Query: stroke

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Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China.
Conclusions: Among patients with incident PD, a higher serum Lp(a) level may predict a lower risk of hemorrhagic stroke. PMID: 31498021 [PubMed - in process]
Source: Renal Failure - September 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Dendrimer Grafted Albumin Nanoparticles for the Treatment of Post Cerebral Stroke Damages: A Proof of Concept Study
Publication date: Available online 3 September 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Deepak Pradhan, Vishakha Tambe, Nidhi Raval, Piyush Gondalia, Pallab Bhattacharya, Kiran Kalia, Rakesh K. TekadeAbstractStroke is the second largest disease of mortality. The biggest hurdle in designing effective brain drug delivery systems is offered by the blood-brain barrier (BBB), which is highly impermeable to many drugs. Albumin nanoparticles (NP) have gained attention due to their multiple ligand binding sites and long circulatory half-life. Citicoline (CIT) is reported to enhance the acetylcholine secretion i...
Source: Colloids and Surfaces B: Biointerfaces - September 10, 2019 Category: Biochemistry Source Type: research

Game-based hand resistance exercise versus traditional manual hand exercises for improving hand strength, motor function, and compliance in stroke patients: A multi-center randomized controlled study.
CONCLUSIONS: In conclusion, we demonstrated that game-based exercise is more effective than manual exercise in improving muscle strength, motor function, and compliance in stroke patients. PMID: 31498145 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - September 10, 2019 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Efficacy of end-effector robot-assisted gait training in subacute stroke patients: Clinical and gait outcomes from a pilot bi-centre study.
CONCLUSIONS: Both rehabilitation treatments produce promising effects in subacute stroke patients. RAGT device offers a more intensive, controlled, and physiological gait training and significantly improved deambulation. PMID: 31498139 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - September 10, 2019 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

An exploratory investigation of the effect of naturalistic light on fatigue and subjective sleep quality in stroke patients admitted for rehabilitation: A randomized controlled trial.
CONCLUSIONS: Fatigue was significantly reduced in rehabilitation patients exposed to naturalistic lighting during admission. PMID: 31498136 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - September 10, 2019 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Ultrasound imaging of upper extremity spastic muscle post-stroke and the correlation with function: A pilot study.
CONCLUSIONS: An objective method of quantifying spasticity can assist in determining if functional gains made post stroke are due to compensations in movement, or due to physiological changes. Ultrasound imaging may be used as an alternative to the Modified Ashworth score to quantify muscular parameters in spastic muscles post stroke. PMID: 31498134 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - September 10, 2019 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats
In this study, we explored the effects of treadmill exercise on sensorimotor and cognitive functional recovery, as well as the potential molecular mechanisms underlying the promotion of neurogenesis in a rat model of transient middle cerebral artery occlusion (tMCAO). We found that treadmill exercise facilitated sensorimotor and cognitive functional recovery after tMCAO, and that neural stem/progenitor cell proliferation, differentiation, and migration were enhanced in the ipsilateral subventricular and subgranular zones after tMCAO. Meanwhile, the newborn neurons induced by treadmill exercise after tMCAO had the similar f...
Source: Brain, Behavior, and Immunity - September 10, 2019 Category: Neurology Source Type: research

Having HIV May Heighten Stroke Risk
Title: Having HIV May Heighten Stroke RiskCategory: Health NewsCreated: 9/9/2019 12:00:00 AMLast Editorial Review: 9/10/2019 12:00:00 AM
Source: MedicineNet HIV General - September 10, 2019 Category: Infectious Diseases Source Type: news

Secondary stroke prevention: a population-based cohort study on anticoagulation and antiplatelet treatments, and the risk of death or recurrence.
Abstract Using claims databases of a public healthcare program (Quebec) for the years 2010 - 2013, we conducted a cohort study of acute ischemic stroke (AIS) patients to describe secondary prevention treatments and determine how they stood against practice guidelines. We compared the risk of death or AIS recurrence over one year in patients treated with anticoagulants, antiplatelets and/or other cardiovascular drugs. In the month after discharge, 44.3% patients did not receive the recommended treatment and more than 20% did not have any treatment. Untreated patients were younger, had less comorbidities and a more ...
Source: Clinical Pharmacology and Therapeutics - September 10, 2019 Category: Drugs & Pharmacology Authors: Faure M, Castilloux AM, Lillo-Le-Louet A, Bégaud B, Moride Y Tags: Clin Pharmacol Ther Source Type: research

The Benefits and Risks of Statin Therapy in Ischemic Stroke: A Review of the Literature
Wang Zhao, Zhi-Jie Xiao, Shui-Ping ZhaoNeurology India 2019 67(4):983-992 Statins are effective cholesterol-lowering drugs for reducing the risks of mortality and morbidity of cardiovascular diseases. Increasing evidence has shown that statin use is associated with a significant beneficial effect in patients with ischemic stroke. Both pre-stroke and post-stroke statin use has been found to be beneficial in ischemic stroke. Furthermore, good adherence is associated with a better clinical outcome, and statin withdrawal is associated with a poor functional outcome in patients with ischemic stroke. High-intensity statin thera...
Source: Neurology India - September 10, 2019 Category: Neurology Authors: Wang Zhao Zhi-Jie Xiao Shui-Ping Zhao Source Type: research

Post-stroke Visual Gait Measure for Developing Countries: A Reliability and Validity Study
Conclusion: Video-based RVGA is a reliable and valid tool to assess gait-related impairment in post-stroke hemiparesis. This cost-effective measure may be incorporated in the clinical and research practice to discern and quantify complex phenomenon of the gait deviation. RVGA may be considered as a useful tool, especially in developing countries where expensive gait analyzer is usually not available.
Source: Neurology India - September 10, 2019 Category: Neurology Authors: Kamal Narayan Arya Shanta Pandian Vikas Kumar GG Agarwal Akash Asthana Source Type: research

Concomitant Anticoagulant and Antidepressant Therapy in Atrial Fibrillation Patients and Risk of Stroke and Bleeding.
In conclusion, concomitant use of an OAC and an AD is associated with an increased bleeding risk. PMID: 31506933 [PubMed - as supplied by publisher]
Source: Clinical Pharmacology and Therapeutics - September 10, 2019 Category: Drugs & Pharmacology Authors: Komen JJ, Hjemdahl P, Mantel-Teeuwisse AK, Klungel OH, Wettermark B, Forslund T Tags: Clin Pharmacol Ther Source Type: research

MoCA Subgroups in Stroke Rehabilitation Subgroups Defined by the Montreal Cognitive Assessment Differ in Functional Gain During Acute Inpatient Stroke Rehabilitation
To validate subgroups of cognitive impairment on the Montreal Cognitive Assessment (MoCA) —defined as Normal (score of 25-30), Mildly Impaired (score of 20-24), and Moderately Impaired (score less than 19)—by determining whether they differ in rehabilitation gain during inpatient stroke rehabilitation.
Source: Archives of Physical Medicine and Rehabilitation - September 10, 2019 Category: Rehabilitation Authors: Abhishek Jaywant, Joan Toglia, Faith M. Gunning, Michael W. O ’Dell Source Type: research

Immediate Adaptations to Post-Stroke Walking Performance Using a Wearable Robotic Exoskeleton
To examine the immediate effects of a hip-assistive wearable robotic exoskeleton on clinical walking performance, walking energetics, gait kinematics, and corticomotor excitability in individuals with stroke.
Source: Archives of Physical Medicine and Rehabilitation - September 10, 2019 Category: Rehabilitation Authors: Arun Jayaraman, Megan K. O ’Brien, Sangeetha Madhavan, Kiyoshi Oikawa, Yosuke Endo, Shailesh Kantak, James Stinear, T. George Hornby, William Zev Rymer Source Type: research

Subgroups Defined by the Montreal Cognitive Assessment Differ in Functional Gain During Acute Inpatient Stroke Rehabilitation
To validate subgroups of cognitive impairment on the Montreal Cognitive Assessment (MoCA) —defined as normal (score of 25-30), mildly impaired (score of 20-24), and moderately impaired (score less than 19)—by determining whether they differ in rehabilitation gain during inpatient stroke rehabilitation.
Source: Archives of Physical Medicine and Rehabilitation - September 10, 2019 Category: Rehabilitation Authors: Abhishek Jaywant, Joan Toglia, Faith M. Gunning, Michael W. O ’Dell Tags: Original Research Source Type: research

Increased risk for cancer after stroke at a young age: etiological relevance or incidental finding?
ConclusionIn our cohort, young individuals aged  ≤ 55 years who suffered a stroke had twice as high risk for developing cancer within 10 years after the index event compared to the control group. Stroke might have implication regarding the subsequent development of cancer and vice versa.
Source: Journal of Cancer Research and Clinical Oncology - September 10, 2019 Category: Cancer & Oncology Source Type: research

Rich-Club Organization: An Important Determinant of Functional Outcome After Acute Ischemic Stroke
Conclusion: In this proof-of-concept study, the number of rich-club nodes affected by a stroke lesion presents a translational biomarker of stroke outcome, which can be readily assessed using standard clinical AIS imaging protocols and considered in functional outcome prediction models beyond traditional factors.
Source: Frontiers in Neurology - September 10, 2019 Category: Neurology Source Type: research

Heat shock protein 27 as a neuroprotective biomarker and a suitable target for stem cell therapy and pharmacotherapy in ischemic stroke.
This article is protected by copyright. All rights reserved. PMID: 31502740 [PubMed - as supplied by publisher]
Source: Cell Biology International - September 10, 2019 Category: Cytology Authors: Behdarvandy M, Karimian M, Atlasi MA, Tameh AA Tags: Cell Biol Int Source Type: research

Measurement of Patients' Perceptions of the Quality of Acute Stroke Services: Development and Validation of the STROKE Perception Report
CONCLUSION The STROKE Perception Report enables understanding of patients' and family's beliefs about the quality of acute stroke care in essential new domains never explored before.
Source: Journal of Neuroscience Nursing - September 9, 2019 Category: Neuroscience Tags: Article Source Type: research

Relationship Between Anticoagulant Medication Adherence and Satisfaction in Patients With Stroke
CONCLUSION: Stroke patients were adherent and satisfied with the oral anticoagulant therapy. The MTA had good sensitivity and poor specificity. Sociodemographic and clinical characteristics identified were not associated with adherence and satisfaction with treatment.
Source: Journal of Neuroscience Nursing - September 9, 2019 Category: Neuroscience Tags: Article Source Type: research

A Pilot Randomized Controlled Trial Testing the Feasibility and Acceptability of a SystemCHANGE Intervention to Improve Medication Adherence in Older Adult Stroke Survivors
BACKGROUND: Adhering to an antithrombotic medication regimen is essential to reducing recurrent stroke in adult stroke survivors. The purpose of this study was to evaluate the feasibility and acceptability of the SystemCHANGE (SC) and attention control (AC) intervention in older adult, nonadherent ischemic stroke patients. METHODS: A pilot randomized controlled trial was conducted to determine the feasibility and acceptability of an SC versus AC intervention in older adult, nonadherent stroke survivors in the management of antithrombotic medication. Participants were masked to group assignment. Stroke survivors 50 years or...
Source: Journal of Neuroscience Nursing - September 9, 2019 Category: Neuroscience Tags: Article Source Type: research

Frequency, Risk Factors, and Clinical Significance of Incorrect Dose of Alteplase Due to Weight Estimation in Acute Ischemic Stroke Patients: A Single-Center Retrospective Study
Stroke is a clinical emergency requiring urgent recombinant tissue-type plasminogen activator treatment in eligible patients. The dosage of thrombolytic agent (alteplase) is weight dependent. However, many patients receive thrombolytic therapy based on weight estimation. Here, we assess the frequency of incorrect thrombolytic therapy dose as a result of weight estimation and evaluate the short-term safety and efficacy of alteplase misdose. Of 237 patients, weight was estimated in 147 (62%), of which 33 patients (22.4%) were treated with an erroneous dose of alteplase. An incorrect dose was associated with neither poor outc...
Source: Journal of Neuroscience Nursing - September 9, 2019 Category: Neuroscience Tags: Article Source Type: research

Having HIV May Heighten Stroke Risk
MONDAY, Sept. 9, 2019 -- People with HIV have a greatly increased risk of a common heart rhythm disorder that ' s a leading cause of stroke, a new study shows. The increased risk of atrial fibrillation (AF) from HIV is similar to or higher than known...
Source: Drugs.com - Daily MedNews - September 9, 2019 Category: General Medicine Source Type: news

Association between Epicardial Adipose Tissue and Embolic Stroke after Catheter Ablation of Atrial Fibrillation
ConclusionLarger peri ‐atrial EAT volume, in addition to prior TE and lower CCr, was independently associated with post‐ablation ES regardless of AF recurrence and CHA2DS2‐VASc score. (ClinicalTrials.gov number, NCT03479073)This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - September 9, 2019 Category: Cardiology Authors: Jinhee Ahn, Seung Yong Shin, Jaemin Shim, Young ‐Hoon Kim, Sang‐Jin Han, Eue‐Keun Choi, Seil Oh, Ji Yeon Shin, Jeong Cheon Choe, Jin Sup Park, Hye Won Lee, Jun‐Hyok Oh, Jung Hyun Choi, Han‐Cheol Lee, Kwang Soo Cha, Taek Jong Hong, Tags: ORIGINAL ‐ CLINICAL Source Type: research

Hemicraniectomy for Supratentorial Primary Intracerebral Hemorrhage: A Retrospective, Propensity Score Matched Study
Background and Purpose: Spontaneous supratentorial intracerebral hemorrhage (ICH) contributes disproportionately to stroke mortality, and randomized trials of surgical treatments for ICH have not shown benefit. Decompressive hemicraniectomy (DHC) improves functional outcome in patients with malignant middle cerebral artery ischemic stroke, but data in ICH patients is limited. We hypothesized that DHC would reduce in-hospital mortality and poor functional status (defined as modified Rankin scale ≥5) among survivors at 3 months, without increased complications.
Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2019 Category: Neurology Authors: Kasey L. Gildersleeve, Mohammad I. Hirzallah, Yoshua Esquenazi, Charles J. Moomaw, Padmini Sekar, Chunyan Cai, Nitin Tandon, Daniel Woo, Nicole R. Gonzales Source Type: research

Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats.
In this study, we explored the effects of treadmill exercise on sensorimotor and cognitive functional recovery, as well as the potential molecular mechanisms underlying the promotion of neurogenesis in a rat model of transient middle cerebral artery occlusion (tMCAO). We found that treadmill exercise facilitated sensorimotor and cognitive functional recovery after tMCAO, and that neural stem/progenitor cell proliferation, differentiation, and migration were enhanced in the ipsilateral subventricular and subgranular zones after tMCAO. Meanwhile, the newborn neurons induced by treadmill exercise after tMCAO had the similar f...
Source: Brain, Behavior, and Immunity - September 9, 2019 Category: Neurology Authors: Sun H, Li A, Hou T, Tao X, Chen M, Wu C, Chen S, Zhu L, Liao H Tags: Brain Behav Immun Source Type: research

Rehabilitation of patients after transient ischaemic attack or minor stroke: pilot feasibility randomised trial of a home-based prevention programme.
CONCLUSION: Findings indicate that implementation of this novel cardiac rehabilitation programme, and of a trial to evaluate its effectiveness, is feasible, with potential for clinically important benefits and improved secondary prevention after TIA or 'minor' stroke. PMID: 31501165 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - September 9, 2019 Category: Primary Care Authors: Heron N, Kee F, Mant J, Cupples ME, Donnelly M Tags: Br J Gen Pract Source Type: research

The effect of anterior communicating artery flow on neurovascular injury and neurobehavioral outcomes in mice with recurrent stroke.
CONCLUSIONS: The results of this study demonstrate that anterior communicating artery flow alleviates recurrent stroke-induced neurovascular injury and improves neurobehavioral outcomes by promoting the establishment of collateral circulation. PMID: 31513789 [PubMed - as supplied by publisher]
Source: Brain Research - September 9, 2019 Category: Neurology Authors: Wen Z, Jiang Y, Zhang L, Xu X, Zhao N, Xu X, Wang F, Gao J, Yang GY, Liu X Tags: Brain Res Source Type: research

The Association between Presentation by EMS and EMS Prenotification with Receipt of Intravenous Tissue-type Plasminogen Activator in a State Implementing Stroke Systems of Care.
Authors: Nielsen VM, Dejoie-Stanton C, Song G, Christie A, Guo J, Zachrison KS Abstract Collaboration between emergency medical services (EMS) and hospitals receiving stroke patients is critical to ensure prompt, effective treatment, and is a key component of the stroke systems of care (SSoC). The goal of our study was to evaluate the association between presentation by EMS and EMS prenotification with odds of receiving Tissue-type Plasminogen Activator (IV-tPA) in a state implementing SSoC while rigorously accounting for missing data. We utilized data from the Massachusetts Paul Coverdell Stroke Registry for this ...
Source: Prehospital Emergency Care - September 8, 2019 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Initial Experience of ACE68 Reperfusion Catheter in Patients with Acute Ischemic Stroke Related to Internal Carotid Artery Occlusion.
CONCLUSION: EVT using ACE68 reperfusion catheter can be considered a first-line therapy in patients with acute ICA occlusion as it can achieve rapid recanalization and reduce the frequency of conversion to stent-retrieve therapy. PMID: 31484230 [PubMed]
Source: Journal of Korean Neurosurgical Society - September 7, 2019 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Intracarotid cold saline infusion contributes to neuroprotection in MCAO ‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1.
Intracarotid cold saline infusion contributes to neuroprotection in MCAO‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1. Mol Med Rep. 2019 Aug 21;: Authors: Wang D, Huang Z, Li L, Yuan Y, Xiang L, Wu X, Ni C, Yu W Abstract Intracarotid cold saline infusion (ICSI) brings about neuroprotective effects in ischemic stroke. However, the involvement of serum and glucocorticoid‑regulated kinase 1 (SGK1) in the underlying mechanism of ICSI is not fully understood; therefore, we used the rat middle cerebral artery occlusion (MCAO) model to investigate the neuroprotective ...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Are we there yet? Exploring the journey to quality stroke care for Aboriginal and Torres Strait Islander peoples in rural and remote Queensland.
CONCLUSION: An integrated patient centred model of care that spans the care continuum and places value on an extended role for the Aboriginal and Torres Strait Islander health worker workforce is indicated, as is an increased utilisation of allied health and specialist follow-up close to home. PMID: 31487467 [PubMed - in process]
Source: Rural and Remote Health - September 7, 2019 Category: Rural Health Tags: Rural Remote Health Source Type: research

Stroke atlas of the brain: Voxel-wise density-based clustering of infarct lesions topographic distribution
ConclusionsApplying voxel-wise data-driven hierarchical density clustering on a large number of infarct lesions, we have parcellated the brain tissue into clusters of voxels that tend to be part of same infarct lesion, and presumably representing end-arterial supply territories. This hierarchical stroke atlas of the brain is shared publicly, and can potentially be applied for future infarct location-outcome analysis.
Source: NeuroImage: Clinical - September 7, 2019 Category: Radiology Source Type: research

Application of Meridian Electrical Conductance in the Setting of Acute Ischemic Stroke: A Cross-Sectional Study.
In this study, a total of 102 subjects diagnosed with acute ischemic stroke within 7 days of onset were recruited, and the meridian energy analysis device (MEAD) was used to record the meridian electrical conductance (MEC) values of twelve meridians on unaffected and affected limbs. We found that the MEC value of the twelve meridians on the affected limbs was significantly higher than that on the unaffected limbs (P=0.001). Compared with the unaffected limbs, there was a higher value of MEC on the affected limbs of the lung meridian, heart meridian, pericardium meridian, and small intestine meridian, with significant dif...
Source: Evidence-based Complementary and Alternative Medicine - September 7, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Association of blood lipids, atherosclerosis and statin use with dementia and cognitive impairment after stroke: a systematic review and meta-analysis.
CONCLUSION: Atherosclerosis may be associated with an increased risk of post-stroke dementia. Post-stroke statin use was associated with decreased risk of cognitive impairment. To confirm whether or not statins confer advantages in the post-stroke population in terms of preventing cognitive decline over and above their known effectiveness in reducing risk of further vascular events, further stroke trials including cognitive assessment and observational analyses adjusted for key confounders, focusing on key subgroups or statin use patterns are required. PMID: 31505259 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - September 7, 2019 Category: Genetics & Stem Cells Authors: Yang Z, Wang H, Edwards D, Ding C, Yan L, Brayne C, Mant J Tags: Ageing Res Rev Source Type: research

Age-related burden and characteristics of embolic stroke of undetermined source in the real world clinical practice
AbstractFew data are available on age-related burden and characteristics of embolic stroke of undetermined source (ESUS) in the real world clinical practice. The aim of our study was to provide information about it. We retrospectively analyzed data of patients consecutively admitted to our Stroke Unit along 1  year (2017, November 1st–2018, October 31st). The etiology of ischemic stroke was defined at hospital discharge; ESUS was considered as a subset of cryptogenic stroke, and defined according to the 2014 international criteria. In the analyzed period, 306 patients, 52.3% females, mean age ± S D 77.9 ± 11.9...
Source: Journal of Thrombosis and Thrombolysis - September 7, 2019 Category: Hematology Source Type: research

Efficacy of RehaCom cognitive rehabilitation software in activities of daily living, attention and response control in chronic stroke patients
ConclusionsIn conclusion, RehaCom cognitive rehabilitation software has improvement effect on ADL, attention and response control in patients with chronic stroke. Our study reveals a new information about the efficacy of computerized training in the rehabilitation of stroke patients.
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

“Sequential multimodality stimulation” for post-stroke-hemineglect: Feasibility and outcome in a pilot randomized controlled trial
ConclusionMultimodality stimulation, in addition to standard physiotherapy, is feasible and potentially results in better neurocognitive and functional recovery following right hemispheric ischemic strokes. However, larger studies are warranted to prove these preliminary observations beyond doubt.
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Can the positions of the spastic upper limb in stroke survivors help muscle choice for botulinum toxin injections?
Conclusion: Frequencies of upper-limb postures differed from previous reports. Other clinical features, besides spasticity, interfered with muscle choice for BoNT-A injection, which only partially followed the recommendations in the literature.RESUMO As defici ências motoras que ocorrem nos indivíduos com doença cerebrovascular (DCV) são prevalentes e contribuem para dependência, dor e incapacidade, o que pode atrasar a reabilitação do membro superior e sua funcionalidade. O tratamento com toxina botulínica do tipo A (BoNT-A) é indicado para a es pasticidade focal e requer conhecimento da biomecánica e anatomia p...
Source: Arquivos de Neuro-Psiquiatria - September 6, 2019 Category: Neurology Source Type: research

Going Vegetarian Good for Your Heart, But May Up Stroke Risk
Title: Going Vegetarian Good for Your Heart, But May Up Stroke RiskCategory: Health NewsCreated: 9/5/2019 12:00:00 AMLast Editorial Review: 9/6/2019 12:00:00 AM
Source: MedicineNet Heart General - September 6, 2019 Category: Cardiology Source Type: news

AHA News: Now a 2-Time Survivor, Tedy Bruschi Still Tackling Stroke Awareness
Title: AHA News: Now a 2-Time Survivor, Tedy Bruschi Still Tackling Stroke AwarenessCategory: Health NewsCreated: 9/5/2019 12:00:00 AMLast Editorial Review: 9/6/2019 12:00:00 AM
Source: MedicineNet Heart General - September 6, 2019 Category: Cardiology Source Type: news

Use of insertable cardiac monitors for the detection of atrial fibrillation in patients with cryptogenic stroke in the United States is cost-effective.
Authors: Maervoet J, Bossers N, Borge RP, Thompson Hilpert S, van Engen A, Smala A Abstract Atrial fibrillation (AF) is the most common arrhythmia and a major marker of stroke risk. Early detection is crucial and, once diagnosed, anticoagulation therapy can be initiated to reduce stroke risk. The aim of this study was to assess the cost-effectiveness of employing an insertable cardiac monitor (ICM), BIOMONITOR, for the detection of AF compared to standard of care (SoC) ECG and Holter monitoring in patients with cryptogenic stroke, that is, stroke of unknown origin and where paroxysmal, silent AF is suspected. A Mar...
Source: Journal of Medical Economics - September 6, 2019 Category: Health Management Tags: J Med Econ Source Type: research

Social work support and unmet social needs in life after stroke: a cross-sectional exploratory study
Stroke patients are often affected by long-term disabilities with needs concerning social issues. There is relatively little consideration of social recovery of patients and the support required to return to w...
Source: BMC Neurology - September 6, 2019 Category: Neurology Authors: Sophie Lehnerer, Benjamin Hotter, Inken Padberg, Petra Knispel, Dike Remstedt, Andrea Liebenau, Ulrike Grittner, Ian Wellwood and Andreas Meisel Tags: Research article Source Type: research

A newly designed intensive caregiver education program reduces cognitive impairment, anxiety, and depression in patients with acute ischemic stroke.
In conclusion, ICEP effectively reduced cognitive impairment, anxiety, and depression in AIS patients. PMID: 31483000 [PubMed - in process]
Source: Brazilian Journal of Medical and Biological Research - September 6, 2019 Category: Research Tags: Braz J Med Biol Res Source Type: research

MMP-9-Related microRNAs as Prognostic Markers for Hemorrhagic Transformation in Cardioembolic Stroke Patients
Studies suggest that microRNAs that regulate expression of matrix metalloproteinase (MMP)-9 may be involved in hemorrhagic transformation (HT) after cardioembolic stroke, so we examined whether such microRNAs could predict HT in acute cardioembolic stroke patients. Blood samples were prospectively collected from patients who later experienced HT (n =29) or did not (n =29), and the samples were assayed for eight microRNAs identified as related to MMP-9 based on three microRNA databases. Expression levels of these microRNAs were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) in 28 of the 58 patients, ...
Source: Frontiers in Neurology - September 6, 2019 Category: Neurology Source Type: research

Prognostic Value of Cystatin C in Acute Ischemic Stroke Patients with Intravenous Thrombolysis.
CONCLUSIONS: Higher levels of serum cystatin C in AIS patients after IVT were independently associated with increased risks of poor functional outcomes and vascular events, especially combining conventional risk factors, suggesting that serum cystatin C might improve risk prediction for the poor prognosis in AIS patients receiving rt-PA treatment. PMID: 31490754 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - September 6, 2019 Category: Neurology Authors: Shi J, Zhang C, Cao Y, Qu X, Liu H, You S Tags: Curr Neurovasc Res Source Type: research

Factors Associated with Risk of Stroke-Associated Pneumonia in Patients with Dysphagia: A Systematic Review
AbstractDysphagia is associated with increased risk of stroke-associated pneumonia (SAP). However, it is unclear what other factors contribute to that risk or which measures may reduce it. This systematic review aimed to provide evidence on interventions and care processes associated with SAP in patients with dysphagia. Studies were screened for inclusion if they included dysphagia only patients, dysphagia and non-dysphagia patients or unselected patients that included dysphagic patients and evaluated factors associated with a recorded frequency of SAP. Electronic databases were searched from inception to February 2017. El...
Source: Dysphagia - September 6, 2019 Category: Speech-Language Pathology Source Type: research

Renal Dysfunction Associated with Symptomatic Intracranial Hemorrhage after Intravenous Thrombolysis
Background and Aim: Renal dysfunction (RD) is prevalent in patients with acute ischemic stroke requiring intravenous thrombolysis. The relationship between renal function and thrombolysis related intracranial hemorrhagic (ICH) complications is contradictory according to previous studies. The current study is to clarify whether RD could increase the risk of symptomatic intracranial hemorrhage (SICH) after recombinant tissue plasminogen activator (IV rtPA) in acute ischemic stroke patients. Methods: In this observational study, acute ischemic stroke patients who received IV rtPA within 4.5 hours of symptom onset were retrospectively analyzed.
Source: Journal of Stroke and Cerebrovascular Diseases - September 6, 2019 Category: Neurology Authors: Juehua Zhu, Xiahong Shen, Chunyan Han, Chunhao Mei, Yun Zhou, Hui Wang, Yan Kong, Yongjun Jiang, Qi Fang, Xiuying Cai Source Type: research

Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice.
CONCLUSIONS: We conclude that activation of endothelial Rac1 improves functional recovery and angiogenesis after stroke, and this process is mediated by Pak1 signaling. This study provides novel insight for Rac1 in the mechanism of long-term stroke recovery. PMID: 31499064 [PubMed - as supplied by publisher]
Source: Experimental Neurology - September 6, 2019 Category: Neurology Authors: Bu F, Min JW, Munshi Y, Lai YJ, Qi L, Urayama A, McCullough LD, Li J Tags: Exp Neurol Source Type: research

IJERPH, Vol. 16, Pages 3272: The Effect of Animal-Assisted Therapy on the State of Patients ’ Health After a Stroke: A Pilot Study
IJERPH, Vol. 16, Pages 3272: The Effect of Animal-Assisted Therapy on the State of Patients’ Health After a Stroke: A Pilot Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16183272 Authors: Kristýna Machová Radka Procházková Michal Říha Ivona Svobodová A stroke is a condition that can give rise to consequences such as cognitive and physical constraints, which sometimes manifest in the psychological condition of the patient. Such patients commence rehabilitation as soon as is possible, which involves a multi-disciplinary approach to treatment. One aspect of c...
Source: International Journal of Environmental Research and Public Health - September 6, 2019 Category: Environmental Health Authors: Krist ýna Machová Radka Proch ázková Michal Říha Ivona Svobodov á Tags: Article Source Type: research