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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Arterial Cannulation and Cerebral Perfusion Strategies for Aortic Arch Operations
Neurologic injuries following aortic arch operations can be devastating, with stroke occurring in up to 12% of elective operations and significant cerebral dysfunction occurring in up to 25% of cases. The primary challenge unique to aortic arch operations involves interruption of direct perfusion of the brachiocephalic vessels during arch reconstruction. For this reason, neuroprotection is paramount. The 2 main modes of protection are (1) reducing metabolic demand through hypothermia and (2) limiting, or even eliminating, the ischemic period. Preoperative selection of the cerebral perfusion plan for each operation is imper...
Source: Seminars in Cardiothoracic and Vascular Anesthesia - November 5, 2016 Category: Anesthesiology Authors: Foley, L. S., Yamanaka, K., Reece, T. B. Tags: Reviews Source Type: research

Moderate hypothermia >=24 and
CONCLUSIONS Moderate hypothermia for HCA during ACP is being used with increasing frequency, but has not been thoroughly evaluated in patients undergoing cardiovascular reoperations. Our experience suggests that in patients with previous cardiac surgery who are undergoing hemiarch and total aortic arch operations, moderate hypothermia is safe and produces respectable results.
Source: European Journal of Cardio-Thoracic Surgery - November 3, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Preventza, O., Garcia, A., Kashyap, S. A., Akvan, S., Cooley, D. A., Simpson, K., Rammou, A., Price, M. D., Omer, S., Bakaeen, F. G., Cornwell, L. D., Coselli, J. S. Tags: Extracorporeal circulation, Pericardium, Vascular malformations AORTIC SURGERY Source Type: research

Letter by Mattingly et al Regarding Article, “Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion” Letter to the Editor
Source: Stroke - October 23, 2016 Category: Neurology Authors: Mattingly, T. K., Lownie, S. P., Pelz, D. M. Tags: Ischemic Stroke, Neuroprotectants Letters to the Editor Source Type: research

Response by Chen et al to Letter Regarding Article, “Endovascular Hypothermia in Acute Ischemic Stroke: A Pilot Study of Selective Intra-Arterial Cold Saline Infusion” Letter to the Editor
Source: Stroke - October 23, 2016 Category: Neurology Authors: Chen, J., Ding, Y., Ji, X. Tags: Revascularization, Ischemic Stroke Letters to the Editor Source Type: research

Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke.
DISCUSSION: With hypothermia being a good standard neuroprotectant reference, these results provide additional proof of principle for EGF and GHRP-6 co-administration as a potentially neuroprotective stroke therapy. PMID: 27665924 [PubMed - as supplied by publisher]
Source: Neurological Research - September 27, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion.
In conclusion, we demonstrated the neuroprotective effects of transarterial regional hypothermia in an ischemic model of pMCAO with tCHP. Even though MCAO is persistent, cold infusion via the ICA is neuroprotective for the penumbra, suggesting the wider therapeutic application of this therapy. PMID: 27663968 [PubMed - as supplied by publisher]
Source: Brain Research - September 19, 2016 Category: Neurology Authors: Kurisu K, Abumiya T, Ito M, Gekka M, Osanai T, Shichinohe H, Nakayama N, Kazumata K, Houkin K Tags: Brain Res Source Type: research

Regulation of Therapeutic Hypothermia on Inflammatory Cytokines, Microglia Polarization, Migration and Functional Recovery after Ischemic Stroke in Mice.
This study reveals the first evidence for hypothermia mediated regulation on inflammatory factor expression, microglia polarization, migration and indicates that the anti-inflammatory effect is an important mechanism underlying the brain protective effects of a TH therapy. PMID: 27659107 [PubMed - as supplied by publisher]
Source: Neurobiology of Disease - September 18, 2016 Category: Neurology Authors: Lee JH, Wei ZZ, Cao W, Won S, Gu X, Winter M, Dix TA, Wei L, Yu SP Tags: Neurobiol Dis Source Type: research

Distinguishing Arterial Ischemic Stroke From Hypoxic-Ischemic Encephalopathy in the Neonate at Birth.
CONCLUSION: Stroke is associated with increased initial platelet counts and is not associated with cesarean delivery for nonreassuring fetal heart rate tracings, sentinel events, or perinatal metabolic acidosis. Stroke is a form of neonatal brain injury not associated with perinatal risk factors that allow early identification. PMID: 27607878 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - September 4, 2016 Category: OBGYN Authors: Adami RR, Grundy ME, Poretti A, Felling RJ, Lemmon M, Graham EM Tags: Obstet Gynecol Source Type: research

Effect of Air Temperature and Universal Thermal Climate Index on Respiratory Diseases Mortality in Mashhad, Iran.
CONCLUSION: Generally, mortality increases with decreasing temperature and increasing cold stresses and the mortality risk increases by 1.36% per 10°C reduction. PMID: 27631176 [PubMed - in process]
Source: Archives of Iranian Medicine - August 31, 2016 Category: Middle East Health Authors: Fallah Ghalhari G, Mayvaneh F Tags: Arch Iran Med Source Type: research

Neuroprotective hypothermia – Why keep your head cool during ischemia and reperfusion
Publication date: November 2016 Source:Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 1860, Issue 11, Part A Author(s): N. Talma, W.F. Kok, C.F. de Veij Mestdagh, N.C. Shanbhag, H.R. Bouma, R.H. Henning Background Targeted temperature management (TTM) is the induced cooling of the entire body or specific organs to help prevent ischemia and reperfusion (I/R) injury, as may occur during major surgery, cardiac resuscitation, traumatic brain injury and stroke. Ischemia and reperfusion induce neuronal damage by mitochondrial dysfunction and oxidative injury, ER stress, neuronal excitotoxicity, and a neuroinflam...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - August 30, 2016 Category: Biochemistry Source Type: research

The contribution of heart rate to the oxygen consumption of the chicken embryo during cold- or hypoxia-hypometabolism
Publication date: Available online 30 August 2016 Source:Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology Author(s): Satoko Tomita Ide, Ryoji Ide, Jacopo P. Mortola In embryos, cooling and hypoxia cause a decrease in oxygen consumption ( V ̇ O 2 ); we asked what was the relative contribution of heart rate (HR) and of the ‘not-HR’ factor (the product of stroke volume and arterial-venous O2 difference) to the drop in V ̇ O 2 . Data of HR (with subcutaneous electrodes) and V ̇ O 2 (by an open-flow methodology) were collected simultaneously on chicken embryos close to end-incub...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - August 29, 2016 Category: Biochemistry Source Type: research

The contribution of heart rate to the oxygen consumption of the chicken embryo during cold- or hypoxia-hypometabolism.
Abstract In embryos, cooling and hypoxia cause a decrease in oxygen consumption ( [Formula: see text] ); we asked what was the relative contribution of heart rate (HR) and of the 'not-HR' factor (the product of stroke volume and arterial-venous O2 difference) to the drop in [Formula: see text] . Data of HR (with subcutaneous electrodes) and [Formula: see text] (by an open-flow methodology) were collected simultaneously on chicken embryos close to end-incubation. Over the last four days of incubation (E16-E20) differences in HR contributed about 30% of the differences in resting [Formula: see text] among embryos. A...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - August 28, 2016 Category: Physiology Authors: Ide ST, Ide R, Mortola JP Tags: Comp Biochem Physiol A Mol Integr Physiol Source Type: research

Impact of Hypothermia Initiation and Duration on Perihemorrhagic Edema Evolution After Intracerebral Hemorrhage Clinical Sciences
Conclusions— Early hypothermia initiation after ICH onset seems to have an important impact on PHE evolution, whereas our data suggest only limited impact later than day 3 after onset.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Volbers, B., Herrmann, S., Willfarth, W., Lucking, H., Kloska, S. P., Doerfler, A., Huttner, H. B., Kuramatsu, J. B., Schwab, S., Staykov, D. Tags: Computerized Tomography (CT), Intracranial Hemorrhage Clinical Sciences Source Type: research

Straight incision for extended descending and thoracoabdominal aortic replacement: novel and simple exposure with rib-cross thoracotomy
CONCLUSIONS This new exposure with straight incision with rib-cross thoracotomy provided excellent exposures for the long segment of the thoracoabdominal aorta, and it enabled extended replacement from the ascending aorta to the abdominal aorta.
Source: Interactive CardioVascular and Thoracic Surgery - August 21, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Minatoya, K., Seike, Y., Itonaga, T., Oda, T., Inoue, Y., Kawamoto, N., Miura, S., Tanaka, H., Sasaki, H., Kobayashi, J. Tags: Pericardium, Vascular malformations Adult Cardiac Source Type: research

Is moderate hypothermic circulatory arrest with selective antegrade cerebral perfusion superior to deep hypothermic circulatory arrest in elective aortic arch surgery?
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether moderate hypothermia circulatory arrest with selective antegrade cerebral perfusion (SACP) is more beneficial than deep hypothermic circulatory arrest in elective aortic arch surgery. Altogether, 1028 papers were found using the reported search, of which 6 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. There were four retrospective obser...
Source: Interactive CardioVascular and Thoracic Surgery - August 21, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Poon, S. S., Estrera, A., Oo, A., Field, M. Tags: Extracorporeal circulation Adult Cardiac Source Type: research