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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Malignant Hyperthermia: A Killer If Ignored
J Perianesth Nurs. 2022 Apr 9:S1089-9472(21)00353-1. doi: 10.1016/j.jopan.2021.08.018. Online ahead of print.ABSTRACTMalignant hypothermia (MH) is a potentially fatal hypermetabolic reaction of skeletal muscle. It is an autosomal dominant disorder that generally occurs in people with RYR1, CACNA1S, or STAC3 mutations. And these genetic abnormalities often cause the imperfection of calcium release channels of skeletal muscle. The incidence of MH among different racial groups across the world ranges from approximately 1:5,000-1:250,000, but there is no national statistic MH incidence in China. It is not clear whether there a...
Source: Journal of Perianesthesia Nursing - April 13, 2022 Category: Nursing Authors: Xin Bin Baisheng Wang Zhangui Tang Source Type: research

New aspects in neurointensive and emergency medicine: the most important studies in a review and overview
Nervenarzt. 2022 Apr 5. doi: 10.1007/s00115-022-01285-3. Online ahead of print.ABSTRACTThis review article summarizes the major clinical studies in neurological emergency and intensive care medicine from the end of 2020 to 2021 on the topics: recanalizing treatment in ischemic stroke, usefulness and effect of brain tissue oxygen monitoring in subarachnoid hemorrhage, efficacy of induced hypothermia in patients with cardiac arrest (CA), value of early cranial imaging after CA, relevance of rapid management and effects of different anticonvulsants in status epilepticus and incidence of critical illness polyneuropathy myopath...
Source: Der Nervenarzt - April 5, 2022 Category: Neurology Authors: Angelika Alonso Rainer Kollmar Konstantin Dimitriadis Source Type: research

Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL-1 β, IL-6, ICAM-1 and MMP-2 in patients with acute cerebral infarction and clinical significance
In conclusion, mild hypothermia treatment in addition to intravenous thrombolysis significantly reduced the levels of IL-1β, IL-6, CRP, ICAM-1 and MMP-2 in patients with acute cerebral infarction and reduced inflammation, and should therefore be incorporated in clinical practice.PMID:35222700 | PMC:PMC8812145 | DOI:10.3892/etm.2022.11147
Source: Experimental and Therapeutic Medicine - February 28, 2022 Category: General Medicine Authors: Chaosheng Li Lingling Hu Jilai Zhao Meiqi Di Changyan Fan Likun Han Xuying Zhu Source Type: research

Case Report: Myxedema Coma Caused by Immunoglobulin A Vasculitis in a Patient With Severe Hypothyroidism
Myxedema coma is a critical disorder with high mortality rates. Disruption of the compensatory mechanism for severe and long-term hypothyroidism by various causes leads to critical conditions, including hypothermia, respiratory failure, circulatory failure, and central nervous system dysfunction. Infectious diseases, stroke, myocardial infarction, sedative drugs, and cold exposure are considered the main triggers for myxedema coma. A 59-year-old Japanese woman presented with bilateral painful purpura on her lower legs. She was diagnosed with coexisting immunoglobulin A (IgA) vasculitis and severe IgA vasculitis with nephri...
Source: Frontiers in Immunology - February 18, 2022 Category: Allergy & Immunology Source Type: research

What are Some Risk Factors for Hypoxic-Ischemic Encephalopathy Outcomes?
Discussion “Neonatal encephalopathy, manifesting as altered responsiveness, seizures, apnea and abnormal muscle tone and reflexes, resulting from hypoxic-ischemic injury is termed hypoxic-ischemic encephalopathy (HIE).” Neonatal encephalopathy can be associated with other problems including stroke, hemorrhage, infection, pre-term brain injury and hypoglycemia as some examples. Sometimes more than one of these entities occurs simultaneously such as hypoglycemia and HIE. HIE can result in long-term neurological problems including motor, behavioral, and cognitive problems that can become apparent even years later....
Source: PediatricEducation.org - December 13, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Ultra-Short Duration Hypothermia Prevents Intracranial Pressure Elevation Following Ischaemic Stroke in Rats
There is a transient increase in intracranial pressure (ICP) 18–24 h after ischaemic stroke in rats, which is prevented by short-duration hypothermia using rapid cooling methods. Clinical trials of long-duration hypothermia have been limited by feasibility and associated complications, which may be avoided by short-duration cooling. Animal studies have cooled faster than is achievable in patients. We aimed to determine whether gradual cooling at a rate of 2°C/h to 33°C or 1°C/h to 34.5°C, with a 30 min duration at target temperatures, prevented ICP elevation and reduced infarct volume in rats. Transient middle cerebr...
Source: Frontiers in Neurology - September 20, 2021 Category: Neurology Source Type: research

Targeting focal ischemic and hemorrhagic stroke neuroprotection: current prospects for local hypothermia
AbstractTherapeutic hypothermia (TH) has applications dating back millennia. In modern history, however, TH saw its importation into medical practice where investigations have demonstrated that TH is efficacious in ischemic insults, notably cardiac arrest and hypoxic-ischemic encephalopathy. As well, studies have been undertaken to investigate whether TH can provide benefit in focal stroke (i.e., focal ischemia and intracerebral hemorrhage). However, clinical studies have encountered various challenges with induction and maintenance of post-stroke TH. Most clinical studies have attempted to use body-wide cooling protocols,...
Source: Journal of Neurochemistry - September 9, 2021 Category: Neuroscience Authors: Lane J. Liddle, Anna C.J. Kalisvaart, Ashley H. Abrahart, Mohammed Almekhlafi, Andrew Demchuk, Frederick Colbourne Tags: REVIEW Source Type: research