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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Hypothermia in Addition to Decompressive Hemicraniectomy in Malignant Middle Cerebral Artery Stroke
This randomized clinical trial assesses whether moderate hypothermia after early hemicraniectomy reduces mortality in patients with malignant MCA stroke, compared with standard treatment.
Source: JAMA Neurology - January 18, 2019 Category: Neurology Source Type: research

Inflammatory cytokines are involved in dihydrocapsaicin (DHC) and regional cooling infusion (RCI)-induced neuroprotection in ischemic rat.
CONCLUSIONS: The combination approach enhanced the efficacy of hypothermia-induced neuroprotection following ischemic stroke. Our findings provide a hint to translate the combination method from bench to bedside. PMID: 30584925 [PubMed - as supplied by publisher]
Source: Brain Research - December 22, 2018 Category: Neurology Authors: Wu D, Zhi X, Duan Y, Zhang M, An H, Wei W, Dong K, Zhang Y, Shi J, He X, Zhang J, Wu C, Meng R, Ding Y, Ji X Tags: Brain Res Source Type: research

Therapeutic Target and Cell-signal Communication of Chlorpromazine and Promethazine in Attenuating Blood-Brain Barrier Disruption after Ischemic Stroke.
This study clearly indicates a beneficial effect of C+P on BBB integrity after stroke, which may be independent of drug-induced hypothermia. These findings further prove the clinical target and cell-signal communication of C+P treatment, which may direct us closer toward the development of an efficacious neuroprotective therapy. PMID: 30569751 [PubMed - as supplied by publisher]
Source: Cell Transplantation - December 20, 2018 Category: Cytology Authors: Li F, Geng X, Yip J, Ding Y Tags: Cell Transplant Source Type: research

Neuroprotective role of hypothermia in hypoxic-ischemic brain injury: combined therapies using estrogen.
Abstract Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge on underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulato...
Source: Current Neuropharmacology - December 5, 2018 Category: Drugs & Pharmacology Authors: Toro-Urrego N, Vesga-Jiménez DJ, Herrera MI, Luaces JP, Capani F Tags: Curr Neuropharmacol Source Type: research

Deep Hypothermia + Retrograde Cerebral Perfusion vs. Moderate Hypothermia + Antegrade Cerebral Perfusion for Arch Surgery
ConclusionsAlthough there was no significant difference in clinically evident neurologic injury, this pilot study suggests that MHCA+ACP may be associated with a higher incidence of radiographic neurologic injury than DHCA+RCP in patients undergoing elective hemiarch replacement.
Source: The Annals of Thoracic Surgery - November 16, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Deep Hypothermia + Retrograde Cerebral Perfusion vs. Moderate Hypothermia + Antegrade Cerebral Perfusion for Arch Surgery.
CONCLUSIONS: Although there was no significant difference in clinically evident neurologic injury, this pilot study suggests that MHCA+ACP may be associated with a higher incidence of radiographic neurologic injury than DHCA+RCP in patients undergoing elective hemiarch replacement. PMID: 30448484 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - November 15, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Leshnower BG, Rangaraju S, Allen JW, Stringer AY, Gleason TG, Chen EP Tags: Ann Thorac Surg Source Type: research

Intracranial atherosclerotic disease.
Abstract Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensiv...
Source: Neurobiology of Disease - November 12, 2018 Category: Neurology Authors: Wang Y, Meng R, Liu G, Cao C, Chen F, Jin K, Ji X, Cao G Tags: Neurobiol Dis Source Type: research

Role of Moderate Hypothermia and Antegrade Cerebral Perfusion during Repair of Type A Aortic Dissection
Int J Angiol DOI: 10.1055/s-0038-1675204The goal of this study was to compare early postoperative outcomes and actuarial survival between patients who underwent repair of acute type A aortic dissection with deep or moderate hypothermia.A total of 132 consecutive patients from a single academic medical center underwent repair of acute type A aortic dissection between January 2000 and June 2014. Of those, 105 patients were repaired under deep hypothermia (< 24 C°), while 27 patients were repaired under moderate hypothermia (≥24 C°). Median ages were 62 years (range: 27–86) and 59 years (range: 35–83) for patients ...
Source: International Journal of Angiology - October 29, 2018 Category: Cardiology Authors: Stamou, Sotiris C. McHugh, Michael A. Conway, Brian D. Nores, Marcos Tags: Original Article Source Type: research

Levetiracetam-mediated improvement of decreased NMDA-induced glutamate release from nerve terminals during hypothermia.
Abstract A combination of a beneficial neuroprotectant, hypothermia, with targeted medication is a perspective therapeutic approach. Here, we analyzed both non-specific (deep and profound hypothermia, 27 °C and 17 °C, respectively) and targeted (anticonvulsant drug levetiracetam) modulation of l-[14C]glutamate release induced by activation of presynaptic NMDA, AMPA, and kainate receptors in rat brain nerve terminals (synaptosomes). Gradual dynamics of hypothermia-mediated decrease in synaptosomal l-[14C]glutamate release evoked by the receptor agonists NMDA-, AMPA-, and kainate (250 μM) has been demonstra...
Source: Brain Research - October 24, 2018 Category: Neurology Authors: Pastukhov A, Borisova T Tags: Brain Res Source Type: research

Hypothermia Used in Medical Applications for Brain and Spinal Cord Injury Patients.
Authors: Zhu L Abstract Despite more than 80 years of animal experiments and clinical practice, efficacy of hypothermia in improving treatment outcomes in patients suffering from cell and tissue damage caused by ischemia is still ongoing. This review will first describe the history of utilizing cooling in medical treatment, followed by chemical and biochemical mechanisms of cooling that can lead to neuroprotection often observed in animal studies and some clinical studies. The next sections will be focused on current cooling approaches/devices, as well as cooling parameters recommended by researchers and clinicians...
Source: Advances in Experimental Medicine and Biology - October 14, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Early Clinical Outcomes of Hybrid Arch Frozen Elephant Trunk Repair with the Thoraflex Hybrid Graft
ConclusionsHybrid aortic arch and FET repair with the Thoraflex hybrid graft appears to be associated with good clinical outcomes, despite being early in the learning curve with this graft. Further investigation with this device is warranted to establish its role within the variations of hybrid arch repair.
Source: The Annals of Thoracic Surgery - October 4, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Early Clinical Outcomes of Hybrid Arch Frozen Elephant Trunk Repair with the Thoraflex Hybrid Graft.
CONCLUSIONS: Hybrid aortic arch and FET repair with the Thoraflex hybrid graft appears to be associated with good clinical outcomes, despite being early in the learning curve with this graft. Further investigation with this device is warranted to establish its role within the variations of hybrid arch repair. PMID: 30291835 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - October 3, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Chu MWA, Losenno KL, Dubois LA, Jones PM, Ouzounian M, Whitlock R, Dagenais F, Boodhwani M, Bhatnagar G, Poostizadeh A, Pozeg Z, Moon M, Kiaii B, Peterson MD, Canadian Thoracic Aortic Collaborative (CTAC) Investigators Tags: Ann Thorac Surg Source Type: research

Innovations, new strategies and surprising twists in Neurology: captured in new journal Neurological Research and Practice
What are the current hot topics in neurology, what do you anticipate will be the challenges and trends in the future within the field? Neurology is such a rapidly moving field that it is impossible to anticipate what the new trends will be. We were frequently proven wrong with our predictions in the past, while completely unexpected developments happened and new avenues were opened. One thing however is for sure: There will be numerous innovations, new strategies, surprising twists and turns, and within the new journal Neurological Research and Practice we try to capture some of them. What are your research interests and w...
Source: BioMed Central Blog - October 1, 2018 Category: General Medicine Authors: Victoria Hentschke Tags: Biology Medicine Open Access Publishing Neurological Research and Practice Source Type: blogs

Targeted temperature management in the ICU: Guidelines from a French expert panel
We present herein recommendations for the use of TTM in adult and paediatric critically ill patients developed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. These guidelines were conducted by a group of experts from the French Intensive Care Society (Société de réanimation de langue française [SRLF]) and the French Society of Anesthesia and Intensive Care Medicine (Société francaise d’anesthésie réanimation [SFAR]) with the participation of the French Emergency Medicine Association (Société française de médecine d’urgence [SFMU]), the French Group for Pediatric...
Source: Anaesthesia, Critical Care and Pain Medicine - September 18, 2018 Category: Anesthesiology Source Type: research

Pre-travel advice for the Hungarian pilgrims of El Camino. Travel risks and instructions.
This study could be a useful guideline for pre-travel advice for El Camino pilgrims as only limited information can be gained from the Pilgrims' Reception Office (PRO) in Santiago de Compostela. Some information was collected from the relevant pages of the internet. Therefore the author could draw limited consequences from the statistical data. Yet, the analysis of the medical causes of the deceased pilgrims told more about the hazards of 'The Way'. Although the number of female and male pilgrims was equal in the statistical data, yet the mortality rate of the male pilgrims is much more higher than that of the female pilgr...
Source: Orvosi Hetilap - September 1, 2018 Category: General Medicine Authors: Felkai P Tags: Orv Hetil Source Type: research