Jama
(Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Review of Acute Pulmonary Embolism
This Review discusses the incidence, diagnosis, symptomatic characteristics, treatment, and prognosis for patients with pulmonary embolism. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Notes on Healing After a Missed Diagnosis
In this narrative medicine essay, a family physician maintains her patient ’s trust despite missing what could have been a catastrophic diagnosis because she apologized for her oversight. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

The Phlebotomist Shows You Her Tattoo
After she ’s sanitized, pricked (on demand), suctioned your blood, the phlebotomist bares her arm voluntarily, (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam in Complicated UTI or Acute Pyelonephritis
This randomized clinical trial compares the efficacy of cefepime/enmetazobactam vs piperacillin/tazobactam in achieving overall treatment success in patients with complicated urinary tract infections (UTIs) or acute pyelonephritis. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Effect of Opioid-Sparing Protocol vs Standard Prescribing on Opioid Consumption After Knee or Shoulder Arthroscopy
This clinical trial compares the amount of opioids used by patients who underwent arthroscopic knee or shoulder surgery randomized to a pain management protocol involving patient education, nonsteroidal anti-inflammatories, and acetaminophen or to the current pain management care. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Effect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery Disease
This randomized clinical trial compares the effect of telmisartan on 6-minute walk distance compared with placebo in patients with lower extremity peripheral artery disease at 6-month follow-up. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Effect of Awake Prone Positioning on Patients With COVID-19 and Acute Respiratory Failure —Reply
In Reply In response to our recently published trial about the effect of awake prone positioning in patients with COVID-19 and acute respiratory failure, Dr Gershengorn states that to minimize bias we should have either mandated criteria for endotracheal intubation or used another primary outcome. Although we agree, in principle, that standardizing co-interventions and trial outcomes is important in situations when blinding is not possible, there were barriers to implementing this concept in our trial. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Recent Trends in Prescription Drug Launch Prices —Reply
In Reply In our Research Letter, we reported that average manufacturer list prices for newly marketed drugs increased by 20% per year from 2008 to 2021. We believe our results provide important insight into some of the broader trends in the prescription drug market. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Effect of Awake Prone Positioning on Patients With COVID-19 and Acute Respiratory Failure
To the Editor We are writing about the recent COVI-PRONE (Awake Prone Position in Hypoxemic Patients with Coronavirus Disease 19) trial, which investigated the effect of awake prone positioning on endotracheal intubation in patients with COVID-19 and acute respiratory failure. Culture varies across countries and may affect the causal pathway being tested. The findings in this trial, which included aggregated data from 4 countries, may differ if data from Middle Eastern and Western countries are analyzed separately. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Effect of Awake Prone Positioning on Patients With COVID-19 and Acute Respiratory Failure
To the Editor In their recently published randomized clinical trial evaluating the efficacy of awake prone positioning in patients with COVID-19 and acute respiratory failure, the authors chose the primary outcome of endotracheal intubation within 30 days of randomization. I wonder about the implications of this choice because there was no provision of a standardized approach to intubation decisions and this trial was unblinded; the participants, research team, and treating clinicians all knew the group to which patients were assigned. Because blinding is used to avoid introducing bias, it is really important that the prim...
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Recent Trends in Prescription Drug Launch Prices
To the Editor We believe that a recent Research Letter advanced a misleading narrative —namely, that US prescription drug spending is growing at alarming rates—because it does not consider the broader pharmaceutical life cycle that uses competition to create savings while simultaneously incentivizing the development of new medicines to address unmet needs. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Preventable Disease and Map-Changing Medicine
When huge armies were throwing every ounce of their energies against the opposing line, it was constantly realized that the spread of epidemic disease might mean defeat for the affected side. Preventive medicine, in thus being called on to keep every possible man at the front, came into unusual prominence. Foci of contagion existed in various parts of the globe, and the intermingling of peoples, and the crossing and recrossing of seas, invited contagion to spread; but with one exception, the major demons were kept confined to regions in which they commonly prevail in endemic form. With the World War ended, the sanitary org...
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Fertility Preservation After Breast Cancer Diagnosis
More evidence about the safety of fertility preservation procedures in women with breast cancer is reported in a study in JAMA Oncology. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research

Chronic Disease Burden and Financial Problems Are Intertwined
The likelihood of financial problems increases with a greater number of chronic medical conditions, according to the results of a study published in JAMA Internal Medicine. (Source: JAMA)
Source: JAMA - October 4, 2022 Category: General Medicine Source Type: research