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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Normothermia and Stroke
Opinion statementIn the past two decades, there has been much focus on the adverse effect of fever on neurologic outcome, the benefits of hypothermia on functional outcomes, and the interplay of associated complications. Despite decades of experience regarding randomized, safety and feasibility, case-controlled, retrospective studies, there has yet to be a large, randomized, multicenter, clinical trial with the appropriate power to address the potential benefits of targeted temperature modulation compared to hypothermia alone. What remains unanswered is the appropriate timing of initiation, duration, rewarming speed, and d...
Source: Current Treatment Options in Neurology - February 26, 2017 Category: Neurology Source Type: research

Hypothermia for Neuroprotection in Convulsive Status Epilepticus
This study aims to see if there are any similar advantages to therapeutic hypothermia in mechanically ventilated status epilepticus patients as neuroprotective properties were previously detected in animal studies of hypothermia.
Source: The Journal of Emergency Medicine - February 17, 2017 Category: Emergency Medicine Authors: Stephanie Diebold Tags: Abstract Source Type: research

Chapter 37 Neurologic complications of acute environmental injuries
Publication date: 2017 Source:Handbook of Clinical Neurology, Volume 141 Author(s): I.R.F. da Silva, J.A. Frontera Environmental injuries can result in serious neurologic morbidity. This chapter reviews neurologic complications of thermal burns, smoke inhalation, lightning strikes, electric injury, near drowning, decompression illness, as well as heat stroke and accidental hypothermia. Knowing the pathophysiology and clinical presentation of such injuries is essential to proper management of primary and secondary medical complications. This chapter highlights the most frequently encountered neurologic injuries secondary t...
Source: Handbook of Clinical Neurology - February 9, 2017 Category: Neurology Source Type: research

Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia
In conclusion, inhibiting the peak of BBB disruption is not an effective neuroprotective strategy, especially in comparison to the inhibitors of the neuronal death signaling cascade; these, in fact, can attenuate the i nfarct volume measured at 24 h post-ischemia when administered at 6 h in our same stroke model.
Source: PLoS One - January 23, 2017 Category: Biomedical Science Authors: Yu-Cheng Liu Source Type: research

Vitamin D Insufficiency in Neonatal Hypoxic-Ischemic Encephalopathy.
CONCLUSIONS: Serum 25(OH) vitamin D insufficiency is present in the majority of term HIE neonates and is related to lower circulating anti-inflammatory IL-17E. Hypothermia does not mitigate vitamin D deficiency in HIE.Pediatric Research (2017); doi:10.1038/pr.2017.13. PMID: 28099429 [PubMed - as supplied by publisher]
Source: Pediatric Research - January 17, 2017 Category: Pediatrics Authors: Lowe DW, Hollis BW, Wagner CL, Bass T, Kaufman DA, Horgan MJ, Givelichian LM, Sankaran K, Yager JY, Katikaneni LD, Wiest D, Jenkins D Tags: Pediatr Res Source Type: research

Moderate Hypothermia Improves Cardiac and Vascular Function in a Pig Model of Ischemic Cardiogenic Shock Treated With Veno-Arterial ECMO
In conclusion, moderate and rapid hypothermia improves hemodynamics and cardiac and vascular function in a pig model of ischemic CS treated with ECMO.
Source: Shock - January 14, 2017 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Induced Hypothermia in Neurocritical Care: A Review
This article will review indications for IH administration, methods of providing IH, nursing responsibilities, and identifying and/or managing complications.
Source: Journal of Neuroscience Nursing - January 7, 2017 Category: Neuroscience Tags: Clinical Nursing Focus Source Type: research

TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats
Conclusions: TFP5 is comparable to MH in improving neurological outcomes in early-stage adult ischemic stroke. When TFP5 is given along with MH, less neurological deficit tends to be achieved.
Source: Neuroscience - January 1, 2017 Category: Neuroscience Source Type: research

Personalized approach in brain protection by hypothermia: individual changes in non-pathological and ischemia-related glutamate transport in brain nerve terminals
ConclusionsTherefore, the direction of hypothermia-induced changes in extracellular glutamate is unpredictable in “healthy” nerve terminals and depends on hypothermia sensitivity of uptake vs. tonic release. In affected nerve terminals (e.g., in brain regions suffering from a reduction of blood circulation during cardiac surgery, and core and penumbra zones of the insult), pathological transporter-mediated glutamate release from nerve terminals decreases with progressive significance from deep to profound hypothermia, thereby underlying its potent neuroprotective action. So, alterations in extracellular glutamate durin...
Source: EPMA Journal - December 14, 2016 Category: Global & Universal Source Type: research

The future of off-pump coronary artery bypass grafting: a North American perspective.
Authors: Yanagawa B, Nedadur R, Puskas JD Abstract Off-pump coronary artery bypass graft (OPCAB) is currently performed routinely in a minority of specialized centers and in many more centers, utilized only when a porcelain aorta mandates a no-touch aortic technique. The OPCAB literature can be summarized as follows: (I) large-scale randomized trials in relatively low risk patients that include surgeons with a range of experience demonstrating no consistent beneficial differences in major cardiovascular and cerebrovascular outcomes but lower transfusion rates and shorter length of stay, tempered by some reports of ...
Source: Journal of Thoracic Disease - December 14, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Impact of immediate post-reperfusion cooling on outcome in patients with acute stroke and substantial ischemic changes
Conclusions The use of post-reperfusion cooling as a rescue treatment in patients with substantial ischemia at baseline might improve clinical outcome.
Source: Journal of NeuroInterventional Surgery - December 13, 2016 Category: Neurosurgery Authors: Hwang, Y.-H., Jeon, J.-S., Kim, Y.-W., Kang, D.-H., Kim, Y.-S., Liebeskind, D. S. Tags: Ischemic stroke Source Type: research

Comparison of Early Outcomes with Three Approaches for Combined Coronary Revascularization and Carotid Endarterectomy
Conclusion: We identified no significant difference in mortality or neurologic complications among three approaches for synchronous surgery for coronary and carotid d isease. Therefore it is impossible to conclude that a single principle might be adapted into standard practice. Patient specific risk factors and clinical conditions might be important in determining the surgical tecnnique.
Source: Revista Brasileira de Cirurgia Cardiovascular - December 12, 2016 Category: Cardiovascular & Thoracic Surgery Source Type: research

Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application
AbstractHypothermia and hypometabolism (hypometabothermia) normally observed during natural hibernation and torpor, allow animals to protect their body and brain against the damaging effects of adverse environment. A similar state of hypothermia can be achieved under artificial conditions through physical cooling or pharmacological effects directed at suppression of metabolism and the processes of thermoregulation. In these conditions called torpor-like states, the mammalian ability to recover from stroke, heart attack, and traumatic injuries greatly increases. Therefore, the development of therapeutic methods for differen...
Source: Psychopharmacology - December 7, 2016 Category: Psychiatry Source Type: research

Neuroprotection in Critical Care Neurology
Semin Neurol 2016; 36: 642-648 DOI: 10.1055/s-0036-1592359Ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury—all have in common early brain injury due to brain tissue destruction, reduced cerebral blood flow and oxygen delivery, and overall substantial morbidity and mortality. The pathophysiology of brain tissue damage likely includes common cellular mechanisms. Neuroprotection has seldom, if ever, been shown to reduce early brain injury. Secondary brain injury develops after these conditions due to macroscopic events such as increased intracranial pressure and reduced cerebral...
Source: Seminars in Neurology - November 30, 2016 Category: Neurology Authors: Germans, Menno R. Boogaarts, Hieronymus D. Macdonald, R. Loch Tags: Review Article Source Type: research

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2) Major Clinical Trial
Conclusions—Intravascular therapeutic hypothermia was confirmed to be safe and feasible in recombinant tissue-type plasminogen activator–treated acute ischemic stroke patients. Protocol changes designed to reduce pneumonia risk appeared to fail, although the sample is small.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01123161.
Source: Stroke - November 27, 2016 Category: Neurology Authors: Patrick Lyden, Thomas Hemmen, James Grotta, Karen Rapp, Karin Ernstrom, Teresa Rzesiewicz, Stephanie Parker, Mauricio Concha, Syed Hussain, Sachin Agarwal, Brett Meyer, Julie Jurf, Irfan Altafullah, Rema Raman Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Major Clinical Trials Source Type: research