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Condition: Hypothermia

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Total 450 results found since Jan 2013.

The Standardized Concept of Moderate-to-Mild ( ≥28°C) Systemic Hypothermia During Selective Antegrade Cerebral Perfusion for All-Comers in Aortic Arch Surgery: Single-Center Experience in 587 Consecutive Patients Over a 15-Year Period
Conclusions Current data suggest that selective ACP in combination with moderate-to-mild systemic hypothermia offers sufficient neurologic and visceral organ protection to all-comers requiring aortic arch surgery without pathological or procedural limitations.
Source: The Annals of Thoracic Surgery - June 17, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Useful Computed Tomography Score for Estimation of Early Neurologic Outcome in Post-Cardiac Arrest Patients With Therapeutic Hypothermia.
CONCLUSIONS: These findings suggest that an initial CT score (ASPECTS-b) could help estimate early neurologic outcomes in post-cardiac arrest patients treated with therapeutic hypothermia. PMID: 28592725 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 6, 2017 Category: Cardiology Authors: Lee KS, Lee SE, Choi JY, Gho YR, Chae MK, Park EJ, Choi MH, Hong JM Tags: Circ J Source Type: research

Hypothermia and Selective Antegrade Cerebral Perfusion Is Safe for Arch Repair in Type A Dissection.
CONCLUSIONS: Unilateral selective antegrade cerebral perfusion with moderate hypothermic circulatory arrest remains a safe strategy for cerebral protection during emergent surgical repair of acute type A dissection and provides equivalent outcomes for both limited and extensive aortic arch reconstruction. Based on these data, unilateral selective antegrade cerebral perfusion and moderate hypothermic circulatory arrest may represent an optimal strategy for cerebral protection in this acute setting. PMID: 28551049 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 24, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Keeling WB, Leshnower BG, Hunting JC, Binongo J, Chen EP Tags: Ann Thorac Surg Source Type: research

Therapeutic dormancy to delay postsurgical glioma recurrence: the past, present and promise of focal hypothermia
AbstractSurgery precedes both radiotherapy and chemotherapy as the first-line therapy for glioma. However, despite multimodal treatment, most glioma patients die from local recurrence in the resection margin. Glioma surgery is inherently lesional, and the response of brain tissue to surgery includes hemostasis, angiogenesis, reactive gliosis and inflammation. Unfortunately, these processes are also associated with tumorigenic side-effects. An increasing amount of evidence indicates that the response to a surgery-related brain injury is hijacked by residual glioma cells and participates in the local regeneration of tumor ti...
Source: Journal of Neuro-Oncology - May 17, 2017 Category: Cancer & Oncology Source Type: research

The clinical study on the treatment for acute cerebral infarction by intra-arterial thrombolysis combined with mild hypothermia.
CONCLUSIONS: Treatment of patients suffering from acute cerebral infarction by means of intra-arterial thrombolysis in combination with mild hypothermia can result in reduced risk of hemorrhagic transformation and improve clinical outcome. PMID: 28485774 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - May 11, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The beneficial hemodynamic effects of afterload reduction by sodium nitroprusside during rewarming from experimental hypothermia.
CONCLUSION: When rewarming the present model of HCD a significant increase in SVR takes place. In this context, pharmacologic intervention aimed at reducing SVR show clear positive results on CO and SV. However, a reduction in SVR alone is not sufficient to fully alleviate CO during HCD, and indicate the need of additional inotropic support. PMID: 28479295 [PubMed - as supplied by publisher]
Source: Cryobiology - May 4, 2017 Category: Biology Authors: Håheim B, Kondratiev T, Dietrichs ES, Tveita T Tags: Cryobiology Source Type: research

Added value of interleukin-1 blockade to hypothermia in neonatal encephalopathy due to inflammatory-sensitized hypoxia-ischemia: a preclinical study. (P3.212)
Conclusions:Our results demonstrate that IL-1Ra (50mg/kg) has an added value to the neuroprotective effect of HT in LPS+HI-induced NE. This project could open new therapeutic avenues to prevent CP.Study Supported by:CIHR, FRQ-S, Heart and Stroke Foundation, "Tranzyme-Pharma" scholarship fom Université de Sherbrooke, and Foundation of Stars.Disclosure: Dr. Chevin has nothing to disclose. Dr. Guiraut has nothing to disclose. Dr. Sebire has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chevin, M., Guiraut, C., Sebire, G. Tags: Child Neurology I Source Type: research

Facial weakness and ophthalmoplegia in a 4-day old infant
We present a neonate with neurologic deficits recognized at 4 days of age. A male infant was born at term via emergency caesarian section due to failure to progress and fetal decelerations. He underwent therapeutic hypothermia for hypoxic ischemic encephalopathy. Upon completion of rewarming, he was noted to have left facial palsy, abduction deficit on the left eye past the midline and nystagmus involving the right eye. Brain MRI showed a pontine stroke and CT angiogram revealed basilar artery thrombosis.
Source: Seminars in Pediatric Neurology - April 1, 2017 Category: Neurology Authors: Ioanna Kouri, Katherine Mathews, Charuta Joshi Source Type: research

Facial Weakness and Ophthalmoplegia in a 4-Day-Old Infant
We present a neonate with neurologic deficits recognized at 4 days of age. A male infant was born at term via emergency cesarian section due to failure to progress and fetal decelerations. He underwent therapeutic hypothermia for hypoxic ischemic encephalopathy. Upon completion of rewarming, he was noted to have left facial palsy, abduction deficit on the left eye past the midline, and nystagmus involving the right eye. Brain magnetic resonance imaging showed a pontine stroke, and computed tomography angiogram revealed basilar artery thrombosis.
Source: Seminars in Pediatric Neurology - April 1, 2017 Category: Neurology Authors: Ioanna Kouri, Katherine Mathews, Charuta Joshi Source Type: research

Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke.
Abstract Stroke is a leading cause of disability in the US. Although there has been significant progress in the area of medical and surgical thrombolytic technologies, neuroprotective agents to prevent secondary cerebral injury and to minimize disability remain limited. Only limited success has been reported in preclinical and clinical trials evaluating a variety of compounds. In this review, the authors discuss the most up-to-date information regarding the underlying molecular biology of stroke as well as strategies that aim to mitigate this complex signaling cascade. Results of historical research trials involvi...
Source: Neurosurgical Focus - April 1, 2017 Category: Neurosurgery Authors: Karsy M, Brock A, Guan J, Taussky P, Kalani MY, Park MS Tags: Neurosurg Focus Source Type: research

Facial Weakness and Ophthalmoplegia in a 4-Day-Old Infant
We present a neonate with neurologic deficits recognized at 4 days of age. A male infant was born at term via emergency cesarian section due to failure to progress and fetal decelerations. He underwent therapeutic hypothermia for hypoxic ischemic encephalopathy. Upon completion of rewarming, he was noted to have left facial palsy, abduction deficit on the left eye past the midline, and nystagmus involving the right eye. Brain magnetic resonance imaging showed a pontine stroke, and computed tomography angiogram revealed basilar artery thrombosis.
Source: Seminars in Pediatric Neurology - April 1, 2017 Category: Neurology Authors: Ioanna Kouri, Katherine Mathews, Charuta Joshi Source Type: research

Longitudinal MRI evaluation of neuroprotective effects of pharmacologically induced hypothermia in experimental ischemic stroke
Pharmacologically induced hypothermia (PIH) shows promising neuroprotective effects after stroke insult. However, the dynamic evolution of stroke infarct during the hypothermic therapy has not been understood very well. In the present study, MRI was utilized to longitudinally characterize the infarct evolution in a mouse model of ischemic stroke treated by PIH using the neurotensin agonist HPI201. Adult male C57BL/6 mice underwent permanent occlusion of the right middle cerebra artery (MCA). Each animal received a vehicle or HPI201 intraperitoneal injection.
Source: Magnetic Resonance Imaging - April 1, 2017 Category: Radiology Authors: Silun Wang, Xiaohuan Gu, Ramesh Paudyal, Ling Wei, Thomas A. Dix, Shan P. Yu, Xiaodong Zhang Tags: Original contribution Source Type: research

Sedation vs Intubation for Patients With Acute Stroke Undergoing Thrombectomy
To the Editor The Sedation vs Intubation for Endovascular Stroke Treatment (SIESTA) trial found no difference in the primary outcome (change in the NIHSS score after 24 hours) in patients receiving general anesthesia vs conscious sedation. However, there were differences in secondary outcomes, with patients receiving general anesthesia having a 10-minute delay in the door-to-needle interval and increased postinterventional complications, including hypothermia, delayed extubation, and pneumonia.
Source: JAMA - March 21, 2017 Category: Journals (General) Source Type: research

Hypothermia decreased the expression of heat shock proteins in neonatal rat model of hypoxic ischemic encephalopathy.
Abstract Hypothermia (HT) is a well-established neuroprotective strategy against neonatal hypoxic ischemic encephalopathy (HIE). The overexpression of heat shock proteins (HSP) has been shown to provide neuroprotection in animal models of stroke. We aimed to investigate the effect of HT on HSP70 and HSP27 expression in a neonatal rat model of HIE. Seven-day-old rat pups were exposed to hypoxia for 90 min to establish the Rice-Vannucci model and were assigned to the following four groups: hypoxic injury (HI)-normothermia (NT, 36 °C), HI-HT (30 °C), sham-NT, and sham-HT. After temperature intervention for 24 h...
Source: Cell Stress and Chaperones - March 10, 2017 Category: Cytology Authors: Lee BS, Jung E, Lee Y, Chung SH Tags: Cell Stress Chaperones Source Type: research

Epilepsy, Stroke, and More Stroke: New Data Epilepsy, Stroke, and More Stroke: New Data
Dr Diener reviews recent findings on epilepsy and hypothermia, along with the risk for bleeding associated with anticoagulant medications.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - March 3, 2017 Category: Neurology Tags: Neurology & Neurosurgery Commentary Source Type: news