Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder
Curr Neuropharmacol. 2023 Oct 16. doi: 10.2174/1570159X22666231003121513. Online ahead of print.ABSTRACTAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased prevalence and incidence in recent decades. Its etiology remains largely unclear, but it seems to involve a strong genetic component and environmental factors that, in turn, induce epigenetic changes during embryonic and postnatal brain development. In recent decades, clinical studies have shown that inutero exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug, is an environmental factor associated with an increased risk o...
Source: Current Neuropharmacology - October 24, 2023 Category: Drugs & Pharmacology Authors: David Zarate-Lopez Ana Laura Torres-Ch ávez Alma Yadira G álvez-Contreras Oscar Gonzalez-Perez Source Type: research
Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder
Curr Neuropharmacol. 2023 Oct 16. doi: 10.2174/1570159X22666231003121513. Online ahead of print.ABSTRACTAutism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased prevalence and incidence in recent decades. Its etiology remains largely unclear, but it seems to involve a strong genetic component and environmental factors that, in turn, induce epigenetic changes during embryonic and postnatal brain development. In recent decades, clinical studies have shown that inutero exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug, is an environmental factor associated with an increased risk o...
Source: Current Neuropharmacology - October 24, 2023 Category: Drugs & Pharmacology Authors: David Zarate-Lopez Ana Laura Torres-Ch ávez Alma Yadira G álvez-Contreras Oscar Gonzalez-Perez Source Type: research
Smoking, Symptoms Improvement, and Total Antioxidant Capacity in Patients with Drug-naive First-episode Schizophrenia: A Prospective Cohort Study
CONCLUSION: Our study suggested that smoking affected the severity of baseline negative symptoms and further contributed to their reduction after risperidone treatment. However, improvement in negative symptoms was not dependent on the changes in TAOC.PMID:37859307 | DOI:10.2174/1570159X22666231019105328 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 20, 2023 Category: Drugs & Pharmacology Authors: Zhiyong Gao Meihong Xiu Jiahong Liu Fengchun Wu Xiangyang Zhang Source Type: research
Smoking, Symptoms Improvement, and Total Antioxidant Capacity in Patients with Drug-naive First-episode Schizophrenia: A Prospective Cohort Study
CONCLUSION: Our study suggested that smoking affected the severity of baseline negative symptoms and further contributed to their reduction after risperidone treatment. However, improvement in negative symptoms was not dependent on the changes in TAOC.PMID:37859307 | DOI:10.2174/1570159X22666231019105328 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 20, 2023 Category: Drugs & Pharmacology Authors: Zhiyong Gao Meihong Xiu Jiahong Liu Fengchun Wu Xiangyang Zhang Source Type: research
Smoking, Symptoms Improvement, and Total Antioxidant Capacity in Patients with Drug-naive First-episode Schizophrenia: A Prospective Cohort Study
CONCLUSION: Our study suggested that smoking affected the severity of baseline negative symptoms and further contributed to their reduction after risperidone treatment. However, improvement in negative symptoms was not dependent on the changes in TAOC.PMID:37859307 | DOI:10.2174/1570159X22666231019105328 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 20, 2023 Category: Drugs & Pharmacology Authors: Zhiyong Gao Meihong Xiu Jiahong Liu Fengchun Wu Xiangyang Zhang Source Type: research
Sex Differences in Stress Response: Classical Mechanisms and Beyond
Curr Neuropharmacol. 2023 Oct 5. doi: 10.2174/1570159X22666231005090134. Online ahead of print.ABSTRACTNeuropsychiatric disorders, which are associated with stress hormone dysregulation, occur at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence demonstrates that sex and gender can lead to differences in stress responses that predispose males and females to different expressions of similar pathologies. In this curated review, we focus on what is known about sex differences in classic mechanisms of stress response, such as glucocorticoid hormones and corticotrophin-releasing factor (CRF...
Source: Current Neuropharmacology - October 19, 2023 Category: Drugs & Pharmacology Authors: Georgia E Hodes Debra Bangasser Ioannis Sotiropoulos Nikolaos Kokras Christina Dalla Source Type: research
Sex Differences in Stress Response: Classical Mechanisms and Beyond
Curr Neuropharmacol. 2023 Oct 5. doi: 10.2174/1570159X22666231005090134. Online ahead of print.ABSTRACTNeuropsychiatric disorders, which are associated with stress hormone dysregulation, occur at different rates in men and women. Moreover, nowadays, preclinical and clinical evidence demonstrates that sex and gender can lead to differences in stress responses that predispose males and females to different expressions of similar pathologies. In this curated review, we focus on what is known about sex differences in classic mechanisms of stress response, such as glucocorticoid hormones and corticotrophin-releasing factor (CRF...
Source: Current Neuropharmacology - October 19, 2023 Category: Drugs & Pharmacology Authors: Georgia E Hodes Debra Bangasser Ioannis Sotiropoulos Nikolaos Kokras Christina Dalla Source Type: research
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.PMID:37818587 | DOI:10.2174/1570159X22666231002145440 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mattia I Gerin Essi Viding Vanessa B Puetz Diana J N Armbruster-Genc Georgia Rankin Eamon J McCrory Source Type: research
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.PMID:37818587 | DOI:10.2174/1570159X22666231002145440 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mattia I Gerin Essi Viding Vanessa B Puetz Diana J N Armbruster-Genc Georgia Rankin Eamon J McCrory Source Type: research
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.PMID:37818587 | DOI:10.2174/1570159X22666231002145440 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mattia I Gerin Essi Viding Vanessa B Puetz Diana J N Armbruster-Genc Georgia Rankin Eamon J McCrory Source Type: research
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.PMID:37818587 | DOI:10.2174/1570159X22666231002145440 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mattia I Gerin Essi Viding Vanessa B Puetz Diana J N Armbruster-Genc Georgia Rankin Eamon J McCrory Source Type: research
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.PMID:37818587 | DOI:10.2174/1570159X22666231002145440 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mattia I Gerin Essi Viding Vanessa B Puetz Diana J N Armbruster-Genc Georgia Rankin Eamon J McCrory Source Type: research
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.PMID:37818587 | DOI:10.2174/1570159X22666231002145440 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mattia I Gerin Essi Viding Vanessa B Puetz Diana J N Armbruster-Genc Georgia Rankin Eamon J McCrory Source Type: research
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.PMID:37818587 | DOI:10.2174/1570159X22666231002145440 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - October 11, 2023 Category: Drugs & Pharmacology Authors: Mattia I Gerin Essi Viding Vanessa B Puetz Diana J N Armbruster-Genc Georgia Rankin Eamon J McCrory Source Type: research
Abusive use of Zolpidem as a Result of COVID-19 and Perspectives of Continuity of the Problem in the Post-Pandemic Period
Curr Neuropharmacol. 2023 Sep 20. doi: 10.2174/1570159X21666230920123401. Online ahead of print.ABSTRACTZolpidem is a non-benzodiazepine hypnotic drug that works as a positive modulator of Gamma-Amino Butyric Acid-A (GABA-A) receptors, with high selectivity for α1 subunits. Given this selective binding, the drug has a strong hypnotic activity. Social isolation during the SARS-CoV-2 pandemic has contributed to increased rates of anxiety, depression, and insomnia. As a result, studies have pointed to a possible increase in the indiscriminate use of drugs with sedative effects, such as Zolpidem, during the pandemic. The aim ...
Source: Current Neuropharmacology - October 9, 2023 Category: Drugs & Pharmacology Authors: Wesley Dawison de Lima Michael Douglas da Silva Eurico de Souza Costa Francisco Irochima Pinheiro Eduardo Pereira de Azevedo Ricardo Ney Cobucci Jos é Rodolfo Lopes de Paiva Cavalcanti Fausto Pierdon á Guzen Source Type: research
