Immune System and Methamphetamine: Molecular Basis of a Relationship
Curr Neuropharmacol. 2021 Apr 28. doi: 10.2174/1570159X19666210428121632. Online ahead of print.ABSTRACTUse of methamphetamine (Meth) as a drug of abuse is on the rise worldwide. Besides its effect on the function of the brain, Meth has detrimental effects on how the immune system functions. As documented in the literature, various experimental models (cellular, animal, mice, and non-human primates) have been used that have contributed to the overall knowledge about immune system impairments from Meth exposure. It has to be noted that while Meth is used in very few treatments, it affects a broad range of biological mechani...
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Katarzyna Macur Pawel Ciborowski Source Type: research

Contributions of Zebrafish Studies on the Behavioural Consequences of Early Alcohol Exposure: A Systematic Review
CONCLUSION: This systematic review serves to further promote the use of zebrafish as a model system to study the pathophysiological and behavioural consequences of early alcohol exposure.PMID:33913405 | DOI:10.2174/1570159X19666210428114317 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Fl ávia Gheller Schaidhauer Higor Arruda Caetano Guilherme Pietro da Silva Rosane Souza da Silva Source Type: research

Plant-Derived Natural Compounds for the treatment of Amyotrophic Lateral Sclerosis: An Update
CONCLUSION: These plant-derived compounds may be considered as supplements to conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structure-activity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.PMID:33913406 | DOI:10.2174/1570159X19666210428120514 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Roohi Mohi-Ud-Din Reyaz Hassan Mir Abdul Jalil Shah Saba Sabreen Taha Umair Wani Mubashir Hussain Masoodi Esra K üpeli Akkol Zulfiqar Ali Bhat Haroon Khan Source Type: research

Immune System and Methamphetamine: Molecular Basis of a Relationship
Curr Neuropharmacol. 2021 Apr 28. doi: 10.2174/1570159X19666210428121632. Online ahead of print.ABSTRACTUse of methamphetamine (Meth) as a drug of abuse is on the rise worldwide. Besides its effect on the function of the brain, Meth has detrimental effects on how the immune system functions. As documented in the literature, various experimental models (cellular, animal, mice, and non-human primates) have been used that have contributed to the overall knowledge about immune system impairments from Meth exposure. It has to be noted that while Meth is used in very few treatments, it affects a broad range of biological mechani...
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Katarzyna Macur Pawel Ciborowski Source Type: research

Contributions of Zebrafish Studies on the Behavioural Consequences of Early Alcohol Exposure: A Systematic Review
CONCLUSION: This systematic review serves to further promote the use of zebrafish as a model system to study the pathophysiological and behavioural consequences of early alcohol exposure.PMID:33913405 | DOI:10.2174/1570159X19666210428114317 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Fl ávia Gheller Schaidhauer Higor Arruda Caetano Guilherme Pietro da Silva Rosane Souza da Silva Source Type: research

Plant-Derived Natural Compounds for the treatment of Amyotrophic Lateral Sclerosis: An Update
CONCLUSION: These plant-derived compounds may be considered as supplements to conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structure-activity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.PMID:33913406 | DOI:10.2174/1570159X19666210428120514 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Roohi Mohi-Ud-Din Reyaz Hassan Mir Abdul Jalil Shah Saba Sabreen Taha Umair Wani Mubashir Hussain Masoodi Esra K üpeli Akkol Zulfiqar Ali Bhat Haroon Khan Source Type: research

Immune System and Methamphetamine: Molecular Basis of a Relationship
Curr Neuropharmacol. 2021 Apr 28. doi: 10.2174/1570159X19666210428121632. Online ahead of print.ABSTRACTUse of methamphetamine (Meth) as a drug of abuse is on the rise worldwide. Besides its effect on the function of the brain, Meth has detrimental effects on how the immune system functions. As documented in the literature, various experimental models (cellular, animal, mice, and non-human primates) have been used that have contributed to the overall knowledge about immune system impairments from Meth exposure. It has to be noted that while Meth is used in very few treatments, it affects a broad range of biological mechani...
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Katarzyna Macur Pawel Ciborowski Source Type: research

Contributions of Zebrafish Studies on the Behavioural Consequences of Early Alcohol Exposure: A Systematic Review
CONCLUSION: This systematic review serves to further promote the use of zebrafish as a model system to study the pathophysiological and behavioural consequences of early alcohol exposure.PMID:33913405 | DOI:10.2174/1570159X19666210428114317 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Fl ávia Gheller Schaidhauer Higor Arruda Caetano Guilherme Pietro da Silva Rosane Souza da Silva Source Type: research

Plant-Derived Natural Compounds for the treatment of Amyotrophic Lateral Sclerosis: An Update
CONCLUSION: These plant-derived compounds may be considered as supplements to conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structure-activity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.PMID:33913406 | DOI:10.2174/1570159X19666210428120514 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Roohi Mohi-Ud-Din Reyaz Hassan Mir Abdul Jalil Shah Saba Sabreen Taha Umair Wani Mubashir Hussain Masoodi Esra K üpeli Akkol Zulfiqar Ali Bhat Haroon Khan Source Type: research

Immune System and Methamphetamine: Molecular Basis of a Relationship
Curr Neuropharmacol. 2021 Apr 28. doi: 10.2174/1570159X19666210428121632. Online ahead of print.ABSTRACTUse of methamphetamine (Meth) as a drug of abuse is on the rise worldwide. Besides its effect on the function of the brain, Meth has detrimental effects on how the immune system functions. As documented in the literature, various experimental models (cellular, animal, mice, and non-human primates) have been used that have contributed to the overall knowledge about immune system impairments from Meth exposure. It has to be noted that while Meth is used in very few treatments, it affects a broad range of biological mechani...
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Katarzyna Macur Pawel Ciborowski Source Type: research

Contributions of Zebrafish Studies on the Behavioural Consequences of Early Alcohol Exposure: A Systematic Review
CONCLUSION: This systematic review serves to further promote the use of zebrafish as a model system to study the pathophysiological and behavioural consequences of early alcohol exposure.PMID:33913405 | DOI:10.2174/1570159X19666210428114317 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Fl ávia Gheller Schaidhauer Higor Arruda Caetano Guilherme Pietro da Silva Rosane Souza da Silva Source Type: research

Plant-Derived Natural Compounds for the treatment of Amyotrophic Lateral Sclerosis: An Update
CONCLUSION: These plant-derived compounds may be considered as supplements to conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structure-activity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.PMID:33913406 | DOI:10.2174/1570159X19666210428120514 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Roohi Mohi-Ud-Din Reyaz Hassan Mir Abdul Jalil Shah Saba Sabreen Taha Umair Wani Mubashir Hussain Masoodi Esra K üpeli Akkol Zulfiqar Ali Bhat Haroon Khan Source Type: research

Immune System and Methamphetamine: Molecular Basis of a Relationship
Curr Neuropharmacol. 2021 Apr 28. doi: 10.2174/1570159X19666210428121632. Online ahead of print.ABSTRACTUse of methamphetamine (Meth) as a drug of abuse is on the rise worldwide. Besides its effect on the function of the brain, Meth has detrimental effects on how the immune system functions. As documented in the literature, various experimental models (cellular, animal, mice, and non-human primates) have been used that have contributed to the overall knowledge about immune system impairments from Meth exposure. It has to be noted that while Meth is used in very few treatments, it affects a broad range of biological mechani...
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Katarzyna Macur Pawel Ciborowski Source Type: research

Contributions of Zebrafish Studies on the Behavioural Consequences of Early Alcohol Exposure: A Systematic Review
CONCLUSION: This systematic review serves to further promote the use of zebrafish as a model system to study the pathophysiological and behavioural consequences of early alcohol exposure.PMID:33913405 | DOI:10.2174/1570159X19666210428114317 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Fl ávia Gheller Schaidhauer Higor Arruda Caetano Guilherme Pietro da Silva Rosane Souza da Silva Source Type: research

Plant-Derived Natural Compounds for the treatment of Amyotrophic Lateral Sclerosis: An Update
CONCLUSION: These plant-derived compounds may be considered as supplements to conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structure-activity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.PMID:33913406 | DOI:10.2174/1570159X19666210428120514 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 29, 2021 Category: Drugs & Pharmacology Authors: Roohi Mohi-Ud-Din Reyaz Hassan Mir Abdul Jalil Shah Saba Sabreen Taha Umair Wani Mubashir Hussain Masoodi Esra K üpeli Akkol Zulfiqar Ali Bhat Haroon Khan Source Type: research

Depression: An insight into Heterocyclic and Cyclic Hydrocarbon Compounds inspired from Natural Sources
Curr Neuropharmacol. 2021 Apr 25. doi: 10.2174/1570159X19666210426115234. Online ahead of print.ABSTRACTDepression, a well know mental disorder has global prevalence, nearly affecting 17% of population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main source for new drug candidates in depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic sys...
Source: Current Neuropharmacology - April 27, 2021 Category: Drugs & Pharmacology Authors: Abdul Jalil Shah Reyaz Hassan Mir Roohi Mohi-Ud-Din Faheem Hyder Pottoo Mubashir Hussain Masoodi Zulfiqar Ali Bhat Source Type: research

Depression: An insight into Heterocyclic and Cyclic Hydrocarbon Compounds inspired from Natural Sources
Curr Neuropharmacol. 2021 Apr 25. doi: 10.2174/1570159X19666210426115234. Online ahead of print.ABSTRACTDepression, a well know mental disorder has global prevalence, nearly affecting 17% of population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main source for new drug candidates in depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic sys...
Source: Current Neuropharmacology - April 27, 2021 Category: Drugs & Pharmacology Authors: Abdul Jalil Shah Reyaz Hassan Mir Roohi Mohi-Ud-Din Faheem Hyder Pottoo Mubashir Hussain Masoodi Zulfiqar Ali Bhat Source Type: research

Depression: An insight into Heterocyclic and Cyclic Hydrocarbon Compounds inspired from Natural Sources
Curr Neuropharmacol. 2021 Apr 25. doi: 10.2174/1570159X19666210426115234. Online ahead of print.ABSTRACTDepression, a well know mental disorder has global prevalence, nearly affecting 17% of population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main source for new drug candidates in depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic sys...
Source: Current Neuropharmacology - April 27, 2021 Category: Drugs & Pharmacology Authors: Abdul Jalil Shah Reyaz Hassan Mir Roohi Mohi-Ud-Din Faheem Hyder Pottoo Mubashir Hussain Masoodi Zulfiqar Ali Bhat Source Type: research

Essential oils in experimental models of neuropsychiatric disorders: A review
CONCLUSION: EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.PMID:33882807 | DOI:10.2174/1570159X19666210421091734 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Luciana Cristina B Fernandes Ianara Mendon ça Costa Marco Aurelio M Freire Francisca Overl ânia V Lima Francisca Idalina Neta Eudes Euler de Souza Lucena Rodrigo Dias Alves Jose Rodolfo Lopes P Cavalcanti Francisco Irochima Pinheiro Eduardo Pereira de A Source Type: research

Do naturally occurring antioxidants protect against neurodegeneration of the dopaminergic system? A systematic revision in animal models of Parkinson's disease
In conclusion, the results of this review suggest that exogenous antioxidants can be promising therapeutic candidates for the prevention and treatment of PD.PMID:33882808 | DOI:10.2174/1570159X19666210421092725 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: C Costas L R F Faro Source Type: research

Uncoupling Protein 2 as a pathogenic determinant and therapeutic target in cardiovascular and metabolic diseases
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421094204. Online ahead of print.ABSTRACTUncoupling protein 2 (UCP2) is a mitochondrial protein that acts as an anion carrier. It is involved in the regulation of several processes including mitochondrial membrane potential, generation of reactive oxygen species within the inner mitochondrial membrane and calcium homeostasis. UCP2 expression can be regulated at different levels: genetic (gene variants), transcriptional [by peroxisome proliferator-activated receptors (PPARs) and microRNAs], and post-translational. Experimental evidence indicates that activation ...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Carla Letizia Busceti Francesco Fornai Speranza Rubattu Source Type: research

Cholinergic Modulation of General Anesthesia
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421095504. Online ahead of print.ABSTRACTAcetylcholine in the brain serves arousal and cognitive functions. Cholinergic neurons in the mesopontine brainstem and basal forebrain are important for activation of the cerebral cortex, which is characterized by suppression of irregular slow waves and increase in gamma (30-100 Hz) activity in the electroencephalogram, and appearance of a hippocampal theta rhythm. During general anesthesia, decrease in acetylcholine release and cholinergic functions contribute to the desirable outcomes of general anesthesia such as amn...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: L Stan Leung Tao Luo Source Type: research

Essential oils in experimental models of neuropsychiatric disorders: A review
CONCLUSION: EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.PMID:33882807 | DOI:10.2174/1570159X19666210421091734 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Luciana Cristina B Fernandes Ianara Mendon ça Costa Marco Aurelio M Freire Francisca Overl ânia V Lima Francisca Idalina Neta Eudes Euler de Souza Lucena Rodrigo Dias Alves Jose Rodolfo Lopes P Cavalcanti Francisco Irochima Pinheiro Eduardo Pereira de A Source Type: research

Do naturally occurring antioxidants protect against neurodegeneration of the dopaminergic system? A systematic revision in animal models of Parkinson's disease
In conclusion, the results of this review suggest that exogenous antioxidants can be promising therapeutic candidates for the prevention and treatment of PD.PMID:33882808 | DOI:10.2174/1570159X19666210421092725 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: C Costas L R F Faro Source Type: research

Uncoupling Protein 2 as a pathogenic determinant and therapeutic target in cardiovascular and metabolic diseases
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421094204. Online ahead of print.ABSTRACTUncoupling protein 2 (UCP2) is a mitochondrial protein that acts as an anion carrier. It is involved in the regulation of several processes including mitochondrial membrane potential, generation of reactive oxygen species within the inner mitochondrial membrane and calcium homeostasis. UCP2 expression can be regulated at different levels: genetic (gene variants), transcriptional [by peroxisome proliferator-activated receptors (PPARs) and microRNAs], and post-translational. Experimental evidence indicates that activation ...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Carla Letizia Busceti Francesco Fornai Speranza Rubattu Source Type: research

Cholinergic Modulation of General Anesthesia
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421095504. Online ahead of print.ABSTRACTAcetylcholine in the brain serves arousal and cognitive functions. Cholinergic neurons in the mesopontine brainstem and basal forebrain are important for activation of the cerebral cortex, which is characterized by suppression of irregular slow waves and increase in gamma (30-100 Hz) activity in the electroencephalogram, and appearance of a hippocampal theta rhythm. During general anesthesia, decrease in acetylcholine release and cholinergic functions contribute to the desirable outcomes of general anesthesia such as amn...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: L Stan Leung Tao Luo Source Type: research

Essential oils in experimental models of neuropsychiatric disorders: A review
CONCLUSION: EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.PMID:33882807 | DOI:10.2174/1570159X19666210421091734 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Luciana Cristina B Fernandes Ianara Mendon ça Costa Marco Aurelio M Freire Francisca Overl ânia V Lima Francisca Idalina Neta Eudes Euler de Souza Lucena Rodrigo Dias Alves Jose Rodolfo Lopes P Cavalcanti Francisco Irochima Pinheiro Eduardo Pereira de A Source Type: research

Do naturally occurring antioxidants protect against neurodegeneration of the dopaminergic system? A systematic revision in animal models of Parkinson's disease
In conclusion, the results of this review suggest that exogenous antioxidants can be promising therapeutic candidates for the prevention and treatment of PD.PMID:33882808 | DOI:10.2174/1570159X19666210421092725 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: C Costas L R F Faro Source Type: research

Uncoupling Protein 2 as a pathogenic determinant and therapeutic target in cardiovascular and metabolic diseases
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421094204. Online ahead of print.ABSTRACTUncoupling protein 2 (UCP2) is a mitochondrial protein that acts as an anion carrier. It is involved in the regulation of several processes including mitochondrial membrane potential, generation of reactive oxygen species within the inner mitochondrial membrane and calcium homeostasis. UCP2 expression can be regulated at different levels: genetic (gene variants), transcriptional [by peroxisome proliferator-activated receptors (PPARs) and microRNAs], and post-translational. Experimental evidence indicates that activation ...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Carla Letizia Busceti Francesco Fornai Speranza Rubattu Source Type: research

Cholinergic Modulation of General Anesthesia
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421095504. Online ahead of print.ABSTRACTAcetylcholine in the brain serves arousal and cognitive functions. Cholinergic neurons in the mesopontine brainstem and basal forebrain are important for activation of the cerebral cortex, which is characterized by suppression of irregular slow waves and increase in gamma (30-100 Hz) activity in the electroencephalogram, and appearance of a hippocampal theta rhythm. During general anesthesia, decrease in acetylcholine release and cholinergic functions contribute to the desirable outcomes of general anesthesia such as amn...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: L Stan Leung Tao Luo Source Type: research

Essential oils in experimental models of neuropsychiatric disorders: A review
CONCLUSION: EOs from different species of medicinal plants have shown positive responses in neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia and oxidative toxicity. Thus, EOs emerges with the potential to be used as alternative agents in the treatment of neurological disorders.PMID:33882807 | DOI:10.2174/1570159X19666210421091734 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Luciana Cristina B Fernandes Ianara Mendon ça Costa Marco Aurelio M Freire Francisca Overl ânia V Lima Francisca Idalina Neta Eudes Euler de Souza Lucena Rodrigo Dias Alves Jose Rodolfo Lopes P Cavalcanti Francisco Irochima Pinheiro Eduardo Pereira de A Source Type: research

Do naturally occurring antioxidants protect against neurodegeneration of the dopaminergic system? A systematic revision in animal models of Parkinson's disease
In conclusion, the results of this review suggest that exogenous antioxidants can be promising therapeutic candidates for the prevention and treatment of PD.PMID:33882808 | DOI:10.2174/1570159X19666210421092725 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: C Costas L R F Faro Source Type: research

Uncoupling Protein 2 as a pathogenic determinant and therapeutic target in cardiovascular and metabolic diseases
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421094204. Online ahead of print.ABSTRACTUncoupling protein 2 (UCP2) is a mitochondrial protein that acts as an anion carrier. It is involved in the regulation of several processes including mitochondrial membrane potential, generation of reactive oxygen species within the inner mitochondrial membrane and calcium homeostasis. UCP2 expression can be regulated at different levels: genetic (gene variants), transcriptional [by peroxisome proliferator-activated receptors (PPARs) and microRNAs], and post-translational. Experimental evidence indicates that activation ...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Carla Letizia Busceti Francesco Fornai Speranza Rubattu Source Type: research

Cholinergic Modulation of General Anesthesia
Curr Neuropharmacol. 2021 Apr 20. doi: 10.2174/1570159X19666210421095504. Online ahead of print.ABSTRACTAcetylcholine in the brain serves arousal and cognitive functions. Cholinergic neurons in the mesopontine brainstem and basal forebrain are important for activation of the cerebral cortex, which is characterized by suppression of irregular slow waves and increase in gamma (30-100 Hz) activity in the electroencephalogram, and appearance of a hippocampal theta rhythm. During general anesthesia, decrease in acetylcholine release and cholinergic functions contribute to the desirable outcomes of general anesthesia such as amn...
Source: Current Neuropharmacology - April 22, 2021 Category: Drugs & Pharmacology Authors: L Stan Leung Tao Luo Source Type: research

The Astrogenic Balance in the Aging Brain
Curr Neuropharmacol. 2021 Apr 19. doi: 10.2174/1570159X19666210420095118. Online ahead of print.ABSTRACTAn inverse correlation between the incidence of cancer and neurodegenerative disease has been observed, with the prevalence of cancer peaking around 60 years of age, then slowly tapering off as neurodegenerative diseases increase in the elderly. Although the diseases rarely occur concurrently, the same genes are differentially expressed between the diseases, with four transcription factors found to be in common for their expression. In the brain, mature astrocytes are the origin of astrocytoma, which make up 58.2% of mal...
Source: Current Neuropharmacology - April 21, 2021 Category: Drugs & Pharmacology Authors: Fotis Andromidas Saeid Atashpanjeh Abigail J Myers Brooke E MacKinnon Melanie M Shaffer Andrew O Koob Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research

Synthetic cannabinoids and cathinones cardiotoxicity: evidences actualities and perspectives
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412101929. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which is not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly develop new substances and place them on the market to replace the ones that have been banned; for this reason, during the last decade this class of ...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Davide Radaelli Alessandro Manfredi Martina Zanon Paolo Fattorini Matteo Scopetti Margherita Neri Paolo Frisoni Stefano D'Errico Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research

Synthetic cannabinoids and cathinones cardiotoxicity: evidences actualities and perspectives
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412101929. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which is not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly develop new substances and place them on the market to replace the ones that have been banned; for this reason, during the last decade this class of ...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Davide Radaelli Alessandro Manfredi Martina Zanon Paolo Fattorini Matteo Scopetti Margherita Neri Paolo Frisoni Stefano D'Errico Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research

Synthetic cannabinoids and cathinones cardiotoxicity: evidences actualities and perspectives
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412101929. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which is not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly develop new substances and place them on the market to replace the ones that have been banned; for this reason, during the last decade this class of ...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Davide Radaelli Alessandro Manfredi Martina Zanon Paolo Fattorini Matteo Scopetti Margherita Neri Paolo Frisoni Stefano D'Errico Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research

Synthetic cannabinoids and cathinones cardiotoxicity: evidences actualities and perspectives
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412101929. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which is not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly develop new substances and place them on the market to replace the ones that have been banned; for this reason, during the last decade this class of ...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Davide Radaelli Alessandro Manfredi Martina Zanon Paolo Fattorini Matteo Scopetti Margherita Neri Paolo Frisoni Stefano D'Errico Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research

Synthetic cannabinoids and cathinones cardiotoxicity: evidences actualities and perspectives
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412101929. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which is not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly develop new substances and place them on the market to replace the ones that have been banned; for this reason, during the last decade this class of ...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Davide Radaelli Alessandro Manfredi Martina Zanon Paolo Fattorini Matteo Scopetti Margherita Neri Paolo Frisoni Stefano D'Errico Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research

Synthetic cannabinoids and cathinones cardiotoxicity: evidences actualities and perspectives
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412101929. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which is not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly develop new substances and place them on the market to replace the ones that have been banned; for this reason, during the last decade this class of ...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Davide Radaelli Alessandro Manfredi Martina Zanon Paolo Fattorini Matteo Scopetti Margherita Neri Paolo Frisoni Stefano D'Errico Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research

Synthetic cannabinoids and cathinones cardiotoxicity: evidences actualities and perspectives
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412101929. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) constitute a group of psychotropic substances, designed to mimic the effects of traditional substances like cannabis, cocaine, MDMA, khat, which is not regulated by the 1961 United Nations Convention on Narcotics or the 1971 United Nations Convention on Psychotropic Substances. Illegal laboratories responsible for their production regularly develop new substances and place them on the market to replace the ones that have been banned; for this reason, during the last decade this class of ...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Davide Radaelli Alessandro Manfredi Martina Zanon Paolo Fattorini Matteo Scopetti Margherita Neri Paolo Frisoni Stefano D'Errico Source Type: research

Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid- β-related toxicity, and glutamate-induced excitotoxicity in human neural cells
Curr Neuropharmacol. 2021 Apr 11. doi: 10.2174/1570159X19666210412095251. Online ahead of print.ABSTRACTAlzheimer's disease (AD) and Parkinson disease (PD) are notorious neurodegenerative diseases amongst the general population. Being age-associated diseases, the prevalence of AD and PD is forecasted to rapidly escalate with the progressive aging population of the world. These diseases are complex and multifactorial. Among the different events, amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which plays a vital function in AD. Glutamate, the major excitatory transmitte...
Source: Current Neuropharmacology - April 13, 2021 Category: Drugs & Pharmacology Authors: Devina Lobine Nabeelah Sadeer Sharmeen Jugreet Shanoo Suroowan Bibi Sumera Keenoo Muhammad Imran Katharigatta N Venugopala Faten Mohamed Ibrahim Gokhan Zengin Mohamad Fawzi Mahomoodally Source Type: research