Melatonin: a Potential Shield against Electromagnetic Waves
Curr Neuropharmacol. 2021 Jun 9. doi: 10.2174/1570159X19666210609163946. Online ahead of print.ABSTRACTMelatonin, a vital hormone synthesized by the pineal gland, has been implicated in various physiological functions and in circadian rhythm regulation. Its role in the protection against the non-ionizing electromagnetic field (EMF), known to disrupt the body's oxidative/anti-oxidative balance, has been called into question due to inconsistent results observed across studies. This review provides the current state of knowledge on the interwoven relationship between melatonin, EMF, and oxidative stress. Based on synthesized ...
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Maya Jammoul Nada Lawand Source Type: research

Computer Aided Drug Design Methodologies With Natural Products In The Drug Research Against Alzheimer's Disease
This study aims to carry out a literature review with articles that address the In silico studies of natural products aimed at potential drugs against alzheimer's disease (AD) in the period from 2015 to 2021.PMID:34636299 | DOI:10.2174/1570159X19666211005145952 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Nat ália Ferreira de Sousa Luciana Scotti Érika Paiva de Moura Mayara Dos Santos Maia A Gabriela Cristina Soares Rodrigues Herbert Igor Rodrigues de Medeiros Simone Mendes Lopes Marcus Tullius Scotti Source Type: research

Perspective on mTOR-dependent Protection in Status Epilepticus
Conclusions: The perspective offered by this manuscript provides a novel scenario to understand refractory epilepsy and self-sustaining status epilepticus. This is expected to provide a beneficial outcome in patients suffering from temporal lobe epilepsy.PMID:34636300 | DOI:10.2174/1570159X19666211005152618 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Francesca Biagioni Roberta Celli Filippo Sean Giorgi Ferdinando Nicoletti Francesco Fornai Source Type: research

Melatonin: a Potential Shield against Electromagnetic Waves
Curr Neuropharmacol. 2021 Jun 9. doi: 10.2174/1570159X19666210609163946. Online ahead of print.ABSTRACTMelatonin, a vital hormone synthesized by the pineal gland, has been implicated in various physiological functions and in circadian rhythm regulation. Its role in the protection against the non-ionizing electromagnetic field (EMF), known to disrupt the body's oxidative/anti-oxidative balance, has been called into question due to inconsistent results observed across studies. This review provides the current state of knowledge on the interwoven relationship between melatonin, EMF, and oxidative stress. Based on synthesized ...
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Maya Jammoul Nada Lawand Source Type: research

Computer Aided Drug Design Methodologies With Natural Products In The Drug Research Against Alzheimer's Disease
This study aims to carry out a literature review with articles that address the In silico studies of natural products aimed at potential drugs against alzheimer's disease (AD) in the period from 2015 to 2021.PMID:34636299 | DOI:10.2174/1570159X19666211005145952 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Nat ália Ferreira de Sousa Luciana Scotti Érika Paiva de Moura Mayara Dos Santos Maia A Gabriela Cristina Soares Rodrigues Herbert Igor Rodrigues de Medeiros Simone Mendes Lopes Marcus Tullius Scotti Source Type: research

Perspective on mTOR-dependent Protection in Status Epilepticus
Conclusions: The perspective offered by this manuscript provides a novel scenario to understand refractory epilepsy and self-sustaining status epilepticus. This is expected to provide a beneficial outcome in patients suffering from temporal lobe epilepsy.PMID:34636300 | DOI:10.2174/1570159X19666211005152618 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Francesca Biagioni Roberta Celli Filippo Sean Giorgi Ferdinando Nicoletti Francesco Fornai Source Type: research

Melatonin: a Potential Shield against Electromagnetic Waves
Curr Neuropharmacol. 2021 Jun 9. doi: 10.2174/1570159X19666210609163946. Online ahead of print.ABSTRACTMelatonin, a vital hormone synthesized by the pineal gland, has been implicated in various physiological functions and in circadian rhythm regulation. Its role in the protection against the non-ionizing electromagnetic field (EMF), known to disrupt the body's oxidative/anti-oxidative balance, has been called into question due to inconsistent results observed across studies. This review provides the current state of knowledge on the interwoven relationship between melatonin, EMF, and oxidative stress. Based on synthesized ...
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Maya Jammoul Nada Lawand Source Type: research

Computer Aided Drug Design Methodologies With Natural Products In The Drug Research Against Alzheimer's Disease
This study aims to carry out a literature review with articles that address the In silico studies of natural products aimed at potential drugs against alzheimer's disease (AD) in the period from 2015 to 2021.PMID:34636299 | DOI:10.2174/1570159X19666211005145952 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Nat ália Ferreira de Sousa Luciana Scotti Érika Paiva de Moura Mayara Dos Santos Maia A Gabriela Cristina Soares Rodrigues Herbert Igor Rodrigues de Medeiros Simone Mendes Lopes Marcus Tullius Scotti Source Type: research

Perspective on mTOR-dependent Protection in Status Epilepticus
Conclusions: The perspective offered by this manuscript provides a novel scenario to understand refractory epilepsy and self-sustaining status epilepticus. This is expected to provide a beneficial outcome in patients suffering from temporal lobe epilepsy.PMID:34636300 | DOI:10.2174/1570159X19666211005152618 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Francesca Biagioni Roberta Celli Filippo Sean Giorgi Ferdinando Nicoletti Francesco Fornai Source Type: research

Melatonin: a Potential Shield against Electromagnetic Waves
Curr Neuropharmacol. 2021 Jun 9. doi: 10.2174/1570159X19666210609163946. Online ahead of print.ABSTRACTMelatonin, a vital hormone synthesized by the pineal gland, has been implicated in various physiological functions and in circadian rhythm regulation. Its role in the protection against the non-ionizing electromagnetic field (EMF), known to disrupt the body's oxidative/anti-oxidative balance, has been called into question due to inconsistent results observed across studies. This review provides the current state of knowledge on the interwoven relationship between melatonin, EMF, and oxidative stress. Based on synthesized ...
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Maya Jammoul Nada Lawand Source Type: research

Computer Aided Drug Design Methodologies With Natural Products In The Drug Research Against Alzheimer's Disease
This study aims to carry out a literature review with articles that address the In silico studies of natural products aimed at potential drugs against alzheimer's disease (AD) in the period from 2015 to 2021.PMID:34636299 | DOI:10.2174/1570159X19666211005145952 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Nat ália Ferreira de Sousa Luciana Scotti Érika Paiva de Moura Mayara Dos Santos Maia A Gabriela Cristina Soares Rodrigues Herbert Igor Rodrigues de Medeiros Simone Mendes Lopes Marcus Tullius Scotti Source Type: research

Perspective on mTOR-dependent Protection in Status Epilepticus
Conclusions: The perspective offered by this manuscript provides a novel scenario to understand refractory epilepsy and self-sustaining status epilepticus. This is expected to provide a beneficial outcome in patients suffering from temporal lobe epilepsy.PMID:34636300 | DOI:10.2174/1570159X19666211005152618 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 12, 2021 Category: Drugs & Pharmacology Authors: Francesca Biagioni Roberta Celli Filippo Sean Giorgi Ferdinando Nicoletti Francesco Fornai Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research

cGAS-STING-mediated IFN-I response in host defense and neuro-inflammatory diseases
Curr Neuropharmacol. 2021 Sep 24. doi: 10.2174/1570159X19666210924110144. Online ahead of print.ABSTRACTThe presence of foreign or misplaced nucleic acids is a danger signal that triggers innate immune responses through activating cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) and binding to its downstream signaling effector stimulator of interferon genes (STING). Then the cGAS-STING pathway activation links nucleic acid sensing to immune responses and pathogenic entities clearance. However, overactivation of this signaling pathway leads to fatal immune disorders and contributes to the progression of many human inflam...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Kai Chen Chuan Lai Yin Su Wen Dai Bao Liu Nan Yang Ping-Ping Xu Ling-Qiang Zhu Source Type: research

The epigenetic mechanisms involved in chronic pain in rodents: A mini-review
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924104757. Online ahead of print.ABSTRACTChronic pain, as a common distressing neurological disorder, about 30% of the global population suffers from it. In addition to being highly prevalent, chronic pain causes heavy economic and social burden. Although substantial progress has been achieved to dissect the underlying mechanism of chronic pain in the past few decades, the incidence and treatment of this neurological illness is yet not properly managed in clinical practice. While nerve injury-, chemotherapy- or inflammation-induced functional regulation of gene...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Ting Xu Cui-Cui Liu Wen-Jun Xin Source Type: research

Effects of Natural Products on Neuromuscular Junction
Curr Neuropharmacol. 2021 Sep 23. doi: 10.2174/1570159X19666210924092627. Online ahead of print.ABSTRACTNeuromuscular junction (NMJ) disorders result from damage, malfunction or absence of one or more key proteins involved in neuromuscular transmission, comprising a wide range of disorders. The most common pathology is antibody-mediated or downregulation of ion channels or receptors, resulting in Lambert-Eaton myasthenic syndrome, myasthenia gravis, and acquired neuromyotonia (Isaac's syndrome), and rarely congenital myasthenic syndromes caused by mutations in NMJ proteins. A wide range of symptomatic treatments, immunomod...
Source: Current Neuropharmacology - September 25, 2021 Category: Drugs & Pharmacology Authors: Esra K üpeli Akkol G ökçe Şeker Karatoprak Elif Carpar Yaseen Hussain Haroon Khan Michael Aschner Source Type: research