Filtered By:
Condition: Hypothermia
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 450 results found since Jan 2013.
Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32 °C) With Spontaneous Circulation in an Intact Porcine Model
Conclusion: Administration of both 30 ng/kg/min and 90 ng/kg/min at 32°C had a positive inotropic effect and reduced afterload. We found no evidence of increased pro-arrhythmic activity after epinephrine infusion in hypothermic pigs. Our experiment therefore suggests that β₁-receptor stimulation with epinephrine could be a favorable strategy for providing cardiovascular support in hypothermic patients, at core temperatures >32°C.
Source: Frontiers in Physiology - September 6, 2021 Category: Physiology Source Type: research
Phenothiazine Inhibits Neuroinflammation and Inflammasome Activation Independent of Hypothermia After Ischemic Stroke
In conclusion, C + P treatment conferred neuroprotection in stroke by suppressing neuroinflammation and NLRP3 inflammasome activation. The present study suggests that JAK2/STAT3/p38/HIF-1α/FoxO1 are vital regulators and potential targets for efficacious therapy following ischemic stroke.PMID:34455546 | DOI:10.1007/s12035-021-02542-3
Source: Molecular Medicine - August 29, 2021 Category: Molecular Biology Authors: Sichao Guo Xiaokun Geng Hangil Lee Yuchuan Ding Source Type: research
Hypothermia Promotes Mitochondrial Elongation In Cardiac Cells Via Inhibition Of Drp1
In conclusion hypothermia promoted elongation of cardiac mitochondria via reduced pDrp1S616 abundance which was also associated with suppression of cellular oxygen consumption. Silencing of TRPV1 in H9c2 cardiomyocytes reproduced the morphological and respirometric phenotype of hypothermia. This report demonstrates a novel mechanism of cold-induced inhibition of mitochondrial fission.PMID:34331901 | DOI:10.1016/j.cryobiol.2021.07.013
Source: Cryobiology - July 31, 2021 Category: Biology Authors: David Taylor Juliana Germano Yang Song Hanane Hadj-Moussa Stefanie Marek-Iannucci Raeesa Dhanji Jon Sin Lawrence S C Czer Kenneth B Storey Roberta A Gottlieb Source Type: research
P-006 Update on the reperfusion with cooling in cerebral acute ischemia II (RECCLAIM II) trial
ConclusionThere is limited evidence demonstrating the clinical benefit or impact of neuroprotection in conjunction with endovascular reperfusion therapy for acute ischemic stroke. Combining intravascular therapeutic hypothermia with endovascular reperfusion therapy may provide an opportunity to enhance clinical outcomes in patients with large vessel occlusion.Disclosures R. Gupta: 1; C; Stryker Neurovascular PI ASSIST Registry, Zoll PI RECCLAIM II (No compensation), Cerenovous Steering Committee MEMBRANE study, Medtronic Steering Committee ELEVATE Study, Penumbra CEC MIND Trial, Vesalio PI CLEAR Study, Rapid Medical PI Tig...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Gupta, R., Zaidi, S., Jumaa, M., Badjatia, N., Yoo, A. Tags: Oral poster abstracts Source Type: research
E-074 Predictors of hemorrhagic conversion following mechanical thrombectomy for acute ischemic stroke (AIS)
ConclusionHistory of prior stroke, radiographic evidence of infarct burden, and radiographic success of thrombectomy may be considered significant predictors for hemorrhagic conversion following AIS in patients who undergo mechanical thrombectomy.Disclosures A. Boyke: None. K. Javed: None. J. Dardick: None. I. Naidu: None. J. Ryvlin: None. D. Kadaba: None. N. Haranhalli: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Boyke, A., Javed, K., Dardick, J., Naidu, I., Ryvlin, J., Kadaba, D., Haranhalli, N. Tags: Electronic poster abstracts Source Type: research
Advancement in research on the role of the transient receptor potential vanilloid channel in cerebral ischemic injury (Review)
Exp Ther Med. 2021 Aug;22(2):881. doi: 10.3892/etm.2021.10313. Epub 2021 Jun 15.ABSTRACTStroke is a common critical disease occurring in middle-aged and elderly individuals, and is characterized by high morbidity, lethality and mortality. As such, it is of great concern to medical professionals. The aim of the present review was to investigate the effects of transient receptor potential vanilloid (TRPV) subtypes during cerebral ischemia in ischemia-reperfusion animal models, oxygen glucose deprivation and in other administration cell models in vitro to explore new avenues for stroke research and clinical treatments. TRPV1,...
Source: Experimental and Therapeutic Medicine - July 1, 2021 Category: General Medicine Authors: Qian Xie Rong Ma Hongyan Li Jian Wang Xiaoqing Guo Hai Chen Source Type: research
