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Amyloid pathology in the brain after ischemia.
Authors: Pluta R, Ułamek-Kozioł M, Januszewski S, Czuczwar S Abstract As the population is aging all over the world, the economic burden of ischemic brain injuries is constantly increasing. Human brain ischemia is one of the leading causes of premature death, significant morbidity and physical and mental disabilities, resulting in a lower quality of life and unusually high costs of health and social care. One of the most difficult problems associated with the pathology of the brain after ischemia is progressive dementia observed in people who survived the stroke. More recently, brain ischemia has been shown to el...
Source: Folia Neuropathologica - October 8, 2019 Category: Neurology Tags: Folia Neuropathol Source Type: research
Neuro-arrhythmology: a challenging field of action and research: a review from the Task Force of Neuro-arrhythmology of Italian Association of Arrhythmias and Cardiac Pacing
There is a growing interest in the study of the mechanisms of heart and brain interactions with the aim to improve the management of high-impact cardiac rhythm disorders, first of all atrial fibrillation. However, there are several topics to which the scientific interests of cardiologists and neurologists converge constituting the basis for enhancing the development of neuro-arrhythmology. This multidisciplinary field should cover a wide spectrum of diseases, even beyond the classical framework corresponding to stroke and atrial fibrillation and include the complex issues of seizures as well as loss of consciousness and sy...
Source: Journal of Cardiovascular Medicine - October 8, 2019 Category: Cardiology Tags: Review Source Type: research
PREventive left atrial appenDage resection for the predICtion of fuTure atrial fibrillation: design of the PREDICT AF study
Conclusion We here describe the PREDICT AF trial design, which will enable the discovery of biomarkers that truly predict POAF and new-onset atrial fibrillation by combining tissue and plasma-derived biomarkers with comprehensive clinical follow-up data. Trial registration Retrospectively registered NCT03130985 27 April 2017.
Source: Journal of Cardiovascular Medicine - October 8, 2019 Category: Cardiology Tags: Research articles: Arrhythmias Source Type: research
Relationship between left atrial strain, diastolic dysfunction and subclinical atrial fibrillation in patients with cryptogenic stroke: the SURPRISE echo substudy
In conclusion, LAs associates with PAF independent of GLS and LA size, and may be used to improve the performance of DDF grading for identifying PAF in CS patients.
Source: The International Journal of Cardiovascular Imaging - October 8, 2019 Category: Radiology Source Type: research
Impact of Vessel Wall MR Imaging in the Work-Up for Ischemic Stroke COMMENTARIES
Source: American Journal of Neuroradiology - October 8, 2019 Category: Radiology Authors: Song, J. W. Tags: COMMENTARIES Source Type: research
Mortality risk in atrial fibrillation: the role of aspirin, vitamin K and non-vitamin K antagonists
Conclusion Non vitamin K oral anticoagulants are associated with a higher risk on all-cause mortality, particularly in men and in patients with higher stroke risk.
Source: International Journal of Clinical Pharmacy - October 8, 2019 Category: Drugs & Pharmacology Source Type: research
UK research reveals racial inequalities in diabetes care
Black and minority ethnic people less likely than white people to get newer diabetes drugs and be adequately monitored Related items fromOnMedica Should we recognise obesity as a disease? Type 2 diabetes in 10 times more young people than realised GPs failing to follow women at risk after gestational diabetes Heart disease and stroke deaths plummet in Scotland Diabetes will soon cost NHS £16.9bn
Source: OnMedica Latest News - October 8, 2019 Category: UK Health Source Type: news
Impacts of Clinical Pharmacist Intervention on the Secondary Prevention of Coronary Heart Disease: A Randomized Controlled Clinical Study
This study aimed to investigate the impact of clinical pharmacist intervention on the prognosis of acute coronary syndrome (ACS) in Chinese patients with CHD. Two hundred and forty patients who had ACS were recruited. Participants were randomly assigned to the intervention group (n = 120) or the control group (n = 120). The intervention group received a medication assessment and education by the clinical pharmacist at discharge and telephone follow-ups at 1 week and 1 and 3 months after discharge. The control group received usual care. The primary outcomes of this study were the proportion of patients who had major adverse...
Source: Frontiers in Pharmacology - October 8, 2019 Category: Drugs & Pharmacology Source Type: research
Hemodynamics and Prognostic Impact of Concomitant Mitral Stenosis in Patients Undergoing Surgical or Transcatheter Aortic Valve Replacement for Aortic Stenosis.
CONCLUSIONS: MVA improved after AVR in nearly half of patients with severe aortic stenosis and mitral stenosis. MVA remained ≤2.0 cm2 (true mitral stenosis) in nearly half of patients with severe aortic stenosis and significant mitral stenosis; this was associated with worse survival among patients undergoing AVR for severe aortic stenosis. PMID: 31589485 [PubMed - in process]
Source: Circulation - October 8, 2019 Category: Cardiology Authors: Kato N, Padang R, Pislaru C, Miranda WR, Hoshina M, Shibayama K, Watanabe H, Scott CG, Greason KL, Pislaru SV, Nkomo VT, Pellikka PA Tags: Circulation Source Type: research
Hypertension in Pregnancy May Portend Cardiovascular Ills in Mothers
Pre-eclampsia was tied to a higher risk of stroke, heart attacks and other problems in mothers.
Source: NYT Health - October 7, 2019 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Pregnancy and Childbirth Blood Pressure Heart Preeclampsia Source Type: news
‘Salty’ Concern: Tackling High Salt Consumption in China
Veena S. Kulkarni, Associate Professor, Department of Criminology, Sociology and Geography, Arkansas State University, USA; and Raghav Gaiha, (Hon.) Professorial Research Fellow, Global Development Institute, University of Manchester, England.By Veena S. Kulkarni and Raghav GaihaNEW DELHI, India and JONESBORO, US, Oct 7 2019 (IPS) China’s almost meteoric transition from a being a low income to a middle income country within a span of four decades is often perceived as a miracle analogous to the post Second World War Japanese economic development experience. China’s GDP rose from $200 current United States dollars (US$ ...
Source: IPS Inter Press Service - Health - October 7, 2019 Category: International Medicine & Public Health Authors: Veena Kulkarni and Raghav Gaiha Tags: Asia-Pacific Development & Aid Economy & Trade Food & Agriculture Food Sustainability Globalisation Headlines Health Labour TerraViva United Nations Barilla Center for Food and Nutrition Foundation (BCFN) Source Type: news
Forest Devices Is Crushing It This Year
Forest Devices added another feather to its cap at TheÂ MedTech Conference in Boston, MA where the startup won the MedTech Innovator 2019 ShowcaseÂ and received a $350,000 grand prize award. Forest is developing AlphaStroke, the first device designed to detect a stroke in any environment. TheÂ portable device uses electroencephalogramÂ monitoring and machine learning to diagnose large vessel occlusions and other strokeÂ subtypes, enabling first responders to triage patients to proper stroke centers. In 2018, the Pittsburgh, PA-based company closed an oversubscribed see...
Source: MDDI - October 7, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Business Source Type: news
Understanding the Global Prevalence of Hypertension in Children and Adolescents
Hypertension is a major risk factor for the development of cardiovascular disease morbidity and mortality worldwide. Stroke, heart failure, myocardial infarction, and peripheral arterial disease are all outcomes associated with hypertension in adults. Hypertension is also considered to be a major cause of poorer disability-adjusted life-years. The prevalence of hypertension in adults has been debated in part because the definition of hypertension has changed over time. The association between blood pressure and cardiovascular disease is a continuous one, making the establishment of a cut point for hypertension difficult. H...
Source: JAMA Pediatrics - October 7, 2019 Category: Pediatrics Source Type: research
Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier
Ischemic stroke causes blood–brain barrier (BBB) breakdown due to significant damage to the integrity of BBB components. Recent studies have highlighted the importance of pericytes in the repair process of BBB functions triggered by PDGFRβ up-regulation. Here, we show that perlecan, a major heparan sulfate proteoglycan of basement membranes, aids in BBB maintenance and repair through pericyte interactions. Using a transient middle cerebral artery occlusion model, we found larger infarct volumes and more BBB leakage in conditional perlecan (Hspg2)-deficient (Hspg2–/–-TG) mice than in control mice. Con...
Source: Journal of Cell Biology - October 7, 2019 Category: Cytology Authors: Nakamura, K., Ikeuchi, T., Nara, K., Rhodes, C. S., Zhang, P., Chiba, Y., Kazuno, S., Miura, Y., Ago, T., Arikawa-Hirasawa, E., Mukouyama, Y.-s., Yamada, Y. Tags: Disease, Cell Signaling, Migration, Motility, Neuroscience Articles Source Type: research
Predicting gait adaptations due to ankle plantarflexor muscle weakness and contracture using physics-based musculoskeletal simulations
by Carmichael F. Ong, Thomas Geijtenbeek, Jennifer L. Hicks, Scott L. Delp Deficits in the ankle plantarflexor muscles, such as weakness and contracture, occur commonly in conditions such as cerebral palsy, stroke, muscular dystrophy, Charcot-Marie-Tooth disease, and sarcopenia. While these deficits likely contribute to observed gait pathologies, determining cause-effect relationships is difficult due to the often co-occurring biomechanical and neural deficits. To elucidate the effects of weakness and contracture, we systematically introduced isolated deficits into a musculoskeletal model and generated simulations of walk...
Source: PLoS Computational Biology - October 7, 2019 Category: Biology Authors: Carmichael F. Ong Source Type: research
One for all and all for one? The dilemma of optimal management of atrial fibrillation with cardiac co-morbidities
Patients with non-valvular atrial fibrillation (AF) and concomitant heart failure or coronary artery disease (CAD) are at particularly high risk of thromboembolic complications, requiring careful stroke prevention management. The development of the direct oral anticoagulants has undoubtedly improved secondary prevention of stroke arising from venous sources, while antiplatelet therapy is an essential mainstay of secondary prevention in patients with CAD. The combination, however, is associated with an increased risk of major bleeds, so the decision whether to continue with antiplatelet treatment on top of life-long anticoa...
Source: International Journal of Cardiology - October 7, 2019 Category: Cardiology Authors: Anke C. Fender, Dobromir Dobrev Source Type: research
Tamoxifen promotes white matter recovery and cognitive functions in male mice after chronic hypoperfusion
Publication date: Available online 5 October 2019Source: Neurochemistry InternationalAuthor(s): Yuxue Chen, Yeye Tian, Hao Tian, Qibo Huang, Yongkang Fang, Wei Wang, Yue Wan, Dengji Pan, Minjie XieAbstractCerebral white matter lesions (WMLs) induced by chronic cerebral hypoperfusion are one of the major components of stroke pathology and closely associated with cognitive impairment. However, the repair and related pathophysiology of white matter after brain injury remains relatively elusive and underexplored. Successful neuroregeneration is a method for the potential treatment of CNS disorders. A non-steroidal estrogen rec...
Source: Neurochemistry International - October 6, 2019 Category: Neuroscience Source Type: research
An unusual internal carotid artery compression as a possible cause of Eagle syndrome - A novel hypothesis and an innovative surgical technique.
Conclusion: A styloid/C1 transverse process juxtaposition should be considered as an alternative pathogenetic mechanism in vascular ES. When a posterior ICA compression by C1 transverse process is present, a bone reshaping of C1 rather than a conventional styloidectomy can be considered an efficacious treatment which allows a good preservation of the styloid muscles and ligaments. PMID: 31583171 [PubMed]
Source: Surgical Neurology International - October 6, 2019 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Role of MafB in macrophages.
Authors: Hamada M, Tsunakawa Y, Jeon H, Yadav MK, Takahashi S Abstract The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been reported to be involved in various diseases related to macrophages. Studies using macrophage-specific Mafb-deficient mice show that MafB is linked to atherosclerosis, autoimmunity, obesity, and ischemic stroke, all of which exhibit macrophage abnormal...
Source: Experimental Animals - October 6, 2019 Category: Research Tags: Exp Anim Source Type: research
Association between abdominal hernia and the risk of subsequent dementia
ConclusionPatients with hernias were associated with a higher incidence of dementia than those without. Our finding should be validated in further prospective studies with larger samples.
Source: Brain and Behavior - October 6, 2019 Category: Neurology Authors: Kuo ‐Chuan Hung, Cheuk‐Kwan Sun, Jen‐Yin Chen, Hsiang‐Chi Wang, Chia‐Hung Kao Tags: ORIGINAL RESEARCH Source Type: research
Ablation Index guided 50 Watts ablation for pulmonary vein isolation in patients with atrial fibrillation: procedural data, lesion analysis and initial results from the FAFA AI High Power Study
CONCLUSIONAblation ‐index guided high‐power (50W) ablation appears to be a feasible, safe, fast and effective ablation technique for PVI.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - October 6, 2019 Category: Cardiology Authors: Shaojie Chen, Boris Schmidt, Stefano Bordignon, Lukas Urbanek, Shota Tohoku, Fabrizio Bologna, Lazar Angelkov, Iskren Garvanski, Nikolaos Tsianakas, Athanasios Konstantinou, Luca Trolese, Felix Weise, Laura Perrotta, K. R. Julian Chun Tags: ORIGINAL ‐ CLINICAL Source Type: research
Efficacy And Safety Of Cryoballoon Ablation For Chinese Patients Over 75 Years Old: A Comparison With A Younger Cohort
ConclusionsThe efficacy and safety profiles of CBA in patients older than 75 years are comparable with those in younger patients.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - October 6, 2019 Category: Cardiology Authors: Jun Zhang, Zhongyuan Ren, Songyun Wang, Jingying Zhang, Haotian Yang, Yixing Zheng, Weilun Meng, Dongdong Zhao, Yawei Xu Tags: ORIGINAL ‐ CLINICAL Source Type: research
Cardiac electrophysiological characteristics of silent paroxysmal atrial fibrillation: What causes asymptomaticity?
ConclusionsThe more attenuated atrioventricular conduction properties in silent paroxysmal AF patients may explain their asymptomatic nature, and their higher likelihood of atrial arrhythmias may increase the chance to detect AF episodes. Whether or not they benefit from catheter ablation is uncertain.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - October 6, 2019 Category: Cardiology Authors: Naoya Hironobe, Akinori Sairaku, Yukiko Nakano, Takehito Tokuyama, Sho Okamura, Yosaku Okubo, Wataru Shimizu, Yasuki Kihara Tags: ORIGINAL ‐ CLINICAL Source Type: research
Utilization of a Parental Approach to Informed Consent in Intravenous Tissue Plasminogen Activator Administration Decision-Making: Patient Preference and Ethical Considerations.
Conclusion: Our results indicate that while paternalism is generally discouraged in the medical community, some degree of parental language may be preferred by patients in tough decision-making situations toward consent to receive medical interventions. PMID: 31583134 [PubMed]
Source: Neurology Research International - October 5, 2019 Category: Neurology Tags: Neurol Res Int Source Type: research
Study: Long-term antibiotic use among women linked to increased risk of heart attack and stroke
(Natural News) When you think about what can go wrong when you take antibiotics, there are two major complications that likely come to mind: that all-too-familiar stomach upset and the more big-picture issue of antibiotic resistance and superbugs. However, there’s another potential problem that you might not associate with antibiotic use: a higher risk of...
Source: NaturalNews.com - October 5, 2019 Category: Consumer Health News Source Type: news
Evaluation of Nonfatal Strangulation in Alert Adults
ConclusionAlert, strangled patients had a low rate of injuries. All patients with neck injuries had concerning findings besides neck pain; specifically, GCS score less than 15 or dysphagia. Our findings suggest, but do not prove, that a selective imaging strategy is safe in alert patients after strangulation findings besides neck pain.
Source: Annals of Emergency Medicine - October 5, 2019 Category: Emergency Medicine Source Type: research
Medical Management of LVAD Patients: A Practical Guide for the Non-Expert Clinician
This article provides a concise overview of the medical management of LVAD patients aimed for non-expert clinicians. Our presentation includes the basics of LVAD physiology, design and operation, patient selection, patient assessment, medical management, adverse event identification and management, multidisciplinary care, and management of special circumstances such as non-cardiac surgery, cardiac arrest, and end-of-life care. The clinical examination of LVAD patients is unique in terms of blood-pressure and heart-rate assessment, LVAD ‘hum’ auscultation, driveline/insertion-site inspection, and device-parameter record...
Source: Canadian Journal of Cardiology - October 5, 2019 Category: Cardiology Source Type: research
Total endovascular repair of the aortic arch: initial experience in the Netherlands
ConclusionsTotal endovascular aortic arch repair using the Relay Branch device is technically feasible and effective in excluding aortic arch pathology. The observed stroke rate in the initial experience, however, was considerable. Although appealing, this new lesser-invasive technique should be carefully introduced, and its progress thoroughly evaluated.
Source: The Annals of Thoracic Surgery - October 5, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research
Optimism Tied to Lower Rates of Heart Attacks, Death Optimism Tied to Lower Rates of Heart Attacks, Death
People with a positive outlook on life may be less likely than pessimists to experience events like a heart attack or stroke, and they may live longer, a recent review of existing research suggests.Reuters Health Information
Source: Medscape Medical News Headlines - October 5, 2019 Category: Consumer Health News Tags: Medscape Today News Source Type: news
Preventing unnecessary disability after stroke in Scotland
Publication date: 5–11 October 2019Source: The Lancet, Volume 394, Issue 10205Author(s): Shelagh B Coutts
Source: The Lancet - October 5, 2019 Category: General Medicine Source Type: research
Retrospective study on bevacizumab in the treatment of non-small cell lung cancer with brain metastases
ConclusionsThis retrospective study shows that bevacizumab has efficacy and favorable toxicity in patients with NSCLC and brain metastases and cardiovascular disease might be a risk factor for cerebral toxicity.
Source: International Journal of Clinical Oncology - October 5, 2019 Category: Cancer & Oncology Source Type: research
Total endovascular repair of the aortic arch: initial experience in the Netherlands.
CONCLUSIONS: Total endovascular aortic arch repair using the Relay Branch device is technically feasible and effective in excluding aortic arch pathology. The observed stroke rate in the initial experience, however, was considerable. Although appealing, this new lesser-invasive technique should be carefully introduced, and its progress thoroughly evaluated. PMID: 31593657 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - October 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: van der Weijde E, Heijmen RH, van Schaik PM, Hazenberg CEVB, van Herwaarden JA Tags: Ann Thorac Surg Source Type: research
Intracranial mechanical thrombectomy without extracranial revascularization for a tandem occlusion with robust Circle of Willis: case report
Publication date: Available online 4 October 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Mateja de Leonni Stanonik, Christopher Sy, Cameron McDougall, Lee Birnbaum, Justin MascitelliAbstractA 59-year-old male presented with a severe left middle cerebral artery (MCA) syndrome, a National Institutes of Health Stroke Scale (NIHSS) of 17, and was last known well 26 hours prior. Computed tomography angiography (CTA) of the head demonstrated a tandem extracranial ICA and intracranial ICA/MCA occlusion. Computed tomography perfusion (CTP) demonstrated a large mismatch. The patient underwent a mechanical thrombectomy usin...
Source: Interdisciplinary Neurosurgery - October 4, 2019 Category: Neurosurgery Source Type: research
With Comorbidities, Less Than Six Hours of Sleep Ups Risk for Early Death
Risk for dying from heart attack, stroke twofold higher among those with high BP, diabetes and short sleep
Source: The Doctors Lounge - Oncology - October 4, 2019 Category: Cancer & Oncology Tags: Cardiology, Endocrinology, Family Medicine, Geriatrics, Internal Medicine, Neurology, Oncology, Journal, Source Type: news
A randomized pilot study of patients with tandem carotid lesions undergoing thrombectomy
ConclusionsThis pilot trial of patients with TL undergoing EVT suggests that a sufficiently powered larger TL trial comparing acute c-ICA stenting to no stenting is feasible.Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02157532.Graphical abstract
Source: Journal of Neuroradiology - October 4, 2019 Category: Radiology Source Type: research
Primary diagnosis of pulmonary embolism with unenhanced MRI for patients not eligible for CTPA: Clinical outcome
ConclusionsOur method supported or altered clinical decision-making and treatment in this cohort. A diagnostic tool for PE without intravenous contrast agent or radiation is of great benefit for certain patients.
Source: European Journal of Radiology Open - October 4, 2019 Category: Radiology Source Type: research
With Comorbidities, Less Than Six Hours of Sleep Ups Risk for Early Death
FRIDAY, Oct. 4, 2019 -- Middle-aged adults with high blood pressure, type 2 diabetes, heart disease, or stroke could be at higher risk for cancer and early death when sleeping less than six hours per day, according to a study published online Oct. 2...
Source: Drugs.com - Pharma News - October 4, 2019 Category: Pharmaceuticals Source Type: news
PCI, CABG for Left Main CAD Have Similar Five-Year Outcomes
FRIDAY, Oct. 4, 2019 -- Five-year rates of a composite outcome of death, stroke, and myocardial infarction are similar for patients with left main coronary artery disease following either percutaneous coronary intervention (PCI) or coronary artery...
Source: Drugs.com - Pharma News - October 4, 2019 Category: Pharmaceuticals Source Type: news
HRT reduces morbidity and mortality in women with Turner sydrome
Women undergoing hormone therapy for Turner syndrome found to have reduced risk of diabetes, osteoporotic fractures and stroke, according to findings published inThe Journal of Clinical Endocrinology& Metabolism. Healio
Source: Society for Endocrinology - October 4, 2019 Category: Endocrinology Source Type: news
A drug safety evaluation of apixaban for the treatment of atrial fibrillation, acute coronary syndrome and percutaneous coronary intervention.
Authors: Gumprecht J, Domek M, Lip GY Abstract Introduction: The non-vitamin K antagonist oral anticoagulants (NOACs) are changing the landscape for stroke prevention in atrial fibrillation (AF) and prevention or treatment of venous thromboembolism (VTE). In patients with AF and concomitant acute coronary syndrome (ACS), the treatment regimen of combined NOACs and P2Y12 inhibitors is gaining popularity. Areas covered: The authors conducted a review of studies published in the last 10 years regarding safety evaluation and effectiveness of apixaban for the treatment of AF and ACS, both alone and in combination with d...
Source: Expert Opinion on Drug Safety - October 4, 2019 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Rapamycin for longevity: opinion article.
Abstract From the dawn of civilization, humanity has dreamed of immortality. So why didn't the discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will discuss several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as anti-aging drugs today. Furthermore, the alternative to the reversible (and avoidable) side effects of rapamycin/everolimus are the irreversible (and inevitable) effects of aging: cancer, stroke, infarction, blindness and premature deat...
Source: Aging - October 4, 2019 Category: Biomedical Science Authors: Blagosklonny MV Tags: Aging (Albany NY) Source Type: research
Early and late outcomes of aortic surgery under hypothermic circulatory arrest in the elderly: a single center study.
CONCLUSIONS: Aortic surgery with circulatory arrest in the elderly demonstrated favorable early and late results when compared with younger individuals, with an acceptable operative risk even under emergency conditions, and should not be denied only because of the chronological age of the patients. PMID: 31599143 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - October 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Mauduit M, Anselmi A, Tomasi J, Belahj Soulami R, Roisné A, Flecher E, Rouzé S, Verhoye JP Tags: J Cardiovasc Surg (Torino) Source Type: research
Comparison of automated fastener device Cor-Knot versus manually tied knot in minimally-invasive isolated aortic valve replacement surgery.
CONCLUSIONS: The automated Cor-Knot fastener is an easy-to-use, time-saving device which does not increase perioperative morbidity and mortality in patients undergoing aortic valve replacement by right anterior minithoracotomy. PMID: 31599141 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - October 4, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Morgant MC, Malapert G, Petrosyan A, Pujos C, Jazayeri S, Bouchot O Tags: J Cardiovasc Surg (Torino) Source Type: research
Mayo Clinic Minute: Does eating red meat affect heart health?
Red meat consumption has long been associated with increased risk of diseases, such as heart attack and stroke. A new study suggests that meat may not be so bad after all. Nevertheless, Dr. Stephen Kopecky, a Mayo Clinic cardiologist, says that limiting red meat in your diet is still important for heart health. Watch: The [...]
Source: News from Mayo Clinic - October 4, 2019 Category: Databases & Libraries Source Type: news
Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway
Background: Our previous study showed that propofol, one of the widely used anesthetic agents, can attenuate subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) via inhibiting inflammatory and oxidative reaction. However, it is perplexing whether propofol attenuates inflammatory and oxidative reaction through modulating PI3K/Akt pathway. The present study investigated whether PI3K/Akt pathway is involved in propofol's anti-inflammation, antioxidation, and neuroprotection against SAH-induced EBI.
Source: Journal of Stroke and Cerebrovascular Diseases - October 4, 2019 Category: Neurology Authors: Hua-bin Zhang, Xian-kun Tu, Quan Chen, Song-sheng Shi Source Type: research
Prevalence of Established Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus in the UK
ConclusionApproximately one-third of patients with T2DM in the UK have concomitant CVD.FundingMerck Sharp& Dohme Corp., a subsidiary Merck& Co., Inc., Kenilworth, NJ, USA.
Source: Diabetes Therapy - October 4, 2019 Category: Endocrinology Source Type: research
Prevention of neointimal hyperplasia induced by an endovascular stent via intravenous infusion of mesenchymal stem cells.
CONCLUSIONS: Intravenous infusion of MSCs inhibited the inflammatory reaction to an implanted stent strut, and prevented progressive neointimal hyperplasia in the stented CCA and SCA in a porcine model. Thus, MSC treatment could attenuate the recurrence of cerebral ischemic events after stenting. PMID: 31585431 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - October 4, 2019 Category: Neurosurgery Authors: Nakazaki M, Oka S, Sasaki M, Kataoka-Sasaki Y, Onodera R, Komatsu K, Iihoshi S, Hiroura M, Kawaguchi A, Kocsis JD, Honmou O Tags: J Neurosurg Source Type: research
Racial phenotypes in moyamoya disease: a comparative analysis of clinical presentation and natural history in a single multiethnic cohort of 250 hemispheres.
CONCLUSIONS: This study suggests a comparatively more progressive course of MMD in Asians. Further studies are required to fully characterize the phenotypic distinctions between different races and underlying pathophysiological mechanisms. PMID: 31585430 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - October 4, 2019 Category: Neurosurgery Authors: Feghali J, Xu R, Yang W, Liew J, Tamargo RJ, Marsh EB, Huang J Tags: J Neurosurg Source Type: research
Moyamoya disease versus moyamoya syndrome: comparison of presentation and outcome in 338 hemispheres.
CONCLUSIONS: MMD and MMS have largely comparable clinical and angiographic phenotypes with analogously favorable responses to surgical revascularization. PMID: 31585423 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - October 4, 2019 Category: Neurosurgery Authors: Feghali J, Xu R, Yang W, Liew JA, Blakeley J, Ahn ES, Tamargo RJ, Huang J Tags: J Neurosurg Source Type: research
Optimism tied to lower rates of heart attacks, death
(Reuters Health) - People with a positive outlook on life may be less likely than pessimists to experience events like a heart attack or stroke, and they may live longer, a recent review of existing research suggests.
Source: Reuters: Health - October 3, 2019 Category: Consumer Health News Tags: healthNews Source Type: news