Retraction Note: Effects of melatonin on acute brain reperfusion stress: role of hippo signaling pathway and MFN2-related mitochondrial protection
Cell Stress Chaperones. 2021 Apr 19. doi: 10.1007/s12192-021-01206-4. Online ahead of print.NO ABSTRACTPMID:33871791 | DOI:10.1007/s12192-021-01206-4 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 19, 2021 Category: Cytology Authors: Song Lan Jingfang Liu Xiangying Luo Changlong Bi Source Type: research

Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress
Cell Stress Chaperones. 2021 Apr 13. doi: 10.1007/s12192-021-01204-6. Online ahead of print.ABSTRACTThe poultry industry plays a significant role in boosting the economy of several countries, particularly developing countries, and acts as a good, cheap, and affordable source of animal protein. A stress-free environment is the main target in poultry production. There are several stressors, such as cold stress, heat stress, high stocking density, and diseases that can affect birds and cause several deleterious changes. Stress reduces feed intake and growth, as well as impairs immune response and function, resulting in high d...
Source: Cell Stress and Chaperones - April 13, 2021 Category: Cytology Authors: Haitham G Abo-Al-Ela Seham El-Kassas Karima El-Naggar Safaa E Abdo Ali Raza Jahejo Rasha A Al Wakeel Source Type: research

Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress
Cell Stress Chaperones. 2021 Apr 13. doi: 10.1007/s12192-021-01204-6. Online ahead of print.ABSTRACTThe poultry industry plays a significant role in boosting the economy of several countries, particularly developing countries, and acts as a good, cheap, and affordable source of animal protein. A stress-free environment is the main target in poultry production. There are several stressors, such as cold stress, heat stress, high stocking density, and diseases that can affect birds and cause several deleterious changes. Stress reduces feed intake and growth, as well as impairs immune response and function, resulting in high d...
Source: Cell Stress and Chaperones - April 13, 2021 Category: Cytology Authors: Haitham G Abo-Al-Ela Seham El-Kassas Karima El-Naggar Safaa E Abdo Ali Raza Jahejo Rasha A Al Wakeel Source Type: research

Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress
Cell Stress Chaperones. 2021 Apr 13. doi: 10.1007/s12192-021-01204-6. Online ahead of print.ABSTRACTThe poultry industry plays a significant role in boosting the economy of several countries, particularly developing countries, and acts as a good, cheap, and affordable source of animal protein. A stress-free environment is the main target in poultry production. There are several stressors, such as cold stress, heat stress, high stocking density, and diseases that can affect birds and cause several deleterious changes. Stress reduces feed intake and growth, as well as impairs immune response and function, resulting in high d...
Source: Cell Stress and Chaperones - April 13, 2021 Category: Cytology Authors: Haitham G Abo-Al-Ela Seham El-Kassas Karima El-Naggar Safaa E Abdo Ali Raza Jahejo Rasha A Al Wakeel Source Type: research

Stress and immunity in poultry: light management and nanotechnology as effective immune enhancers to fight stress
Cell Stress Chaperones. 2021 Apr 13. doi: 10.1007/s12192-021-01204-6. Online ahead of print.ABSTRACTThe poultry industry plays a significant role in boosting the economy of several countries, particularly developing countries, and acts as a good, cheap, and affordable source of animal protein. A stress-free environment is the main target in poultry production. There are several stressors, such as cold stress, heat stress, high stocking density, and diseases that can affect birds and cause several deleterious changes. Stress reduces feed intake and growth, as well as impairs immune response and function, resulting in high d...
Source: Cell Stress and Chaperones - April 13, 2021 Category: Cytology Authors: Haitham G Abo-Al-Ela Seham El-Kassas Karima El-Naggar Safaa E Abdo Ali Raza Jahejo Rasha A Al Wakeel Source Type: research

Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster
Cell Stress Chaperones. 2021 Apr 7. doi: 10.1007/s12192-021-01203-7. Online ahead of print.ABSTRACTHeat shock proteins, in particular Hsp70, play a central role in proteostasis in eukaryotic cells. Due to its chaperone properties, Hsp70 is involved in various processes after stress and under normal physiological conditions. In contrast to mammals and many Diptera species, inducible members of the Hsp70 family in Drosophila are constitutively synthesized at a low level and undergo dramatic induction after temperature elevation or other forms of stress. In the courtship suppression paradigm used in this study, Drosophila mal...
Source: Cell Stress and Chaperones - April 8, 2021 Category: Cytology Authors: O G Zatsepina E A Nikitina V Y Shilova L N Chuvakova S Sorokina J E Vorontsova E V Tokmacheva S Y Funikov A P Rezvykh M B Evgen'ev Source Type: research

Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster
Cell Stress Chaperones. 2021 Apr 7. doi: 10.1007/s12192-021-01203-7. Online ahead of print.ABSTRACTHeat shock proteins, in particular Hsp70, play a central role in proteostasis in eukaryotic cells. Due to its chaperone properties, Hsp70 is involved in various processes after stress and under normal physiological conditions. In contrast to mammals and many Diptera species, inducible members of the Hsp70 family in Drosophila are constitutively synthesized at a low level and undergo dramatic induction after temperature elevation or other forms of stress. In the courtship suppression paradigm used in this study, Drosophila mal...
Source: Cell Stress and Chaperones - April 8, 2021 Category: Cytology Authors: O G Zatsepina E A Nikitina V Y Shilova L N Chuvakova S Sorokina J E Vorontsova E V Tokmacheva S Y Funikov A P Rezvykh M B Evgen'ev Source Type: research

Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster
Cell Stress Chaperones. 2021 Apr 7. doi: 10.1007/s12192-021-01203-7. Online ahead of print.ABSTRACTHeat shock proteins, in particular Hsp70, play a central role in proteostasis in eukaryotic cells. Due to its chaperone properties, Hsp70 is involved in various processes after stress and under normal physiological conditions. In contrast to mammals and many Diptera species, inducible members of the Hsp70 family in Drosophila are constitutively synthesized at a low level and undergo dramatic induction after temperature elevation or other forms of stress. In the courtship suppression paradigm used in this study, Drosophila mal...
Source: Cell Stress and Chaperones - April 8, 2021 Category: Cytology Authors: O G Zatsepina E A Nikitina V Y Shilova L N Chuvakova S Sorokina J E Vorontsova E V Tokmacheva S Y Funikov A P Rezvykh M B Evgen'ev Source Type: research

Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster
Cell Stress Chaperones. 2021 Apr 7. doi: 10.1007/s12192-021-01203-7. Online ahead of print.ABSTRACTHeat shock proteins, in particular Hsp70, play a central role in proteostasis in eukaryotic cells. Due to its chaperone properties, Hsp70 is involved in various processes after stress and under normal physiological conditions. In contrast to mammals and many Diptera species, inducible members of the Hsp70 family in Drosophila are constitutively synthesized at a low level and undergo dramatic induction after temperature elevation or other forms of stress. In the courtship suppression paradigm used in this study, Drosophila mal...
Source: Cell Stress and Chaperones - April 8, 2021 Category: Cytology Authors: O G Zatsepina E A Nikitina V Y Shilova L N Chuvakova S Sorokina J E Vorontsova E V Tokmacheva S Y Funikov A P Rezvykh M B Evgen'ev Source Type: research

Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster
Cell Stress Chaperones. 2021 Apr 7. doi: 10.1007/s12192-021-01203-7. Online ahead of print.ABSTRACTHeat shock proteins, in particular Hsp70, play a central role in proteostasis in eukaryotic cells. Due to its chaperone properties, Hsp70 is involved in various processes after stress and under normal physiological conditions. In contrast to mammals and many Diptera species, inducible members of the Hsp70 family in Drosophila are constitutively synthesized at a low level and undergo dramatic induction after temperature elevation or other forms of stress. In the courtship suppression paradigm used in this study, Drosophila mal...
Source: Cell Stress and Chaperones - April 8, 2021 Category: Cytology Authors: O G Zatsepina E A Nikitina V Y Shilova L N Chuvakova S Sorokina J E Vorontsova E V Tokmacheva S Y Funikov A P Rezvykh M B Evgen'ev Source Type: research

In Memoriam Claudina Rodrigues-Pousada (1941-2021), a dedicated woman in science
Cell Stress Chaperones. 2021 Apr 2. doi: 10.1007/s12192-021-01202-8. Online ahead of print.NO ABSTRACTPMID:33797714 | DOI:10.1007/s12192-021-01202-8 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 2, 2021 Category: Cytology Authors: Olivier Bensaude Source Type: research

In Memoriam Claudina Rodrigues-Pousada (1941-2021), a dedicated woman in science
Cell Stress Chaperones. 2021 Apr 2. doi: 10.1007/s12192-021-01202-8. Online ahead of print.NO ABSTRACTPMID:33797714 | DOI:10.1007/s12192-021-01202-8 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 2, 2021 Category: Cytology Authors: Olivier Bensaude Source Type: research

In Memoriam Claudina Rodrigues-Pousada (1941-2021), a dedicated woman in science
Cell Stress Chaperones. 2021 Apr 2. doi: 10.1007/s12192-021-01202-8. Online ahead of print.NO ABSTRACTPMID:33797714 | DOI:10.1007/s12192-021-01202-8 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 2, 2021 Category: Cytology Authors: Olivier Bensaude Source Type: research

In Memoriam Claudina Rodrigues-Pousada (1941-2021), a dedicated woman in science
Cell Stress Chaperones. 2021 Apr 2. doi: 10.1007/s12192-021-01202-8. Online ahead of print.NO ABSTRACTPMID:33797714 | DOI:10.1007/s12192-021-01202-8 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 2, 2021 Category: Cytology Authors: Olivier Bensaude Source Type: research

In Memoriam Claudina Rodrigues-Pousada (1941-2021), a dedicated woman in science
Cell Stress Chaperones. 2021 Apr 2. doi: 10.1007/s12192-021-01202-8. Online ahead of print.NO ABSTRACTPMID:33797714 | DOI:10.1007/s12192-021-01202-8 (Source: Cell Stress and Chaperones)
Source: Cell Stress and Chaperones - April 2, 2021 Category: Cytology Authors: Olivier Bensaude Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1 α signaling pathway in 3T3-L1 preadipocytes
This study was conducted to investigate the effect and the underlying mechanism of HS on the proliferation and differentiation process of 3T3-L1 preadipocytes. 3T3-L1 preadipocytes were treated at 37 °C or 41.5 °C. HS up-regulated the mRNA and protein expression level of heat shock protein 70 (HSP70). Furthermore, the proliferation of 3T3-L1 preadipocytes were significantly inhibited after HS treatment for 2 days. A large number of accumulated lipid droplets were observed under the microscope after HS treatment for 8 days. Notably, the result of oil red O staining showed that the number of lipid droplets increased ...
Source: Cell Stress and Chaperones - March 20, 2021 Category: Cytology Authors: Yanna Huang Hongyue Xie Peng Pan Qiuhong Qu Qin Xia Xiaotong Gao Sanbao Zhang Qinyang Jiang Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
The objective of our study was to elucidate the molecular mechanism of the anticancer effect of urolithin A (UA) on colorectal cancer cells. UA was found to inhibit the cell proliferation of CRC cell lines in a dose-dependent and time-dependent manner in HT29, SW480, and SW620 cells. Exposure to UA resulted in cell cycle arrest in a dose-dependent manner along with alteration in the expression of cell cycle-related protein. Treatment of CRC cell lines with UA resulted in the induction of apoptosis. Treatment of HT29, SW480, and SW620 with UA resulted in increased expression of the pro-apoptotic proteins, p53 and p21. Simil...
Source: Cell Stress and Chaperones - March 5, 2021 Category: Cytology Authors: Mohammad S El-Wetidy Rehan Ahmad Islam Rady Hamed Helal Mohamad I Rady Mansoor-Ali Vaali-Mohammed Khayal Al-Khayal Thamer Bin Traiki Maha-Hamadien Abdulla Source Type: research

Isoflurane and low-level carbon monoxide exposures increase expression of pro-survival miRNA in neonatal mouse heart
Cell Stress Chaperones. 2021 Mar 4. doi: 10.1007/s12192-021-01199-0. Online ahead of print.ABSTRACTAnesthetics such as isoflurane are known to cause apoptosis in the developing mammalian brain. However, isoflurane may have protective effects on the heart via relieving ischemia and downregulating genes related to apoptosis. Ischemic preconditioning, e.g. through the use of low levels of carbon monoxide (CO), has promise in preventing ischemia-reperfusion injury and cell death. However, it is still unclear how it either triggers the stress response in neonatal hearts. For this reason, thirty-three microRNAs (miRNAs) known to...
Source: Cell Stress and Chaperones - March 4, 2021 Category: Cytology Authors: Samantha M Logan Aakriti Gupta Aili Wang Richard J Levy Kenneth B Storey Source Type: research

Isoflurane and low-level carbon monoxide exposures increase expression of pro-survival miRNA in neonatal mouse heart
Cell Stress Chaperones. 2021 Mar 4. doi: 10.1007/s12192-021-01199-0. Online ahead of print.ABSTRACTAnesthetics such as isoflurane are known to cause apoptosis in the developing mammalian brain. However, isoflurane may have protective effects on the heart via relieving ischemia and downregulating genes related to apoptosis. Ischemic preconditioning, e.g. through the use of low levels of carbon monoxide (CO), has promise in preventing ischemia-reperfusion injury and cell death. However, it is still unclear how it either triggers the stress response in neonatal hearts. For this reason, thirty-three microRNAs (miRNAs) known to...
Source: Cell Stress and Chaperones - March 4, 2021 Category: Cytology Authors: Samantha M Logan Aakriti Gupta Aili Wang Richard J Levy Kenneth B Storey Source Type: research

NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells
In this study, the analyses of the disease-free survival (DFS) showed that high NIX protein level is related to poor prognosis in patients of PCPG. Consistent with this, high level of NIX protein upregulates the level of p-NF-κB and promotes the migration of PC12 cells. In NIX-over-expressing PC12 cells, the level of reactive oxygen species (ROS) is decreased while trolox-equivalent antioxidant capacity (TEAC) increased. But in NIX-silencing cells, ROS level is increased, while TEAC reversely reduced, consequently antioxidase and phase II enzymes of NRF2 signaling were activated, and elevated endoplasmic reticulum (E...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: Hong Zhang Fanghui Ge Xindong Shui Yuling Xiang Xinxin Wang Chang Liao Jiandong Wang Source Type: research

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients
Cell Stress Chaperones. 2021 Feb 24:1-11. doi: 10.1007/s12192-021-01197-2. Online ahead of print.ABSTRACTHyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that ...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: M Hernandez-Cede ño R Venegas-Rodriguez R Pe ña-Ruiz M Bequet-Romero R Santana-Sanchez E Penton-Arias G Martinez-Donato G Guill én-Nieto Mar ía Del Carmen Dominguez-Horta Source Type: research

NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells
In this study, the analyses of the disease-free survival (DFS) showed that high NIX protein level is related to poor prognosis in patients of PCPG. Consistent with this, high level of NIX protein upregulates the level of p-NF-κB and promotes the migration of PC12 cells. In NIX-over-expressing PC12 cells, the level of reactive oxygen species (ROS) is decreased while trolox-equivalent antioxidant capacity (TEAC) increased. But in NIX-silencing cells, ROS level is increased, while TEAC reversely reduced, consequently antioxidase and phase II enzymes of NRF2 signaling were activated, and elevated endoplasmic reticulum (E...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: Hong Zhang Fanghui Ge Xindong Shui Yuling Xiang Xinxin Wang Chang Liao Jiandong Wang Source Type: research

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients
Cell Stress Chaperones. 2021 Feb 24:1-11. doi: 10.1007/s12192-021-01197-2. Online ahead of print.ABSTRACTHyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that ...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: M Hernandez-Cede ño R Venegas-Rodriguez R Pe ña-Ruiz M Bequet-Romero R Santana-Sanchez E Penton-Arias G Martinez-Donato G Guill én-Nieto Mar ía Del Carmen Dominguez-Horta Source Type: research

NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells
In this study, the analyses of the disease-free survival (DFS) showed that high NIX protein level is related to poor prognosis in patients of PCPG. Consistent with this, high level of NIX protein upregulates the level of p-NF-κB and promotes the migration of PC12 cells. In NIX-over-expressing PC12 cells, the level of reactive oxygen species (ROS) is decreased while trolox-equivalent antioxidant capacity (TEAC) increased. But in NIX-silencing cells, ROS level is increased, while TEAC reversely reduced, consequently antioxidase and phase II enzymes of NRF2 signaling were activated, and elevated endoplasmic reticulum (E...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: Hong Zhang Fanghui Ge Xindong Shui Yuling Xiang Xinxin Wang Chang Liao Jiandong Wang Source Type: research

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients
Cell Stress Chaperones. 2021 Feb 24:1-11. doi: 10.1007/s12192-021-01197-2. Online ahead of print.ABSTRACTHyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that ...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: M Hernandez-Cede ño R Venegas-Rodriguez R Pe ña-Ruiz M Bequet-Romero R Santana-Sanchez E Penton-Arias G Martinez-Donato G Guill én-Nieto Mar ía Del Carmen Dominguez-Horta Source Type: research

NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells
In this study, the analyses of the disease-free survival (DFS) showed that high NIX protein level is related to poor prognosis in patients of PCPG. Consistent with this, high level of NIX protein upregulates the level of p-NF-κB and promotes the migration of PC12 cells. In NIX-over-expressing PC12 cells, the level of reactive oxygen species (ROS) is decreased while trolox-equivalent antioxidant capacity (TEAC) increased. But in NIX-silencing cells, ROS level is increased, while TEAC reversely reduced, consequently antioxidase and phase II enzymes of NRF2 signaling were activated, and elevated endoplasmic reticulum (E...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: Hong Zhang Fanghui Ge Xindong Shui Yuling Xiang Xinxin Wang Chang Liao Jiandong Wang Source Type: research

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients
Cell Stress Chaperones. 2021 Feb 24:1-11. doi: 10.1007/s12192-021-01197-2. Online ahead of print.ABSTRACTHyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that ...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: M Hernandez-Cede ño R Venegas-Rodriguez R Pe ña-Ruiz M Bequet-Romero R Santana-Sanchez E Penton-Arias G Martinez-Donato G Guill én-Nieto Mar ía Del Carmen Dominguez-Horta Source Type: research

NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells
In this study, the analyses of the disease-free survival (DFS) showed that high NIX protein level is related to poor prognosis in patients of PCPG. Consistent with this, high level of NIX protein upregulates the level of p-NF-κB and promotes the migration of PC12 cells. In NIX-over-expressing PC12 cells, the level of reactive oxygen species (ROS) is decreased while trolox-equivalent antioxidant capacity (TEAC) increased. But in NIX-silencing cells, ROS level is increased, while TEAC reversely reduced, consequently antioxidase and phase II enzymes of NRF2 signaling were activated, and elevated endoplasmic reticulum (E...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: Hong Zhang Fanghui Ge Xindong Shui Yuling Xiang Xinxin Wang Chang Liao Jiandong Wang Source Type: research

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients
Cell Stress Chaperones. 2021 Feb 24:1-11. doi: 10.1007/s12192-021-01197-2. Online ahead of print.ABSTRACTHyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that ...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: M Hernandez-Cede ño R Venegas-Rodriguez R Pe ña-Ruiz M Bequet-Romero R Santana-Sanchez E Penton-Arias G Martinez-Donato G Guill én-Nieto Mar ía Del Carmen Dominguez-Horta Source Type: research

NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells
In this study, the analyses of the disease-free survival (DFS) showed that high NIX protein level is related to poor prognosis in patients of PCPG. Consistent with this, high level of NIX protein upregulates the level of p-NF-κB and promotes the migration of PC12 cells. In NIX-over-expressing PC12 cells, the level of reactive oxygen species (ROS) is decreased while trolox-equivalent antioxidant capacity (TEAC) increased. But in NIX-silencing cells, ROS level is increased, while TEAC reversely reduced, consequently antioxidase and phase II enzymes of NRF2 signaling were activated, and elevated endoplasmic reticulum (E...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: Hong Zhang Fanghui Ge Xindong Shui Yuling Xiang Xinxin Wang Chang Liao Jiandong Wang Source Type: research

CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients
Cell Stress Chaperones. 2021 Feb 24. doi: 10.1007/s12192-021-01197-2. Online ahead of print.ABSTRACTHyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that CIGB-...
Source: Cell Stress and Chaperones - February 25, 2021 Category: Cytology Authors: M Hernandez-Cede ño R Venegas-Rodriguez R Pe ña-Ruiz M Bequet-Romero R Santana-Sanchez E Penton-Arias G Martinez-Donato G Guill én-Nieto Mar ía Del Carmen Dominguez-Horta Source Type: research

Protein products of nonstop mRNA disrupt nucleolar homeostasis
Cell Stress Chaperones. 2021 Feb 22. doi: 10.1007/s12192-021-01200-w. Online ahead of print.ABSTRACTStalled mRNA translation results in the production of incompletely synthesized proteins that are targeted for degradation by ribosome-associated quality control (RQC). Here we investigated the fate of defective proteins translated from stall-inducing, nonstop mRNA that escape ubiquitylation by the RQC protein LTN1. We found that nonstop protein products accumulated in nucleoli and this localization was driven by polylysine tracts produced by translation of the poly(A) tails of nonstop mRNA. Nucleolar sequestration increased ...
Source: Cell Stress and Chaperones - February 23, 2021 Category: Cytology Authors: Zoe H Davis Laura Mediani Francesco Antoniani Jonathan Vinet Shuangxi Li Simon Alberti Bingwei Lu Alex S Holehouse Serena Carra Onn Brandman Source Type: research