Source: Frontiers in Neurology - October 9, 2020 Category: Neurology Source Type: research

Stroke Care Within the COVID-19 Pandemic —Increasing Awareness of Transient and Mild Stroke Symptoms Needed
Conclusions: During the COVID-19 pandemic, resources of the healthcare system in a primary care university hospital in Germany still allowed for unchanged numbers of recanalization procedures due to ischemic stroke. However, the numbers of patients admitted to the hospital specifically due to ischemic stroke or TIA decreased, suggesting that the awareness for non-disabling stroke symptoms has to be increased.
Source: Frontiers in Neurology - October 9, 2020 Category: Neurology Source Type: research

Statin Effects in Atrial Fibrillation-Related Stroke: A Systematic Review and Meta-Analysis
Conclusions: Statin therapy for AF-related stroke may reduce all-cause mortality and improve functional outcomes. Randomized controlled studies are warranted to confirm the effects of statins on the outcomes of AF-related stroke.
Source: Frontiers in Neurology - October 9, 2020 Category: Neurology Source Type: research

Remote Ischemic Postconditioning May Aid Stroke Recovery
THURSDAY, Oct. 8, 2020 -- For patients with acute ischemic stroke (AIS) undergoing intravenous thrombolysis (IVT), remote ischemic postconditioning (RIPC) is associated with improved clinical prognosis, according to a study published online Oct. 7...
Source: Drugs.com - Pharma News - October 8, 2020 Category: Pharmaceuticals Source Type: news

Arm Squeezes With Blood Pressure Cuffs Might Aid Recovery After Stroke
THURSDAY, Oct. 8, 2020 -- After administering clot-busting drugs to treat a stroke, using blood pressure cuffs to squeeze each arm might aid recovery, a new, small Chinese study suggests. In the technique -- called remote ischemic post-conditioning...
Source: Drugs.com - Daily MedNews - October 8, 2020 Category: General Medicine Source Type: news

Engaging occupations among persons at risk for stroke: A health paradox.
CONCLUSIONS AND SIGNIFICANCE: The paradox conceptually challenges some of the core values inherent in occupational therapy regarding the relationship between engaging occupations, health and well-being. Gaining a deeper understanding of experiences of occupations and studying this in relation to health promoting or compromising characteristics of occupations, can facilitate lifestyle programs that support changes in everyday life. Moreover, programs need to be designed to offer personal relevance and to facilitate a positive balance between health compromising occupations and health promoting occupations in everyday life. ...
Source: Scandinavian Journal of Occupational Therapy - October 8, 2020 Category: Occupational Health Tags: Scand J Occup Ther Source Type: research

An AIE probe for imaging mitochondrial SO2-induced stress and SO2 levels during heat stroke
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC05803C, CommunicationXiaopeng Yang, Jun Tang, Di Zhang, Xiaojing Han, Jianfei Liu, Jinsa Li, Yufen Zhao, Yong Ye An AIE-based fluorescent probe was developed for imaging the misregulation of SO2 levels in mitochondria during heat stroke. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - October 8, 2020 Category: Chemistry Authors: Xiaopeng Yang Source Type: research

COVID-19 Era Stroke Service: Virtually Normal
ConclusionsZoom conferences are a promising technology for stroke services. Further studies are needed to further elucidate their benefits and drawbacks.
Source: Current Treatment Options in Neurology - October 8, 2020 Category: Neurology Source Type: research

Impact of pulmonary embolism on in-hospital mortality of patients with ischemic stroke
Pulmonary embolism (PE) is a frequent complication in immobile stroke patients and an important cause of death in stroke patients. We aimed to investigate predictors of PE and impact of PE on survival of ischemic stroke patients.
Source: Journal of the Neurological Sciences - October 8, 2020 Category: Neurology Authors: Karsten Keller, Lukas Hobohm, Thomas M ünzel, Mareike Lankeit, Mir Abolfazl Ostad Source Type: research

The stroke mothership model survived during COVID-19 era: an observational single-center study in Emilia-Romagna, Italy
ConclusionDuring COVID-19 pandemic, TIA and minor stroke consistently reduced compared to the same timeframe in 2019. Longer stroke-to-call and door-to-scan times, attributable to change in citizen behavior and screening at hospital arrival, did not impact on stroke-to-treatment time. Mothership model might have minimized the effects of the pandemic on the stroke care organization.
Source: Neurological Sciences - October 8, 2020 Category: Neurology Source Type: research

Impact of COVID-19 on stroke caseload in a major HyperAcute Stroke Unit
Northwick Park Hospital in London, United Kingdom (UK) is one of the busiest stroke units in the country and is located in one of the areas most heavily affected by the COVID-19 pandemic in the first half of 2020. Admissions to the stroke unit and changes during the peak of COVID-19 were reviewed. Compared with the previous year, mean 96 patients were admitted with suspected stroke during April and May 2020 compared with mean 116 per month in non-COVID periods, ratio 0.82, P=0.01. This reduction involved both strokes and mimics and was unlikely to have occurred by chance.
Source: Journal of Stroke and Cerebrovascular Diseases - October 5, 2020 Category: Neurology Authors: Fionn Mag Uidhir, Raj Bathula, Aravinth Sivagnanaratnam, Mudhar Abdul-Saheb, Joseph Devine, David L. Cohen Source Type: research

A scoping review of psychoeducational interventions for people after transient ischemic attack and minor stroke.
CONCLUSIONS: Definitions of stroke severity are not adequately reported. There are a variety of interventions including education about a range of stroke-specific topics. Many interventions are not adequately described, thus making it difficult to determine if the aim was to provide information or support post-TIA/minor stroke. There is a need for an in-depth systematic review to develop a clear definition of psychoeducation. PMID: 32996432 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 29, 2020 Category: Neurology Authors: Kontou E, Kettlewell J, Condon L, Thomas S, Lee AR, Sprigg N, Watkins DC, Walker MF, Shokraneh F Tags: Top Stroke Rehabil Source Type: research

Stroke Systems of Care during the COVID-19 Epidemic in Kobe City
The novel coronavirus disease 2019  (COVID-19), first reported in Wuhan, China, in December 2019, spread worldwide in 2020. As of June 1, 2020, the estimated number of global cases and deaths has exceeded 6 million and 370,000, respectively.1 In Japan, the number of reported cases increased sharply in March 2020, with community tran smission presenting at the highest rate in urban areas, leading to a state of emergency being declared by the Japanese government on April 7. Subsequently, on April 9, the Japan Stroke Society and the Japanese Circulation Society issued a joint statement on the importance of maintaining high-q...
Source: Journal of Stroke and Cerebrovascular Diseases - September 29, 2020 Category: Neurology Authors: Nobuyuki Ohara, Hirotoshi Imamura, Hidemitsu Adachi, Yoshie Hara, Kohkichi Hosoda, Hidehito Kimura, Kazuyuki Kuwayama, Takashi Mizowaki, Yasuhiko Motooka, Kazuya Nakashima, Narihide Shinoda, Takeshi Takamoto, Yasushi Ueno, Ikuya Yamaura, Chie Yanagihara, Source Type: research

Unusual Pattern of Arterial Macrothrombosis Causing Stroke in a Young Adult Recovered from COVID-19
Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Neurological manifestations related to COVID-19, including acute ischemic Stroke (AIS), have been reported in recent studies. In most of these, the patients are older, have multiple co-morbidities as risk factors for AIS and have developed a severe respiratory illness. Herein, we report a 36-year-old man with no significant past medical history who recently recovered from a mild COVID-19 infection and presented with unusual pattern of arterial macrothrombosis causing AIS.
Source: Journal of Stroke and Cerebrovascular Diseases - September 24, 2020 Category: Neurology Authors: Ashkan Mowla, Saman Sizdahkhani, Maryam Sharifian Dorche, Prad Selvan, Benjamin A. Emanuel, Matthew S. Tenser, Arun P. Amar, William J. Mack Tags: Case Report Source Type: research

The Impact of COVID-19 on Acute Ischemic Stroke Admissions: Analysis from a Community-Based Tertiary Care Center
To evaluate the impact of the COVID-19 pandemic on hospital admissions and outcomes in patients admitted with acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - September 24, 2020 Category: Neurology Authors: Jing Wang, Saqib A. Chaudhry, Pouya Tahsili-Fahadan, Laith R. Altaweel, Sairah Bashir, Zelalem Bahiru, Yun Fang, Adnan I. Qureshi Tags: Original Investigation - Rapid Communications Source Type: research

Rasch analysis of the Burke Lateropulsion Scale (BLS).
CONCLUSIONS: This study identified good psychometric properties of the BLS using Rasch analysis and supports the use of the BLS as a measure of lateropulsion following stroke. Further use of Rasch analysis on the BLS using a larger sample is recommended to confirm these preliminary findings and allow transformation into an interval-level scale. PMID: 32975165 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 24, 2020 Category: Neurology Authors: Birnbaum M, Brock K, Parkinson S, Burton E, Clark R, Hill KD Tags: Top Stroke Rehabil Source Type: research

Subacute ischemic stroke rehabilitation outcomes in working-age adults: The role of aphasia in cognitive functional independence.
CONCLUSIONS: We identified no significant differences in C-FIM outcomes (gain, efficiency and effectiveness) either in LOS between PWA and patients without aphasia, though C-FIM differences were significant at admission and discharge. Aphasia was a significant predictor of C-FIM gain and C-FIM at discharge. PMID: 32967590 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 23, 2020 Category: Neurology Authors: García-Rudolph A, García-Molina A, Cegarra B, Opisso E, Saurí J, Tormos JM, Bernabeu M Tags: Top Stroke Rehabil Source Type: research

Time of stroke onset in Coronavirus disease 2019 patients around the globe: a systematic review and analysis.
Coronavirus disease 2019 (COVID-19) rapidly became a pandemic. As of August 29th, 2020, over 24 million cases have been confirmed worldwide1. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection is associated with diverse neurological manifestations involving both the central and peripheral nervous system2,3. In fact, reports of ischemic stroke in patients with COVID-19 have increasingly been published, suggesting an association between these conditions. It has been proposed that SARS-CoV-2 infection induces a severe inflammatory response and hypercoagulable state, making patients susceptible to thromboti...
Source: Journal of Stroke and Cerebrovascular Diseases - September 17, 2020 Category: Neurology Authors: Natalia Valencia-Enciso, M ónica Ortiz-Pereira, María Paula Zafra-Sierra, Laura Espinel-Gómez, Hernan Bayona Source Type: research

Pathophysiology, Mechanism, and Outcome of Ischemic Stroke in Cancer Patients
The purpose of this study is to assess the risk factors, biomarkers of stroke, mechanism, and outcomes of cerebral infarction among cancerous diseases.
Source: Journal of Stroke and Cerebrovascular Diseases - September 17, 2020 Category: Neurology Authors: Mohamed Abdelsalam, Mohammad Abu-Hegazy, Hend Ahmed El-Hadaad, Hanan Wahba, Hossam Egila, Ahmed Esmael Source Type: research

Verbal feedback enhances motor learning during post-stroke gait retraining.
CONCLUSIONS: Addition of individualized verbal feedback (FF+PT) to a single session of gait training may enhance within- and across-session learning of targeted gait variables in people post-stroke, and merits more investigation. PMID: 32942960 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 17, 2020 Category: Neurology Authors: Rendos NK, Zajac-Cox L, Thomas R, Sato S, Eicholtz S, Kesar TM Tags: Top Stroke Rehabil Source Type: research

Stroke care trends during COVID-19 pandemic in Zanjan Province, Iran. From the CASCADE Initiative: statistical analysis plan and preliminary results
This study examines the changes in stroke epidemiology and care during the COVID-19 pandemic in Zanjan Province, Iran.
Source: Journal of Stroke and Cerebrovascular Diseases - September 15, 2020 Category: Neurology Authors: Abdoreza Ghoreishi, Shahram Arsang-Jang, Ziad Sabaa-Ayoun, Nawaf Yassi, P.N. Sylaja, Yama Akbari, Afshin A. Divani, Jose Biller, Thanh Phan, Sandy Steinwender, Brian Silver, Ramin Zand, Hamidon Bin Basri, Omer M. Iqbal, Annemarei Ranta, Sean Ruland, Eliza Source Type: research

Reliability and validity of the incremental shuttle walking test in individuals after stroke.
CONCLUSIONS: The ISWT demonstrated adequate reliabilities and construct validity for exercise capacity assessment. However, the concurrent validity of the ISWT as an estimation of cardiopulmonary fitness still requires further research. PMID: 32924882 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - September 13, 2020 Category: Neurology Authors: Quintino LF, Aguiar LT, de Brito SAF, Pereira AS, Teixeira-Salmela LF, de Morais Faria CDC Tags: Top Stroke Rehabil Source Type: research

Characteristics of a Diverse Cohort of Stroke Patients with SARS-CoV-2 and Outcome by Sex
Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), usually presents as a respiratory illness. Neurological manifestations can be seen in 36.4% of patients.1 Patients with vascular risk factors (VRFs), including history of stroke, tend to have worse prognosis.2 COVID-19 triggers a robust inflammatory response which leads to hypercoagulability and thromboembolism.3 Reports of stroke in patients with COVID-19 are mostly limited to small case series or case reports of ischemic stroke (IS), though intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) have also been reported.
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2020 Category: Neurology Authors: G. Trifan, F.D. Goldenberg, F.C. Caprio, J. Biller, M. Schneck, A. Khaja, T. Terna, J. Brorson, C. Lazaridis, Z. Bulwa, R. Alvarado-Dyer, F.G. Saleh-Velez, S. Prabhakaran, E.M. Liotta, A. Batra, N.J. Reish, S. Ruland, M. Teitcher, W. Taylor, P. De la Pena Source Type: research

Autologous Mesenchymal Stem Cells Improve Motor Recovery in Subacute Ischemic Stroke: a Randomized Clinical Trial
AbstractWhile preclinical stroke studies have shown that mesenchymal stem cells (MSCs) promote recovery, few randomized controlled trials (RCT) have assessed cell therapy in humans. In this RCT, we assessed the safety, feasibility, and efficacy of intravenous autologous bone marrow-derived MSCs in subacute stroke. ISIS-HERMES was a single-center, open-label RCT, with a 2-year follow-up. We enrolled patients aged 18 –70 years less than 2 weeks following moderate-severe ischemic carotid stroke. Patients were randomized 2:1 to receive intravenous MSCs or not. Primary outcomes assessed feasibility and safety. Secondary out...
Source: Translational Stroke Research - September 10, 2020 Category: Neurology Source Type: research

The prevalence and predictors of post-stroke depression and anxiety during COVID-19 pandemic
In this study, we evaluated the impact of COVID-19 pandemic on the rates of PSD and PSA.
Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2020 Category: Neurology Authors: Zakaria M. Ahmed, Mohamed F. Khalil, Ahmed M. Kohail, Islam F. Eldesouky, Ahmed Elkady, Ashfaq Shuaib Source Type: research

Iodinated Contrast Agents Reduce the Efficacy of Intravenous Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke Patients: a Multicenter Cohort Study
This study aimed to investigate whether the application of iodinated contrast agents before intravenous (IV) recombinant tissue plasminogen activator (rt-PA) reduces the efficacy in acute ischemic stroke (AIS) patients. To determine whether the application of iodinated contrast agents before intravenous rt-PA reduces the efficacy in AIS patients. We analyzed our prospectively collected data of consecutive AIS patients receiving IV rt-PA treatment in the MISSION CHINA study. Clinical outcome at 3  months was assessed with modified Rankin Scale (mRS) score and dichotomized into good outcome (0–2) and poor outcome (3–6)....
Source: Translational Stroke Research - September 7, 2020 Category: Neurology Source Type: research

Benefit and risk of early intravenous heparin after thrombolysis in patients with acute ischemic stroke
ConclusionsIVH immediately after thrombolysis seems to be safe and potentially more effective as compared with standard ATT delay of 24  hr for a subset of AIS patients.
Source: Brain and Behavior - September 4, 2020 Category: Neurology Authors: Xu Tong, Yibin Cao, Wenzhi Wang, David Wang, Yongjun Wang, Yilong Wang, the Thrombolysis Implementation, Monitor of Acute Ischemic Stroke in China (TIMS ‐China) Investigators Tags: ORIGINAL RESEARCH Source Type: research