Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?
Publication date: Available online 28 May 2020Source: Progress in NeurobiologyAuthor(s): Carolina Pellegrini, Luca Antonioli, Vincenzo Calderone, Rocchina Colucci, Matteo Fornai, Corrado Blandizzi (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 28, 2020 Category: Neuroscience Source Type: research

The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling
Publication date: Available online 25 May 2020Source: Progress in NeurobiologyAuthor(s): Christopher Lee, Stephanie M. Willerth, Haakon B. Nygaard (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 26, 2020 Category: Neuroscience Source Type: research

Neural activity underlying the detection of an object movement by an observer during forward self-motion: dynamic decoding and temporal evolution of directional cortical connectivity
Publication date: Available online 22 May 2020Source: Progress in NeurobiologyAuthor(s): N. Kozhemiako, A.S. Nunes, A. Samal, K.D. Rana, F.J. Calabro, M.S. Hämäläinen, S. Khan, L.M. Vaina (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 23, 2020 Category: Neuroscience Source Type: research

Prediction and memory: a predictive coding account
Publication date: Available online 21 May 2020Source: Progress in NeurobiologyAuthor(s): Helen C. Barron, Ryszard Auksztulewicz, Karl Friston (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 22, 2020 Category: Neuroscience Source Type: research

PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment
Publication date: Available online 5 May 2020Source: Progress in NeurobiologyAuthor(s): Marta Pérez-González, Maite Mendioroz, Sara Badesso, Diego Sucunza, Miren Roldan, Maria Espelosín, Susana Ursua, Rafael Luján, Mar Cuadrado-Tejedor, Ana Garcia-Osta (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 19, 2020 Category: Neuroscience Source Type: research

Unmasking the relevance of hemispheric asymmetries – break on through (to the other side)
Publication date: Available online 17 May 2020Source: Progress in NeurobiologyAuthor(s): Esteves Madalena, Susana S. Lopes, Armando Almeida, Nuno Sousa, Hugo Leite-Almeida (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 19, 2020 Category: Neuroscience Source Type: research

Presynaptic failure in Alzheimer's disease
Publication date: Available online 16 May 2020Source: Progress in NeurobiologyAuthor(s): Gael Barthet, Christophe Mulle (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 16, 2020 Category: Neuroscience Source Type: research

Interstitial ions: A key regulator of state-dependent neural activity?
Publication date: Available online 13 May 2020Source: Progress in NeurobiologyAuthor(s): Rune Rasmussen, John O’Donnell, Fengfei Ding, Maiken Nedergaard (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 14, 2020 Category: Neuroscience Source Type: research

Epigenetic Regulation in the pathophysiology of Lewy Body Dementia
Publication date: Available online 12 May 2020Source: Progress in NeurobiologyAuthor(s): Leonidas Chouliaras, Gautham S. Kumar, Alan J. Thomas, Katie Lunnon, Patrick F. Chinnery, John T. O’Brien (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 13, 2020 Category: Neuroscience Source Type: research

Elevated basal transcription can underlie timothy channel association with autism related disorders
Publication date: Available online 11 May 2020Source: Progress in NeurobiologyAuthor(s): Evrim Servili, Michael Trus, Julia Sajman, Eilon Sherman, Daphne Atlas (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 11, 2020 Category: Neuroscience Source Type: research

Functions of ventral visual cortex after bilateral medial temporal lobe damage
Publication date: Available online 4 May 2020Source: Progress in NeurobiologyAuthor(s): Jiye G. Kim, Emma Gregory, Barbara Landau, Michael McCloskey, Nicholas B. Turk-Browne, Sabine Kastner (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 5, 2020 Category: Neuroscience Source Type: research

PLA2 G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment
Publication date: Available online 5 May 2020Source: Progress in NeurobiologyAuthor(s): Marta Perez-Gonzalez, Maite Mendioroz, Sara Badesso, Diego Sucunza, Miren Roldan, Maria Espelosín, Susana Ursua, Rafael Lujan, Mar Cuadrado-Tejedor, Ana Garcia-Osta (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 5, 2020 Category: Neuroscience Source Type: research

Tryptophan metabolites modify brain Aβ peptide degradation: A role in Alzheimer’s disease?
Publication date: Available online 29 April 2020Source: Progress in NeurobiologyAuthor(s): Michel Maitre, Christian Klein, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 1, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: June 2020Source: Progress in Neurobiology, Volume 189Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 1, 2020 Category: Neuroscience Source Type: research

Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation
Publication date: Available online 29 April 2020Source: Progress in NeurobiologyAuthor(s): Michy P. Kelly, Pim R.A. Heckman, Robbert Havekes (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 29, 2020 Category: Neuroscience Source Type: research

Glaucoma as a Neurodegenerative Disease Caused by Intrinsic Vulnerability Factors
Publication date: Available online 29 April 2020Source: Progress in NeurobiologyAuthor(s): Ana Artero-Castro, Francisco Javier Rodriguez-Jimenez, Pavla Jendelova, Kirstin B. VanderWall, Jason S. Meyer, Slaven Erceg (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 29, 2020 Category: Neuroscience Source Type: research

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms
Publication date: Available online 24 April 2020Source: Progress in NeurobiologyAuthor(s): Angélica María Sabogal-Guáqueta, Alejandro Marmolejo-Garza, Vítor Passos de Pádua, Bart Eggen, Erik Boddeke, Amalia M. Dolga (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 25, 2020 Category: Neuroscience Source Type: research

miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis
Publication date: Available online 24 April 2020Source: Progress in NeurobiologyAuthor(s): Alessia Loffreda, Monica Nizzardo, Alessandro Arosio, Marc-David Ruepp, Raffaele A. Calogero, Stefano Volinia, Marco Galasso, Caterina Bendotti, Carlo Ferrarese, Christian Lunetta, Mafalda Rizzuti, Antonella Ronchi, Oliver Mühlemann, Lucio Tremolizzo, Stefania Corti, Silvia M.L. Barabino (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 25, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: May 2020Source: Progress in Neurobiology, Volume 188Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 12, 2020 Category: Neuroscience Source Type: research

Implied motion as a possible mechanism for encoding other people’s attention
Publication date: Available online 23 March 2020Source: Progress in NeurobiologyAuthor(s): Arvid Guterstam, Michael S.A. Graziano (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 25, 2020 Category: Neuroscience Source Type: research

MeCP2 mediates transgenerational transmission of chronic pain
Publication date: Available online 18 March 2020Source: Progress in NeurobiologyAuthor(s): Wenjuan Tao, Changmao Chen, Yuping Wang, Wenjie Zhou, Yan Jin, Yu Mao, Haitao Wang, Likui Wang, Wen Xie, Xulai Zhang, Jie Li, Juan Li, Xiangyao Li, Zhen-Quan Tang, Chenghua Zhou, Zhizhong Z. Pan, Zhi Zhang (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 19, 2020 Category: Neuroscience Source Type: research

A multimodal approach to identify clinically relevant biomarkers to comprehensively monitor disease progression in a mouse model of pediatric neurodegenerative disease
Publication date: Available online 18 March 2020Source: Progress in NeurobiologyAuthor(s): Tyler B. Johnson, Jon J. Brudvig, Kimmo K. Lehtimäki, Jacob T. Cain, Katherine A. White, Timo Bragge, Jussi Rytkönen, Tuulia Huhtala, Derek Timm, Maria Vihma, Jukka T. Puoliväli, Pekka Poutiainen, Antti Nurmi, Jill M. Weimer (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 18, 2020 Category: Neuroscience Source Type: research

Changes in human brain dynamics during behavioral priming and repetition suppression
Publication date: Available online 18 March 2020Source: Progress in NeurobiologyAuthor(s): Anna Korzeniewska, Yujing Wang, Heather L. Benz, Matthew S. Fifer, Max Collard, Griffin Milsap, Mackenzie C. Cervenka, Alex Martin, Stephen J. Gotts, Nathan E. Crone (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 18, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: April 2020Source: Progress in Neurobiology, Volume 187Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 15, 2020 Category: Neuroscience Source Type: research

Primary afferent-driven presynaptic inhibition of C-fiber inputs to spinal lamina I neurons
Publication date: Available online 12 March 2020Source: Progress in NeurobiologyAuthor(s): E.C. Fernandes, C. Pechincha, L.L. Luz, E. Kokai, P. Szucs, B.V. Safronov (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 13, 2020 Category: Neuroscience Source Type: research

Network neuroscience of apathy in cerebrovascular disease
Publication date: Available online 6 March 2020Source: Progress in NeurobiologyAuthor(s): Jonathan Tay, Danuta M. Lisiecka-Ford, Matthew J. Hollocks, Anil M. Tuladhar, Thomas R. Barrick, Anne Forster, Michael J. O’Sullivan, Masud Husain, Frank-Erik de Leeuw, Robin G. Morris, Hugh S. Markus (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 7, 2020 Category: Neuroscience Source Type: research

A thermodynamic function of glycogen in brain and muscle
Publication date: Available online 6 March 2020Source: Progress in NeurobiologyAuthor(s): Raymond A. Swanson (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 7, 2020 Category: Neuroscience Source Type: research

Platelets promote epileptic seizures by modulating brain serotonin level, enhancing neuronal electric activity, and contributing to neuroinflammation and oxidative stress
Publication date: Available online 3 March 2020Source: Progress in NeurobiologyAuthor(s): Ekaterina Kopeikina, Marina Dukhinova, Amanda W.Y. Yung, Tatyana Veremeyko, Inna S. Kuznetsova, Thomas Y.B. Lau, Kseniia Levchuk, Eugene D. Ponomarev (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - March 4, 2020 Category: Neuroscience Source Type: research

Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy
Publication date: Available online 24 February 2020Source: Progress in NeurobiologyAuthor(s): Seulgi Shin, Dohee Kim, Ji Yeon Song, Hyeanjeong Jeong, Seung Jae Hyeon, Neil W. Kowall, Hoon Ryu, Ae Nim Pae, Sungsu Lim, Yun Kyung Kim (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 25, 2020 Category: Neuroscience Source Type: research

The functional architecture, receptive field characteristics, and representation of objects in the visual network of the pigeon brain
Publication date: Available online 22 February 2020Source: Progress in NeurobiologyAuthor(s): William James Clark, Michael ColomboAbstractWe provide an extensive review of the pigeon visual system, focussing on the known cell types, receptive field characteristics, mechanisms of perception/visual attention, and projection profiles of neurons in the thalamofugal and tectofugal pathways. The similarities and differences with the primate visual system at each stage of the visual hierarchy are highlighted. We conclude with a discussion of object and face processing in birds, as well as the current state of knowledge in the sea...
Source: Progress in Neurobiology - February 23, 2020 Category: Neuroscience Source Type: research

Distinct roles of parvalbumin- and somatostatin-expressing neurons in flexible representation of task variables in the prefrontal cortex
Publication date: Available online 15 February 2020Source: Progress in NeurobiologyAuthor(s): Huijeong Jeong, Dohoung Kim, Min Song, Se-Bum Paik, Min Whan JungABSTRACTA hallmark of the prefrontal cortex (PFC) is flexible representation of task-relevant variables. To investigate roles of different interneuron subtypes in this process, we examined discharge characteristics and inactivation effects of parvalbumin (PV)- and somatostatin (SST)-expressing neurons in the mouse PFC during probabilistic classical conditioning. We found activity patterns and inactivation effects differed between PV and SST neurons: SST neurons conve...
Source: Progress in Neurobiology - February 16, 2020 Category: Neuroscience Source Type: research

Deep phenotyping of peripheral tissue facilitates mechanistic disease stratification in sporadic Parkinson’s disease
Publication date: Available online 11 February 2020Source: Progress in NeurobiologyAuthor(s): Phillippa J Carling, Heather Mortiboys, Claire Green, Simeon Mihaylov, Cynthia Sandor, Aurelie Schwartzentruber, Rosie Taylor, Wenbin Wei, Chris Hastings, Siew Wong, Christine Lo, Samuel Evetts, Hannah Clemmens, Matthew Wyles, Sam Willcox, Thomas Payne, Rachel Hughes, Laura Ferraiuolo, Caleb Webber, Winston HideAbstractMechanistic disease stratification will be crucial to develop a precision medicine approach for future disease modifying therapy in sporadic Parkinson’s disease (sPD). Mitochondrial and lysosomal dysfunction a...
Source: Progress in Neurobiology - February 13, 2020 Category: Neuroscience Source Type: research

Role of spontaneous and sensory orexin network dynamics in rapid locomotion initiation
Publication date: Available online 11 February 2020Source: Progress in NeurobiologyAuthor(s): Mahesh M. Karnani, Cornelia Schöne, Edward F. Bracey, J. Antonio González, Paulius Viskaitis, Han-Tao Li, Antoine Adamantidis, Denis BurdakovSummaryAppropriate motor control is critical for normal life, and requires hypothalamic hypocretin/orexin neurons (HONs). HONs are slowly regulated by nutrients, but also display rapid (subsecond) activity fluctuations in vivo. The necessity of these activity bursts for sensorimotor control and their roles in specific phases of movement are unknown. Here we show that temporally-re...
Source: Progress in Neurobiology - February 12, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: March 2020Source: Progress in Neurobiology, Volume 186Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 12, 2020 Category: Neuroscience Source Type: research

Cysteine String Proteins
Publication date: Available online 7 February 2020Source: Progress in NeurobiologyAuthor(s): Cameron B. GundersenAbstractCysteine string protein (CSP) was discovered by use of a synapse-specific, monoclonal antibody to screen a cDNA expression library in Drosophila. A vertebrate CSP homolog was later identified and shown to co-purify with synaptic vesicles. CSP-α is now recognized as a membrane constituent of many regulated secretory organelles. Knockout of the csp gene in Drosophila produced temperature-sensitive paralysis reflecting a loss of evoked (but not spontaneous) transmitter release. However, CSP’s ro...
Source: Progress in Neurobiology - February 9, 2020 Category: Neuroscience Source Type: research

White matter structure and myelin-related gene expression alterations with experience in adult rats
In conclusion, macroscale measures of WM plasticity are supported by both molecular and cellular evidence and confirm that myelination is one of the underlying mechanisms. (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - January 29, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: February 2020Source: Progress in Neurobiology, Volume 185Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - January 23, 2020 Category: Neuroscience Source Type: research

Corrigendum to “Dystonia and dopamine: From phenomenology to pathophysiology” [Prog. Neurobiol. 182 (November) (2019), 101678, 18]
Publication date: Available online 9 January 2020Source: Progress in NeurobiologyAuthor(s): Bastien Ribot, Jérome Aupy, Marie Vidailhet, Joachim Mazère, Antonio Pisani, Erwan Bezard, Dominique Guehl, Pierre Burbaud (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - January 10, 2020 Category: Neuroscience Source Type: research

Role of Circular RNAs in Brain Development and CNS Diseases
Publication date: Available online 10 January 2020Source: Progress in NeurobiologyAuthor(s): Suresh L. Mehta, Robert J. Dempsey, Raghu VemugantiAbstractIn mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher level in the brain than in other organs. Recent studies have identified a new class of ncRNAs called circular RNAs (circRNAs), which are produced by back-splicing and fusion of either exons, introns, or both exon-intron into covalently closed loops. The circRNAs are also highly enriched in the brain and increase continuously from the embryonic to the adult stage. Although the functional signi...
Source: Progress in Neurobiology - January 10, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: January 2020Source: Progress in Neurobiology, Volume 184Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - December 28, 2019 Category: Neuroscience Source Type: research

Regional iron distribution and soluble ferroprotein profiles in the healthy human brain
This study is the first of its kind in human brain tissue, providing a valuable resource and new insight for iron biologists and neuroscientists, alike.Graphical abstract (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - December 22, 2019 Category: Neuroscience Source Type: research

Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy
Publication date: Available online 20 December 2019Source: Progress in NeurobiologyAuthor(s): Daniela Rossi, Agnès Gruart, Gerardo Contreras-Murillo, Ashraf Muhaisen, Jesús Ávila, José María Delgado-García, Lluís Pujadas, Eduardo SorianoAbstractReelin is an extracellular protein crucial for adult brain plasticity. Moreover, Reelin is protective against amyloid-β (Aβ) pathology in Alzheimer’s Disease (AD), reducing plaque deposition, synaptic loss and cognitive decline. Given that Tau protein plays a key role in AD pathogenesis, and that the Reelin pathway mod...
Source: Progress in Neurobiology - December 22, 2019 Category: Neuroscience Source Type: research

A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
Publication date: Available online 18 December 2019Source: Progress in NeurobiologyAuthor(s): Velmarini Vasquez, Joy Mitra, Haibo Wang, Pavana M. Hegde, K.S. Rao, Muralidhar L. HegdeAbstractα-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) that are found in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) of α-synuclein neurobiology and crosstalk among pathological events that are critical for PD progression remains enigmatic, creating a roadblock for effective intervention strategies. One confo...
Source: Progress in Neurobiology - December 19, 2019 Category: Neuroscience Source Type: research

Deciphering midbrain mechanisms underlying prepulse inhibition of startle
Publication date: Available online 19 December 2019Source: Progress in NeurobiologyAuthor(s): Niveen Fulcher, Erin Azzopardi, Cleusa De Oliveira, Roger Hudson, Ashley L. Schormans, Tariq Zaman, Brian L. Allman, Steven R. Laviolette, Susanne SchmidAbstractPrepulse inhibition (PPI) is an operational measure of sensorimotor gating. Deficits of PPI are a hallmark of schizophrenia and associated with several other psychiatric illnesses such as e.g. autism spectrum disorder, yet the mechanisms underlying PPI are still not fully understood. There is growing evidence contradicting the long-standing hypothesis that PPI is mediated ...
Source: Progress in Neurobiology - December 19, 2019 Category: Neuroscience Source Type: research

Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos
Publication date: Available online 14 December 2019Source: Progress in NeurobiologyAuthor(s): Vijaykumar Yogesh Muley, Carlos Javier López-Victorio, Jorge Tonatiuh Ayala-Sumuano, Adriana González-Gallardo, Leopoldo González-Santos, Carlos Lozano-Flores, Gregory Wray, Maribel Hernández, Alfredo Varela-EchavarríaAbstractThe mammalian and the avian telencephalon are nearly indistinguishable at early embryonic vesicle stages but differ substantially in form and function at their adult stage. We sequenced and analyzed RNA populations present in mouse and chick during the early stages of embryo...
Source: Progress in Neurobiology - December 14, 2019 Category: Neuroscience Source Type: research

Identifying neuronal correlates of dying and resuscitation in a model of reversible brain anoxia
Publication date: Available online 10 December 2019Source: Progress in NeurobiologyAuthor(s): Adrien E. Schramm, Antoine Carton-Leclercq, Shana Diallo, Vincent Navarro, Mario Chavez, Séverine Mahon, Stéphane CharpierAbstractWe developed a new rodent model of reversible brain anoxia and performed continuous electrocorticographic (ECoG) and intracellular recordings of neocortical neurons to identify in real-time the cellular and network dynamics that successively emerge throughout the dying-to-recovery process. Along with a global decrease in ECoG amplitude, deprivation of oxygen supply resulted in an early sur...
Source: Progress in Neurobiology - December 12, 2019 Category: Neuroscience Source Type: research

Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers becau...
Source: Progress in Neurobiology - December 7, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2019Source: Progress in Neurobiology, Volume 183Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - November 27, 2019 Category: Neuroscience Source Type: research

Dissecting beta-state changes during timed movement preparation in Parkinson’s disease
Publication date: Available online 25 November 2019Source: Progress in NeurobiologyAuthor(s): Simone G. Heideman, Andrew J. Quinn, Mark W. Woolrich, Freek van Ede, Anna C. NobreAbstractAn emerging perspective describes beta-band (15-28 Hz) activity as consisting of short-lived high-amplitude events that only appear sustained in conventional measures of trial-average power. This has important implications for characterising abnormalities observed in beta-band activity in disorders like Parkinson’s disease. Measuring parameters associated with beta-event dynamics may yield more sensitive measures, provide more s...
Source: Progress in Neurobiology - November 26, 2019 Category: Neuroscience Source Type: research

Traumatic Brain Injury Triggers APP and Tau Cleavage by Delta-secretase, Mediating Alzheimer’s Disease Pathology
Publication date: Available online 25 November 2019Source: Progress in NeurobiologyAuthor(s): Zhourui Wu, Zhi-Hao Wang, Xia Liu, Zhentao Zhang, Shan Ping Yu, C. Dirk Keene, Liming Cheng, Keqiang YeAbstractTraumatic brain injury (TBI) is associated in some studies with clinical dementia, and neuropathological features, including amyloid plaque deposition and Tau neurofibrillary degeneration commonly identified in Alzheimer’s disease (AD). However, the molecular mechanisms linking TBI to AD remain unclear. Here we show that TBI activates transcription factor CCAAT/Enhancer Binding Protein Beta (C/EBPβ), increasing...
Source: Progress in Neurobiology - November 26, 2019 Category: Neuroscience Source Type: research