Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging
AbstractEpendymoma withRELA fusion has been defined as a novel entity of the revised World Health Organization 2016 classification of tumors of the central nervous system (CNS), characterized by fusion transcripts of theRELA gene and consequent pathological activation of the NFkB pathway. These tumors represent the majority of supratentorial ependymomas in children. The validation of diagnostic tools to identify this clinically relevant ependymoma entity is essential. Here, we have used interphase fluorescentin situ hybridization (FISH) forC11orf95andRELA, immunohistochemistry (IHC) for p65 ‐RelA and the recently develop...
Source: Brain Pathology - November 28, 2018 Category: Neurology Authors: M élanie Pagès, Kristian W. Pajtler, Stéphanie Puget, David Castel, Nathalie Boddaert, Arnault Tauziède‐Espariat, Stéphanie Picot, Marie‐Anne Debily, Marcel Kool, David Capper, Christian Sainte‐Rose, Fabrice Chrétien, Stefan M. Pfi Tags: Research Article Source Type: research

Dysregulation of TDP ‐43 Intracellular Localization and Early‐Onset ALS are Associated with a TARDBP S375G Variant
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - November 21, 2018 Category: Neurology Authors: Kathy Newell, Francesca Paron, Miguel Mompean, Jill Murrell, Elisa Salis, Cristiana Stuani, Gary Pattee, Maurizio Romano, Douglas Laurents, Bernardino Ghetti, Emanuele Buratti Tags: Research Article Source Type: research

Genome ‐Wide Identification of microRNAs Regulating the Human Prion Protein
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - November 19, 2018 Category: Neurology Authors: Daniel Pease, Claudia Scheckel, Elke Schaper, Valeria Eckhardt, Marc Emmenegger, Ioannis Xenarios, Adriano Aguzzi Tags: Research Article Source Type: research

Oligodendroglial A ‐synucleinopathy driven neuroinflammation in multiple system atrophy
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - November 16, 2018 Category: Neurology Authors: Alana Hoffmann, Benjamin Ettle, Kristina Battis, Simone Reiprich, Johannes C. M. Schlachetzki, Eliezer Masliah, Michael Wegner, Tanja Kuhlmann, Markus J. Riemenschneider, J ürgen Winkler Tags: Research Article Source Type: research

Clarity reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - November 16, 2018 Category: Neurology Authors: Maura T. Weber, John D. Arena, Rui Xiao, John A. Wolf, Victoria E. Johnson Tags: Research Article Source Type: research

Clinicopathologic features of Anaplastic Myxopapillary Ependymomas
AbstractMyxopapillary ependymomas (MPE) are considered benign (WHO grade I) neoplasms with favorable prognosis. However, malignant behavior occurs in a small subset. To our knowledge, only five anaplastic MPEs have been reported without consensus on diagnostic criteria. We retrieved fourteen anaplastic MPEs from the pathology archives of six institutions. Each tumor included at least two of the following features:> 5 mitoses per 10 high power fields, Ki ‐67 labeling index (LI)> 10%, microvascular proliferation (MVP), and spontaneous necrosis. These features were typically encountered in foci of hypercellularity and...
Source: Brain Pathology - November 12, 2018 Category: Neurology Authors: Julieann C. Lee, Nima Sharifai, Sonika Dahiya, B.K. Kleinschmidt ‐DeMasters, Marc K. Rosenblum, Gerald F. Reis, David Samuel, Aleli M. Siongco, Mariarita Santi, Phillip B. Storm, Sean P. Ferris, Andrew W. Bollen, Melike Pekmezci, David A. S Tags: Research Article Source Type: research

Regulation of glioma cell invasion by 3q26 gene products PIK3CA, SOX2 and OPA1
This article is protected by copyright. All rights reserved. (Source: Brain Pathology)
Source: Brain Pathology - November 7, 2018 Category: Neurology Authors: Thorsten Schaefer, Archana Ramadoss, Severina Leu, Lionel Tintignac, Cristobal Tostado, Andrea Bink, Christoph Sch ürch, Joelle Müller, Jonas Schärer, Giusi Moffa, Philippe Demougin, Suzette Moes, Christoph Stippich, Simona Falbo, Heike N Tags: Research Article Source Type: research

Issue Information
Brain Pathology,Volume 28, Issue 5, Page 593-594, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Source Type: research

Magnetic resonance imaging correlates of neuro ‐axonal pathology in the MS spinal cord
Brain Pathology,Volume 28, Issue 5, Page 765-772, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Authors: Klaus Schmierer, Marc E Miquel Source Type: research

Myelin water imaging to detect demyelination and remyelination and its validation in pathology
Brain Pathology,Volume 28, Issue 5, Page 750-764, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Authors: Cornelia Laule, G.R. Wayne Moore Source Type: research

A 66 ‐year‐old woman with progressive dementia
Brain Pathology,Volume 28, Issue 5, Page 779-781, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Authors: Sheng Chen, Meng ‐Sha Yao, Fei Yuan Source Type: research

Multiple Sclerosis Pathology and its Reflection by Imaging Technologies: Introduction
Brain Pathology,Volume 28, Issue 5, Page 721-722, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Authors: Hans Lassmann Source Type: research

A 77 ‐year‐old man with parkinsonism and rapidly progressive dementia
Brain Pathology,Volume 28, Issue 5, Page 777-778, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Authors: Henrique Soares Dutra Oliveira, Pedro Sudbrack de Oliveira, Victor Calil, Philippe Joaquim Oliveira Menezes Mac êdo, Nathalie Canedo, Luiz Felipe Rocha Vasconcellos Source Type: research

66 Year ‐Old Woman With Muscle Weakness And Respiratory Failure
Brain Pathology,Volume 28, Issue 5, Page 775-776, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Authors: J Bernardo ‐Cofiño, R Gómez‐Illán, C Nicolás, A Astudillo, I Fernandez‐Vega Source Type: research

A 3 ‐Month‐Old Boy With Progressive Weakness
Brain Pathology,Volume 28, Issue 5, Page 773-774, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Authors: Soo Yeon Kim, Jung Min Ko, Sun Ah Choi, Anna Cho, Jin Sook Lee, Byung Chan Lim, Ki Joong Kim, Jong ‐Hee Chae Source Type: research

Society News
Brain Pathology,Volume 28, Issue 5, Page 782-785, September 2018. (Source: Brain Pathology)
Source: Brain Pathology - October 30, 2018 Category: Neurology Source Type: research

Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - October 28, 2018 Category: Neurology Authors: Alan J. Mejia Maza, Rogger P. Carmen ‐Orozco, Emma Carter, Danitza G. Dávila, Gino Castillo, Jemina D. Morales, Javier Mamani, Cesar Gavídia, Joseph Alroy, Charles R. Sterling, Armando E Gonzalez, Héctor H. García, Randy L. Woltjer, Man Source Type: research

Diagnostics of Paediatric Supratentorial RELA Ependymomas: Integration of information from Histopathology, Genetics, DNA Methylation and Imaging
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - October 16, 2018 Category: Neurology Authors: M élanie Pagès, Kristian W Pajtler, Stéphanie Puget, David Castel, Nathalie Boddaert, Arnault Tauziède‐Espariat, Stéphanie Picot, Debily Marie‐Anne, Marcel Kool, David Capper, Christian Sainte‐Rose, Fabrice Chrétien, Stefan M Pfist Source Type: research

Subicular hypotrophy in fetuses with down syndrome and in the ts65dn model of down syndrome
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - October 16, 2018 Category: Neurology Authors: Fiorenza Stagni, Andrea Giacomini, Marco Emili, Beatrice Uguagliati, Maria Paola Bonasoni, Renata Bartesaghi, Sandra Guidi Source Type: research

Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - October 10, 2018 Category: Neurology Authors: Andrea Arena, Till S. Zimmer, Jackelien van Scheppingen, Anatoly Korotkov, Jasper J. Anink, Angelika M ühlebner, Floor E. Jansen, Wim van Hecke, Wim G. Spliet, Peter C. van Rijen, Annamaria Vezzani, Johannes C. Baayen, Sander Idema, Anand M. Source Type: research

Granular cell astrocytoma: an aggressive IDH ‐wildtype diffuse glioma with molecular genetic features of primary glioblastoma
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - October 10, 2018 Category: Neurology Authors: M. Adelita Vizcaino, Doreen N. Palsgrove, Ming Yuan, Caterina Giannini, Eibar Ernesto Cabrera ‐Aldana, Aparna Pallavajjala, Peter C. Burger, Fausto J. Rodriguez Source Type: research

Clusterin contributes to early stage of Alzheimer's disease pathogenesis
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - October 8, 2018 Category: Neurology Authors: Shin ‐Bi Oh, Min Sun Kim, SuJi Park, HyunJu Son, Seog‐Young Kim, Min‐Seon Kim, Dong‐Gyu Jo, Eunyoung Tak, Joo‐Yong Lee Source Type: research

Childhood supratentorial ependymomas with YAP1 ‐MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - September 24, 2018 Category: Neurology Authors: Felipe Andreiuolo, Pascale Varlet, Arnault Tauzi ède‐Espariat, Stephanie T Jünger, Evelyn Dörner, Verena Dreschmann, Klaus Kuchelmeister, Andreas Waha, Christine Haberler, Irene Slavc, Selim Corbacioglu, Markus J. Riemenschneider, Alfred Source Type: research

Granular cell astrocytoma: an aggressive IDH ‐wildtype diffuse gliomarwith molecular genetic features of primary glioblastoma
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - September 17, 2018 Category: Neurology Authors: M Adelita Vizcaino , Doreen N Palsgrove , Ming Yuan , Caterina Giannini , Eibar Ernesto Cabrera ‐Aldana , Aparna Pallavajjala , Peter C Burger , Fausto J Rodriguez Source Type: research

Deep cervical lymph node ligation aggravates AD ‐like pathology of APP/PS1 mice
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - September 7, 2018 Category: Neurology Authors: Linmei Wang , Yanli Zhang , Ying Zhao , Charles Marshall , Ting Wu , Ming Xiao Source Type: research

Alternative lengthening of telomeres, ATRX loss and h3 ‐k27m mutations in histologically defined pilocytic astrocytoma with anaplasia
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - September 7, 2018 Category: Neurology Authors: Fausto J. Rodriguez , Jacqueline A. Brosnan ‐Cashman , Sariah J. Allen , M. Adelita Vizcaino , Caterina Giannini , Sandra Camelo‐Piragua , Milad Webb , Marcus Matsushita , Nitin Wadhwani , Abeer Tabbarah , Dima Hamideh , Liqun J Source Type: research

Alzheimer's disease and Type 2 Diabetes mellitus are distinct diseases with potential overlapping metabolic dysfunction upstream of observed cognitive decline
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - August 14, 2018 Category: Neurology Authors: Yevgen Chornenkyy , Wang ‐Xia Wang , Angela Wei , Peter T. Nelson Source Type: research

The association between hypertensive arteriopathy and cerebral amyloid angiopathy in spontaneously hypertensive stroke ‐prone rats
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 31, 2018 Category: Neurology Authors: Solveig Jandke , Cornelia Garz , Daniel Schwanke , Michael Sendtner , Hans ‐Jochen Heinze , Roxana O. Carare , Stefanie Schreiber Source Type: research

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 31, 2018 Category: Neurology Authors: Parul H. Kothari , Grant R. Kolar , Joanna C. Jen , Rula Hajj ‐Ali , Paula Bertram , Robert E. Schmidt , John P. Atkinson Source Type: research

Knockdown of HIF ‐1α impairs post‐ischemic vascular reconstruction in the brain via deficient homing and sprouting bmEPCs
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 27, 2018 Category: Neurology Authors: Yang Liu , Ran He , Yaping Xiao , Hongjin Wang , Yi Chen , Weihai Chen , Xiaoyu Xu Source Type: research

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 27, 2018 Category: Neurology Authors: Yuek Ling Chai , Joyce R. Chong , Jiaju Weng , David Howlett , Andrea Halsey , Jasinda H. Lee , Johannes Attems , Dag Aarsland , Paul T. Francis , Christopher P. Chen , Mitchell K.P. Lai Source Type: research

The genetic landscape of anaplastic pleomorphic xanthoastrocytoma
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 27, 2018 Category: Neurology Authors: Joanna J. Phillips , Henry Gong , Katharine Chen , Nancy M. Joseph , Jessica van Ziffle , Boris C. Bastian , James P. Grenert , Cassie N. Kline , Sabine Mueller , Anuradha Banerjee , Theodore Nicolaides , Nalin Gupta , Mitchel S. Source Type: research

A domain responsible for spontaneous conversion of bank vole prion protein
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 27, 2018 Category: Neurology Authors: Atsushi Kobayashi , Yuichi Matsuura , Atsuko Takeuchi , Masahito Yamada , Ichiro Miyoshi , Shirou Mohri , Tetsuyuki Kitamoto Source Type: research

Society news
Brain Pathology,Volume 28, Issue 4, Page 589-592, July 2018. (Source: Brain Pathology)
Source: Brain Pathology - July 23, 2018 Category: Neurology Source Type: research

Issue Information
Brain Pathology,Volume 28, Issue 4, Page 449-450, July 2018. (Source: Brain Pathology)
Source: Brain Pathology - July 23, 2018 Category: Neurology Source Type: research

Traumatic brain injury: a platform for studies in A β processing
Brain Pathology,Volume 28, Issue 4, Page 463-465, July 2018. (Source: Brain Pathology)
Source: Brain Pathology - July 23, 2018 Category: Neurology Authors: Douglas H.Smith , WilliamStewart Source Type: research

A 72 ‐year‐old female with an intraventricular mass
Brain Pathology,Volume 28, Issue 4, Page 587-588, July 2018. (Source: Brain Pathology)
Source: Brain Pathology - July 23, 2018 Category: Neurology Authors: FenghuaZhangMD , LiamChenMD, PhD Source Type: research

Unexpected death of a 9 ‐year‐old girl
Brain Pathology,Volume 28, Issue 4, Page 585-586, July 2018. (Source: Brain Pathology)
Source: Brain Pathology - July 23, 2018 Category: Neurology Authors: Celeste I.HerbstMBChB (US), FC For Path (SA) , John J.DempersMBChB, (US), FC For Path (SA) , S. DanZaharieMBChB, (MD EFN) Source Type: research

A 56 ‐year‐old woman with blindness and mental status changes
Brain Pathology,Volume 28, Issue 4, Page 583-584, July 2018. (Source: Brain Pathology)
Source: Brain Pathology - July 23, 2018 Category: Neurology Authors: Rachael A.VaubelMD, PhD , R.Ross ReichardMD Source Type: research

A 36 ‐year‐old man with headache and fever
Brain Pathology,Volume 28, Issue 4, Page 581-582, July 2018. (Source: Brain Pathology)
Source: Brain Pathology - July 23, 2018 Category: Neurology Authors: Miguel A.RiudavetsMD , AnaL ía TaratutoMD, PhD , FacundoPelorossoPhD , GustavoSevleverMD, PhD Source Type: research

Neuronal Susceptibility to Beta ‐Amyloid Toxicity and Ischemic Injury Involves Histone Deacetylase‐2 Regulation of Endophilin‐B1
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 20, 2018 Category: Neurology Authors: David B. Wang , Chizuru Kinoshita , Yoshito Kinoshita , Bryce L. Sopher , Takuma Uo , Rona J. Lee , Joon Kyu Kim , Sean P. Murphy , C.Dirk Keene , Gwenn A. Garden , Richard S. Morrison Source Type: research

Dissecting the neuronal vulnerability underpinning Alpers ’ syndrome: A clinical and neuropathological study
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 18, 2018 Category: Neurology Authors: Hannah Hayhurst , Maria ‐Eleni Anagnostou , Helen J. Bogle , John P. Grady , Robert W. Taylor , Laurence A. Bindoff , Robert McFarland , Doug M. Turnbull , Nichola Z. Lax Source Type: research

A clinical and histopathological study of malformations observed in fetuses infected by the Zika virus
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 18, 2018 Category: Neurology Authors: A Beaufr ère , B Bessières , M Bonnière , M Driessen , C Alfano , T Couderc , M Thiry , N Thelen , M Lecuit , T Attié‐Bitach , M Vekemans , Y Ville , L Nguyen , M Leruez‐Ville , F Encha‐Razavi Source Type: research

Iron related changes in MS lesions and their validity to characterize MS lesion types and dynamics with Ultra ‐high field magnetic resonance imaging
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 18, 2018 Category: Neurology Authors: Simon Hametner , Assunta Dal Bianco , Siegfried Trattnig , Hans Lassmann Source Type: research

Exploring the heterogeneity of MS lesions using positron emission tomography: a reappraisal of their contribution to disability?
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 18, 2018 Category: Neurology Authors: Bruno Stankoff , Emilie Poirion , Matteo Tonietto , Benedetta Bodini Source Type: research

MRI of cortical lesions and its use in studying their role in MS pathogenesis and disease course
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - July 18, 2018 Category: Neurology Authors: R Magliozzi , R Reynolds , M Calabrese Source Type: research

A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease
Brain Pathology, EarlyView. (Source: Brain Pathology)
Source: Brain Pathology - May 24, 2018 Category: Neurology Authors: W. RobertBell , Alan K.Meeker , AnthonyRizzo , SumitRajpara , Ian M.Rosenthal , MiguelFlores Bellver , SilviaAparicio Domingo , XiufengZhong , John R.Barber , Corinne E.Joshu , M. ValeriaCanto ‐Soler , Charles G.Eberhart Source Type: research

Severe White Matter Astrocytopathy in CADASIL
Brain Pathology,Volume 0, Issue ja, -Not available-. (Source: Brain Pathology)
Source: Brain Pathology - May 14, 2018 Category: Neurology Authors: YoshikiHase , AiqingChen , Letitia L.Bates , Lucinda J.L.Craggs , YumiYamamoto , ElizabethGemmell , Arthur E.Oakley , Viktor I.Korolchuk , Raj N.Kalaria Source Type: research

Corrigendum
Brain Pathology,Volume 28, Issue 3, Page 446-446, May 2018. (Source: Brain Pathology)
Source: Brain Pathology - May 9, 2018 Category: Neurology Source Type: research

Corrigendum
Brain Pathology,Volume 28, Issue 3, Page 447-447, May 2018. (Source: Brain Pathology)
Source: Brain Pathology - May 9, 2018 Category: Neurology Source Type: research