Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice
CONCLUSION: These findings implicate specific roles of integrins in inflammation and tonic pain, as well as in the related central nervous system sequelae.PMID:38073106 | DOI:10.2174/1570159X22999231207105743 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Carmela Belardo Jed Jebali Serena Boccella Rosmara Infantino Antimo Fusco Michela Perrone Roozbe Bonsale Iolanda Manzo Monica Iannotta Damiana Scuteri Franca Ferraraccio Iacopo Panares Giovanna Ferrara Francesca Guida Livio Luongo Enza Palazzo Najet Srair Source Type: research
In Vitro Blood-Brain Barrier Models for Neuroinfectious Diseases: A Narrative Review
Curr Neuropharmacol. 2023 Dec 8. doi: 10.2174/1570159X22666231207114346. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) is a complex, dynamic, and adaptable barrier between the peripheral blood system and the central nervous system. While this barrier protects the brain and spinal cord from inflammation and infection, it prevents most drugs from reaching the brain tissue. With the expanding interest in the pathophysiology of BBB, the development of in vitro BBB models has dramatically evolved. However, due to the lack of a standard model, a range of experimental protocols, BBB-phenotype markers, and permeabili...
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Ahmad Hussein Badawi Nur Afiqah Mohamad Johnson Stanslas Brian P Kirby Vasantha Kumari Neela Rajesh Ramasamy Hamidon Basri Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice
CONCLUSION: These findings implicate specific roles of integrins in inflammation and tonic pain, as well as in the related central nervous system sequelae.PMID:38073106 | DOI:10.2174/1570159X22999231207105743 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Carmela Belardo Jed Jebali Serena Boccella Rosmara Infantino Antimo Fusco Michela Perrone Roozbe Bonsale Iolanda Manzo Monica Iannotta Damiana Scuteri Franca Ferraraccio Iacopo Panares Giovanna Ferrara Francesca Guida Livio Luongo Enza Palazzo Najet Srair Source Type: research
In Vitro Blood-Brain Barrier Models for Neuroinfectious Diseases: A Narrative Review
Curr Neuropharmacol. 2023 Dec 8. doi: 10.2174/1570159X22666231207114346. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) is a complex, dynamic, and adaptable barrier between the peripheral blood system and the central nervous system. While this barrier protects the brain and spinal cord from inflammation and infection, it prevents most drugs from reaching the brain tissue. With the expanding interest in the pathophysiology of BBB, the development of in vitro BBB models has dramatically evolved. However, due to the lack of a standard model, a range of experimental protocols, BBB-phenotype markers, and permeabili...
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Ahmad Hussein Badawi Nur Afiqah Mohamad Johnson Stanslas Brian P Kirby Vasantha Kumari Neela Rajesh Ramasamy Hamidon Basri Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice
CONCLUSION: These findings implicate specific roles of integrins in inflammation and tonic pain, as well as in the related central nervous system sequelae.PMID:38073106 | DOI:10.2174/1570159X22999231207105743 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Carmela Belardo Jed Jebali Serena Boccella Rosmara Infantino Antimo Fusco Michela Perrone Roozbe Bonsale Iolanda Manzo Monica Iannotta Damiana Scuteri Franca Ferraraccio Iacopo Panares Giovanna Ferrara Francesca Guida Livio Luongo Enza Palazzo Najet Srair Source Type: research
In Vitro Blood-Brain Barrier Models for Neuroinfectious Diseases: A Narrative Review
Curr Neuropharmacol. 2023 Dec 8. doi: 10.2174/1570159X22666231207114346. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) is a complex, dynamic, and adaptable barrier between the peripheral blood system and the central nervous system. While this barrier protects the brain and spinal cord from inflammation and infection, it prevents most drugs from reaching the brain tissue. With the expanding interest in the pathophysiology of BBB, the development of in vitro BBB models has dramatically evolved. However, due to the lack of a standard model, a range of experimental protocols, BBB-phenotype markers, and permeabili...
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Ahmad Hussein Badawi Nur Afiqah Mohamad Johnson Stanslas Brian P Kirby Vasantha Kumari Neela Rajesh Ramasamy Hamidon Basri Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice
CONCLUSION: These findings implicate specific roles of integrins in inflammation and tonic pain, as well as in the related central nervous system sequelae.PMID:38073106 | DOI:10.2174/1570159X22999231207105743 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Carmela Belardo Jed Jebali Serena Boccella Rosmara Infantino Antimo Fusco Michela Perrone Roozbe Bonsale Iolanda Manzo Monica Iannotta Damiana Scuteri Franca Ferraraccio Iacopo Panares Giovanna Ferrara Francesca Guida Livio Luongo Enza Palazzo Najet Srair Source Type: research
In Vitro Blood-Brain Barrier Models for Neuroinfectious Diseases: A Narrative Review
Curr Neuropharmacol. 2023 Dec 8. doi: 10.2174/1570159X22666231207114346. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) is a complex, dynamic, and adaptable barrier between the peripheral blood system and the central nervous system. While this barrier protects the brain and spinal cord from inflammation and infection, it prevents most drugs from reaching the brain tissue. With the expanding interest in the pathophysiology of BBB, the development of in vitro BBB models has dramatically evolved. However, due to the lack of a standard model, a range of experimental protocols, BBB-phenotype markers, and permeabili...
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Ahmad Hussein Badawi Nur Afiqah Mohamad Johnson Stanslas Brian P Kirby Vasantha Kumari Neela Rajesh Ramasamy Hamidon Basri Source Type: research
Redox Modulation of Meniere Disease by Coriolus Versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential
CONCLUSIONS: Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on α-synuclein expression and on inflammatory processes NF- kB-mediated.PMID:38073105 | DOI:10.2174/1570159X22666231206153936 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Rosanna Di Paola Rosalba Siracusa Roberta Fusco Marialaura Ontario Gaetano Cammilleri Licia Pantano Maria Scuto Mario Tomasello Sestina Span ò Angela Trovato Salinaro Ali S Abdelhameed Vincenzo Ferrantelli Antonio Arcidiacono Tilman Fritsch Gabriella Lup Source Type: research
Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice
CONCLUSION: These findings implicate specific roles of integrins in inflammation and tonic pain, as well as in the related central nervous system sequelae.PMID:38073106 | DOI:10.2174/1570159X22999231207105743 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - December 11, 2023 Category: Drugs & Pharmacology Authors: Carmela Belardo Jed Jebali Serena Boccella Rosmara Infantino Antimo Fusco Michela Perrone Roozbe Bonsale Iolanda Manzo Monica Iannotta Damiana Scuteri Franca Ferraraccio Iacopo Panares Giovanna Ferrara Francesca Guida Livio Luongo Enza Palazzo Najet Srair Source Type: research
Insights Into the Role of Copper in Neurodegenerative Diseases and the Therapeutic Potential of Natural Compounds
Curr Neuropharmacol. 2023 Nov 15. doi: 10.2174/1570159X22666231103085859. Online ahead of print.ABSTRACTNeurodegenerative diseases encompass a collection of neurological disorders originating from the progressive degeneration of neurons, resulting in the dysfunction of neurons. Unfortunately, effective therapeutic interventions for these diseases are presently lacking. Copper (Cu), a crucial trace element within the human body, assumes a pivotal role in various biological metabolic processes, including energy metabolism, antioxidant defense, and neurotransmission. These processes are vital for the sustenance, growth, and d...
Source: Current Neuropharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: Guangcheng Zhong Xinyue Wang Jiaqi Li Zhouyuan Xie Qiqing Wu Jiaxin Chen Yiyun Wang Ziying Chen Xinyue Cao Tianyao Li Jinman Liu Qi Wang Source Type: research
Insights Into the Role of Copper in Neurodegenerative Diseases and the Therapeutic Potential of Natural Compounds
Curr Neuropharmacol. 2023 Nov 15. doi: 10.2174/1570159X22666231103085859. Online ahead of print.ABSTRACTNeurodegenerative diseases encompass a collection of neurological disorders originating from the progressive degeneration of neurons, resulting in the dysfunction of neurons. Unfortunately, effective therapeutic interventions for these diseases are presently lacking. Copper (Cu), a crucial trace element within the human body, assumes a pivotal role in various biological metabolic processes, including energy metabolism, antioxidant defense, and neurotransmission. These processes are vital for the sustenance, growth, and d...
Source: Current Neuropharmacology - December 1, 2023 Category: Drugs & Pharmacology Authors: Guangcheng Zhong Xinyue Wang Jiaqi Li Zhouyuan Xie Qiqing Wu Jiaxin Chen Yiyun Wang Ziying Chen Xinyue Cao Tianyao Li Jinman Liu Qi Wang Source Type: research
