Onkol ógiai beteg tervezett PET/CT vizsgálata során véletlenszerűen felfedezett COVID-19-betegség.
Onkológiai beteg tervezett PET/CT vizsgálata során véletlenszerűen felfedezett COVID-19-betegség. Orv Hetil. 2020 Jun;161(23):971-976 Authors: Czibor S, Kristóf E, Kecskés K, Barra M, Szántó P, Maurovich-Horvat P, Györke T Abstract The scientific literature of coronavirus-disease 2019 (COVID-19) is rapidly expanding. There is a growing evidence on the discrepancy between clinical symptoms and radiologic findings in many patients. This case report gives details about a patient with only mild symptoms but relatively severe radiological...
Source: Orvosi Hetilap - May 27, 2020 Category: General Medicine Authors: Czibor S, Kristóf E, Kecskés K, Barra M, Szántó P, Maurovich-Horvat P, Györke T Tags: Orv Hetil Source Type: research

Primer peritonitis eg észséges serdülő fiúban.
Primer peritonitis egészséges serdülő fiúban. Orv Hetil. 2020 Jun;161(23):977-979 Authors: Farkas L, Lazáry G, Köves I, Csákváry V, Rónaky R, Nagy T Abstract Primary peritonitis is very rare in healthy children without predisposing factors. In the absence of unique factors and signs, the clinical picture does not differ from secondary peritonitis. Therefore, the diagnosis is almost always an intraoperative diagnosis. Case report: We admitted a previously healthy 15-year-old boy with symptoms of acute enteritis. Within 24 hours, he developed a...
Source: Orvosi Hetilap - May 27, 2020 Category: General Medicine Authors: Farkas L, Lazáry G, Köves I, Csákváry V, Rónaky R, Nagy T Tags: Orv Hetil Source Type: research

A nagy érvasculitisek képalkotó vizsgálatának lehetőségei és azok jelentősége.
A nagyérvasculitisek képalkotó vizsgálatának lehetőségei és azok jelentősége. Orv Hetil. 2020 Jun;161(23):939-950 Authors: Kolossváry E, Balázs G, Dósa E, Moravszki M, Járai Z, Farkas K Abstract According to the nomenclature of the Chapel Hill Consensus Conference, giant-cell arteritis and Takayasu's arteritis belong to the group of large-vessel vasculitis. Recognition of these diseases is primarily based on the clinical assessment and the use of various vascular imaging modalities. With regard to the latter one, sig...
Source: Orvosi Hetilap - May 27, 2020 Category: General Medicine Authors: Kolossváry E, Balázs G, Dósa E, Moravszki M, Járai Z, Farkas K Tags: Orv Hetil Source Type: research

Sziszt émás gyógyszerek szemészeti mellékhatásai.
Szisztémás gyógyszerek szemészeti mellékhatásai. Orv Hetil. 2020 Jun;161(23):951-961 Authors: Czakó C, Sándor G, Horváth H, Szepessy Z, Nagy ZZ, Kovács I Abstract Systemic medications of various diseases can have adverse effects on the eye that range from asymptomatic lesions to potentially blinding complications such as toxic retinopathy and optic neuropathy. In the course of ophthalmological screening, with the early detection of toxic effects, the majority of drug-induced eye disorders can be prevented and even be reversed. Our r...
Source: Orvosi Hetilap - May 27, 2020 Category: General Medicine Authors: Czakó C, Sándor G, Horváth H, Szepessy Z, Nagy ZZ, Kovács I Tags: Orv Hetil Source Type: research

Influenz ához kapcsolódó halálozás 2009/2010 és 2016/2017 között Magyarországon.
CONCLUSIONS: Influenza-related mortality tends to be lower in countries with higher vaccination rates. Increase in vaccination rates seems to be necessary in Hungary. Orv Hetil. 2020; 161(23): 962-970. PMID: 32453699 [PubMed - as supplied by publisher] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - May 27, 2020 Category: General Medicine Authors: Kovács K, Pakot L Tags: Orv Hetil Source Type: research

Neurofibromatosisban szenved ő anya hétéves leánya alsó állcsontjának középvonalában kifejlődő, klinikailag gingivalis hyperplasia képében jelentkező neurofibroma.
Neurofibromatosisban szenvedő anya hétéves leánya alsó állcsontjának középvonalában kifejlődő, klinikailag gingivalis hyperplasia képében jelentkező neurofibroma. Orv Hetil. 2020 May;161(22):924-930 Authors: Eper M, Nagy P, Gera I Abstract A seven-year-old girl was referred to the Department of Periodontology of the Semmelweis University with a symmetric bilateral, painless, non-inflammatory diffuse enlargement on the lingual aspects of her lower jaw. The family history revealed that her mother and elder sister had Reckling...
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Eper M, Nagy P, Gera I Tags: Orv Hetil Source Type: research

Az endog én fémionok koncentrációinak változása különböző kórokú, idült májbetegségekben.
In this study, the authors summarize the physiologically present metal ions' change in liver diseases with various aetiologies, the consequences are discussed as well as the connections with the progression. Further, the authors point out the element concentration changes as diagnostic or prognostic values for the liver diseases as well. Orv Hetil. 2020; 161(22): 917-923. PMID: 32453701 [PubMed - as supplied by publisher] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Gáspár Z, Egresi A, Lengyel G, Blázovics A, Tőke J, Hagymási K Tags: Orv Hetil Source Type: research

Procoagulatio, hypercoagulatio és fibrinolysis "shut down" kimutatása ClotPro® viszkoelasztikus tesztek segítségével COVID-19-betegekben.
CONCLUSION: These findings encourage further investigations to elucidate the underlying pathophysiology of thromboembolic events in COVID-19 patients and may support the introduction of full dose anticoagulation with or without antiplatelet therapy. Interventional clinical trials may be helpful in defining the appropriate drug(s), for this purpose, the algorithms of administration, and the optimal duration of therapy. At present, the authorization of a clinical trial that attempts to answer these questions is in progress. Orv Hetil. 2020; 161(22): 899-907. PMID: 32453702 [PubMed - as supplied by publisher] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Zátroch I, Smudla A, Babik B, Tánczos K, Kóbori L, Szabó Z, Fazakas J Tags: Orv Hetil Source Type: research

Jancs ó Béla működése a kolozsvári magyar Orvostörténeti Intézetben (1940-1944).
Jancsó Béla működése a kolozsvári magyar Orvostörténeti Intézetben (1940-1944). Orv Hetil. 2020 May;161(22):931-935 Authors: Perjámosi S PMID: 32453703 [PubMed - as supplied by publisher] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Perjámosi S Tags: Orv Hetil Source Type: research

Daganatos megbeteged ések és a depresszió: rövid irodalmi áttekintés.
Daganatos megbetegedések és a depresszió: rövid irodalmi áttekintés. Orv Hetil. 2020 May;161(22):908-916 Authors: Szelei A, Döme P Abstract Both depressive and malignant disorders are endemic, furthermore, they are also frequently comorbid. In this narrative review, we briefly discuss the epidemiological aspects of the association between depression and cancer, including the following: 1) the prevalence of depression among patients with cancer is higher than that of the general population; 2) the incidence of cancer is higher among subjects with depression;...
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Szelei A, Döme P Tags: Orv Hetil Source Type: research

[Az intestinalis macrophagok és az enteralis idegrendszer szerepe a bél neuroimmunológiai kapcsolataiban. Alapkutatás és klinikai vonatkozások].
[Az intestinalis macrophagok és az enteralis idegrendszer szerepe a bél neuroimmunológiai kapcsolataiban. Alapkutatás és klinikai vonatkozások]. Orv Hetil. 2020 May 01;161(19):771-779 Authors: Dóra D, Kovács T, Nagy N Abstract A properly functioning gastrointestinal tract is essential for nutrient transport, absorption, digestion, and removal of metabolic waste, but protection from pathogens, allergens and toxins also belongs to its tasks, just as the constant homeostatic control and regulation of its internal microenvironment. The largest part o...
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Dóra D, Kovács T, Nagy N Tags: Orv Hetil Source Type: research

[A specifikus IgM- és IgG-antitesteket detektáló gyorstesztek értéke a SARS CoV-2 vírusfertőzés kimutatásában (A COVID-19-pandémia orvosszakmai kérdései)].
Conclusion: The low positive predictive values indicate that Anhui and Clungene rapid tests detecting the presence of anti-IgM and anti-IgG against SARS-CoV-2 virus infection are not suitable for screening SARS-CoV-2 vírus infection in the general population. These results strongly support that Anhui and Clungene rapid tests detecting IgM and IgG antibodies against SARS-CoV-2 virus should not be used in the differential diagnosis of infection. Orv Hetil. 2020; 161(20): 807-812. PMID: 32364358 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Vásárhelyi B, Kristóf K, Ostorházi E, Szabó D, Prohászka Z, Merkely B Tags: Orv Hetil Source Type: research

[Az örökletes Parkinson-kór mint a POLG-gén károsodásának új klinikai megjelenési formája].
In this study, we would like to call attention to the fact that during the differential diagnosis of parkinsonism, the possible involvement of POLG gene should be kept in mind. Especially in the presence of additional symptoms, such as ophthalmoparesis, non-vascular white matter lesions, psychiatric comorbidity, and relatively early age of onset, the POLG gene should be taken into consideration. Based on previous data from the literature and our own experience, we have summarized a possible diagnostic approach for POLG-associated parkinsonism. Orv Hetil. 2020; 161(20): 821-828. PMID: 32364361 [PubMed - in process] (So...
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Illés A, Balicza P, Gál A, Pentelényi K, Csabán D, Gézsi A, Molnár V, Molnár MJ Tags: Orv Hetil Source Type: research

[18F-FDG-PET/CT-vel szerzett tapasztalataink az akt ív nagyérvasculitisek diagnosztikájában és differenciáldiagnózisában. Prospektív vizsgálat].
Conclusion: 18F-FDG-PET/CT is an effective diagnostic tool for large-vessel vasculitis, and can be used to determine the activity and extent of the disease. Steroid treatment influences the 18F-FDG-uptake of vessel wall. Orv Hetil. 2020; 161(20): 829-838. PMID: 32364657 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Bakos A, Besenyi Z, Sipka G, Urbán S, Hemelein R, Kovács L, Pávics L Tags: Orv Hetil Source Type: research

[Or ális antikoagulánssal kezelt pitvarfibrilláló betegek terápiahűsége a mindennapokban].
[Orális antikoagulánssal kezelt pitvarfibrilláló betegek terápiahűsége a mindennapokban]. Orv Hetil. 2020 May 01;161(20):839-845 Authors: Simonyi G, Paksy A, Várnai R, Medvegy M Abstract Introduction: In the treatment of non-valvular atrial fibrillation (AF) with oral anticoagulant (OAC), the patients' adherence to therapy is a very important factor in stroke prevention. Aim: To investigate the one-year persistence of different OAC therapies (vitamin K antagonist [VKA] and new oral anticoagulants [NOAC]) in patients with AF. Method: The authors investi...
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Simonyi G, Paksy A, Várnai R, Medvegy M Tags: Orv Hetil Source Type: research

[Mal de d ébarquement szindróma - "partraszállási betegség"].
We report a case series of 5 patients who presented with constant rocking, bobbing sensation that had been ongoing for several months. We found normal inner-ear function, non-related abnormalities and normal brain imaging. By presenting our patients' histories, we discuss the different diagnostic issues that help to diagnose this condition. We aimed to report the most recent findings on aetiology and treatment methods and to share our experiences with different therapeutic attempts. Mal de débarquement syndrome is a diagnosis of exclusion and often unrecognized. A thorough clinical history, negative or non-specific ...
Source: Orvosi Hetilap - May 1, 2020 Category: General Medicine Authors: Varga Z, Horváth B, Liktor B, Szirmai Á, Tamás TL, Horváth T Tags: Orv Hetil Source Type: research

[G énexpressziós eltérések keringő fehérvérsejtekben a 2-es típusú cukorbetegek elsőfokú, anyagcseréjüket illetően egészséges rokonaiban].
[Génexpressziós eltérések keringő fehérvérsejtekben a 2-es típusú cukorbetegek elsőfokú, anyagcseréjüket illetően egészséges rokonaiban]. Orv Hetil. 2020 May 01;161(18):738-746 Authors: Vitai M, Kovács G, Pauer J, Nagy BL, Bezzegh K, Korányi L Abstract Introduction and aim: We were looking for altered gene expression on peripheral blood cells significant to type 2 diabetes causing the world epidemic. Method: Muscle biopsy samples of healthy volunteers with (n = 6) or without (n = 6) first degree t...
Source: Orvosi Hetilap - April 29, 2020 Category: General Medicine Authors: Vitai M, Kovács G, Pauer J, Nagy BL, Bezzegh K, Korányi L Tags: Orv Hetil Source Type: research

[Nyel őcső-perforatio miatt végzett oesophagusexstirpatio rekonstrukciója hypopharyngogastrostoma képzésével].
[Nyelőcső-perforatio miatt végzett oesophagusexstirpatio rekonstrukciója hypopharyngogastrostoma képzésével]. Orv Hetil. 2020 May 01;161(18):756-760 Authors: Baranyai Z, Répássy G, Molnár V, Forgács G, Hacki T, Jósa V, Balázs Á, Vass T Abstract Despite the significant improvement in surgical and intensive care therapy, esophageal perforation is still a severe, life-threatening condition. As the underlying causes, the accompanying disorders, the localization and the extent of the inflammation vary, the surgeon may som...
Source: Orvosi Hetilap - April 29, 2020 Category: General Medicine Authors: Baranyai Z, Répássy G, Molnár V, Forgács G, Hacki T, Jósa V, Balázs Á, Vass T Tags: Orv Hetil Source Type: research

[Changes in the care of varicose gastrointestinal bleeding in our department].
acute;ll I, Sebők A, Sahin P Abstract Bevezetés: A nyelőcső-varixruptura a portalis hypertensio életet veszélyeztető szövődménye. A 6 hetes mortalitás kb. 20%. Célkitűzés: Annak elemzése, hogy a varixeredetű gastrointestinalis vérzés ellátásában a 2015-ben osztályunkon bevezetett változások hatással voltak-e ezen betegek kórházi halálozására. Módszer: Retrospektív módszerrel hasonlítottuk össze a 2014-ben és 201...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Rácz S, Molnár P, Héra L, Újhelyi P, Páll I, Sebők A, Sahin P Tags: Orv Hetil Source Type: research

[DOHaD (Barker hypothesis): a disease-oriented, epoch-making theory of British origin with Hungarian roots].
Abstract The "developmental origin of health and disease" (DOHaD) theory emerged in 1986, demonstrating the statistical association of early developmental abnormalities (e.g., malnutrition or overeating, infant mortality) with adult non-communicable diseases (e.g., ischemic heart disease) by comparative epidemiological studies. , hypertension) - and has since become widespread. The theory is very similar to the concept of hormonal imprinting, which appeared 6 years earlier and demonstrated the role of perinatal encounter with hormone-like molecules in the occurrence of adult endocrine and endocrine-regul...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Csaba G Tags: Orv Hetil Source Type: research

[Clinical effect of various trimetazidine preparations in chronic coronary syndrome with stable angina. Updated systematic review and meta-analysis].
Abstract Introduction: Trimetazidine is a metabolically active substance that has been shown to be effective in the treatment of stable coronary syndrome. It is recommended that trimetazidine be considered as a second-line treatment to reduce the incidence of angina and improve exercise tolerance in patients whose symptoms are not adequately controlled with beta-blockers, calcium channel blockers and long-term nitrates. Objective: In the present study, we aimed to elucidate the efficacy of different doses (3 × 20 mg, 2 × 35 mg, 1 × 80 mg) of trimetazidine formulations in stable angina pectoris. T...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Nagy VL, Herold Z Tags: Orv Hetil Source Type: research

[Testicular adrenal rest tumor in the background of congenital adrenal hyperplasia].
, Szalma E, Palkó A, Fejes Z Abstract The prevalence of testicular adrenal rest tumors differs in different manifestations of congenital adrenal hyperplasia. Tactile, usually bilateral, testicular abnormalities occur in 90-95% of cases as a result of adrenal cortical hyperplasia caused by the lack of the enzyme 21-hydroxylase. Adrenal rest tumors, although well known lesions, require a multidisciplinary approach to their diagnosis and treatment. Cooperation between the endocrinological, urological, pathological and radiological professions is of paramount importance. If detected at an early stage, adequate ...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Brzózka Á, Kuthi L, Hajdú E, Magony S, Király IE, Kincses ZT, Szatmári A, Szalma E, Palkó A, Fejes Z Tags: Orv Hetil Source Type: research

[The Dark Side of the Sun: A Multimodal Presentation of the Case of Solar Retinopathy].
der M Abstract Solar retinopathy is photochemical and thermal damage to photoreceptors and the pigment epithelium of the retina caused by ultraviolet (UV) light. The most common complaints due to exposure are visceral impairment, blurred vision, and positive scotomas. Optical coherence tomography (OCT), microperimetry, and fluorescein angiography (FLAG) help in making the diagnosis. The authors present the case of an 18-year-old man who presented at the Department of Ophthalmology at Semmelweis University after prolonged exposure to sunlight due to a central scotoma affecting both eyes. On OCT images, discontinuit...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Molnár A, Gombocz E, Nagy ZZ, Schneider M Tags: Orv Hetil Source Type: research

[He was not only interested in obstetrics - the Transylvanian pioneer of Hungarian archeology: Andr ás Fodor Lugosi (1780? -1859)].
[He was not only interested in obstetrics - the Transylvanian pioneer of Hungarian archeology: András Fodor Lugosi (1780? -1859)]. Orv Hetil. 2020 Apr 01;161(16):637-640 Authors: Kiss L PMID: 32324355 [PubMed - as supplied by publisher] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Kiss L Tags: Orv Hetil Source Type: research

[The coronavirus COVID-19 pandemic. Past experience and scientific evidence at the end of March 2020].
lus A Abstract The COVID-19 epidemic has unexpectedly affected everyone, both professionals and lay people, although the possibility of a global pandemic has long been theoretically considered by epidemiologists, infectologists on the one hand, and sociologists, communication and even social behavioral behaviorists in theory. Yet, faced with "real-time" events, daily infection and mortality statistics, almost everyone feels ignorant or confusingly inexperienced. This summary is intended to provide an overview of scientific evidence. Compiled at the end of March 2020, the not-so-complete material, of cour...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Váradi A, Ferenci T, Falus A Tags: Orv Hetil Source Type: research

[Challenges of anesthesiology and intensive care for COVID-19 infection. Practical recommendation].
eszty Z, Gál J Abstract The treatment of COVID-19 infection poses an increasing challenge to the Hungarian healthcare system and, in particular, to the anesthesiology and intensive care professions responsible for the care of critically ill patients. An essential condition for effective care is to protect intensive care unit staff from the spread of infection during day-to-day patient care and to make knowledge about them widely known. Based on practical considerations, the authors summarize the most important organizational, treatment, and prevention tasks related to intensive care for COVID-19 patients. O...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Fülesdi B, Sárkány P, Szentkereszty Z, Gál J Tags: Orv Hetil Source Type: research

[New information for the clinical detection of COVID-19 virus infection and options for protection of healthcare workers in the head and neck region].
, Piffkó J Abstract The coronavirus disease (COVID-19), which presumably started in China at the end of 2019 and became a pandemic, affects all segments of the health care system worldwide, including Hungary. As healthcare staff can come into contact with viral infections during many healthcare services, it is essential during the epidemic that Hungarian professionals working in various fields receive up-to-date information about the virus and the aspects of the infection that affect patient care and proposed measures. The present paper is a literature review in which the authors have elaborated on the curr...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Antal M, Szabó RM, Juhász Z, Vereb T, Piffkó J Tags: Orv Hetil Source Type: research

[Diagnostic steps and estimation of disease prognosis in COVID-19-infected patients].
acute; Z, Babik B Abstract In December 2019, a new coronavirus outbreak hit his head in Wuhan, China. The identified pathogen is a new coronavirus named "severe acute respiratory syndrome coronavirus 2," or SARS-CoV-2, and the respiratory syndrome it elicits was named "coronavirus disease 2019," or COVID-19. The World Health Organization (WHO) classified the epidemic as a pandemic in March 2020. We reviewed the currently available international literature on the COVID-19 epidemic. In this paper, we summarize the relevant information for the diagnosis and prognosis of the new coronavirus. Detail...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Korsós A, Kupcsulik S, Lovas A, Hankovszky P, Molnár T, Szabó Z, Babik B Tags: Orv Hetil Source Type: research

[Importance of imaging diagnostics in the care of COVID-19 infected patients].
acute; Z, Babik B Abstract The recent coronavirus epidemic poses a serious challenge to practicing intensive care physicians due to the high incidence of hypoxic respiratory failure. Because pneumonia plays a prominent role in the critical pathomechanism of COVID-19, imaging studies are at the forefront of both the diagnosis and follow-up of the disease and the detection of potential complications. Reviewing the literature data so far, we present the characteristic differences between chest CT, chest X-ray and chest wall ultrasound, and make recommendations for the use of different examination modalities. The init...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Lovas A, Hankovszky P, Korsós A, Kupcsulik S, Molnár T, Szabó Z, Babik B Tags: Orv Hetil Source Type: research

[Practical aspects of care for a critically ill COVID-19 infected patient in need of respiratory support].
ute;n Á, Koszta G, Molnár C, Fülesdi B Abstract In December 2019, an outbreak of a new type of pneumonia was reported from the Chinese city of Wuhan, caused by a new coronavirus. The disease, which initially spread from animal to human, later spread from person to person, causing a pandemic. Viral disease (COVID-19) can present in a variety of forms, from asymptomatic to mildly symptomatic with severe, respiratory failure, requiring intensive care. The care of the latter group of patients places a significant burden on health care. The purpose of this summary is to present the practical aspects ...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Végh T, László I, Juhász M, Berhés M, Fábián Á, Koszta G, Molnár C, Fülesdi B Tags: Orv Hetil Source Type: research

[The risk of acquired long QT syndrome during a coronavirus epidemic. Focus on hydroxychloroquine].
acute;nyi K Abstract Hydroxychloroquine is an immunomodulatory agent used primarily in malaria, lupus erythematosus, and rheumatoid arthritis. The authors summarize the potential proarrhythmic effect of this formulation and the key signs of drug-induced long QT syndrome. The topicality of the present summary is given by the more frequent use of hydroxychloroquine (currently without evidence) in the COVID-19 epidemic. Orv Hetil. 2020; 161 (17): 689-691. PMID: 32324363 [PubMed - as supplied by publisher] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Tomcsányi J, Tomcsányi K Tags: Orv Hetil Source Type: research

[Practical Aspects of Anesthesia and Perioperative Care in COVID-19 Infected Patients].
ute;n Á, Koszta G, Molnár C, Fülesdi B Abstract he care of those affected by the coronavirus pandemic that erupted in December 2019 places a significant burden on health. Not only because some patients require intensive therapeutic care, but because patients with any severity of the disease may also need surgical treatment. And solving this poses a significant challenge to anesthesiologists. This summary is intended to present the practical aspects of anesthesiological and perioperative care for patients requiring surgical treatment. Orv Hetil. 2020; 161 (17): 692-695. PMID: 32324364 [PubMe...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Végh T, László I, Juhász M, Berhés M, Fábián Á, Koszta G, Molnár C, Fülesdi B Tags: Orv Hetil Source Type: research

[Respiratory insurance in coronavirus-infected patients].
Aacute;, Berhés M, Juhász M, Fülesdi B Abstract The coronavirus epidemic that is spreading around our world poses a number of challenges for healthcare workers. The virus is spread by droplet infection and has a high virulence, so any intervention that generates airway aerosol formation potentially endangers the health of those involved in care. Severe forms of coronavirus infection are associated with progressive respiratory failure, for the treatment of which early endotracheal intubation and invasive mechanical ventilation are essential. There is an increased risk of airway aerosol formation ...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: László I, Molnár C, Koszta G, Végh T, Fábián Á, Berhés M, Juhász M, Fülesdi B Tags: Orv Hetil Source Type: research

[Advanced organ support and life-sustaining therapies in critically ill COVID-19 infected patients].
ute;gh T, Molnár C, Fülesdi B, Koszta G Abstract In critically ill patients with COVID-19 infection, the cardiorespiratory system may collapse by the following mechanisms: (1) cytokine storm, haemophagocytosis - septic shock, (2) uncontrollable hypoxaemia, (3) specific organ failure or multiple organ failure. In this summary, we review the currently available therapeutic options for the treatment and prevention of the above conditions. Removal of cytokines by CytoSorb haemoperfusion has been used more and more frequently and with encouraging success in recent years to treat septic shock. In the case of...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Berhés M, Fábián Á, László I, Végh T, Molnár C, Fülesdi B, Koszta G Tags: Orv Hetil Source Type: research

[Special aspects of in-hospital resuscitation of COVID-19 patients].
Aacute;, Berhés M, Juhász M, Fülesdi B Abstract The coronavirus pandemic faces a number of challenges for healthcare professionals. The virus is spread by droplet infection and has a high virulence, so any intervention that involves the formation of respiratory aerosols potentially endangers the health of those involved in care. Mortality from coronavirus infection can be as high as 10%, so resuscitation is common in COVID-19 patients. During resuscitation, the likelihood of airway aerosol formation is increased, so there is a high risk of infection for care staff. The aim of our article is to p...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: László I, Molnár C, Koszta G, Végh T, Fábián Á, Berhés M, Juhász M, Fülesdi B Tags: Orv Hetil Source Type: research

[What to do about the deceased in suspected, probable and confirmed COVID-19 cases].
nár C, Jäckel M Abstract The SARS-CoV-2 beta-coronavirus outbreak, which first appeared in Wuhan, China, in late 2019, was declared a pandemic by the World Health Organization on March 11, 2020. The first confirmed case of COVID-19 was reported in Hungary on 4 March 2020, and the first patient infected with a new type of coronavirus died on 15 March. At the time of the deceased's death, there was no central, uniform directive clarifying the range of precautions required or providing a clear description of the safe handling of the corpse. Transporting the dead to a pathology department, storing them, po...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Farkas CB, Petrétei D, Babinszky G, Dudás G, Szabó G, Bognár C, Jäckel M Tags: Orv Hetil Source Type: research

[Potential role of estrogens in colorectal tumour development].
, Molnár B Abstract Colorectal cancer (CRC) is one of the most common types of cancers worldwide. The incidence of sporadic CRC is lower in individuals below 50 years and increases with age, furthermore, it shows typical clinical, macroscopic and molecular differences between females and males. According to the results of epidemiological and molecular biology studies, the estradiol-regulating signaling pathway plays an important role in the development and prognosis of CRC, predominantly through estrogen receptor beta (ERβ), which is dominant in the colonic epithelium. Estradiol has multiple gastrointe...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Leiszter K, Galamb O, Kalmár A, Zsigrai S, Valcz G, Szigeti KA, Barták BK, Nagy ZB, Dank M, Liposits Z, Igaz P, Tulassay Z, Molnár B Tags: Orv Hetil Source Type: research

[When P ál Heim pediatrician worked for the Buda Hospital of the Hospitaller Order of Saint John of God].
[When Pál Heim pediatrician worked for the Buda Hospital of the Hospitaller Order of Saint John of God]. Orv Hetil. 2020 Apr;161(14):556-558 Authors: Gömör B PMID: 32223416 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Gömör B Tags: Orv Hetil Source Type: research

[Miscellaneous].
Authors: PMID: 32223417 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Tags: Orv Hetil Source Type: research

[Final farewell to Professor G ábor Veres (1969-2020)].
[Final farewell to Professor Gábor Veres (1969-2020)]. Orv Hetil. 2020 Apr;161(14):554-555 Authors: Józsa T PMID: 32223418 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Józsa T Tags: Orv Hetil Source Type: research

[Multi-targeting drugs: past, present and future].
yus P Abstract The one disease - one target - one drug paradigm was an almost dominant principle in drug discovery from the 1960s to the 2000s. The stagnation and even decline in the productivity of drug innovation around the turn of the millennium and beyond, the realization of limitations of the one-target approach, especially in the treatment of multifactorial diseases, have drawn attention considerably to the one disease - multiple target - one drug multi-targeting drug concept. In this review, we outline old and new molecular design strategies and their practical implementation with own and other examples tha...
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Mátyus P Tags: Orv Hetil Source Type: research

[Subtotal petrosectomy - indications, surgical technique, experiences in P écs].
Conclusion: STP is an extremely favorable surgical solution for a number of middle-ear pathologies that have previously caused major problems. The main reason for its growing popularity is that it can be combined with a number of modern, effective methods of hearing rehabilitation. Orv Hetil. 2020; 161(14): 544-553. PMID: 32223420 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - April 1, 2020 Category: General Medicine Authors: Gerlinger I, Molnár K, Nepp N, Tóth I, Tóth T, Szanyi I, Bakó P, Pap I Tags: Orv Hetil Source Type: research

[Potential risk factors and consequences of chronic pain among Hungarian adolescents].
Conclusion: The prevalence of chronic pain, medication use and visits to physicians is considerable among Hungarian adolescents. It is an important healthcare challenge with long-term consequences until adulthood. Orv Hetil. 2020; 161(13): 502-509. PMID: 32202148 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Godó K, Major J, Gyimesi-Szikszai A, Ádám S Tags: Orv Hetil Source Type: research

[Serum biomarkers in acute low back pain and sciatica].
gze N, Bereczki D Abstract Inflammation contributes to the pathogenesis of low back pain and sciatica. Growing evidence suggests that elevated levels of some inflammatory biomarkers are associated with these conditions. Much of the research evaluating the association between pro- and anti-inflammatory cytokines, chemokines, other regulatory molecules, and low back pain and sciatica, focused on patients with chronic low back pain, while fewer studies addressed the issue of detectable biomarkers in the acute phase. Previous studies suggest that pro-inflammatory cytokines such as TNF-α, IL-6, and IL-8 and anti-...
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Dénes K, Arányi Z, Csillik A, Simó M, Debreczeni R, Tegze N, Bereczki D Tags: Orv Hetil Source Type: research

[Attachment style, relationship and sexual satisfaction: comparing breast cancer patients and healthy women].
Conclusion: Our results indicate that the attachment pattern of women diagnosed with cancer can play a role in their relationships and sexual satisfaction, along with their subjective health status. Monitoring and supporting physical, mental and relational characteristics may contribute to the attainment of better quality of life. Orv Hetil. 2020; 161(13): 510-518. PMID: 32202150 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Désfalvi J, Lakatos C, Csuka SI, Sallay V, Filep O, Dank M, Martos T Tags: Orv Hetil Source Type: research

[Relative frequency of urinary tract infections in patients affected by diabetes mellitus type 2 treated with metformin and SGLT2 inhibitor. Network meta-analysis].
Conclusion: There was no statistically significant difference between SGLT2 inhibitors investigated in this study in terms of the relative frequency of urinary tract infections. This research demonstrates the applicability of network meta-analyses when assessing the relative effectiveness and safety of interventions. Orv Hetil. 2020; 161(13): 491-501. PMID: 32202151 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Merész G, Szabó S, Dóczy V, Hölgyesi Á, Szakács Z Tags: Orv Hetil Source Type: research

[Miscellaneous].
Authors: PMID: 32172582 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Tags: Orv Hetil Source Type: research

[Kynurenines and drug research].
eacute;kány I, Vécsei L Abstract Currently kynurenines are considered a hot topic, because of their involvement in numerous physiological and pathological processes. The essential amino acid, tryptophan's main metabolism is through the kynurenine pathway. During the degradation of tryptophan, kynurenic acid is formed with the help of kynurenine aminotransferases. Kynurenic acid is an excitatory receptor ligand and it possesses neuroprotective properties. Abnormal decrease or increase in the kynurenic acid level can cause an imbalance in the neurotransmitter systems and it is associated with several n...
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Tóth F, Fülöp F, Szatmári I, Toldi J, Dékány I, Vécsei L Tags: Orv Hetil Source Type: research

[Health policy experiences of publicly financed laboratory services in Hungary with health insurance data analysis].
Conclusion: The activity of laboratories was stabilized in the latest years. After the necessary correction of professional regulations and code maintenance, the laboratory budget can be increased towards the mainly public laboratory services providers. Orv Hetil. 2020; 161(12): 468-473. PMID: 32172584 [PubMed - in process] (Source: Orvosi Hetilap)
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Boncz I, Sebestyén A, Endrei D, Ágoston I, Csákvári T, Kovács LG, Miseta A Tags: Orv Hetil Source Type: research

[Thyrotropin-secreting pituitary adenoma].
e;r B, Piski Z, Kovács M Abstract Thyrotropin-secreting pituitary tumors are rare causes of hyperthyroidism and account for less than 1% of all pituitary adenomas. The number of reported cases increased over the last few years as a consequence of the routine use of ultrasensitive immunometric assays for measuring thyrotropin levels. In the clinical practice, thyrotropin secreting adenomas must be considered in case of inappropriately normal to elevated thyrotropin in the presence of elevated free serum thyroid hormone levels. The authors present the case history of a middle aged female patient, who suffered...
Source: Orvosi Hetilap - March 1, 2020 Category: General Medicine Authors: Sohár G, Györkös A, Dóczi T, Kajtár B, Piski Z, Kovács M Tags: Orv Hetil Source Type: research