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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Protective Effects and Magnetic Resonance Imaging Temperature Mapping of Systemic and Focal Hypothermia in Cerebral Ischemia Basic Science
Conclusions— Focal brain hypothermia requires longer cooling periods to achieve the same protective efficacy as SH. However, FH mainly affects the ischemic region, and therefore represents a promising and nonstressful alternative to SH.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Vieites-Prado, A., Iglesias-Rey, R., Fernandez-Susavila, H., da Silva-Candal, A., Rodriguez-Castro, E., Grohn, O. H. J., Wellmann, S., Sobrino, T., Castillo, J., Campos, F. Tags: Animal Models of Human Disease, Basic Science Research, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Neuroprotectants Source Type: research

Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1
Acute ischemic stroke causes significant chronic disability worldwide. We designed this study to clarify the mechanism by which hypothermia helps alleviate acute ischemic stroke. In a middle cerebral artery oc...
Source: Molecular Brain - August 20, 2016 Category: Neuroscience Authors: Jung Ho Lee, Eun Jang Yoon, Jeho Seo, Adriana Kavoussi, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim and Je Sung You Source Type: research

Complete carotid and coronary revascularization in brain malperfusion
A 54-year-old man presented with unstable angina and stroke with right hemiplegia and aphasia due to left main coronary plus 3-vessel disease, severe stenosis of bilateral internal carotid, proximal left common carotid, and proximal left subclavian arteries. Simultaneous complete revascularization was undertaken with the use of conventional cardiopulmonary bypass and moderate hypothermia (25℃). The left internal mammary artery and two saphenous vein grafts were used for coronary artery bypass, and brain revascularization consisted of a left aorta-to-common carotid Dacron graft and bilateral carotid endarterectomy. Recovery was good.
Source: Asian Cardiovascular and Thoracic Annals - August 11, 2016 Category: Cardiology Authors: Aramendi, C., Cubero, A., Cortes, A., Rivas, D., Crespo, A., Aramendi, J. I. Tags: Cardiac Source Type: research

Optimal temperature management in aortic arch operations
AbstractHypothermic circulatory arrest is a critical component of aortic arch procedures, without which these operations could not be safely performed. Despite the use of hypothermia as a protective adjunct for organ preservation, aortic arch surgery remains complex and is associated with numerous complications despite years of surgical advancement. Deep hypothermic circulatory arrest affords the surgeon a safe period of time to perform the arch reconstruction, but this interruption of perfusion comes at a high clinical cost: stroke, paraplegia, and organ dysfunction are all potential-associated complications. Retrograde c...
Source: General Thoracic and Cardiovascular Surgery - August 7, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Long ‐term Survival and Regeneration of Neuronal and Vasculature Cells inside the Core Region after Ischemic Stroke in Adult Mice
This article is protected by copyright. All rights reserved.
Source: Brain Pathology - June 30, 2016 Category: Neurology Authors: Michael Qize Jiang, Ying ‐Ying Zhao, Wenyuan Cao, Zheng Zachory Wei, Xiaohuan Gu, Ling Wei, Shan Ping Yu Tags: Research Article Source Type: research

Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats Basic Sciences
Conclusions— The centrally acting hypothermic drug HPI-201 greatly enhanced the efficiency and efficacy of conventional PC; this combined cooling therapy may facilitate clinical translation of hypothermic treatment for stroke.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Lee, J. H., Wei, L., Gu, X., Won, S., Wei, Z. Z., Dix, T. A., Yu, S. P. Tags: Ischemic Stroke, Neuroprotectants Basic Sciences Source Type: research

Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion Brief Reports
Conclusions— Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Chen, J., Liu, L., Zhang, H., Geng, X., Jiao, L., Li, G., Coutinho, J. M., Ding, Y., Liebeskind, D. S., Ji, X. Tags: Revascularization, Ischemic Stroke Brief Reports Source Type: research

Hypothermia is an independent predictor of short and intermediate term mortality in acute systolic heart failure: Insights from the ESCAPE trial
Admission hypothermia is associated with increased mortality in patients hospitalized with sepsis, trauma or stroke. We hypothesized that low body temperature patients with acute systolic heart failure (HF) would be associated with worse survival.
Source: International Journal of Cardiology - June 24, 2016 Category: Cardiology Authors: Hesham R. Omar, Maya Guglin Source Type: research

Local cerebral hypothermia induced by selective infusion of cold lactated ringer's: a feasibility study in rhesus monkeys.
CONCLUSION: Local infusion of ice-cold lactated Ringer's solution via micro-catheter is a safe and effective method for selective cerebral hypothermia. This cooling method could potentially be developed as a new treatment in acute ischemic stroke. PMID: 27320250 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Pharmacological hypothermia: a potential for future stroke therapy?
Authors: Liu K, Khan H, Geng X, Zhang J, Ding Y Abstract Mild physical hypothermia after stroke has been associated with positive outcomes. Despite the well-studied beneficial effects of hypothermia in the treatment of stroke, lack of precise temperature control, intolerance for the patient, and immunosuppression are some of the reasons which limit its clinical translation. Pharmacologically induced hypothermia has been explored as a possible treatment option following stroke in animal models. Currently, there are eight classes of pharmacological agents/agonists with hypothermic effects affecting a multitude of sys...
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Therapeutic hypothermia and ischemic stroke: A literature review.
CONCLUSION: Although hypothermia has been used for various purposes over several decades, its efficacy in the treatment of ischemic stroke is debatable. Several trials have proven its safety and feasibility; however, more robust, randomized clinical trials with large volumes of patients are needed to fully establish its utility in the clinical setting. PMID: 27313963 [PubMed]
Source: Surgical Neurology International - June 19, 2016 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Modulation by the Noble Gas Helium of Tissue Plasminogen Activator: Effects in a Rat Model of Thromboembolic Stroke*
Conclusions: In a clinical perspective for the treatment of acute ischemic stroke, these data suggest that helium 1) should not be administered before or together with tissue plasminogen activator therapy due to the risk of inhibiting the benefit of tissue plasminogen activator–induced thrombolysis; and 2) could be an efficient neuroprotective agent if given after tissue plasminogen activator–induced reperfusion.
Source: Critical Care Medicine - May 17, 2016 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Monitoring of newborns at high risk for brain injury
Abstract Due to the increasing number of surviving preterm newborns and to the recognition of therapeutic hypothermia as the current gold standard in newborns with hypoxic-ischaemic encephalopathy, there has been a growing interest in the implementation of brain monitoring tools in newborns at high risk for neurological disorders. Among the most frequent neurological conditions and presentations in the neonatal period, neonatal seizures and neonatal status epilepticus, paroxysmal non-epileptic motor phenomena, hypoxic-ischaemic encephalopathy, white matter injury of prematurity and stroke require specif...
Source: Italian Journal of Pediatrics - May 13, 2016 Category: Pediatrics Source Type: research

Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance INTERVENTIONAL
CONCLUSIONS: Sheep proved a feasible animal model for the intracarotid cooling catheter. Fast induction of selective mild hypothermia was achieved within the cooled cerebral hemisphere, with stable temperature gradients in the contralateral brain and systemic blood. Further studies are required to demonstrate any therapeutic benefit of selective cerebral cooling in a stroke model.
Source: American Journal of Neuroradiology - May 12, 2016 Category: Radiology Authors: Cattaneo, G., Schumacher, M., Maurer, C., Wolfertz, J., Jost, T., Büchert, M., Keuler, A., Boos, L., Shah, M. J., Foerster, K., Niesen, W.- D., Ihorst, G., Urbach, H., Meckel, S. Tags: INTERVENTIONAL Source Type: research

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
Publication date: Available online 11 May 2016 Source:The Lancet Neurology Author(s): Ángel Chamorro, Ulrich Dirnagl, Xabier Urra, Anna M Planas Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately, numerous neuroprotective drugs have failed to show benefit in the treatment of acute ischaemic stroke, making the search for new treatments imperative. Increased awareness of the relevance of rigorous preclinical testing, and appropriate selection of study participants, might overcome the barriers to progress...
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research