Query: stroke

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Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia-reperfusion in rats.
Authors: Yang P, Tian YM, Deng WX, Cai X, Liu WH, Li L, Huang HY Abstract Neurons undergo degeneration, apoptosis and death due to ischaemic stroke. The present study investigated the effect of Sijunzi decoction (SJZD), a type of traditional Chinese medicine known as invigorating spleen therapy, on anoikis (a type of apoptosis) in rat brains following cerebral ischaemia-reperfusion. Rats were randomly divided into sham, model, nimodipine and SJZD low/medium/high dose groups. A middle cerebral artery occlusion model was established. Neurobehavioural scores were evaluated after administration for 14 days using a five...
Source: Experimental and Therapeutic Medicine - October 2, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

miR-183 inhibits microglia activation and expression of inflammatory factors in rats with cerebral ischemia reperfusion via NF- κB signaling pathway.
miR-183 inhibits microglia activation and expression of inflammatory factors in rats with cerebral ischemia reperfusion via NF-κB signaling pathway. Exp Ther Med. 2019 Oct;18(4):2540-2546 Authors: Xiang B, Zhong P, Fang L, Wu X, Song Y, Yuan H Abstract Ischemic stroke represents 87% of all strokes, and is the third leading cause of disability and mortality worldwide. The cause of ischemic stroke is the obstruction of blood flow through the artery that supplies oxygen-rich blood to the brain, with ischemia-reperfusion injury as its major cause. microRNAs (miRNA) are small non-coding RNAs, which serve i...
Source: Experimental and Therapeutic Medicine - October 2, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Medical News Today: What causes left sided facial numbness?
Possible causes of left sided facial numbness include stroke, multiple sclerosis, and Bell ’s palsy. Learn more about left sided facial numbness here.
Source: Health News from Medical News Today - October 2, 2019 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Defining Innovation
What’s behind the record-breaking growth shared in EY’s 2019 “Pulse of the Industry” medtech report? Innovation, along with plenty of opportunities to solve some unmet needs. “We are at an awesome time in terms of innovation,” explained Ashley McEvoy, worldwide chairman, medical devices, Johnson & Johnson. Technology can now reach once-difficult-to-access anatomy, and miniaturization can enable earlier intervention, she pointed out as notable advances. McEvoy was part of EY’s “...
Source: MDDI - October 2, 2019 Category: Medical Devices Authors: Daphne Allen Tags: Business Source Type: news

Transcatheter closure of patent foramen ovale in patients older than 60 years of age with cryptogenic embolism
ConclusionsIn older patients with cryptogenic embolism, PFO closure was safe and associated with a low rate of ischemic events at long-term. However, older patients exhibited a tendency toward a higher incidence of recurrent stroke/TIA compared with younger patients, likely related to a higher burden of CVRF.ResumenIntroducción y objetivosEstudios aleatorizados han mostrado la eficacia del cierre percutáneo del foramen oval permeable (FOP) en pacientes de edad ≤ 60 años con ictus criptogénico. El objetivo de este estudio es determinar la seguridad y la eficacia a largo plazo del cierre percutáneo del FOP en paciente...
Source: Revista Espanola de Cardiologia - October 2, 2019 Category: Cardiology Source Type: research

Agonist-Antagonist Coactivation Enhances Corticomotor Excitability of Ankle Muscles.
Abstract Spinal pathways underlying reciprocal flexion-extension contractions have been well characterized, but the extent to which cortically evoked motor-evoked potentials (MEPs) are influenced by antagonist muscle activation remains unclear. A majority of studies using transcranial magnetic stimulation- (TMS-) evoked MEPs to evaluate the excitability of the corticospinal pathway focus on upper extremity muscles. Due to functional and neural control differences between lower and upper limb muscles, there is a need to evaluate methodological factors influencing TMS-evoked MEPs specifically in lower limb musculatu...
Source: Neural Plasticity - October 2, 2019 Category: Neurology Authors: Kesar TM, Tan A, Eicholtz S, Baker K, Xu J, Anderson JT, Wolf SL, Borich MR Tags: Neural Plast Source Type: research

Comparison of TransFemoral Transcatheter Aortic Valve Replacement Performed With a Minimally Invasive Simplified Technique: "FAST" Versus a Standard Approach.
CONCLUSIONS: FAST can be safely performed and is associated with lower rates of iatrogenic complications and a shorter length of stay. PMID: 31567114 [PubMed - in process]
Source: The Journal of Invasive Cardiology - October 2, 2019 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Early Experience With Embolic Protection Devices During Transcatheter Aortic Valve Replacement.
CONCLUSION: EPD was used in lower-risk patients, possibly related to lower incidence of vessel calcification in those patients that may preclude EPD use. Although postoperative outcomes between groups were comparable, current EPD design use precludes its utilization in higher-risk patients. PMID: 31567113 [PubMed - in process]
Source: The Journal of Invasive Cardiology - October 2, 2019 Category: Cardiology Tags: J Invasive Cardiol Source Type: research

Utilization of an Optimized Radiation Strategy in Primary Percutaneous Coronary Intervention for Patients with ST-Segment-Elevation Myocardial Infarction.
Conclusion: With optimized radiation strategy, significant radiation dose reduction could be achieved in P-PCI for STEMI patients. It appears to be feasible and safe to carry out the optimized radiation strategy in P-PCI for STEMI patients. PMID: 31565430 [PubMed]
Source: Cardiology Research and Practice - October 2, 2019 Category: Cardiology Authors: Zhong X, Gao W, Huang D, Ge L, Qian J, Ge J Tags: Cardiol Res Pract Source Type: research

Late delayed radiation-induced cerebral Arteriopathy by high-resolution magnetic resonance imaging: a case report
Radiation therapy can cause cerebral arteriopahty, resulting in ischemic stroke. We document late-delayed cerebral arteriopathy by high-resolution magnetic resonance imaging (HR-MRI) in a middle aged man who h...
Source: BMC Neurology - October 2, 2019 Category: Neurology Authors: Huan Chen, Xiuhua Li, Xiaoyu Zhang, Wenjuan Xu, Fei Mao, Mengxin Bao and Meijia Zhu Tags: Case report Source Type: research

Establishment of optimal two-point discrimination test method and consideration of reproducibility
Publication date: Available online 30 September 2019Source: Neuroscience LettersAuthor(s): Hirotake Yokota, Naofumi Otsuru, Rie Kikuchi, Rinako Suzuki, Sho Kojima, Kei Saito, Shota Miyaguchi, Yasuto Inukai, Hideaki OnishiAbstractTwo-point discrimination (TPD) has been widely used as a parameter for the examination of higher-order perceptual functions in the field of rehabilitation. Previous research has shown that the threshold of TPD increases with aging or pathological conditions such as stroke or chronic pain. It has also been reported that the threshold can be decreased by continuous tactile or electrical stimulation. ...
Source: Neuroscience Letters - October 2, 2019 Category: Neuroscience Source Type: research

Repetitive Transcranial Magnetic Stimulation for the Treatment of Lower Limb Dysfunction in Patients Poststroke: A Systematic Review with Meta-Analysis
To investigate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in recovery of lower limb dysfunction in patients poststroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 2, 2019 Category: Neurology Authors: Mahboubeh Ghayour-Najafabadi, Amir-Hossein Memari, Lida Hosseini, Ardalan Shariat, Joshua A. Cleland Tags: Review Article Source Type: research

Activation of The Metabolic Master Regulator PPAR γ - A Potential PIOneering Therapy for Pulmonary Arterial Hypertension.
The objective is a data-driven approach to set the preclinical and clinical study record straight. The convincing recent clinical trial data on the lack of significant toxicity in high risk populations justify the timely conduction of clinical studies in order to achieve "repurposing" or "repositioning" of pioglitazone for the treatment of clinical PAH. PMID: 31577451 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - October 2, 2019 Category: Respiratory Medicine Authors: Hansmann G, Calvier L, Risbano MG, Chan SY Tags: Am J Respir Cell Mol Biol Source Type: research

Global multielectrode contact ‐mapping plus ablation with a single catheter in patients with atrial fibrillation: Global AF study
ConclusionsIn this first clinical series, the Globe catheter was found to be an easy ‐to‐use system for single‐shot PVI. The continuously updated multielectrode voltage and activation mapping data indicate future options for mapping and ablation beyond PVI.
Source: Journal of Cardiovascular Electrophysiology - October 2, 2019 Category: Cardiology Authors: Hans Kottkamp, Gerhard Hindricks, Christian P önisch, Livio Bertagnolli, Fabian Moser, Sebastian Hilbert, Andreas Rieger, Philipp Sommer Tags: ORIGINAL ARTICLE Source Type: research

Utredning av pasienter med akutt svimmelhet ved en nevrologisk avdeling.
Abstract BACKGROUND: Acute dizziness may have a number of causes, including cerebrovascular stroke which can present as isolated acute vestibular syndrome. It is recommended that acute episodic dizziness be assessed using positioning tests, and acute persistent dizziness with a focus on the HINTS (Head Impulse, Nystagmus, Test of Skew) battery of tests, which can distinguish cerebrovascular stroke from vestibular neuritis. We wished to identify the prevalence, diagnostic spectrum and approach to acute dizziness in a neurological department. MATERIAL AND METHOD: We undertook a retrospective review of the medic...
Source: Tidsskrift for den Norske Laegeforening - October 2, 2019 Category: General Medicine Authors: Weisshaar M, Mygland Å, Ljøstad U Tags: Tidsskr Nor Laegeforen Source Type: research

Meta-Analysis of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in patients at Low Surgical Risk.
CONCLUSIONS: in patients who are at low surgical risk, TAVI seems to be associated with equivalent mortality up to a median follow up of 2 years compared to SAVR. More data is required before TAVI can be routinely considered as an alternative for SAVR in low risk patients. PMID: 31566571 [PubMed - as supplied by publisher]
Source: EuroIntervention - October 1, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Early Hemodynamic Changes and Long-Term Outcome Of Patients With Severe Low Gradient Aortic Stenosis After Transcatheter Aortic Valve Replacement.
CONCLUSIONS: NFLG-AS was the most prevalent form of LG severe AS and was associated with adequate left ventricular compensation and good prognosis. On the other hand, CLFLG-AS represents the heart-failure with reduced ejection fraction (HFrEF) form of AS and was associated with the worst prognosis, whereas PLFLG-AS represents the heart-failure with preserved ejection fraction (HFpEF) form of AS with intermediary prognosis. Both groups showed early hemodynamic reverse response after TAVR. PMID: 31566569 [PubMed - as supplied by publisher]
Source: EuroIntervention - October 1, 2019 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Five-Year Follow-up of a Severe Case of Pertussis in Oregon, 2012.
We describe the medical course and sequelae of an infant's severe pertussis illness through age 5½ years. The child has failed to meet developmental milestones, requires substantial medical care, and bears the burdens of chronic lung disease, stroke, epilepsy, impaired neurodevelopment, and problems with vision. The medical and social burden of pertussis among infants too young to be vaccinated underscores the importance of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccination during pregnancy. PMID: 31568732 [PubMed - as supplied by publisher]
Source: Public Health Reports - October 1, 2019 Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research

Transcatheter aortic valve replacement: clinical safety and performance data.
Authors: van Baal JWPM, Roszek B, van Elk M, Geertsma RE Abstract Introduction: Patients with severe aortic stenosis and regurgitation who are inoperable or at high-risk for surgery can be treated with transcatheter aortic valve replacement (TAVR). The aim of this study was to provide a comprehensive overview of the literature of TAVR and reported clinical and performance outcomes. Areas covered: A total of 16 devices, described in 204 articles describing clinical and performance outcomes, were included. The most frequently observed outcome was 30-day mortality, ranging between 0-23%. Other commonly reported clinic...
Source: Expert Review of Medical Devices - October 1, 2019 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Comparative effectiveness of different forms of traditional Chinese medicine for treatment of post-stroke depression: Protocol for network meta-analysis of randomized controlled trials: Erratum
No abstract available
Source: Medicine - October 1, 2019 Category: Internal Medicine Tags: Erratum Source Type: research

The Clinical Application of Nerve Injury Unit Mode in Patients with Moderate or Severe Traumatic Brain Injury
Conclusion: For patients with TBI, the nerve injury unit mode can reduce the incidence of complications, improve patient satisfaction rate, shorten the hospitalization time, enhance the daily living ability, improve the patient's neurological function, improve the ability to return to society and have a significant role in promoting the rehabilitation of patients.
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Does the Lag Time Between Injury and Treatment Play a Role in Recovery of Inferior Alveolar Nerve Neurosensory Disturbances Following Mandibular Body Fracture?
Conclusion: It seems that conduction of open reduction with internal rigid fixation shortly after mandibular fracture may shorten the recovery time of NSDs of the IAN following mandibular body fractures.
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Clinical Studies Source Type: research

Approach to Diplopia
This article provides a foundation for formulating an approach to the patient with diplopia and includes practical examples of developing the differential diagnosis, effectively using confirmatory examination techniques, determining an appropriate diagnostic strategy, and (where applicable) providing effective treatment. RECENT FINDINGS Recent population-based analyses have determined that diplopia is a common presentation in both ambulatory and emergency department settings, with 850,000 such visits occurring annually. For patients presenting to an outpatient facility, diagnoses are rarely serious. However, potentially...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2019 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Successful COMPASS, Disappointing COMMANDER HF, What Have We Learned From These Two Trials?
Abstract: Despite considerable progress in the field of heart failure about drugs and device therapy, the mortality rate of patients with heart failure remains high. Studies have shown that thromboembolism and stroke are associated with high mortality in patients with heart failure. Although warfarin therapy reduces the rate of ischemic stroke in patients with heart failure, the overall benefit from warfarin in this population seems to be offset by the increased bleeding risk. Thus, whether patients with chronic heart failure might benefit from anticoagulation, especially in patients with sinus rhythm, is still controver...
Source: Journal of Cardiovascular Pharmacology - October 1, 2019 Category: Cardiology Tags: Perspectives Source Type: research

Factors Affecting Prognosis in Patients With Spontaneous Supratentorial Intracerebral Hemorrhage Under Medical and Surgical Treatment
Spontaneous intracerebral hemorrhage (ICH) is a vascular brain disease that causes very high rates of death and disability. Whether surgical or medical treatment is more appropriate is controversial. The purpose of the study was to examine the morbidity and mortality rates of surgical and medical therapy and their differences in order to determine which patients should be operated. In our study, the authors selected randomly and evaluated retrospectively 49 patients who were operated in Haydarpaşa Numune Research and Education Hospital Neurosurgery Clinic and 51 patients who received medical therapy at Neurology Clinic ...
Source: Journal of Craniofacial Surgery - October 1, 2019 Category: Surgery Tags: Brief Clinical Studies Source Type: research

Drug causes of intracerebral haemorrhage
Summary Many drugs have the potential to cause intracerebral haemorrhage. The mechanisms that underlie this association include elevation of blood pressure and increasing bleeding tendency. The consequences of intracerebral haemorrhage can be devastating for the individual, so careful risk assessment prior to drug initiation and close monitoring during treatment should be enacted when using medicines with an established association with haemorrhagic stroke.
Source: Adverse Drug Reaction Bulletin - October 1, 2019 Category: Drugs & Pharmacology Tags: Invited Review Article Source Type: research

Glowing Proteins Enable Stem Cell Stimulation for Stroke Recovery in Mice
A new method helps neural stem cells form synaptic connections, thereby restoring lost brain function.
Source: The Scientist - October 1, 2019 Category: Science Tags: The Literature Magazine Issue Source Type: news

589PFluoropyrimidine-induced cardiotoxicity in colorectal cancer patients: Preliminary data from the prospective observational CHECKPOINT trial (NCT02665312)
ConclusionsA high incidence of CV events, with no apparent correlation with CV comorbidities or risk factors, was observed. Prompt identification and treatment of CV events allowed most pts to complete the treatment with FP.Clinical trial identificationNCT02665312.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureM. Aglietta: Advisory / Consultancy: Bristol-Myers Squibb; Advisory / Consultancy: Merck; Advisory / Consultancy: Roche. All other authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

General Anesthesia vs Procedural Sedation With Functional Outcome in Patients Undergoing Thrombectomy
This meta-analysis pools individual patient data to estimate the association between receipt of general anesthesia vs procedural sedation and 3-month disability among patients with acute ischemic stroke undergoing mechanical thrombectomy from 3 randomized trials.
Source: JAMA - October 1, 2019 Category: General Medicine Source Type: research

439OA first in human, phase I trial of NP137, a first-in-class antibody targeting netrin-1, in patients with advanced refractory solid tumors
ConclusionsNP137 was well-tolerated, with mild to moderate IRR as the most frequent treatment-related AEs and showed encouraging signs of clinical activity. Updated data will be presented at the meeting.Clinical trial identificationNCT02977195.Legal entity responsible for the studyCentre L éon Bérard.FundingNetris Pharma.DisclosureP. Cassier: Honoraria (self), Research grant / Funding (self), Research grant / Funding (institution), Travel / Accommodation / Expenses: AstraZeneca; Research grant / Funding (institution), Travel / Accommodation / Expenses: BMS; Research grant / Funding (institution), Travel / Accommodation /...
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Cohort Studies.
Conclusion: The magnitude of association between red and processed meat consumption and all-cause mortality and adverse cardiometabolic outcomes is very small, and the evidence is of low certainty. Primary Funding Source: None. (PROSPERO: CRD42017074074). PMID: 31569213 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - October 1, 2019 Category: Internal Medicine Authors: Zeraatkar D, Han MA, Guyatt GH, Vernooij RWM, El Dib R, Cheung K, Milio K, Zworth M, Bartoszko JJ, Valli C, Rabassa M, Lee Y, Zajac J, Prokop-Dorner A, Lo C, Bala MM, Alonso-Coello P, Hanna SE, Johnston BC Tags: Ann Intern Med Source Type: research

Echocardiographic Risk Assessment to Guide Screening for Atrial Fibrillation
Although atrial fibrillation (AF) is a significant population health burden, and an avoidable cause of stroke, AF screening remains controversial. The aim of this study was to investigate whether coincidental echocardiography could provide information about patients at risk for AF.
Source: Journal of the American Society of Echocardiography - October 1, 2019 Category: Cardiology Authors: Satish Ramkumar, Ayame Ochi, Hiroshi Kawakami, Hong Yang, Elizabeth L. Potter, Nicholas D'Elia, Tomoko Negishi, Kazuaki Negishi, Thomas H. Marwick Tags: Clinical Investigation Source Type: research

The number of acute cerebrovascular events in Israel: a forecast until 2040
ConclusionsIn view of the expected increase in the number of acute cerebrovascular events and the changes in the demographic composition of adults suffering from such events, and in order to allow for optimal care and equity, it is imperative to evaluate the preparedness of care provision and the geographical deployment of treatment services in the short and long term.
Source: Israel Journal of Health Policy Research - October 1, 2019 Category: International Medicine & Public Health Source Type: research

P13. Abstract Title: Deep Mutational Scan of VWF to Define Mutations that Enhance or Impair Secretion
Von Willebrand Factor (VWF) is a multimeric glycoprotein that recruits platelets to sites of blood vessel injury and serves as a molecular chaperone for coagulation factor VIII (fVIII). Plasma VWF levels are a known risk factor for various thrombotic disorders including VTE, myocardial infarction, and stroke. GWAS studies have identified genetic variants in VWF that contribute to increased and decreased circulating VWF antigen levels. However, it is currently not known why some variants result in high VWF levels while others cause low VWF levels in circulation.
Source: Thrombosis Research - October 1, 2019 Category: Hematology Authors: T. Sparring, C. Kretz, K. Singh, H. Madarati Source Type: research

Clinical Study of Thirteen Patients with Spinal Cord Infarction
A concept of sensory tracts in the spinal cord has been established in relation to a dorsolateral pathway which is located in the posterior part of the lateral column and conveys the deep sense.
Source: Journal of Stroke and Cerebrovascular Diseases - October 1, 2019 Category: Neurology Authors: Katsuhiko Ogawa, Takayoshi Akimoto, Makoto Hara, Akihiko Morita, Midori Fujishiro, Yutaka Suzuki, Masayoshi Soma, Satoshi Kamei, Hideto Nakajima Source Type: research

P7. Abstract Title: Mapping the Interactome of the Metalloprotease ADAMTS13 in Plasma using In-Vitro BioID
Von Willebrand Factor (VWF) is a multimeric plasma protein that tethers platelets to sites of vascular damage, and is an important initiator of blood clotting. ADAMTS13 is a metalloprotease that cleaves VWF to regulate its platelet binding activity. Decreased activity of ADAMTS13 leads to larger VWF multimers resulting in pathological blood clots, such as thrombotic thrombocytopenic purpura (TTP) and stroke. Unlike other circulating proteases, ADAMTS13 is secreted as an active enzyme and is resistant to all known natural protease inhibitors.
Source: Thrombosis Research - October 1, 2019 Category: Hematology Authors: H. Madarati, C. Kretz Source Type: research

EP.69Disorders of coagulation in Duchenne muscular dystrophy? Results of a registry-based online survey
Several types of coagulation disorders are reported in patients with Duchenne muscular dystrophy (DMD). Those include repeated reports of increased rate of bleeding-complications following scoliosis surgery but also reports of thromboembolic complications. Personalized survey-links were forwarded to 682 registered patients with a genetically confirmed diagnosis of DMD via the German DMD-registry of the Treat-NMD-network. Data on the degree of mobility, disposition to hematoma, epistaxis and gum bleeding, occurrence of postsurgical hemorrhage, stroke, deep vein thrombosis, cardiac thromboembolism, long-term medication and a...
Source: Neuromuscular Disorders - October 1, 2019 Category: Neurology Authors: D. Schorling, C. M üller, A. Pechmann, S. Borell, T. Langer, S. Thiele, M. Walter, B. Zieger, J. Kirschner Source Type: research

OC1. Abstract Title: In-hospital Mortality and Morbidity among Patients Presenting with Intracranial Hemorrhage: A Single Center's Experience with Vitamin K Antagonists and the Direct Oral Anticoagulants
Oral anticoagulants are the preferred therapy for the treatment of venous thromboembolism and for stroke prevention among patients with atrial fibrillation. Given their widespread use, clinicians must balance efficacy of anticoagulation with their associated bleeding risks. Specifically, intracranial hemorrhage (ICH) is the most feared complication as this form of bleeding has the highest mortality and morbidity. To date, clinical trials suggest a lower incidence of ICH and better safety profile among patients prescribed the direct oral anticoagulants (DOACs) compared with traditional vitamin k antagonists (VKAs).
Source: Thrombosis Research - October 1, 2019 Category: Hematology Authors: C. Cipkar, S. Srinathan, P. Chiang, L. Castellucci Tags: Oral Communications Source Type: research

Symptomatic vs. Asymptomatic 20 –40% Internal Carotid Artery Stenosis: Does the Plaque Size Matter?
Conclusion: Large plaques might increase the risk of ischemic stroke or TIA among patients with low-grade ICA-stenosis of 20–40%. Sufficiently powered prospective longitudinal cohort studies are needed to definitively test the stroke risk stratification value of carotid plaque length and cross-sectional area in the setting of current optimal medical treatment.
Source: Frontiers in Neurology - October 1, 2019 Category: Neurology Source Type: research

Saliva-omics in Plasma Cell Disorders-proof of concept and potential as a non-invasive tool for monitoring disease burden and MRD status.
Salivaomics has exciting potential for the diagnosis and monitoring of malignancy, evidence of which has been reported in oral cancer, head and neck malignancies and ovarian cancer. It has been observed that approximately 40% of cancer, stroke and cardiovascular disease biomarkers are present in whole saliva. Salivaomics has become an area of great interest in disease diagnosis over the last number of years, following the footsteps of the other "omics ” based diagnostic tools. Saliva is a fast, inexpensive and non-invasive method of sample collection therefore it might be considered as the biofluid of choice for the diag...
Source: Clinical Lymphoma, Myeloma and Leukemia - October 1, 2019 Category: Hematology Authors: Ciara Tierney, Despina Bazou, Giao Le, Paul Dowling, Peter O'Gorman Source Type: research

Editorial: Geospatial and Transport Modeling in Stroke Service Planning
Source: Frontiers in Neurology - October 1, 2019 Category: Neurology Source Type: research

Anticoagulation: Updated Guidelines for Outpatient Management.
Abstract Anticoagulation therapy is recommended for preventing, treating, and reducing the recurrence of venous thromboembolism, and preventing stroke in persons with atrial fibrillation. Direct oral anticoagulants are first-line agents for eligible patients for treating venous thromboembolism and preventing stroke in those with nonvalvular atrial fibrillation. Vitamin K antagonists are recommended for patients with mechanical valves and valvular atrial fibrillation. Vitamin K antagonists inhibit the production of vitamin K-related factors and require a minimum of five days overlap with parenteral anticoagulants, ...
Source: American Family Physician - October 1, 2019 Category: Primary Care Authors: Wigle P, Hein B, Bernheisel CR Tags: Am Fam Physician Source Type: research

Demystifying spasticity in primary care.
CONCLUSION: Managing spasticity might be unfamiliar to many practitioners. It is important for physicians to understand spasticity and the potential treatment options available to improve quality of life. The current review provides concise information on the clinical relevance of spasticity in primary care and how to assess and manage it effectively and efficiently in those with chronic neurologic conditions. PMID: 31604736 [PubMed - in process]
Source: Canadian Family Physician Medecin de Famille Canadien - October 1, 2019 Category: Primary Care Authors: Milligan J, Ryan K, Lee J Tags: Can Fam Physician Source Type: research

Practical tips for prescribing exercise for fall prevention
ConclusionDepending on the population, exercise as a single or as part of a multifactorial intervention may be beneficial in reducing falls.
Source: Osteoporosis International - October 1, 2019 Category: Orthopaedics Source Type: research

P.59The mutations in mtDNA encoded NADH dehydrogenase subunit genes as common causes of MELAS
The number of molecular causes of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome has steadily increased. Among these, apart from the m.3243A>G mutation, the mutations in mtDNA encoded NADH dehydrogenase subunits genes (MT-ND) have also emerged as hotspot mutations. Herein we reported twelve patients harbored MT-ND mutations and the most common mutation was m.13513G>A in ND5. Additionally, we identified m.13046T>C mutation in ND5, m.10158T>C and m.10191T>C mutation in MT-ND3, m.11777A>C mutation in MT-ND4, m.14487T>C and m.14453G>A mutation in MT-ND6 respectively.
Source: Neuromuscular Disorders - October 1, 2019 Category: Neurology Authors: K. Ji, C. Yan Source Type: research

P.57Isolated mitochondrial myopathy is common presentation in A3243G-related mitochondrial diseases
The A3243G mutation in the mt-tRNA(Leu) gene, first described in mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes (MELAS), accounts for approximately 80% of mutations in individuals with Melas syndrome. Although originally described in patient with a classical syndrome of Melas, the A3243G mutation is increasingly recognized to exhibit marked phenotypic heterogeneity. This paper describes the clinical, laboratory and histopathology features of an unusual phenotype in 6 family harboring the A3243G 'Melas' mutation.
Source: Neuromuscular Disorders - October 1, 2019 Category: Neurology Authors: K. Ji, C. Yan Source Type: research

L-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway.
This study tested the hypothesis that L-arginine regulates the TJ network by activating AMP-activated protein kinase (AMPK) signaling, which in turn improves intestinal barrier functions under HS. IEC-6 cells and rat small intestines were used as experiment models of heat stress. AICAR and dorsomorphin were used to activate and inhibit the AMPK pathway, respectively. Cell proliferation, apoptosis, differential gene expression and KEGG pathway analysis, intestinal paracellular permeability, intestinal morphology, and expression of HSP and TJ proteins, and p-AMPK were determined. L-Arginine promoted cell proliferation and re...
Source: Molecular Biology Reports - October 1, 2019 Category: Molecular Biology Authors: Xia Z, Huang L, Yin P, Liu F, Liu Y, Zhang Z, Lin J, Zou W, Li C Tags: Mol Biol Rep Source Type: research

EXCEL at 5 Years: PCI, CABG ' Relatively Comparable ' in LM Disease EXCEL at 5 Years: PCI, CABG ' Relatively Comparable ' in LM Disease
Which of PCI or CABG for left main disease better prevented death, MI, or stroke? One prevailed early on, the other after a few years. Overall, they matched. The clinical message has shades of gray.Medscape Medical News
Source: Medscape Medical News Headlines - September 30, 2019 Category: Consumer Health News Tags: Cardiology News Source Type: news

Treatment of hypertension in old patients without previous cardiovascular disease
Conclusion: Blood pressure levels lower than those currently recommended are not harmful among older patients. The association between lower SBP and lesser risk of CVD may instead suggest a beneficial effect of lower SBP.
Source: Journal of Hypertension - September 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Weak within-individual association of blood pressure and pulse wave velocity in hemodialysis is related to adverse outcomes
Conclusion: Weaker within-individual MBP–PWV association, based on ABPM recordings, is associated with higher risk of death and cardiovascular events in hemodialysis. These findings support that arterial stiffness insensitive to BP changes is the underlying factor for adverse outcomes in these individuals.
Source: Journal of Hypertension - September 30, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research