Filtered By:
Condition: Hypothermia

This page shows you your search results in order of date. This is page number 20.

Order by Relevance | Date

Total 450 results found since Jan 2013.

Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice.
Abstract Aging is an important risk factor for post-stroke infection, which accounts for a large proportion of stroke-associated mortality. Despite this, studies evaluating post-stroke infection rates in aged animal models are limited. In addition, few studies have assessed gut microbes as a potential source of infection following stroke. Therefore we investigated the effects of age and the role of bacterial translocation from the gut in post-stroke infection in young (8-12 weeks) and aged (18-20 months) C57Bl/6 male mice following transient middle cerebral artery occlusion (MCAO) or sham surgery. Gut permeability...
Source: Aging - April 24, 2016 Category: Biomedical Science Authors: Crapser J, Ritzel R, Verma R, Venna VR, Liu F, Chauhan A, Koellhoffer E, Patel A, Ricker A, Maas K, Graf J, McCullough LD Tags: Aging (Albany NY) Source Type: research

Novel method for inducing rapid, controllable therapeutic hypothermia in rats using a perivascular implanted closed-loop cooling circuit
Conclusions This method will allow future experiments to determine under what conditions therapeutic hypothermia is effective, determine the optimal relationship among delay, duration, and depth, and provide the research community with a new model for conducting further research into mechanistic questions underlying the efficacy of therapeutic hypothermia.
Source: Journal of Neuroscience Methods - April 21, 2016 Category: Neuroscience Source Type: research

Hypothermia followed by rapid rewarming exacerbates ischemia-induced brain injury and augments inflammatory response in rats.
Abstract Hypothermia followed by slow rewarming is neuroprotective for ischemic stroke. However, slow rewarming causes patients' longer stay in intensive care unit and increases the risk of hypothermic complications. Hypothermia followed by rapid rewarming (HTRR) is more convenient; but it exacerbates intracranial hypertension for patients with massive hemispheric infarcts. The present study aims to investigate in detail how HTRR exacerbates ischemic brain injury and what are underlying mechanisms. Rats subjected to transient focal ischemia by middle cerebral artery occlusion were treated with normothermia or hypo...
Source: Biochemical and Biophysical Research communications - April 19, 2016 Category: Biochemistry Authors: Zhu SZ, Gu Y, Wu Z, Hu YF, Pan SY Tags: Biochem Biophys Res Commun Source Type: research

Stroke Due to Air Embolism Related to Laser Ablation of Accessory Vein (P4.357)
Conclusions: Air embolism leading to devastating stroke may occur few hours after laser treatment of varicose veins. Chest symptoms associated with the procedure should raise the possibility of air embolism. Immediate therapeutic measures like 100[percnt] oxygen, hyperbaric oxygen chamber and/or hypothermia should be considered to prevent neurologic complications.Disclosure: Dr. Kale has nothing to disclose. Dr. Javed has nothing to disclose. Dr. Pednekar has nothing to disclose. Dr. Sahni has nothing to disclose. Dr. Resor has nothing to disclose. Dr. Tenner has nothing to disclose. Dr. Ahluwalia-Singh has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kale, P., Javed, B., Pednekar, N., Sahni, R., Resor, L., Tenner, M., Ahluwalia-Singh, B. Tags: Cerebrovascular Case Reports Source Type: research

Combination therapy of normobaric oxygen with hypothermia or ethanol modulates pyruvate dehydrogenase complex in thromboembolic cerebral ischemia
This study evaluates the restoration of oxidative metabolism and energy regulation with a therapeutic combination of normobaric oxygen (NBO) plus either therapeutic hypothermia (TH) or ethanol. Sprague‐Dawley rats were subjected to middle cerebral artery occlusion with an autologous embolus. One hour after occlusion, tissue‐type plasminogen activator (t‐PA) was administered alone or with NBO (60%), EtOH (1.0 g/kg), or TH (33°C), either singly or in combination. Neurological deficit score and infarct volume were assessed 24 hr after t‐PA‐induced reperfusion. PDH activity and reactive oxygen species (ROS) levels w...
Source: Journal of Neuroscience Research - March 30, 2016 Category: Neuroscience Authors: Lipeng Cai, Alexa Thibodeau, Changya Peng, Xunming Ji, Radhika Rastogi, Ruiqiang Xin, Sunpreet Singh, Xiaokun Geng, Jose A. Rafols, Yuchuan Ding Tags: Research Article Source Type: research

Intraoperative mild hypothermia for postoperative neurological deficits in people with intracranial aneurysm.
CONCLUSIONS: It remains possible that intraoperative mild hypothermia could prevent death or dependency in activities of daily living in people with good grade aneurysmal subarachnoid haemorrhage. However, the confidence intervals around this estimate include the possibility of both benefit and harm. There was insufficient information to draw any conclusions about the effects of intraoperative mild hypothermia in people with poor grade aneurysmal subarachnoid haemorrhage or without subarachnoid haemorrhage. We did not identify any reliable evidence to support the routine use of intraoperative mild hypothermia. A high-quali...
Source: Cochrane Database of Systematic Reviews - March 21, 2016 Category: Journals (General) Authors: Li LR, You C, Chaudhary B Tags: Cochrane Database Syst Rev Source Type: research

Id: 64: reversible blindness associated with diabetic ketoacidosis: a rare combination
Discussion Sudden painless vision loss has a wide differential diagnosis and it is usually caused by ischemia at retinal, ocular or cortical level. No history of methanol ingestion or trauma, normal fundoscopy, normal MRI and rapid return of vision after correction of diabetic ketoacidosis strongly suggests that blindness was related to acidosis. Alcoholic ketoacidosis has been reported to cause transient reversible blindness in other case reports and correction of acidosis lead to reversal of blindness. Other rare causes of reversible blindness include posterior reversible encephalopathy syndrome, brain tumors, anterior i...
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Asad, Z., Chaudhary, A., Awab, A. Tags: Pulmonary/Critical Care Source Type: research

Catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine
Conclusions Selective moderate hypothermia was rapidly induced using endovascular techniques in a clinically realistic swine stroke model. A significant reduction in stroke volume on MRI was observed. Endovascular selective hypothermia can provide neuroprotection within time frames relevant to acute ischemic stroke treatment.
Source: Journal of NeuroInterventional Surgery - March 15, 2016 Category: Neurosurgery Authors: Mattingly, T. K., Denning, L. M., Siroen, K. L., Lehrbass, B., Lopez-Ojeda, P., Stitt, L., Pelz, D. M., Das, S., Ang, L.-C., Lee, D. H., Lownie, S. P. Tags: Editor''s choice, Basic science Source Type: research

Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction
Publication date: Available online 7 March 2016 Source:Progress in Neurobiology Author(s): Brian Forreider, David Pozivilko, Qingwen Kawaji, Xiaokun Geng, Yuchuan Ding Many mammalian species naturally undergo hibernation, a process that is associated with drastic changes in metabolism and systemic physiology. Their ability to retain an undamaged central nervous system during severely reduced cerebral blood flow has been studied for possible therapeutic application in human ischemic stroke. By inducing a less extreme ‘hibernation-like’ state, it has been hypothesized that similar neuroprotective effects reduce is...
Source: Progress in Neurobiology - March 8, 2016 Category: Neuroscience Source Type: research

Pediatric neurocritical care in the 21st century: from empiricism to evidence
Purpose of review: Approximately one in five children admitted to a pediatric ICU have a new central nervous system injury or a neurological complication of their critical illness. The spectrum of neurologic insults in children is diverse and clinical practice is largely empirical, as few randomized, controlled trials have been reported. This lack of data poses a substantial challenge to the practice of pediatric neurocritical care (PNCC). PNCC has emerged as a novel subspecialty, and its presence is expanding within tertiary care centers. This review highlights the recent advances in the field, with a focus on traumatic b...
Source: Current Opinion in Critical Care - March 6, 2016 Category: Nursing Tags: NEUROSCIENCE: Edited by J. Claude Hemphill Source Type: research

Post-stroke gaseous hypothermia increases vascular density but not neurogenesisin the ischemic penumbra of aged rats.
CONCLUSION: Long-term hypothermia may be a viable clinical approach by simultaneously targeting multiple processes including better tissue preservation, enhanced vascular density and improved behavioral performance. PMID: 26923618 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - March 1, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Protective effects of cyclosporine A and hypothermia on neuronal mitochondria in a rat asphyxial cardiac arrest model
Cyclosporine A (CsA) was neuroprotective in the settings of traumatic brain injury and stroke. We sought to investigate the protective effects of CsA and hypothermia on neuronal mitochondria after cardiac arrest.Methods and Results.Five groups were included: sham (S), normothermia (N), CsA (C), hypothermia (H), and CsA plus hypothermia (C+H). Cardiac arrest was induced by 10min of asphyxia. CsA (10mg/kg) was administered immediately after return of spontaneous circulation in the CsA groups. Temperature of the rats was maintained at 33±0.5°C after return of spontaneous circulation in the hypothermia groups.
Source: The American Journal of Emergency Medicine - March 1, 2016 Category: Emergency Medicine Authors: Jie Liu, Yue Wang, Qiwei Zhuang, Meng Chen, Yufeng Wang, Lina Hou, Fei Han Tags: Original Contributions Source Type: research

Where in the World of EMS is A.J.? The 2016 Gathering of Eagles in Dallas
This week, JEMS editor-in-chief A.J. Heightman is attending the private two-day conclave of the Major Metropolitan Medical Directors in Dallas, which precedes the Gathering of Eagles conference. This year's closed retreat is attended by 60 medical directors and EMS fellows (tomorrow's leaders) who meet annually to discuss common issues in EMS and medical direction. Heightman reports, via a survey conducted by Eagles historian and archivist Jim Augustine, MD, that the medical directors involved in this year's Eagles Retreat represent an astounding 17 centuries of EMS medical direction experience, 100 million people ser...
Source: JEMS Administration and Leadership - February 18, 2016 Category: Emergency Medicine Authors: JEMS Staff Tags: Administration and Leadership EMS Today Source Type: news