Progression in Moyamoya Disease: Clinical Feature, Neuroimaging Evaluation and Treatment
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716114016. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive stenosis of the arteries of the circle of Willis, with the formation of the collateral vascular network at the base of the brain. Its clinical manifestations are complicated. Numerous studies have attempted to clarify the clinical features of MMD, including its epidemiology, genetic characteristics, and pathophysiology. With the development of neuroimaging techniques, various neuroimaging modalities with different advantages have dee...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Xin Zhang Weiping Xiao Qing Zhang Ding Xia Peng Gao Jiabin Su Heng Yang Xinjie Gao Wei Ni Yu Lei Yuxiang Gu Source Type: research

Neurodevelopment following exposure to antiseizure medications in utero: a review
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716111814. Online ahead of print.ABSTRACTExposure in the womb to antiseizure medications and their potential impact on the developing child's brain has long been researched. Despite this long period of interest, this review highlights above the well-known risks associated with valproate exposure; more data is required for conclusions regarding all other antiseizure medications. Limited experience with phenytoin and phenobarbital in monotherapy clearly defines the risk to later child postnatal functioning difficult. However, the evidence of an impact is stronger...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Rebecca L Bromley Matthew Bluett-Duncan Source Type: research

Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716112351. Online ahead of print.ABSTRACTNicotine induces long-term changes in the neural activity of the mesocorticolimbic reward pathway structures. The mechanisms involved in this process have not been fully characterized. The hypothesis discussed here proposed that epigenetic regulation participates in installing persistent adaptations and long-lasting synaptic plasticity generated by nicotine action on the mesolimbic dopamine neurons of zebrafish. The epigenetic mechanisms induced by nicotine entail histone and DNA chemical modifications, which have been d...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Paula Faillace Ram ón O Bernabeu Source Type: research

Progression in Moyamoya Disease: Clinical Feature, Neuroimaging Evaluation and Treatment
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716114016. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive stenosis of the arteries of the circle of Willis, with the formation of the collateral vascular network at the base of the brain. Its clinical manifestations are complicated. Numerous studies have attempted to clarify the clinical features of MMD, including its epidemiology, genetic characteristics, and pathophysiology. With the development of neuroimaging techniques, various neuroimaging modalities with different advantages have dee...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Xin Zhang Weiping Xiao Qing Zhang Ding Xia Peng Gao Jiabin Su Heng Yang Xinjie Gao Wei Ni Yu Lei Yuxiang Gu Source Type: research

Neurodevelopment following exposure to antiseizure medications in utero: a review
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716111814. Online ahead of print.ABSTRACTExposure in the womb to antiseizure medications and their potential impact on the developing child's brain has long been researched. Despite this long period of interest, this review highlights above the well-known risks associated with valproate exposure; more data is required for conclusions regarding all other antiseizure medications. Limited experience with phenytoin and phenobarbital in monotherapy clearly defines the risk to later child postnatal functioning difficult. However, the evidence of an impact is stronger...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Rebecca L Bromley Matthew Bluett-Duncan Source Type: research

Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716112351. Online ahead of print.ABSTRACTNicotine induces long-term changes in the neural activity of the mesocorticolimbic reward pathway structures. The mechanisms involved in this process have not been fully characterized. The hypothesis discussed here proposed that epigenetic regulation participates in installing persistent adaptations and long-lasting synaptic plasticity generated by nicotine action on the mesolimbic dopamine neurons of zebrafish. The epigenetic mechanisms induced by nicotine entail histone and DNA chemical modifications, which have been d...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Paula Faillace Ram ón O Bernabeu Source Type: research

Progression in Moyamoya Disease: Clinical Feature, Neuroimaging Evaluation and Treatment
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716114016. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive stenosis of the arteries of the circle of Willis, with the formation of the collateral vascular network at the base of the brain. Its clinical manifestations are complicated. Numerous studies have attempted to clarify the clinical features of MMD, including its epidemiology, genetic characteristics, and pathophysiology. With the development of neuroimaging techniques, various neuroimaging modalities with different advantages have dee...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Xin Zhang Weiping Xiao Qing Zhang Ding Xia Peng Gao Jiabin Su Heng Yang Xinjie Gao Wei Ni Yu Lei Yuxiang Gu Source Type: research

Neurodevelopment following exposure to antiseizure medications in utero: a review
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716111814. Online ahead of print.ABSTRACTExposure in the womb to antiseizure medications and their potential impact on the developing child's brain has long been researched. Despite this long period of interest, this review highlights above the well-known risks associated with valproate exposure; more data is required for conclusions regarding all other antiseizure medications. Limited experience with phenytoin and phenobarbital in monotherapy clearly defines the risk to later child postnatal functioning difficult. However, the evidence of an impact is stronger...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Rebecca L Bromley Matthew Bluett-Duncan Source Type: research

Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716112351. Online ahead of print.ABSTRACTNicotine induces long-term changes in the neural activity of the mesocorticolimbic reward pathway structures. The mechanisms involved in this process have not been fully characterized. The hypothesis discussed here proposed that epigenetic regulation participates in installing persistent adaptations and long-lasting synaptic plasticity generated by nicotine action on the mesolimbic dopamine neurons of zebrafish. The epigenetic mechanisms induced by nicotine entail histone and DNA chemical modifications, which have been d...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Paula Faillace Ram ón O Bernabeu Source Type: research

Progression in Moyamoya Disease: Clinical Feature, Neuroimaging Evaluation and Treatment
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716114016. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive stenosis of the arteries of the circle of Willis, with the formation of the collateral vascular network at the base of the brain. Its clinical manifestations are complicated. Numerous studies have attempted to clarify the clinical features of MMD, including its epidemiology, genetic characteristics, and pathophysiology. With the development of neuroimaging techniques, various neuroimaging modalities with different advantages have dee...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Xin Zhang Weiping Xiao Qing Zhang Ding Xia Peng Gao Jiabin Su Heng Yang Xinjie Gao Wei Ni Yu Lei Yuxiang Gu Source Type: research

Neurodevelopment following exposure to antiseizure medications in utero: a review
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716111814. Online ahead of print.ABSTRACTExposure in the womb to antiseizure medications and their potential impact on the developing child's brain has long been researched. Despite this long period of interest, this review highlights above the well-known risks associated with valproate exposure; more data is required for conclusions regarding all other antiseizure medications. Limited experience with phenytoin and phenobarbital in monotherapy clearly defines the risk to later child postnatal functioning difficult. However, the evidence of an impact is stronger...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Rebecca L Bromley Matthew Bluett-Duncan Source Type: research

Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716112351. Online ahead of print.ABSTRACTNicotine induces long-term changes in the neural activity of the mesocorticolimbic reward pathway structures. The mechanisms involved in this process have not been fully characterized. The hypothesis discussed here proposed that epigenetic regulation participates in installing persistent adaptations and long-lasting synaptic plasticity generated by nicotine action on the mesolimbic dopamine neurons of zebrafish. The epigenetic mechanisms induced by nicotine entail histone and DNA chemical modifications, which have been d...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Paula Faillace Ram ón O Bernabeu Source Type: research

Progression in Moyamoya Disease: Clinical Feature, Neuroimaging Evaluation and Treatment
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716114016. Online ahead of print.ABSTRACTMoyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive stenosis of the arteries of the circle of Willis, with the formation of the collateral vascular network at the base of the brain. Its clinical manifestations are complicated. Numerous studies have attempted to clarify the clinical features of MMD, including its epidemiology, genetic characteristics, and pathophysiology. With the development of neuroimaging techniques, various neuroimaging modalities with different advantages have dee...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Xin Zhang Weiping Xiao Qing Zhang Ding Xia Peng Gao Jiabin Su Heng Yang Xinjie Gao Wei Ni Yu Lei Yuxiang Gu Source Type: research

Neurodevelopment following exposure to antiseizure medications in utero: a review
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716111814. Online ahead of print.ABSTRACTExposure in the womb to antiseizure medications and their potential impact on the developing child's brain has long been researched. Despite this long period of interest, this review highlights above the well-known risks associated with valproate exposure; more data is required for conclusions regarding all other antiseizure medications. Limited experience with phenytoin and phenobarbital in monotherapy clearly defines the risk to later child postnatal functioning difficult. However, the evidence of an impact is stronger...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Rebecca L Bromley Matthew Bluett-Duncan Source Type: research

Epigenetic Mechanisms Mediate Nicotine-Induced Reward and Behaviour in Zebrafish
Curr Neuropharmacol. 2021 Jul 15. doi: 10.2174/1570159X19666210716112351. Online ahead of print.ABSTRACTNicotine induces long-term changes in the neural activity of the mesocorticolimbic reward pathway structures. The mechanisms involved in this process have not been fully characterized. The hypothesis discussed here proposed that epigenetic regulation participates in installing persistent adaptations and long-lasting synaptic plasticity generated by nicotine action on the mesolimbic dopamine neurons of zebrafish. The epigenetic mechanisms induced by nicotine entail histone and DNA chemical modifications, which have been d...
Source: Current Neuropharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Maria Paula Faillace Ram ón O Bernabeu Source Type: research

Animal venom peptides cause antinociceptive effects by voltage-gated calcium channels activity blockage
Curr Neuropharmacol. 2021 Jul 13. doi: 10.2174/1570159X19666210713121217. Online ahead of print.ABSTRACTPain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmitting painful stimuli from the periphery until the dorsal horn of the spinal cord. Thus, blocking voltage-gated calcium channels (VGCCs) can effectively control pain refractory to treatments currently used in the clinic, such as cancer and neuropathic pain. VGCCs blockers iso...
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Gabriela Trevisan Sara Marchesan Oliveira Source Type: research

Effects of Di-2-ethylhexyl phthalate on central nervous system functions: A narrative review
CONCLUSION: Overall, it seems that increased levels of oxidative stress and inflammatory mediators possess a pivotal role in DEHP-induced neurobehavioral impairment.PMID:34259148 | DOI:10.2174/1570159X19666210713122517 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Soheila Safarpour Maryam Ghasemi-Kasman Samaneh Safarpour Yasaman Mahdizadeh Darban Source Type: research

Animal venom peptides cause antinociceptive effects by voltage-gated calcium channels activity blockage
Curr Neuropharmacol. 2021 Jul 13. doi: 10.2174/1570159X19666210713121217. Online ahead of print.ABSTRACTPain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmitting painful stimuli from the periphery until the dorsal horn of the spinal cord. Thus, blocking voltage-gated calcium channels (VGCCs) can effectively control pain refractory to treatments currently used in the clinic, such as cancer and neuropathic pain. VGCCs blockers iso...
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Gabriela Trevisan Sara Marchesan Oliveira Source Type: research

Effects of Di-2-ethylhexyl phthalate on central nervous system functions: A narrative review
CONCLUSION: Overall, it seems that increased levels of oxidative stress and inflammatory mediators possess a pivotal role in DEHP-induced neurobehavioral impairment.PMID:34259148 | DOI:10.2174/1570159X19666210713122517 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Soheila Safarpour Maryam Ghasemi-Kasman Samaneh Safarpour Yasaman Mahdizadeh Darban Source Type: research

Animal venom peptides cause antinociceptive effects by voltage-gated calcium channels activity blockage
Curr Neuropharmacol. 2021 Jul 13. doi: 10.2174/1570159X19666210713121217. Online ahead of print.ABSTRACTPain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmitting painful stimuli from the periphery until the dorsal horn of the spinal cord. Thus, blocking voltage-gated calcium channels (VGCCs) can effectively control pain refractory to treatments currently used in the clinic, such as cancer and neuropathic pain. VGCCs blockers iso...
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Gabriela Trevisan Sara Marchesan Oliveira Source Type: research

Effects of Di-2-ethylhexyl phthalate on central nervous system functions: A narrative review
CONCLUSION: Overall, it seems that increased levels of oxidative stress and inflammatory mediators possess a pivotal role in DEHP-induced neurobehavioral impairment.PMID:34259148 | DOI:10.2174/1570159X19666210713122517 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Soheila Safarpour Maryam Ghasemi-Kasman Samaneh Safarpour Yasaman Mahdizadeh Darban Source Type: research

Animal venom peptides cause antinociceptive effects by voltage-gated calcium channels activity blockage
Curr Neuropharmacol. 2021 Jul 13. doi: 10.2174/1570159X19666210713121217. Online ahead of print.ABSTRACTPain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmitting painful stimuli from the periphery until the dorsal horn of the spinal cord. Thus, blocking voltage-gated calcium channels (VGCCs) can effectively control pain refractory to treatments currently used in the clinic, such as cancer and neuropathic pain. VGCCs blockers iso...
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Gabriela Trevisan Sara Marchesan Oliveira Source Type: research

Effects of Di-2-ethylhexyl phthalate on central nervous system functions: A narrative review
CONCLUSION: Overall, it seems that increased levels of oxidative stress and inflammatory mediators possess a pivotal role in DEHP-induced neurobehavioral impairment.PMID:34259148 | DOI:10.2174/1570159X19666210713122517 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 14, 2021 Category: Drugs & Pharmacology Authors: Soheila Safarpour Maryam Ghasemi-Kasman Samaneh Safarpour Yasaman Mahdizadeh Darban Source Type: research

Traumatic internal carotid artery injuries: do we need a screening strategy? Literature review, case report, and forensic evaluation
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712125929. Online ahead of print.ABSTRACTInternal carotid artery dissection (ICAD) represents the cause of ictus cerebral in about 20% of all cases of cerebral infarction among the young adult population. ICAD could involve both the extracranial and intracranial internal carotid artery (ICA). It could be spontaneous (SICAD) or traumatic (TICAD). It has been estimated that carotid injuries could complicate the 0,32% of cases of general blunt trauma and the percentage seems to be higher in severe multiple traumas. TICAD is diagnosed when neurological symptoms hav...
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Aniello Maiese Paola Frati Alice Chiara Manetti Alessandra De Matteis Marco Di Paolo Raffaele La Russa Emanuela Turillazzi Alessandro Frati Vittorio Fineschi Source Type: research

Zebrafish as a tool in the study of sleep and memory-related disorders
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712141041. Online ahead of print.ABSTRACTSleep is an evolutionarily conserved phenomenon, being an essential biological necessity for the learning process and memory consolidation. The brain displays two types of electrical activity during sleep: slow-wave activity or non-rapid eye movement (NREM) sleep and desynchronized brain wave activity or rapid eye movement (REM) sleep. There are many theories about "Why we need to sleep?" among them the synaptic homeostasis. This theory proposes that the role of sleep is the restoration of synaptic homeostasis,...
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Stefani Altenhofen Carla Denise Bonan Source Type: research

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia
CONCLUSION: While benefits were seen in the reviewed studies, significant variability in the WS extracts examined prevents a consensus on the optimum WS preparation or dosage from treating neuropsychiatric conditions. WS generally appears safe for human use; however, it will be important to investigate potential herb-drug interactions involving WS if used alongside pharmaceutical interventions. Further elucidation of active compounds of WS is also needed.PMID:34254920 | DOI:10.2174/1570159X19666210712151556 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Alex B Speers Kadine A Cabey Amala Soumyanath Kirsten M Wright Source Type: research

Exploring CNS effects of American traditional medicines using zebrafish models
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712153329. Online ahead of print.ABSTRACTAlthough American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effect...
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Murilo S de Abreu Fabiano Costa Ana C V V Giacomini Konstantin A Demin Elena V Petersen Denis B Rosemberg Allan V Kalueff Source Type: research

Traumatic internal carotid artery injuries: do we need a screening strategy? Literature review, case report, and forensic evaluation
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712125929. Online ahead of print.ABSTRACTInternal carotid artery dissection (ICAD) represents the cause of ictus cerebral in about 20% of all cases of cerebral infarction among the young adult population. ICAD could involve both the extracranial and intracranial internal carotid artery (ICA). It could be spontaneous (SICAD) or traumatic (TICAD). It has been estimated that carotid injuries could complicate the 0,32% of cases of general blunt trauma and the percentage seems to be higher in severe multiple traumas. TICAD is diagnosed when neurological symptoms hav...
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Aniello Maiese Paola Frati Alice Chiara Manetti Alessandra De Matteis Marco Di Paolo Raffaele La Russa Emanuela Turillazzi Alessandro Frati Vittorio Fineschi Source Type: research

Zebrafish as a tool in the study of sleep and memory-related disorders
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712141041. Online ahead of print.ABSTRACTSleep is an evolutionarily conserved phenomenon, being an essential biological necessity for the learning process and memory consolidation. The brain displays two types of electrical activity during sleep: slow-wave activity or non-rapid eye movement (NREM) sleep and desynchronized brain wave activity or rapid eye movement (REM) sleep. There are many theories about "Why we need to sleep?" among them the synaptic homeostasis. This theory proposes that the role of sleep is the restoration of synaptic homeostasis,...
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Stefani Altenhofen Carla Denise Bonan Source Type: research

Effects of Withania somnifera (Ashwagandha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia
CONCLUSION: While benefits were seen in the reviewed studies, significant variability in the WS extracts examined prevents a consensus on the optimum WS preparation or dosage from treating neuropsychiatric conditions. WS generally appears safe for human use; however, it will be important to investigate potential herb-drug interactions involving WS if used alongside pharmaceutical interventions. Further elucidation of active compounds of WS is also needed.PMID:34254920 | DOI:10.2174/1570159X19666210712151556 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Alex B Speers Kadine A Cabey Amala Soumyanath Kirsten M Wright Source Type: research

Exploring CNS effects of American traditional medicines using zebrafish models
Curr Neuropharmacol. 2021 Jul 12. doi: 10.2174/1570159X19666210712153329. Online ahead of print.ABSTRACTAlthough American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effect...
Source: Current Neuropharmacology - July 13, 2021 Category: Drugs & Pharmacology Authors: Murilo S de Abreu Fabiano Costa Ana C V V Giacomini Konstantin A Demin Elena V Petersen Denis B Rosemberg Allan V Kalueff Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research

The impact of SARS-Cov-2 on the Nervous system and Mental Health
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629151303. Online ahead of print.ABSTRACTThe World Health Organization declared the pandemic situation caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mild-moderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. T...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Mohamed Said Boulkrane Victoria Ilina Roman Melchakov Mikhail Arisov Julia Fedotova Lucia Gozzo Filippo Drago Weihong Lu Alexey Sarapultsev Vadim Tceilikman Denis Baranenko Source Type: research

Role of Gut Microbiota in Multiple Sclerosis and Potential Therapeutic Implications
Curr Neuropharmacol. 2021 Jun 29. doi: 10.2174/1570159X19666210629145351. Online ahead of print.ABSTRACTThe role of gut microbiota in health and diseases has been receiving increased attention recently. Emerging evidence from previous studies on the gut-microbiota-brain axis highlighted the importance of gut microbiota in neurological disorders. Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system (CNS) resulting from T-cell-driven, myelin-directed autoimmunity. The dysbiosis of gut microbiota in MS patients has been reported in published research studies, indicating that ...
Source: Current Neuropharmacology - June 30, 2021 Category: Drugs & Pharmacology Authors: Xu Wang Zhen Liang Shengnan Wang Di Ma Mingqin Zhu Jiachun Feng Source Type: research