Query: stroke

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miR-9-5p attenuates ischemic stroke through targeting ERMP1-mediated endoplasmic reticulum stress.
Abstract Ischemic stroke (IS) is a cerebrovascular disease with serious neurological function impairment, which may activate endoplasmic reticulum (ER) stress. However, the underlying regulatory mechanism of ER stress under IS remains unclear. miR-9-5p is enriched in the brain tissues and plays a role in the pathological process of IS. Therefore, the purpose of this study is to explore the effect of miR-9 on ER stress and underlying mechanism in IS. Here, a middle cerebral artery occlusion (MCAO) rat model was utilized to examine the alteration of brain pathology, and the expressions of miR-9 and ER stress-related...
Source: Acta Histochemica - September 6, 2019 Category: Biochemistry Authors: Chi L, Jiao D, Nan G, Yuan H, Shen J, Gao Y Tags: Acta Histochem Source Type: research

Potential roles of matricellular proteins in stroke.
This article reviews the available information regarding potential roles of matricellular proteins in stroke, and discusses the potential therapeutic approaches against stroke using matricellular proteins. PMID: 31499062 [PubMed - as supplied by publisher]
Source: Experimental Neurology - September 6, 2019 Category: Neurology Authors: Kawakita F, Kanamaru H, Asada R, Suzuki H Tags: Exp Neurol Source Type: research

Vegetarians May Face Higher Stroke Risk
While vegetarians had a 22% lower risk for heart disease, they had a 20% higher risk for stroke, British researchers found. Meanwhile, people who ate fish but no other meats (pescatarians) had a 13% lower risk of heart disease, with no increased stroke risk.
Source: WebMD Health - September 5, 2019 Category: Consumer Health News Source Type: news

Upstate University Hospital sponsors first Stroke Camp Sept. 6, 7 and 8
Upstate University Hospital will sponsor New York state ’s first Stroke Camp Sept. 6 to 8 at Greek Peak Mountain Resort in Cortland, N.Y.
Source: SUNY Upstate Medical - September 5, 2019 Category: Universities & Medical Training Source Type: news

Ischemic Stroke In Neonatal And Adult Astrocytes
The objective of this paper is to review current information regarding astrocytes function after a stroke in neonatal and adult brain. Based on the current literature, there are some molecular differences related to blood brain barrier (BBB) homeostasis disruption, inflammation and reactive oxygen species (ROS) mediated injury between the immature and mature brain after an ischemic event. In particular, astrocytes, the main glial cells in brain, play a different role in neonatal and adult brain after stroke, as time course of glial activation is strongly age dependent. Moreover, the present review provides further insight ...
Source: Mechanisms of Ageing and Development - September 5, 2019 Category: Geriatrics Source Type: research

A New Study Suggests Vegetarians and Vegans Are at Higher Risk of Stroke. But Don ’t Reach for That Steak Just Yet
Vegetarians and vegans are likely to be concerned by the results of a new study with a surprising finding: those following meat-free diets, which are typically associated with better cardiovascular health, may actually have a higher risk of stroke than those who eat meat. But it’s too soon to run out and order a steak. The paper, published in the BMJ, found only a small increase in the risk of stroke, while confirming findings in other studies that vegetarians and vegans may have a lower risk of heart disease than meat-eaters. “It’s important to emphasize that we’ve looked at two outcomes here,R...
Source: TIME: Health - September 5, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Diet/Nutrition onetime Source Type: news

Tanzania: Sharp Rise in Stroke Admissions At Tanzania Hospital
[SciDev.Net] Nairobi -Two cardiovascular diseases - heart failure and stroke - account for 20 per cent of hospital admissions, with stroke rising 70-fold over 43 years, a study of a referral health facility in northern Tanzania has found.
Source: AllAfrica News: Health and Medicine - September 5, 2019 Category: African Health Source Type: news

Going Vegetarian Good for Your Heart, But May Up Stroke Risk
THURSDAY, Sept. 5, 2019 -- Vegetarianism is all the rage these days, but a new study suggests that slicing meat from your diet might raise your risk of stroke slightly. While vegetarians had a 22% lower risk for heart disease, they had a 20% higher...
Source: Drugs.com - Daily MedNews - September 5, 2019 Category: General Medicine Source Type: news

AHA News: Now a 2-Time Survivor, Tedy Bruschi Still Tackling Stroke Awareness
THURSDAY, Sept. 5, 2019 (American Heart Association News) -- Former NFL star Tedy Bruschi spent the last 14 years showing what a stroke survivor could do: continue playing pro football, climb Mount Kilimanjaro, run the Boston Marathon. Now Bruschi...
Source: Drugs.com - Daily MedNews - September 5, 2019 Category: General Medicine Source Type: news

Structural Disconnections Explain Brain Network Dysfunction after Stroke
Publication date: 3 September 2019Source: Cell Reports, Volume 28, Issue 10Author(s): Joseph C. Griffis, Nicholas V. Metcalf, Maurizio Corbetta, Gordon L. ShulmanSummaryStroke causes focal brain lesions that disrupt functional connectivity (FC), a measure of activity synchronization, throughout distributed brain networks. It is often assumed that FC disruptions reflect damage to specific cortical regions. However, an alternative explanation is that they reflect the structural disconnection (SDC) of white matter pathways. Here, we compare these explanations using data from 114 stroke patients. Across multiple analyses, we f...
Source: Cell Reports - September 5, 2019 Category: Cytology Source Type: research

Stroke: This popular diet may raise your risk of the deadly condition by 20 per cent
STROKE is a serious and life-threatening medical condition. While age is a significant risk factor, lifestyle choices can also pose a threat. Recent evidence suggests a popular diet could raise a person ’s risk.
Source: Daily Express - Health - September 5, 2019 Category: Consumer Health News Source Type: news

Identifying and Validating New Drug Targets for Stroke and Beyond.
PMID: 31479321 [PubMed - in process]
Source: Circulation - September 5, 2019 Category: Cardiology Authors: Plump A, Davey Smith G Tags: Circulation Source Type: research

Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia
In conclusion, our findings confirm and extend our understanding of the multidimensionality of stroke aphasia, emphasize the importance of assessing non-verbal cognition in this patient group and provide directions for future research and cl inical practice. We also briefly compare and discuss univariate and multivariate methods for brain-behaviour mapping.
Source: Brain - September 5, 2019 Category: Neurology Source Type: research

Is There Equipoise Regarding the Optimal Medical Treatment of Patients with Asymptomatic White Matter Hyperintensities?
Background: White matter hyperintensity (WMH) is a common manifestation of chronic ischemic microvascular disease that heralds greater risk of functional disability, stroke, and dementia. SPRINT MIND recently reported that intensive blood pressure reduction resulted in lower rates of mild cognitive impairment and WMH progression, suggesting that medical interventions could have a measurable impact on WMH. We conducted an anonymous survey of providers in the NINDS StrokeNet to better understand neurologist attitudes about asymptomatic WMH.
Source: Journal of Stroke and Cerebrovascular Diseases - September 5, 2019 Category: Neurology Authors: Adam de Havenon, Shyam Prabhakaran, Tanya Turan, Rebecca Gottesman, Sharon Yeatts, Natalia Rost Source Type: research

A Preliminary Study of Dual-Task Training Using Virtual Reality: Influence on Walking and Balance in Chronic Poststroke Survivors
Stroke is a leading cause of death and disability in the Western world, and leads to impaired balance and mobility. Objective: To investigate the feasibility of using a Virtual Reality-based dual task of an upper extremity while treadmill walking, to improve gait and functional balance performance of chronic poststroke survivors.
Source: Journal of Stroke and Cerebrovascular Diseases - September 5, 2019 Category: Neurology Authors: Pavel Fishbein, Yeshayahu Hutzler, Motti Ratmansky, Iuly Treger, Ayelet Dunsky Source Type: research

Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice
This study is the first to document functional significance of Nln in pathophysiology of stroke and provide evidence that Nln is an endogenous mechanism functioning to preserve the brain from ischemic injury.This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - September 5, 2019 Category: Neuroscience Authors: Srinidhi Jayaraman, Abdullah Al Shoyaib, Joanna Kocot, Heidi Villalba, Faisal F. Alamri, Mamoon Rashid, Naomi J. Wangler, Ekram A. Chowdhury, Nadezhda German, Thiruma V. Arumugam, Thomas J. Abbruscato, Vardan T. Karamyan Tags: Original Article Source Type: research

Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
AbstractUric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models. Whether serum UA plays a role in hemorrhagic transformation (HT) remains unclear. We aimed to explore the association between serum UA and HT in patients with acute ischemic stroke (AIS). AIS patients within 7  days after stroke onset were consecutively enrolled between January 2016 and October 2017. Patients were categorized into three groups according to serum UA tertiles by sex. HT was detected by follow-up CT or MRI within 7 days after admission. The multivariate logistic analysis was performed to a ssess the associat...
Source: Journal of Molecular Neuroscience - September 5, 2019 Category: Neuroscience Source Type: research

Bridging the Gap Between Diabetes and Stroke in Search of High Clinical Relevance Therapeutic Targets
AbstractDiabetes affects more than 425 million people worldwide, a scale approaching pandemic proportion. Diabetes represents a major risk factor for stroke, and therefore is actively addressed for stroke prevention. However, how diabetes affects stroke severity has not yet been extensively considered, which is surprising given the evident but understudied common mechanistic features of both pathologies. The increase in number of diabetic people, incidence of stroke in the presence of this specific risk factor, and the exacerbation of ischemic brain damage in diabetic conditions (at least in animal models) warrants the nee...
Source: NeuroMolecular Medicine - September 5, 2019 Category: Neurology Source Type: research

Self-perceived impact of stroke: A longitudinal comparison between one and five years post-stroke.
CONCLUSION: The perceived impact of stroke becomes more prominent with time, even for persons with mild-to-moderate stroke. This study highlights the need for long-term support for persons with stroke. PMID: 31478056 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - September 4, 2019 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Intense Step Training Helps After Stroke
Intense Step Training May Improve Walking, Balance After Stroke
Source: eMedicineHealth.com - September 4, 2019 Category: General Medicine Source Type: news

Diagnostic accuracy of clinical tools for assessment of acute stroke: a systematic review
Recanalisation therapy in acute ischaemic stroke is highly time-sensitive, and requires early identification of eligible patients to ensure better outcomes. Thus, a number of clinical assessment tools have bee...
Source: BMC Emergency Medicine - September 4, 2019 Category: Emergency Medicine Authors: Daria Antipova, Leila Eadie, Ashish Macaden and Philip Wilson Tags: Research article Source Type: research

Ramen restaurant prevalence is associated with stroke mortality in Japan: an ecological study
The association between stroke and nutrition has recently been investigated. However, the association between diet and stroke in Japan has not been clarified. We hypothesized that there may be an association b...
Source: Nutrition Journal - September 4, 2019 Category: Nutrition Authors: Kosuke Matsuzono, Makiko Mieno and Shigeru Fujimoto Tags: Research Source Type: research

Defining Ischemic Core in Acute Ischemic Stroke Using CT Perfusion: A Multiparametric Bayesian-Based Model ADULT BRAIN
CONCLUSIONS: We established thresholds for the Bayesian model to estimate the ischemic core. The described multiparametric Bayesian-based model improved consistency in CTP estimation of the ischemic core compared with the methodology used in current clinical routine.
Source: American Journal of Neuroradiology - September 4, 2019 Category: Radiology Authors: Nael, K., Tadayon, E., Wheelwright, D., Metry, A., Fifi, J. T., Tuhrim, S., De Leacy, R. A., Doshi, A. H., Chang, H. L., Mocco, J. Tags: ADULT BRAIN Source Type: research

25-Hydroxyvitamin D Level, Vitamin D Intake, and Risk of Stroke: A Dose –Response Meta-Analysis
A growing number of studies have shown that vitamin D are related to the risk of stroke, however, the dose –response association between vitamin D and the risk of stroke is still unclear. Accordingly, we conducted a dose–response meta-analysis to evaluate the relationships between 25-hydroxyvitamin D [25(OH)D] level, vitamin D intake, and the risk of stroke by summarizing cohort studies.
Source: Clinical Nutrition - September 4, 2019 Category: Nutrition Authors: Han Shi, Hanze Chen, Yun Zhang, Jinwei Li, Kailei Fu, Weishuang Xue, Weiyu Teng, Li Tian Tags: Meta-analyses Source Type: research

Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect
Epidemiological studies suggest that pharmacological reduction of systemic hypertension lowers incidence and severity of stroke. However, whether the reduction of blood pressure per se or the compounds used to reduce hypertension are responsible for this effect received little attention. In the current study we therefore aimed to investigate whether Aliskiren, a renin-inhibitor used to treat arterial hypertension, may improve outcome in a mouse model of ischemic stroke when applied centrally and in a dose not affecting blood pressure. Male C57BL/6 mice received 0.6, 2.0, or 6.0 µg Aliskiren or vehicle by intracerebroven...
Source: Frontiers in Neurology - September 4, 2019 Category: Neurology Source Type: research

Risk factors for decompressive craniectomy after endovascular treatment in acute ischemic stroke
This study aimed to evaluate the risk factors for subsequent DC after EVT. This retrospective cohort study comprised 138 patients who received EVT between April 2015 and June 2019 at our center. The need for subsequent DC was defined as cerebral edema or/and hemorrhagic transformation caused by large ischemic infarction, with a ≥ 5-mm midline shift and clinical deterioration after EVT. The relationship between risk factors and DC after EVT was assessed via univariate and multivariable logistic regression. Thirty (21.7%) patients required DC. These patients tended to have atrial fibrillation (P = 0.037), sedation (P...
Source: Neurosurgical Review - September 4, 2019 Category: Neurosurgery Source Type: research

25-Hydroxyvitamin D level, vitamin D intake, and risk of stroke: A  dose–response meta-analysis
A growing number of studies have shown that vitamin D are related to the risk of stroke, however, the dose –response association between vitamin D and the risk of stroke is still unclear. Accordingly, we conducted a dose–response meta-analysis to evaluate the relationships between 25-hydroxyvitamin D [25(OH)D] level, vitamin D intake, and the risk of stroke by summarizing cohort studies.
Source: Clinical Nutrition - September 4, 2019 Category: Nutrition Authors: Han Shi, Hanze Chen, Yun Zhang, Jinwei Li, Kailei Fu, Weishuang Xue, Weiyu Teng, Li Tian Tags: Meta-analyses Source Type: research

Functions of subventricular zone neural precursor cells in stroke recovery.
Abstract The proliferation and ectopic migration of neural precursor cells (NPCs) in response to ischemic brain injury was first reported two decades ago. Since then, studies of brain injury-induced subventricular zone cytogenesis, primarily in rodent models, have provided insight into the cellular and molecular determinants of this phenomenon and its modulation by various factors. However, despite considerable correlational evidence-and some direct evidence-to support contributions of NPCs to behavioral recovery after stroke, the causal mechanisms have not been identified. Here we discuss the subventricular zone ...
Source: Behavioural Brain Research - September 4, 2019 Category: Neurology Authors: Williamson MR, Jones TA, Drew MR Tags: Behav Brain Res Source Type: research

Mobile CT unit boosts efficiency of stroke triage
Mobile stroke ambulances equipped with a CT scanner and medical personnel can...Read more on AuntMinnie.comRelated Reading: 3 CTA signs show which stroke patients can skip surgery Perfusion imaging expands window for stroke treatment Head CT algorithm a step toward faster stroke care Mobile stroke unit with CT scanner speeds care in Cleveland Ambulance with mobile CT cuts stroke treatment times
Source: AuntMinnie.com Headlines - September 3, 2019 Category: Radiology Source Type: news

Intense Step Training May Improve Walking, Balance After Stroke Intense Step Training May Improve Walking, Balance After Stroke
Challenging patients after a stroke with intense and complex tasks that mirror real-world challenges may improve walking skills such as gait symmetry, new research suggests.Medscape Medical News
Source: Medscape Cardiology Headlines - September 3, 2019 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Neurotechnology for Upper Limb Motor Rehabilitation in Stroke Neurotechnology for Upper Limb Motor Rehabilitation in Stroke
Learn how neurotechnologies, including robotics, muscular electrical stimulation, brain stimulation and brain-computer/machine interfaces can support upper limb motor recovery in severe stroke.Brain
Source: Medscape Today Headlines - September 3, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Prehospital Stroke Management Optimized by the Use of Clinical Scoring vs Mobile Stroke Unit
This randomized clinical trial explores how prehospital management optimized by the use of the Los Angeles Motor Scale compares with prehospital management in a mobile stroke unit that includes vascular imaging in accurately triaging patients with stroke to the appropriate target hospital providing (comprehensive stroke center) or not providing (primary stroke center) neurointerventional treatment.
Source: JAMA Neurology - September 3, 2019 Category: Neurology Source Type: research

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: A Meta-Analysis of Population-Based Studies Involving 17,180 Individuals.
CONCLUSIONS: Higher circulating levels of MCP-1 are associated with increased long-term risk of stroke. Our findings along with genetic and experimental evidence suggest that MCP-1-signaling might represent a therapeutic target to lower stroke risk. PMID: 31476962 [PubMed - as supplied by publisher]
Source: Circulation Research - September 3, 2019 Category: Cardiology Authors: Georgakis MK, Malik R, Björkbacka H, Pana TA, Demissie S, Ayers C, Elhadad MA, Fornage M, Beiser AS, Benjamin EJ, Boekholdt MS, Engström G, Herder C, Hoogeveen RC, Koenig W, Melander O, Orho-Melander M, Schiopu A, Söderholm M, Wareham N, Ballantyne CM, Tags: Circ Res Source Type: research

Low homoarginine/SDMA ratio is associated with poor short- and long-term outcome after stroke in two prospective studies
ConclusionThese results from two prospective stroke studies reveal that hArg/SDMA ratio could prove a valuable blood-based biomarker to discriminate patients with poor short- and long-term outcome, increased neurological impairment, and severe disability after stroke.
Source: Neurological Sciences - September 3, 2019 Category: Neurology Source Type: research

In-Hospital and Long-Term Prognosis after Spontaneous Intracerebral Hemorrhage among Young Adults Aged 18-65 Years
Background: Spontaneous intracerebral hemorrhage (ICH) accounts for 10%-15% of all strokes and has an estimated annual incidence of 5/100,000 in young adults. Limited data on prognosis after ICH in young adults are available. We aimed to identify prognostic predictors after ICH among adults aged 18-65 years. Methods: We retrospectively selected all patients with ICH from a prospective single-center registry of adults with first stroke before 65 years between 1997 and 2002. We recorded in-hospital mortality as well as mortality and recurrent stroke after discharge until December 1, 2018.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2019 Category: Neurology Authors: Francisco Bernardo, Leonor Rebord ão, Sara Machado, Vasco Salgado, Amélia Nogueira Pinto Source Type: research

ADAMTS13 activity is associated with early neurological improvement in acute ischemic stroke patients treated with intravenous thrombolysis
AbstractAlthough intravenous thrombolysis (IVT) with recombinant tissue-plasminogen-activator represents a highly effective treatment in acute ischemic stroke patients, not every patient benefits. We hypothesized that pretreatment levels of mediators of hemostasis (VWF and ADAMTS13) and dimethylarginines (ADMA and SDMA) are associated with early neurological improvement and outcome after IVT in ischemic stroke. Moreover we aimed to investigate the link between ADAMTS13 and markers of inflammation (CRP, IL-6, MMP-9 and MCP-1). In 43 patients with acute ischemic stroke treated with IVT blood samples for determination of the ...
Source: Journal of Thrombosis and Thrombolysis - September 3, 2019 Category: Hematology Source Type: research

Society of Interventional Radiology Training Guidelines for Endovascular Stroke Treatment
In 2009, the Society of Interventional Radiology (SIR) published training guidelines for intraarterial catheter-directed treatment of acute ischemic stroke (1). At that time, catheter-directed thrombolysis was the dominant endovascular therapy and the only such therapy studied in randomized trials (2,3). Only first-generation mechanical thrombectomy devices were available. Computed tomographic (CT) angiography, magnetic resonance (MR) angiography, and perfusion imaging were not routinely used for assessment of large-vessel occlusion and/or parenchymal infarction and ischemia.
Source: Journal of Vascular and Interventional Radiology : JVIR - September 3, 2019 Category: Radiology Authors: David Sacks, Mazen K. AbuAwad, Sun Ho Ahn, Mark O. Baerlocher, Paul S. Brady, John W. Cole, Sabeen Dhand, Benjamin D. Fox, Joseph J. Gemmete, Joanna W. Kee-Sampson, Vance McCollom, Parag J. Patel, Martin G. Radvany, Robert D. Tomalty, Venu Vadlamudi, Mich Tags: Standards of Practice Source Type: research

Baroreflex sensitivity is associated with post-stroke infections. An open, prospective study
Autonomic nervous system (ANS) seems to play an important role in the post-stroke immunosuppression syndrome with increased susceptibility to infections. The aim of this study was to investigate if ANS activity measured at admission is associated with post-stroke infections.
Source: Journal of the Neurological Sciences - September 3, 2019 Category: Neurology Authors: Marek Sykora, Pavel Siarnik, Jozef Szabo, Peter Turcani, Stefan Krebs, Wilfried Lang, Stanislava Jakubicek, Marek Czosnyka, Peter Smielewski Source Type: research

Interleukin-17 receptor C  gene polymorphism reduces treatment effect and promotes poor prognosis of ischemic stroke.
CONCLUSION: IS up-regulates the expression of IL-17 and IL-17RC. IL-17RC re37511 indicates the patients have a poorer treatment effect and prognosis. PMID: 31481525 [PubMed - as supplied by publisher]
Source: Bioscience Reports - September 3, 2019 Category: Biomedical Science Authors: Tian J, Bai Y, You A, Shen R, Yan J, Deng W, Wen L, Li M, Teng J Tags: Biosci Rep Source Type: research

Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion
AbstractMechanical thrombectomy for the treatment of ischemic stroke shows high rates of recanalization; however, some patients still have a poor clinical outcome. A proposed reason for this relates to the fact that the ischemic infarct growth differs significantly between patients. While some patients demonstrate rapid evolution of their infarct core (fast evolvers), others have substantial potentially salvageable penumbral tissue even hours after initial vessel occlusion (slow evolvers). We show that the dog middle cerebral artery occlusion model recapitulates this key aspect of human stroke rendering it a highly desirab...
Source: Translational Stroke Research - September 3, 2019 Category: Neurology Source Type: research

Deep regression neural networks for collateral imaging from dynamic susceptibility contrast-enhanced magnetic resonance perfusion in acute ischemic stroke
ConclusionThe results suggested that the proposed network performs equally well for both control and acute ischemic stroke groups. The proposed network could help automate the assessment of collateral status in an efficient and effective manner and improve the quality and yield of diagnosis of acute ischemic stroke. The follow-up study will entail the clinical evaluation of the collateral images that are generated by the proposed network.
Source: International Journal of Computer Assisted Radiology and Surgery - September 3, 2019 Category: Intensive Care Source Type: research

Polish Helicopter Emergency Medical Service (HEMS) Response to Stroke: A Five-Year Retrospective Study.
CONCLUSIONS The use of HEMS in Poland in the case of patients with stroke symptoms ensures fast and professional assistance at the site of the medical emergency as well as safe transport to specialized centers, shortening the time of proper treatment implementation. PMID: 31473759 [PubMed - in process]
Source: Medical Science Monitor - September 2, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Inclusion of a care bundle for fever, hyperglycaemia and swallow management in a National Audit for acute stroke: evidence of upscale and spread
In the Quality in Acute Stroke Care (QASC) trial undertaken in stroke units (SUs) located in New South Wales (NSW), Australia (2005 –2010), facilitated implementation of a nurse-led care bundle to manage fever,...
Source: Implementation Science - September 2, 2019 Category: Health Management Authors: Tara Purvis, Sandy Middleton, Louise E. Craig, Monique F. Kilkenny, Simeon Dale, Kelvin Hill, Catherine D ’Este and Dominique A. Cadilhac Tags: Research Source Type: research

Genetic modulators of fetal hemoglobin expression and ischemic stroke occurrence in African descendant children with sickle cell anemia
This study aimed to investigate the influence of genetic variants on the levels of fetal hemoglobin (Hb F) and biochemical parameters related with chronic hemolysis, as well as on ischemic stroke risk, in ninety-one unrelated SCA patients, children of sub-Saharan progenitors. Our results show that a higher Hb F level has an inverse relationship with the occurrence of stroke, since the group of patients who suffered stroke presents a significantly lower mean Hb F level (5.34  ± 4.57% versus 9.36 ± 6.48%;p = 0.024). Furthermore, the co-inheritance of alpha-thalassemia improves the chronic hemolytic pattern, evid...
Source: Annals of Hematology - September 2, 2019 Category: Hematology Source Type: research