Log in to search using one of your social media accounts:

 

Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer's disease: A systematic review.
CONCLUSION: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration. PMID: 29338678 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - January 16, 2018 Category: Drugs & Pharmacology Authors: da Costa IM, de Moura Freire MA, de Paiva Cavalcanti JRL, Pessoa de Araujo D, Norrara B, Rosa IMMM, Pereira de Azevedo E, Meneses do Rego AC, Filho IA, Guzen FP Tags: Curr Neuropharmacol Source Type: research

"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities".
"Understanding the Role of Hypoxia inducible factor during neurodegeneration for new therapeutics opportunities". Curr Neuropharmacol. 2018 Jan 10;: Authors: Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Alberto L Abstract Neurodegeneration (NDG) is linked with the progressive loss of neural function with intellectual and/or motor impairment. Several diseases affecting older individuals, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Parkinson's disease, stroke, Multiple Sclerosis and many others, are the most relevant disorders associated wit...
Source: Current Neuropharmacology - January 10, 2018 Category: Drugs & Pharmacology Authors: Merelli A, Rodriguez JCG, Folch J, Regueiro MR, Camins A, Alberto L Tags: Curr Neuropharmacol Source Type: research

Preface.
PMID: 29301483 [PubMed - in process] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - January 7, 2018 Category: Drugs & Pharmacology Authors: Salt TE Tags: Curr Neuropharmacol Source Type: research

Editorial: Recent Advances in Pathophysiological Studies and Treatment of Epilepsy.
PMID: 29301484 [PubMed - in process] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - January 7, 2018 Category: Drugs & Pharmacology Authors: Yin G, Yao G, Zhang K, Li B Tags: Curr Neuropharmacol Source Type: research

Putative mechanisms of action and clinical use of lithium in children and adolescents: a critical review.
CONCLUSIONS: Lithium seems an effective and well-tolerated medication on pediatric bipolar disorder and aggression, while further evidences are needed for other clinical indications. PMID: 29256353 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 19, 2017 Category: Drugs & Pharmacology Authors: Pisano S, Pozzi M, Catone G, Scrinzi G, Clementi E, Coppola G, Milone A, Bravaccio C, Santosh P, Masi G Tags: Curr Neuropharmacol Source Type: research

Glaucoma and Alzheimer Disease: A Single Age-Related Neurodegenerative Disease of the Brain.
Abstract Open Angle Glaucoma is one of the leading causes of irreversible blindness worldwide. Elevated intraocular pressure is considered an important risk factor for glaucoma, however a subset of patients experience disease progression even in presence of normal intraocular pressure values. This implies that risk factors other than intraocular pressure are involved in the pathogenesis of glaucoma. A possible relationship between glaucoma and neurodegenerative diseases such as Alzheimer Disease has been suggested. In this regard, we have recently described a high prevalence of alterations typical of glaucoma, usi...
Source: Current Neuropharmacology - December 6, 2017 Category: Drugs & Pharmacology Authors: Raffaele M, Alessio M, Massimo C, Clarissa G, Tiziana CM, Giacinto B, Carlo N Tags: Curr Neuropharmacol Source Type: research

Autophagy after subarachnoid hemorrhage: Can cell death be good?
Abstract Autophagy is a prosurvival, reparative process that maintains cellular homeostasis through lysosomal degradation of selected cytoplasmic components and programmed death of old, dysfunctional, or unnecessary cytoplasmic entities. According to growing evidence, autophagy shows beneficial effects following subarachnoid hemorrhage (SAH). SAH is considered one of the most devastating forms of stroke. Though autophagy is prosurvival and aids in repair, deregulated or excessive autophagy results in increased cell death, more brain injury, and worse outcome. The aim of this review lies in revealing the pathophysi...
Source: Current Neuropharmacology - November 23, 2017 Category: Drugs & Pharmacology Authors: Ho WM, Akyol O, Reis H, Reis C, McBride D, Thome C, Zhang J Tags: Curr Neuropharmacol Source Type: research

Imaging the role of inflammation in mood and anxiety-related disorders.
CONCLUSIONS: Neuroimaging effects of inflammation on reward and threat circuitry may be used as biomarkers of inflammation for future development of novel therapeutic strategies to better treat mood and anxiety-related disorders in patients with high inflammation. PMID: 29173175 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 23, 2017 Category: Drugs & Pharmacology Authors: Felger JC Tags: Curr Neuropharmacol Source Type: research

Noninvasive cerebellar stimulation as a complement tool to pharmacotherapy.
Abstract Cerebellar ataxias represent a wide and heterogeneous group of diseases characterized by balance and coordination disturbance, dysarthria, dyssynergia and adyadococinesia, caused by a dysfunction in the cerebellum. In recent years there has been growing interest in discovering therapeutical strategy for specific forms of cerebellar ataxia. Together with pharmacological studies, there has been growing interest in non-invasive cerebellar stimulation techniques to improve ataxia and limb coordination. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are non-inva...
Source: Current Neuropharmacology - November 14, 2017 Category: Drugs & Pharmacology Authors: Ferrucci R, Bocci T, Cortese F, Ruggiero F, Priori A Tags: Curr Neuropharmacol Source Type: research

" The role of CXCR3 in neurological diseases".
" The role of CXCR3 in neurological diseases". Curr Neuropharmacol. 2017 Nov 09;: Authors: Zhou YQ, Liu DQ, Chen SP, Sun J, Zhou XR, Xing C, Ye DW, Tian YK Abstract Neurological diseases have become an obvious challenge due to insufficient therapeutic intervention. Therefore, novel drugs for various neurological disorders are in desperate need. Recently, compelling evidence has demonstrated that chemokine receptor CXCR3, which is a G protein-coupled receptor in the CXC chemokine receptor family, may play a pivotal role in the development of neurological diseases. The expression level of CXCR...
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Zhou YQ, Liu DQ, Chen SP, Sun J, Zhou XR, Xing C, Ye DW, Tian YK Tags: Curr Neuropharmacol Source Type: research

Gene-environment interactions in late life: linking psychosocial stress with brain aging.
This article reviews evidence showing how gene-stress interactions can impact the aging brain and related phenotypes in late life, and it discusses the potential mechanisms underlying such GxE and their implications for the prevention and treatment of late-life neuropsychiatric syndromes. PMID: 29119927 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Zannas AS Tags: Curr Neuropharmacol Source Type: research

Rational Basis For Nutraceuticals In The Treatment Of Glaucoma.
Abstract Glaucoma, the second leading cause of blindness worldwide, is a chronic optic neuropathy characterized by progressive retinal ganglion cell (RGC) axons degeneration and death. The pathogenesis of primary open-angle glaucoma (OAG), the most common type, is still largely unknown and it is often associated with increased intraocular pressure (IOP) although IOP-independent mechanisms play also a role. Neurodegenerative process, including oxidative stress, excitotoxicity and neuroinflammation, and an impaired ocular blood flow are examples of mechanisms supposed to contribute to the IOP independent deteriorati...
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Antonio ML, Laura R, Annagrazia A, Tiziana CM, Rossella R Tags: Curr Neuropharmacol Source Type: research

Mean diffusivity in the dopaminergic system and neural differences related to dopaminergic system.
Abstract The mean diffusivity (MD) parameter obtained by diffusion tensor imaging provides a measure of how freely water molecules move in brain tissue. Greater tissue density conferred by closely arrayed cellular structures is assumed to lower MD by inhibiting the free diffusion of water molecules. In this paper, we review studies showing MD variation among regions of the brain dopaminergic system (MDDS), especially subcortical structures such as the putamen, caudate nucleus, and globus pallidus, in different conditions with known associations to dopaminergic system function or dysfunction. The methodologies and ...
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Takeuchi H, Kawashima R Tags: Curr Neuropharmacol Source Type: research

Anti-Oxidant Drugs: Novelties and Clinical Implications in Cerebellar Ataxias.
Conclusion Antioxidant therapy in cerebellar ataxias is a promising field of investigations. To achieve the success in identifying the correct treatment more work needs to be done. In particular, needed is a combined effort by basic scientists in developing more efficient molecules, and by clinical researchers together with patients communities, to run clinical trials in order to identify conclusive treatments strategies. PMID: 29119930 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Barca E, Emmanuele V, DiMauro S, Toscano A, Quinzii CM Tags: Curr Neuropharmacol Source Type: research

Extend, pathomechanism and clinical consequences of brain volume changes in anorexia nervosa.
CONCLUSION: Brain volume deficits in AN seem to play a causal role in the course and the prognosis of AN. A better understanding of these brain changes could lead to more targeted therapies for patients with AN, including astrocyte-directed approaches. PMID: 29119931 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Seitz J, Konrad K, Herpertz-Dahlmann B Tags: Curr Neuropharmacol Source Type: research

Relevance of CYP2C9 Function in Valproate Therapy.
Abstract Genetic polymorphisms of drug metabolizing enzymes can substantially modify the pharmacokinetics of a drug and eventually its efficacy or toxicity; however, inferring a patient's drug metabolizing capacity merely from his or her genotype can lead to false prediction. Non-genetic host factors (age, sex, disease states) and environmental factors (nutrition, co-medication) can transiently alter the enzyme expression and activities resulting in genotype-phenotype mismatch. Although valproic acid is a well-tolerated anticonvulsant, pediatric patients are particularly vulnerable to valproate injury that can be ...
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Monostory K, Nagy A, Toth K, Budi T, Kiss A, Deri M, Csukly G Tags: Curr Neuropharmacol Source Type: research

Pharmacological and non-pharmacological therapies of cognitive impairment in multiple sclerosis.
This article is an overview of the current state of knowledge related to cognition impairment treatment in MS. Additionally, novel strategies for cognitive impairments such as cryostimulation and other complementary methods are presented. PMID: 29119933 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - November 9, 2017 Category: Drugs & Pharmacology Authors: Miller E, Morel A, Redlicka J, Miller I, Saluk J Tags: Curr Neuropharmacol Source Type: research

Cognitive Effects of Nicotine: Recent Progress.
Abstract Cigarette smoking is the main cause of preventable death in developed countries. Given the limited effectiveness of currently available treatments, there is a great need to identify new treatment approaches for tobacco use disorder (TUD). While the direct positive behavioral reinforcing effect of nicotine has historically been considered the primary mechanism driving the development of TUD, accumulating contemporary research suggests that the cognitive-enhancing effects of nicotine may also significantly contribute to the initiation and maintenance of TUD, especially in individuals with pre-existing cogni...
Source: Current Neuropharmacology - November 3, 2017 Category: Drugs & Pharmacology Authors: Valentine G, Sofuoglu M Tags: Curr Neuropharmacol Source Type: research

Combining in vitro and in silico approaches to find new drugs targeting the pathological proteins related to the Alzheimer's disease.
Abstract Alzheimer's disease (AD) is a multifactorial and complicate disorder with a progressive and irreversible cognition, memory, and behavior deficiency. This disease is pathologically characterized by the amyloid beta (Aβ) protein neutric plaques and fibrillary tangles composed of hyperphosphorylated tau protein. Thus, misfolding, aggregation and propagation of Aβ and tau in the brain of AD patient is considered as the main pathological cause. Currently, the clinical approved drugs for AD treatment are mainly acetylcholinerase inhibitors and N-methyl-d-aspartate receptor antagonists. Combined method...
Source: Current Neuropharmacology - October 30, 2017 Category: Drugs & Pharmacology Authors: Li H, Wang X, Yu H, Zhu J, Jin H, Wang A, Yang Z Tags: Curr Neuropharmacol Source Type: research

Neural network alterations across eating disorders: a narrative review of fMRI studies.
ute;ndez-Aranda F Abstract Functional magnetic resonance imaging (fMRI) has provided insight on how neural abnormalities are related to the symptomatology of the eating disorders (EDs): anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). More specifically, an increasingly growing number of brain imaging studies has shed light on how functionally connected brain networks contribute not only to disturbed eating behavior, but also to transdiagnostic alterations in body/interoceptive perception, reward processing and executive functions. This narrative review aims to summarize recent advances...
Source: Current Neuropharmacology - October 17, 2017 Category: Drugs & Pharmacology Authors: Steward T, Menchón JM, Jiménez-Murcia S, Soriano-Mas C, Fernández-Aranda F Tags: Curr Neuropharmacol Source Type: research

Impact of dietary fats on brain functions.
llo R Abstract Adequate dietary intake and nutritional status have important effects on brain functions and on brain health. Energy intake and specific nutrients excess or deficiency from diet differently affect cognitive processes, emotions, behaviour, neuroendocrine functions and synaptic plasticity with possible protective or detrimental effects on neuronal physiology. Lipids, in particular, play structural and functional roles in neurons. Here the importance of dietary fats and the need to understand the brain mechanisms activated by peripheral and central metabolic sensors. Thus, the manipulation of lifestyle...
Source: Current Neuropharmacology - October 17, 2017 Category: Drugs & Pharmacology Authors: Chianese R, Coccurello R, Viggiano A, Scafuro M, Fiore M, Coppola G, Operto FF, Fasano S, Layé S, Pierantoni R, Meccariello R Tags: Curr Neuropharmacol Source Type: research

Potential Therapeutics for Vascular Cognitive Impairment and Dementia.
Abstract As the human lifespan increases, the number of people affected by age-related dementia is growing at an epidemic pace. Vascular pathology dramatically affects cognitive profiles, resulting in dementia and cognitive impairment. While vascular dementia itself constitutes a medical challenge, hypoperfusion/vascular risk factors enhance amyloid toxicity and other memory-damaging factors and hasten Alzheimer's disease (AD) and other memory disorders' progression, as well as negatively affect treatment outcome. Few therapeutic options are, however, currently available to improve the prognosis of patients with v...
Source: Current Neuropharmacology - October 16, 2017 Category: Drugs & Pharmacology Authors: Sun MK Tags: Curr Neuropharmacol Source Type: research

Computer aided drug design and its application to the development of potential drugs for neurodegenerative disorders.
Abstract Neurodegenerative disorders (NDs) are diverse group of disorders characterized by dysfunctioning neurons in the central nervous system, and the search for potent drugs to treat NDs continues to attract considerable research interest. In this era of advance techniques, Computer-Aided Drug Design (CADD) has emerged as an efficient means of developing candidate drugs for the treatment of many disease types. In this review, we have briefly described about CADD and its use in the development of the therapeutic drug candidates against NDs. Here we have also discussed successful application of CADD in NDs. Moreo...
Source: Current Neuropharmacology - October 16, 2017 Category: Drugs & Pharmacology Authors: Baig MH, Ahmad K, Rabbani G, Danishuddin, Choi I Tags: Curr Neuropharmacol Source Type: research

Blood brain barrier and Alzheimer's disease: Similarity and dissimilarity of molecular alerts.
CONCLUSION: The facts from published papers; and technical details of QSAR built up in this study give possibility to formulate the following rules: (i) there are molecular alerts, which are promoters of increase of blood brain barrier and therapeutic activity of anti-Alzheimer disease agents; (ii) there are molecular alerts, which contradict each other. PMID: 29046157 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 16, 2017 Category: Drugs & Pharmacology Authors: Toropova AP, Toropov AA, Begum S, Achary PGR Tags: Curr Neuropharmacol Source Type: research

E-cigarettes: Impact of E-Liquid Components and Device Characteristics on Nicotine Exposure.
Abstract Electronic cigarettes (e-cigarettes) use has increased substantially in recent years. While e-cigarettes have been proposed as a potentially effective smoking cessation tool, dual-use in smokers is common and e-cigarettes are widely used by non-smokers, including youth and young-adult non-smokers. Nicotine, the primary addictive component in cigarettes, is present at varying levels in many e-liquids. E-cigarettes may lead to initiation of nicotine use in adult and youth non-smokers, re-initiation of nicotine dependence in ex-smokers or increased severity of nicotine dependence in dual-users of cigarettes ...
Source: Current Neuropharmacology - October 16, 2017 Category: Drugs & Pharmacology Authors: DeVito EE, Krishnan-Sarin S Tags: Curr Neuropharmacol Source Type: research

Coping with stress during aging: the importance of a resilient brain.
CONCLUSION: Future research should identify different biomarkers that increase the resistance to develop mood disorders and based on this knowledge, develop new potential therapeutic targets. PMID: 28925881 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Sampedro-Piquero P, Álvarez-Suárez P, Begega A Tags: Curr Neuropharmacol Source Type: research

Why are antidepressant drugs effective smoking cessation aids?
Abstract Before the advent of varenicline, antidepressant drugs were reported to exhibit better clinical efficacy than nicotine replacement therapy as smoking cessation aids. The most studied is bupropion, a clinically-effective antidepressant, the first to be marketed throughout Europe for smoking cessation. The mechanisms behind bupropion's efficacy as a smoking cessation compound remains unclear. Since depression and tobacco smoking have a high incidence of co-occurrence, this would implicate an underlying link between these two conditions. If this correlation can be confirmed, then by treating one condition th...
Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Shoaib M, Buhidma Y Tags: Curr Neuropharmacol Source Type: research

Novel therapeutics in glaucoma management.
Abstract Glaucoma is a progressive optic neuropathy characterized by retinal ganglion cell death and alterations of visual field. Elevated intraocular pressure (IOP) is considered the main risk factor of glaucoma, even though other factors cannot be ruled out, such as epigenetic mechanisms. An overview of the ultimate promising experimental drugs to manage glaucoma has been provided. In particular, we have focused on purinergic ligands, KATP channel activators, gases (nitric oxide, carbon monoxide and hydrogen sulfide), non-glucocorticoid steroidal compounds, neurotrophic factors, PI3K/Akt activators, citicoline, ...
Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Bucolo C, Platania CBM, Drago F, Reibaldi M, Bonfiglio V, Avitabile T, Uva M Tags: Curr Neuropharmacol Source Type: research

Prevention and Treatment for Chemotherapy-Induced Peripheral Neuropathy: Therapies Based on CIPN Mechanisms.
CONCLUSIONS: Multiple drugs have been used and studied for decades, their effect against CIPN are still controversial according to different antineoplastic agents due to the diverse manifestations among different antineoplastic agents and complex drug-drug interactions. In addition, novel therapies or drugs that have proven to be effective in animals require further investigation, and it will take time to confirm their efficacy and safety. PMID: 28925884 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Hu LY, Mi WL, Wu GC, Wang YQ, Mao-Ying QL Tags: Curr Neuropharmacol Source Type: research

Spreading Depolarization Waves in Neurological Diseases: A Short Review about its Pathophysiology and Clinical Relevance.
Ouml;zdemir Y Abstract Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental st...
Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Taş YÇ, Solaroğlu İ, Gürsoy-Özdemir Y Tags: Curr Neuropharmacol Source Type: research

The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments.
CONCLUSION: The microbiota-gut-brain axis might provide novel targets for prevention and treatment of neuropsychiatric disorders. However, further studies are required to substantiate the clinical use of probiotics, prebiotics and FMT. PMID: 28925886 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 15, 2017 Category: Drugs & Pharmacology Authors: Kim YK, Shin C Tags: Curr Neuropharmacol Source Type: research

Neuroinflammation and the Immune-Kynurenine Pathway in Anxiety Disorders.
CONCLUSION: We hope that our understanding of the psychoimmunological mechanisms of anxiety will be expanded and anxiety-related studies will receive greater attention. PMID: 28901278 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 12, 2017 Category: Drugs & Pharmacology Authors: Kim YK, Jeon SW Tags: Curr Neuropharmacol Source Type: research

Role of physical exercise and omega-3 fatty acids on depressive illness in the elderly.
CONCLUSION: From here the awareness emerges that an active lifestyle and a balanced diet may constitute valid low-cost prevention strategies to counteract depressive illness in the elderly. PMID: 28901279 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 11, 2017 Category: Drugs & Pharmacology Authors: Farioli-Vecchioli S, Sacchetti S, di Robilant VN, Cutuli D Tags: Curr Neuropharmacol Source Type: research

Neuronal and extraneuronal nicotinic acetylcholine receptors.
Abstract Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cys-loop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are involved in a variety of physiological and pathophysiological processes. Numerous studies have shown that the expression and/or function of nAChRs is compromised in many neurological and psychiatric diseases. Furthermore, recent studies have shown that neuronal nAChRs are found in a large num...
Source: Current Neuropharmacology - September 11, 2017 Category: Drugs & Pharmacology Authors: Zoli M, Pucci S, Vilella A, Gotti C Tags: Curr Neuropharmacol Source Type: research

Review: 5-Ht1, 5-Ht2, 5-Ht3, And 5-Ht7 Receptors And Their Role In The Modulation Of Pain Response In The Central Nervous System.
Conclusions We concluded that 5-HT1, 5-HT2, 5-HT3, and 5-HT7 receptors in the CNS modulate the pain, but this depends on the distribution of the receptors, dose of agonists or antagonists, administration route, pain type and duration to order to inhibit, to excite, or even maintain the nociceptive response. PMID: 28901281 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 11, 2017 Category: Drugs & Pharmacology Authors: Luis CJ, Adriana OH, Herlinda BJ, Paul CM, Cindy B, Reyes-Long S, Alfonso AR Tags: Curr Neuropharmacol Source Type: research

Structure, gating and basic functions of the Ca2+-activated K channel of intermediate conductance.
Abstract The KCa3.1 channel is the intermediate-conductance member of the Ca2+-activated K channel superfamily. Expressed in excitable and non-excitable cells, the KCa3.1 channel is voltage independent, its opening being exclusively gated by the binding of intracellular Ca2+ to calmodulin, a Ca2+-binding protein constitutively associated with the C-terminus of each KCa3.1 channel α subunit. Upon Ca2+ binding, the KCa3.1 channel activates with high affinity and in highly coordinated fashion giving steep Hill functions and relatively low EC50 values (100-350 nM). This high Ca2+ sensitivity is physiologically m...
Source: Current Neuropharmacology - August 30, 2017 Category: Drugs & Pharmacology Authors: Sforna L, Megaro A, Pessia M, Franciolini F, Catacuzzeno L Tags: Curr Neuropharmacol Source Type: research

Correlation between blood and oral fluid psychoactive drug concentrations and cognitive impairment in Driving Under the Influence of Drugs.
ano S Abstract Licit and illicit drugs affecting the central nervous system have the potential to impair driving ability. The effects of drugs on driving performance should be checked with drug concentration in the brain and at the same time with the evaluation of both the behavioural and neurophysiological effects. The best accessible indicator of this information is the concentration of the drug and/or metabolites in blood and, to a certain extent, oral fluid. Neurocognitive tasks under the influence of drugs should be also monitored. Up to 2010, no epidemiological studies were available on this matter and Inter...
Source: Current Neuropharmacology - August 28, 2017 Category: Drugs & Pharmacology Authors: Busardò FP, Pichini S, Pellegrini M, Montana A, Faro AFL, Zaami S, Graziano S Tags: Curr Neuropharmacol Source Type: research

Therapeutic strategies for treatment of inflammation-related depression.
Abstract Mounting evidence demonstrates enhanced systemic levels of inflammatory mediators in depressed patients, indicating that inflammation may play a role in the etiology and course of mood disorders. Indeed, proinflammatory cytokines induce a behavioral state of conservation-withdrawal resembling human depression, characterized by negative mood, fatigue, anhedonia, psychomotor retardation, loss of appetite, and cognitive deficits. Mechanisms of cytokine actions on behavior involve activation of inflammatory signaling pathways in the brain, resulting in changes of neurotransmitter metabolism (monoamine, glutam...
Source: Current Neuropharmacology - August 28, 2017 Category: Drugs & Pharmacology Authors: Adzic M, Brkic Z, Mitic M, Francija E, Jovicic MJ, Radulovic J, Maric NP Tags: Curr Neuropharmacol Source Type: research

Combination Therapy for Multi-Target Manipulation of Secondary Brain Injury Mechanisms.
Abstract Traumatic brain injury (TBI) is a major healthcare problem that affects millions of people worldwide. Despite advances in understanding and developing preventative and treatment strategies using preclinical animal models, clinical trials to date have failed, and a "magic bullet" for effectively treating TBI-induced damage does not exist. Thus, novel pharmacological strategies to effectively manipulate the complex and heterogeneous pathophysiology of secondary injury mechanisms are needed. Given that goal, this paper discusses the relevance and advantages of combination therapies (COMTs) for &quo...
Source: Current Neuropharmacology - August 28, 2017 Category: Drugs & Pharmacology Authors: Somayaji MR, Mahadevabharath R, Przekwas, Andrzej J, Gupta, Raj K Tags: Curr Neuropharmacol Source Type: research

Neuron-glia interaction as a possible pathophysiological mechanism of bipolar disorder.
Abstract Accumulating evidence has shown the importance of glial cells in the neurobiology of bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as potential biomarkers of bipolar disorder. Indeed, recent studies have shown that bipolar disorder involves microglial activation in the hippocampus and alterations in peripheral cytokines, suggesting a potential link between neuroinflammation and peripheral toxicity. These abnormalities may also be the biological underpinnings of outcomes related to neuroprogression, such as cognitive impairment and brain changes. Additionally, astro...
Source: Current Neuropharmacology - August 28, 2017 Category: Drugs & Pharmacology Authors: Pinto JV, Passos IC, Librenza-Garcia D, Marcon G, Schneider MA, Conte JH, da Silva JPA, Lima LP, Quincozes-Santos A, Kauer-Sant'Anna M, Kapczinski F Tags: Curr Neuropharmacol Source Type: research

NGF and BDNF Alterations by Prenatal Alcohol Exposure.
CONCLUSIONS: The review suggests a possible therapeutic intervention based on the use of specific molecules with antioxidant properties in order to induce a potential prevention of the harmful effects of the paternal and/or maternal alcohol exposure. PMID: 28847297 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 24, 2017 Category: Drugs & Pharmacology Authors: Carito V, Ceccanti M, Ferraguti G, Coccurello R, Ciafrè S, Tirassa P, Fiore M Tags: Curr Neuropharmacol Source Type: research

In silico studies in drug research against neurodegenerative diseases.
Abstract Neurodegenerative diseases such as Alzheimer's disease (AD), progressive neurodegenerative forms of Huntington's disease, Parkinson's disease (PD), amyotrophic lateral sclerosis, spinal cerebellar ataxias, and spinal and bulbar muscular atrophy are described by slow and selective dysfunction and degeneration of neurons and axons in the central nervous system (CNS). Computer-aided or in silico design methods have matured into powerful tools for reducing the number of ligands that should be screened in experimental assays. In the present review, the authors provide a basic background about ne...
Source: Current Neuropharmacology - August 22, 2017 Category: Drugs & Pharmacology Authors: Makhouri FR, Ghasemi JB Tags: Curr Neuropharmacol Source Type: research

New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs.
New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs. Curr Neuropharmacol. 2017 Aug 17;: Authors: Bagdas D, Gurun MS, Flood P, Papke RL, Damaj MI Abstract Nicotine and nicotinic receptors have been explored for the past three decades as targets for pain control. Accumulating evidences suggest that selective ligands for α7 nicotinic acetylcholine receptors (nAChRs) hold promise in the treatment of chronic pain conditions as they lack many of side effects associated with other nicotinic receptor types. This review provides the ...
Source: Current Neuropharmacology - August 17, 2017 Category: Drugs & Pharmacology Authors: Bagdas D, Gurun MS, Flood P, Papke RL, Damaj MI Tags: Curr Neuropharmacol Source Type: research

Neurobiological mechanisms of stress resilience and implications for the aged population.
In conclusion, we consider the possible methods that may be used to induce resilient phenotypes, prophylactically in at-risk populations, such as in military personnel or in older MDD patients. Research in the mechanisms of stress resilience may not only elucidate novel targets for antidepressant treatments, but also provide novel insight about how to prevent these debilitating disorders from developing. PMID: 28820053 [PubMed - as supplied by publisher] (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 17, 2017 Category: Drugs & Pharmacology Authors: Faye C, Mcgowan JC, Denny CA, David DJ Tags: Curr Neuropharmacol Source Type: research

Qsar Modeling Of Histamine H3r Antagonists/Inverse Agonists As Future Drugs For Neurodegenerative Diseases.
s JP Abstract Histamine H3 receptor (H3R) is associated with several neuropsychological diseases. It is predominantly expressed in the central nervous system as presynaptic receptor, especially in regions associated with cognition and behavior, and is responsible for modulate the synthesis and release of histamine and other neurotransmitters such as acetylcholine, dopamine and serotonin. Therefore, H3R is an important target involved in several CNS disorders, such as narcolepsy, attention deficit hyperactivity disorder and schizophrenia. H3R antagonists/inverse agonists have also demonstrated pro-cognitive effects...
Source: Current Neuropharmacology - August 17, 2017 Category: Drugs & Pharmacology Authors: Corrêa MF, Dos Santos Fernandes JP Tags: Curr Neuropharmacol Source Type: research

Neuroprotective role of Agmatine in Neurological Diseases.
Abstract Neurological diseases have always been one of the leading cause of mobility and mortality world-widely. However, it is still lack of efficient agents. Agmatine, an endogenous polyamine, exerts its diverse biological characteristics and therapeutic potential in varied aspects. Moreover, there has been numerous studies demonstrated the neuroprotective effect of agmatine in varied types of neurological diseases, including acute attack (stroke and trauma brain injury) and chronic neurodegenerative diseases (Parkinson's disease, Alzheimer's disease). The potential mechanism of agmatine -induced neuroprote...
Source: Current Neuropharmacology - August 8, 2017 Category: Drugs & Pharmacology Authors: Xu W, Gao L, Li T, Shao A, Zhang J Tags: Curr Neuropharmacol Source Type: research

KCa3.1 channels and glioblastoma: in vitro studies.
Abstract Several tumor entities including brain tumors aberrantly overexpress intermediate conductance Ca2+ activated KCa3.1 K+ channels. These channels contribute significantly to the transformed phenotype of the tumor cells. By modulating membrane potential, cell volume, Ca2+ signals and the respiration chain, KCa3.1 channels in both, plasma and inner mitochondrial membrane, have been demonstrated to regulate many cellular processes such as migration and tissue invasion, metastasis, cell cycle progression, oxygen consumption and metabolism, DNA damage response and cell death of cancer cells. Moreover, KCa3.1 cha...
Source: Current Neuropharmacology - August 8, 2017 Category: Drugs & Pharmacology Authors: Klumpp L, Sezgin EC, Skardelly M, Eckert F, Huber SM Tags: Curr Neuropharmacol Source Type: research

Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.
Abstract Nicotinic acetylcholine receptors (nAChRs) belong to the Cys-loop ligand-gated ion-channel (LGIC) superfamily, which also includes the GABA, glycine, and serotonin receptors. Many nAChR subunits have been identified and shown to be involved in signal transduction on binding to them of either the neurotransmitter acetylcholine or exogenous ligands such as nicotine. The nAChRs are pentameric assemblies of homologous subunits surrounding a central pore that gates cation flux, and they are expressed at neuromuscular junctions throughout the nervous system. Because different nAChR subunits assemble into a vari...
Source: Current Neuropharmacology - August 1, 2017 Category: Drugs & Pharmacology Authors: Liu W, Li MD Tags: Curr Neuropharmacol Source Type: research

The Influence of Vaccine on Febrile Seizure.
Abstract The protective value of vaccines to the public has made vaccines among the major public health prophylactic measures through the entire history. However, there has been some controversy about their safety; particularly concerns have been rising about febrile seizures (FS). Until now, other studies could not prove a causal relationship between FS and vaccination. This relationship is complex by other factors, such as age, genetic inheritance, type of vaccine, combination of different types of vaccines and the timing of vaccination. Other studies proved that all of these factors have been associated with an...
Source: Current Neuropharmacology - July 26, 2017 Category: Drugs & Pharmacology Authors: Li X, Wang Y Tags: Curr Neuropharmacol Source Type: research

Neuroprotection by (endo)cannabinoids in glaucoma and retinal neurodegenerative diseases.
Abstract Emerging neuroprotective strategies are being explored to preserve the retina from degeneration, that occurs in eye pathologies like glaucoma, diabetic retinopathy, age-related macular degeneration, and retinitis pigmentosa. Incidentally, neuroprotection of retina is a defending mechanism designed to prevent or delay neuronal cell death, and to maintain neural function following an initial insult, thus avoiding loss of vision. Numerous studies have investigated potential neuroprotective properties of plant-derived phytocannabinoids, as well as of their endogenous counterparts collectively termed endocanna...
Source: Current Neuropharmacology - July 24, 2017 Category: Drugs & Pharmacology Authors: Rapino C, Tortolani D, Scipioni L, Maccarrone M Tags: Curr Neuropharmacol Source Type: research