Angioneurins – Key regulators of blood–brain barrier integrity during hypoxic and ischemic brain injury
Publication date: Available online 7 April 2019Source: Progress in NeurobiologyAuthor(s): Reiner Kunze, Hugo H. MartiAbstractThe loss of blood–brain barrier (BBB) integrity leading to vasogenic edema and brain swelling is a common feature of hypoxic/ischemic brain diseases such as stroke, but is also central to the etiology of other CNS disorders. In the past decades, numerous proteins, belonging to the family of angioneurins, have gained increasing attention as potential therapeutic targets for ischemic stroke, but also other CNS diseases attributed to BBB dysfunction. Angioneurins encompass mediators that affect bo...
Source: Progress in Neurobiology - May 15, 2019 Category: Neuroscience Source Type: research

Microglia: Lifelong Patrolling Immune Cells of the Brain
Publication date: Available online 7 May 2019Source: Progress in NeurobiologyAuthor(s): Ukpong B. Eyo, Long-Jun WuAbstractMicroglial cells are the predominant parenchymal immune cell of the brain. Recent evidence suggests that like peripheral immune cells, microglia patrol the brain in health and disease. Reviewing these data, we first examine the evidence that microglia invade the brain mesenchyme early in embryonic development, establish residence therein, proliferate and subsequently maintain their numbers throughout life. We, then, summarize established and novel evidence for microglial process surveillance in the heal...
Source: Progress in Neurobiology - May 9, 2019 Category: Neuroscience Source Type: research

A review of neurobiological factors underlying the selective enhancement of memory at encoding, consolidation, and retrieval
Publication date: Available online 2 May 2019Source: Progress in NeurobiologyAuthor(s): Rebecca Crowley, Daniel Bendor, Amir-Homayoun JavadiAbstractHow is the strength of a memory determined? This review discusses three main factors that contribute to memory enhancement - 1) emotion, 2) targeted memory reactivation, and 3) neural reinstatement. Whilst the mechanisms through which memories become enhanced vary, this review demonstrates that activation of the basolateral amygdala and hippocampal formation are crucial for facilitating encoding, consolidation, and retrieval. Here we suggest methodological factors to consider i...
Source: Progress in Neurobiology - May 3, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: June 2019Source: Progress in Neurobiology, Volume 177Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 27, 2019 Category: Neuroscience Source Type: research

8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes
Publication date: Available online 23 April 2019Source: Progress in NeurobiologyAuthor(s): Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Gabriele De Luca, Margherita Bignami, Yusaku NakabeppuAbstractIn mammals, including humans, MTH1 with 8-oxo-dGTPase and OGG1 with 8-oxoguanine DNA glycosylase minimize 8-oxoguanine accumulation in genomic DNA. We investigated age-related alterations in behavior, 8-oxoguanine levels, and neurogenesis in the brains of Mth1/Ogg1-double knockout (TO-DKO), Ogg1-knockout, and human MTH1-transgenic (hMTH1-Tg) mice. Spontaneous locomotor activity was significantly decrease...
Source: Progress in Neurobiology - April 24, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: May 2019Source: Progress in Neurobiology, Volume 176Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 12, 2019 Category: Neuroscience Source Type: research

Angioneurins–key regulators of blood-brain barrier integrity during hypoxic and ischemic brain injury
Publication date: Available online 7 April 2019Source: Progress in NeurobiologyAuthor(s): Reiner Kunze, Hugo H. MartiAbstractThe loss of blood-brain barrier (BBB) integrity leading to vasogenic edema and brain swelling is a common feature of hypoxic/ischemic brain diseases such as stroke, but is also central to the etiology of other CNS disorders. In the past decades, numerous proteins, belonging to the family of angioneurins, have gained increasing attention as potential therapeutic targets for ischemic stroke, but also other CNS diseases attributed to BBB dysfunction. Angioneurins encompass mediators that affect both neu...
Source: Progress in Neurobiology - April 9, 2019 Category: Neuroscience Source Type: research

Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
Publication date: Available online 17 February 2019Source: Progress in NeurobiologyAuthor(s): Carlos Silva, Neil McNaughtonAbstractMany see the periaqueductal gray (PAG) as a region responsible for the downstream control of defensive reactions. Here we provide a detailed review of anatomical and functional data on the different parts of the PAG together with the dorsal raphe, which completes the circle of periaqueductal nuclei. Based on anatomical features, we propose a new subdivision of the periaqueductal gray that accounts for the distinct characteristics of the area. We provide a comprehensive functional view of the pe...
Source: Progress in Neurobiology - April 5, 2019 Category: Neuroscience Source Type: research

Microglia: brain cells on the move
Publication date: Available online 4 April 2019Source: Progress in NeurobiologyAuthor(s): Sophie Marie-Thérèse Smolders, Sofie Kessels, Tim Vangansewinkel, Jean-Michel Rigo, Pascal Legendre, Bert BrôneAbstractIn the last decade, tremendous progress has been made in understanding the biology of microglia - i.e. The fascinating immigrated resident immune cell population of the central nervous system (CNS). Recent literature reviews have largely dealt with the plentiful functions of microglia in CNS homeostasis, development and pathology, and the influences of sex and the microbiome. In this review, the in...
Source: Progress in Neurobiology - April 5, 2019 Category: Neuroscience Source Type: research

Progress in neuromodulation of the brain: A role for magnetic nanoparticles?
Publication date: Available online 13 March 2019Source: Progress in NeurobiologyAuthor(s): Milaine Roet, Sarah-Anna Hescham, Ali Jahanshahi, Bart P.F. Rutten, Polina O. Anikeeva, Yasin TemelAbstractThe field of neuromodulation is developing rapidly. Current techniques, however, are still limited as they i) either depend on permanent implants, ii) require invasive procedures, iii) are not cell-type specific, iv) involve slow pharmacokinetics or v) have a restricted penetration depth making it difficult to stimulate regions deep within the brain. Refinements into the different fields of neuromodulation are thus needed. In th...
Source: Progress in Neurobiology - March 27, 2019 Category: Neuroscience Source Type: research

Role and Mechanisms of Cytokines in the Secondary Brain Injury After Intracerebral Hemorrhage
Publication date: Available online 25 March 2019Source: Progress in NeurobiologyAuthor(s): Huimin Zhu, Zhiqiang Wang, Jixu Yu, Xiuli Yang, Feng He, Zhenchuan Liu, Fengyuan Che, Xuemei Chen, Honglei Ren, Michael Hong, Jian WangAbstractIntracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Inflammatory cytokines are important participants in secondary injury after ICH. Increases in proinflammatory cytokines may aggravate the tissue injury, wherea...
Source: Progress in Neurobiology - March 26, 2019 Category: Neuroscience Source Type: research

Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Publication date: Available online 21 March 2019Source: Progress in NeurobiologyAuthor(s): Dick R. Nässel, Meet ZandawalaAbstractThis review focuses on neuropeptides and peptide hormones, the largest and most diverse class of neuroactive substances, known in Drosophila and other animals to play roles in almost all aspects of daily life, as well as in developmental processes. We provide an update on novel neuropeptides and receptors identified in the last decade, and highlight progress in analysis of neuropeptide signaling in Drosophila. Especially exciting is the huge amount of work published on novel functions of neu...
Source: Progress in Neurobiology - March 23, 2019 Category: Neuroscience Source Type: research

Progress in neuromodulation of the brain; a role for magnetic nanoparticles?
Publication date: Available online 13 March 2019Source: Progress in NeurobiologyAuthor(s): Milaine Roet, Sarah-Anna Hescham, Ali Jahanshahi, Bart P.F. Rutten, Polina O. Anikeeva, Yasin TemelAbstractThe field of neuromodulation is developing rapidly. Current techniques, however, are still limited as they i) either depend on permanent implants, ii) require invasive procedures, iii) are not cell-type specific, iv) involve slow pharmacokinetics or v) have a restricted penetration depth making it difficult to stimulate regions deep within the brain. Refinements into the different fields of neuromodulation are thus needed. In th...
Source: Progress in Neurobiology - March 14, 2019 Category: Neuroscience Source Type: research

Effects of estrogens and androgens on mitochondria under normal and pathological conditions
Publication date: Available online 7 March 2019Source: Progress in NeurobiologyAuthor(s): Mohammad Mohajeri, Cynthia Martín-Jiménez, George E. Barreto, Amirhossein SahebkarAbstractSeveral lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated with deleterious effects on brain function and progression to neurodegenerative diseases. Recent in vitro and in vivo...
Source: Progress in Neurobiology - March 8, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: April 2019Source: Progress in Neurobiology, Volume 175Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 27, 2019 Category: Neuroscience Source Type: research

Are periaqueductal grey and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
Publication date: Available online 17 February 2019Source: Progress in NeurobiologyAuthor(s): Carlos Silva, Neil McNaughtonAbstractMany see the periaqueductal grey (PAG) as a region responsible for the downstream control of defensive reactions. Here we provide a detailed review of anatomical and functional data on the different parts of the PAG together with the dorsal raphe, which completes the circle of periaqueductal nuclei. Based on anatomical features, we propose a new subdivision of the periaqueductal grey that accounts for the distinct characteristics of the area. We provide a comprehensive functional view of the pe...
Source: Progress in Neurobiology - February 18, 2019 Category: Neuroscience Source Type: research

Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back
Publication date: Available online 13 February 2019Source: Progress in NeurobiologyAuthor(s): Chiara Demartini, Rosaria Greco, Anna Maria Zanaboni, Grazia Sances, Roberto De Icco, David Borsook, Cristina TassorelliAbstractMigraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migra...
Source: Progress in Neurobiology - February 14, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: March 2019Source: Progress in Neurobiology, Volume 174Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 12, 2019 Category: Neuroscience Source Type: research

The Roles of Supervised Machine Learning in Systems Neuroscience
We describe four primary roles of ML within neuroscience: 1) creating solutions to engineering problems, 2) identifying predictive variables, 3) setting benchmarks for simple models of the brain, and 4) serving itself as a model for the brain. The breadth and ease of its applicability suggests that machine learning should be in the toolbox of most systems neuroscientists. (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 8, 2019 Category: Neuroscience Source Type: research

Sex Differences in Depression: Insights from Clinical and Preclinical Studies
Publication date: Available online 2 February 2019Source: Progress in NeurobiologyAuthor(s): Rand S. Eid, Aarthi R. Gobinath, Liisa A.M. GaleaAbstractDepression represents a global mental health concern, and disproportionally affects women as they are twice more likely to be diagnosed than men. In this review, we provide a summary of evidence to support the notion that differences in depression between men and women span multiple facets of the disease, including epidemiology, symptomology, treatment, and pathophysiology. Through a lens of biological sex, we overview depression-related transcriptional patterns, changes in n...
Source: Progress in Neurobiology - February 3, 2019 Category: Neuroscience Source Type: research

Action Perception and Motor Imagery: Mental Practice of Action
Publication date: Available online 31 January 2019Source: Progress in NeurobiologyAuthor(s): Helen E. Savaki, Vassilis RaosAbstractMotor cognition is related to the planning and generation of actions as well as to the recognition and imagination of motor acts. Recently, there is evidence that the motor system participates not only in overt actions but also in mental processes supporting covert actions. Within this framework, we have investigated the cortical areas engaged in execution, observation, and imagination of the same action, by the use of the high resolution quantitative 14C-deoxyglucose method in monkeys and by f...
Source: Progress in Neurobiology - February 1, 2019 Category: Neuroscience Source Type: research

New windows into the brain: Central nervous system-derived extracellular vesicles in blood
Publication date: Available online 25 January 2019Source: Progress in NeurobiologyAuthor(s): Min Shi, Lifu Sheng, Tessandra Stewart, Cyrus P. Zabetian, Jing ZhangAbstractExtracellular vesicles (EVs), including exosomes and (shedding) microvesicles, are released by nearly all cell types and carry a cargo of proteins and nucleic acids that varies by the cell of origin. They are thought to play critical roles in normal central nervous system (CNS) function and neurological disorders. A recently revealed key characteristic of EVs is that they may travel between the CNS and peripheral circulation. This property has led to inten...
Source: Progress in Neurobiology - January 25, 2019 Category: Neuroscience Source Type: research

Precision in the Development of Neocortical Architecture: from Progenitors to Cortical Networks
Publication date: Available online 21 January 2019Source: Progress in NeurobiologyAuthor(s): Ryan J. Kast, Pat LevittAbstractOf all brain regions, the 6-layered neocortex has undergone the most dramatic changes in size and complexity during mammalian brain evolution. These changes, occurring in the context of a conserved set of organizational features that emerge through stereotypical developmental processes, are considered responsible for the cognitive capacities and sensory specializations represented within the mammalian clade. The modern experimental era of developmental neurobiology, spanning 6 decades, has deciphered...
Source: Progress in Neurobiology - January 22, 2019 Category: Neuroscience Source Type: research

The circuit architecture of cortical multisensory processing: distinct functions jointly operating within a common anatomical network
Publication date: Available online 21 January 2019Source: Progress in NeurobiologyAuthor(s): Guido T. Meijer, Paul E.C. Mertens, Cyriel M.A. Pennartz, Umberto Olcese, Carien S. LansinkAbstractOur perceptual systems continuously process sensory inputs from different modalities and organize these streams of information such that our subjective representation of the outside world is a unified experience. By doing so, they also enable further cognitive processing and behavioral action. While cortical multisensory processing has been extensively investigated in terms of psychophysics and mesoscale neural correlates, an in depth...
Source: Progress in Neurobiology - January 22, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: February 2019Source: Progress in Neurobiology, Volume 173Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - January 18, 2019 Category: Neuroscience Source Type: research

Chronotherapies for Parkinson’s Disease
Publication date: Available online 15 January 2019Source: Progress in NeurobiologyAuthor(s): Karim Fifel, Aleksandar VidenovicAbstractParkinson’s disease (PD) is the second-most common progressive neurodegenerative disorder. Although the clinical diagnosis of PD is still based on its cardinal motor dysfunctions, several non-motor symptoms (NMS) have been established as integral part of the disease. Unlike motor disorders, development of therapies against NMS are still challenging and remain a critical unmet clinical need. During the last decade, several studies have characterised the molecular, physiological and beha...
Source: Progress in Neurobiology - January 16, 2019 Category: Neuroscience Source Type: research

Adult neurogenesis promotes balance recovery after vestibular loss
Publication date: Available online 15 January 2019Source: Progress in NeurobiologyAuthor(s): Brahim Tighilet, Christian ChabbertAbstractA phenomenon called vestibular compensation occurs after peripheral vestibular loss. This process involves a mosaic of profound structural rearrangements within the vestibular nuclei. Among them, adult reactive neurogenesis is perhaps the most unexpected, as it occurs in a brain area that was never reported as neurogenic before. Both the survival and functionality of this newly generated neuronal network depend on its integration into preexisting networks in the deafferented structure. Far...
Source: Progress in Neurobiology - January 16, 2019 Category: Neuroscience Source Type: research

It’s all about tau
Publication date: Available online 31 December 2018Source: Progress in NeurobiologyAuthor(s): Cheril Tapia-Rojas, Fabian Cabezas-Opazo, Carol A. Deaton, Erick H. Vergara, Gail V.W. Johnson, Rodrigo A. QuintanillaAbstractTau is a protein that is highly enriched in neurons and was originally defined by its ability to bind and stabilize microtubules. However, it is now becoming evident that the functions of tau extend beyond its ability to modulate microtubule dynamics. Tau plays a role in mediating axonal transport, synaptic structure and function, and neuronal signaling pathways. Although tau plays important physiological r...
Source: Progress in Neurobiology - January 1, 2019 Category: Neuroscience Source Type: research

Transcriptional and epigenetic mechanisms underlying astrocyte identity
Publication date: Available online 29 December 2018Source: Progress in NeurobiologyAuthor(s): Maria Angeliki S. Pavlou, Luc Grandbarbe, Noel J. Buckley, Simone P. Niclou, Alessandro MichelucciAbstractAstrocytes play a significant role in coordinating neural development and provide critical support for the function of the CNS. They possess important adaptation capacities that range from their transition towards reactive astrocytes to their ability to undergo reprogramming, thereby revealing their potential to retain latent features of neural progenitor cells. We propose that the mechanisms underlying reactive astrogliosis o...
Source: Progress in Neurobiology - December 30, 2018 Category: Neuroscience Source Type: research

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies
Publication date: Available online 30 December 2018Source: Progress in NeurobiologyAuthor(s): Piyoosh Sharma, Pavan Srivastava, Ankit Seth, Prabhash Nath Tripathi, Anupam G. Banerjee, Sushant K. ShrivastavaAbstractAD is a progressive neurodegenerative disorder and a leading cause of dementia in an aging population worldwide. The enormous challenge which AD possesses to global healthcare makes it as urgent as ever for the researchers to develop innovative treatment strategies to fight this disease. An in-depth analysis of the extensive available data associated with the AD is needed for a more comprehensive understanding of...
Source: Progress in Neurobiology - December 30, 2018 Category: Neuroscience Source Type: research

Pivotal role of carnosine in the modulation of brain cells activity: multimodal mechanism of action and therapeutic potential in neurodegenerative disorders
Publication date: Available online 26 December 2018Source: Progress in NeurobiologyAuthor(s): Giuseppe Caruso, Filippo Caraci, Renaud B. JolivetAbstractCarnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Although discovered more than a hundred years ago and having been extensively studied in the periphery, the role of carnosine in the brain remains mysterious. Carnosinemia, a rare metabolic disorder with increased levels of carnosine in urine and low levels or absence of carnosinase in the blood, is associated with severe neuro...
Source: Progress in Neurobiology - December 27, 2018 Category: Neuroscience Source Type: research

Lateral parietal cortex in the generation of behavior: implications for apathy
Publication date: Available online 24 December 2018Source: Progress in NeurobiologyAuthor(s): S. Tumati, S. Martens, B.M. de Jong, A. AlemanAbstractA reduction in goal-directed behavior, or apathy, occurs in neurological and psychiatric disorders, while its neural substrates remain unclear. Deficits in circuits connecting the prefrontal cortex to subcortical regions are considered to underlie apathy. Although apathy is empirically associated with widespread changes in these regions, studies across disorders also link apathy with the lateral parietal cortex. Such variety in regional involvement is consistent with the establ...
Source: Progress in Neurobiology - December 25, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: January 2019Source: Progress in Neurobiology, Volume 172Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - December 25, 2018 Category: Neuroscience Source Type: research

Brain changes in a maternal Immune activation model of neurodevelopmental brain disorders
Publication date: Available online 24 December 2018Source: Progress in NeurobiologyAuthor(s): Lara Bergdolt, Anna DunaevskyAbstractThe developing brain is sensitive to a variety of insults. Epidemiological studies have identified prenatal exposure to infection as a risk factor for a range of neurological disorders, including autism spectrum disorder and schizophrenia. Animal models corroborate this association and have been used to probe the contribution of gene-environment interactions to the etiology of neurodevelopmental disorders. Here we review the behavior and brain phenotypes that have been characterized in MIA offs...
Source: Progress in Neurobiology - December 24, 2018 Category: Neuroscience Source Type: research

Macrophage Biology in the Peripheral Nervous System after Injury
Publication date: Available online 21 December 2018Source: Progress in NeurobiologyAuthor(s): Richard E. Zigmond, Franklin D. EchevarriaAbstractNeuroinflammation has positive and negative effects. This review focuses on the roles of macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of the distal nerve and to changes in the region of the axotomized cell bodies. In both locations, resident and infiltrating macrophages are found. Macrophages enter these areas in response to expression of the chemokine CCL2 acting on the macrophage receptor CCR2. In the distal nerve, macrophages and other phag...
Source: Progress in Neurobiology - December 21, 2018 Category: Neuroscience Source Type: research

Axonal fusion: an alternative and efficient mechanism of nerve repair
Publication date: Available online 27 November 2018Source: Progress in NeurobiologyAuthor(s): Brent Neumann, Casey Linton, Rosina Giordano-Santini, Massimo A. HilliardAbstractInjuries to the nervous system can cause lifelong morbidity due to the disconnect that occurs between nerve cells and their cellular targets. Re-establishing these lost connections is the ultimate goal of endogenous regenerative mechanisms, as well as those induced by exogenous manipulations in a laboratory or clinical setting. Reconnection between severed neuronal fibers occurs spontaneously in some invertebrate species and can be induced in mammalia...
Source: Progress in Neurobiology - November 28, 2018 Category: Neuroscience Source Type: research

Exercise as a therapeutic intervention for motor and non-motor symptoms in Parkinson’s disease: evidence from rodent models
Publication date: Available online 24 November 2018Source: Progress in NeurobiologyAuthor(s): Crowley E.K., Nolan Y.M., Sullivan A.M.AbstractParkinson’s disease (PD) is characterised by degeneration of dopaminergic neurons of the nigrostriatal pathway, which leads to the cardinal motor symptoms of the disease - tremor, rigidity and postural instability. A number of non-motor symptoms are also associated with PD, including cognitive impairment, mood disturbances and dysfunction of gastrointestinal and autonomic systems. Current therapies provide symptomatic relief but do not halt the disease process, so there is an ur...
Source: Progress in Neurobiology - November 25, 2018 Category: Neuroscience Source Type: research

Welcome from the new Editor-in-Chief!
Publication date: Available online 23 November 2018Source: Progress in NeurobiologyAuthor(s): Sabine Kastner (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - November 24, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2018Source: Progress in Neurobiology, Volume 171Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - November 23, 2018 Category: Neuroscience Source Type: research

Humble beginnings with big goals: Small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders
Publication date: Available online 14 November 2018Source: Progress in NeurobiologyAuthor(s): Sydney Zarriello, Julian Tuazon, Sydney Corey, Samantha Schimmel, Mira Rajani, Anna Gorsky, Diego Incontri, Bruce D. Hammock, Cesar V. BorlonganAbstractSoluble epoxide hydrolase (sEH) degrades epoxides of fatty acids including epoxyeicosatrienoic acid isomers (EETs), which are produced as metabolites of the cytochrome P450 branch of the arachidonic acid pathway. EETs exert a variety of largely beneficial effects in the context of inflammation and vascular regulation. sEH inhibition is shown to be therapeutic in several cardiovascu...
Source: Progress in Neurobiology - November 14, 2018 Category: Neuroscience Source Type: research

Oxytocin receptor signaling in the hippocampus: role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory
Publication date: Available online 22 October 2018Source: Progress in NeurobiologyAuthor(s): Yu-Ting Lin, Kuei-Sen HsuAbstractBeyond its well-known role in reproduction, the hypothalamic neuropeptide oxytocin (OXT) has been implicated in a broad spectrum of social and nonsocial behaviors. The biological actions of OXT are exerted through specific OXT receptors (OXTR) that belong to the family of G protein-coupled receptors. OXTR is abundantly expressed in the hippocampus, and the past decade has witnessed tremendous progress in our understanding of the physiological significance of hippocampal OXTR signaling. In this revie...
Source: Progress in Neurobiology - October 23, 2018 Category: Neuroscience Source Type: research

Memory integration: An alternative to the consolidation/reconsolidation hypothesis
Publication date: Available online 18 October 2018Source: Progress in NeurobiologyAuthor(s): Pascale Gisquet-Verrier, David C. RiccioAbstractThe original concept of consolidation considers that memory requires time to be fixed. Since 2000, a comparable protein-dependent re-stabilization phase, called reconsolidation, has been assumed to take place after memory retrieval. This consolidation/reconsolidation hypothesis, has dominated the literature for more than 50 years, despite compelling evidence that is inconsistent with it. In this review, we present an historical overview and explain how, despite serious criticisms, thi...
Source: Progress in Neurobiology - October 20, 2018 Category: Neuroscience Source Type: research

Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence
Publication date: Available online 11 October 2018Source: Progress in NeurobiologyAuthor(s): Fawaz Alasmari, Sunil Goodwani, Robert E. McCullumsmith, Youssef SariAbstractEmerging evidence demonstrates that alcohol dependence is associated with dysregulation of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric acid release are linked to chronic alcohol exposure. The effects of alcohol on the glutamatergic system in the mesocorticolimbic areas have been investigated extensively. Several studies have demonstrated dysregulation in the glutamatergic systems in animal models exposed to alcohol....
Source: Progress in Neurobiology - October 12, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: November 2018Source: Progress in Neurobiology, Volume 170Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - October 12, 2018 Category: Neuroscience Source Type: research

Neural stem cell heterogeneity
Publication date: November 2018Source: Progress in Neurobiology, Volume 170Author(s): Jean-Stéphane Joly, Vincent Tropepe (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - October 12, 2018 Category: Neuroscience Source Type: research

Vesicular glutamate transporter isoforms: The essential players in the somatosensory systems
Publication date: Available online 28 September 2018Source: Progress in NeurobiologyAuthor(s): Fu-Xing Zhang, Shun-Nan Ge, Yu-Lin Dong, Juan Shi, Yu-Peng Feng, Yang Li, Yun-Qing Li, Jin-Lian LiAbstractIn nervous system, glutamate transmission is crucial for centripetal conveyance and cortical perception of sensory signals of different modalities, which necessitates vesicular glutamate transporters 1-3 (VGLUT1-3), the three homologous membrane-bound protein isoforms, to load glutamate into the presysnaptic vesicles. These VGLUTs, especially VGLUT1 and VGLUT2, selectively label and define functionally distinct neuronal subpo...
Source: Progress in Neurobiology - October 5, 2018 Category: Neuroscience Source Type: research

Caspases orchestrate microglia instrumental functions
Publication date: Available online 2 October 2018Source: Progress in NeurobiologyAuthor(s): Xianli Shen, Jose Luis Venero, Bertrand Joseph, Miguel Angel BurguillosAbstractMicroglia, the resident immune cells of the brain, can acquire various cell phenotypes based on their location and current role. This level of plasticity is required to fulfil the vast variety of functions that microglia perform. Adequate microglial functions are crucial for a healthy brain. However, microglial activation can also contribute to both degenerative/traumatic and proliferative diseases. We review current evidence supporting roles for caspases...
Source: Progress in Neurobiology - October 5, 2018 Category: Neuroscience Source Type: research

New insights into the complex role of mitochondria in Parkinson’s disease
We describe the contribution of mitochondrial genome alterations and PD-associated genes to mitochondrial maintenance. We highlight mitophagy as a key mechanism in neurodegeneration. Moreover, we focus on the reciprocal interaction between alpha-synuclein aggregation and mitochondrial dysfunction. We discuss a novel trafficking pathway involving mitochondrial-derived vesicles within the context of PD and provide a synopsis of the most recently emerging topics in PD research with respect to mitochondria. This includes the relationship between mitochondria and cell-mediated immunity, the ER-mitochondria axis, sirtuin-mediate...
Source: Progress in Neurobiology - September 14, 2018 Category: Neuroscience Source Type: research

Spatial representations in the primate hippocampus, and their functions in memory and navigation
Publication date: Available online 13 September 2018Source: Progress in NeurobiologyAuthor(s): Edmund T. Rolls, Sylvia WirthAbstractHippocampal spatial view neurons in primates respond to the place where a monkey is looking, with some modulation by place. In contrast, hippocampal neurons in rodents respond mainly to the place where the animal is located. We relate this difference to the development of a fovea in primates, and the highly developed primate visual system which enables identification of what is at the fovea, and a system for moving the eyes to view different parts of the environment. We show that the spatial v...
Source: Progress in Neurobiology - September 14, 2018 Category: Neuroscience Source Type: research

Neurobiological characteristics underlying metabolic differences between males and females
Publication date: Available online 5 September 2018Source: Progress in NeurobiologyAuthor(s): Julie A. Chowen, Alejandra Freire-Regatillo, Jesús ArgenteAbstractThe hypothalamus is the main integrating center for metabolic control. Our understanding of how hypothalamic circuits function to control appetite and energy expenditure has increased dramatically in recent years, due to the rapid rise in the incidence of obesity and the search for effective treatments. Increasing evidence indicates that these treatments will most likely differ between males and females. Indeed, sex differences in metabolism have been demonst...
Source: Progress in Neurobiology - September 6, 2018 Category: Neuroscience Source Type: research