Histaminergic System and Vestibular Function in Normal and Pathological Conditions
Curr Neuropharmacol. 2024 Mar 19. doi: 10.2174/1570159X22666240319123151. Online ahead of print.ABSTRACTMost neurotransmitter systems are represented in the central and peripheral vestibular system and are thereby involved both in normal vestibular signal processing and the pathophysiology of vestibular disorders. However, there is a special relationship between the vestibular system and the histaminergic system. The purpose of this review is to document how the histaminergic system interferes with normal and pathological vestibular function. In particular, we will discuss neurobiological mechanisms such as neuroinflammati...
Source: Current Neuropharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Brahim Tighilet Jessica Trico Emna Marouane Andreas Zwergal Christian Chabbert Source Type: research
Histaminergic System and Vestibular Function in Normal and Pathological Conditions
Curr Neuropharmacol. 2024 Mar 19. doi: 10.2174/1570159X22666240319123151. Online ahead of print.ABSTRACTMost neurotransmitter systems are represented in the central and peripheral vestibular system and are thereby involved both in normal vestibular signal processing and the pathophysiology of vestibular disorders. However, there is a special relationship between the vestibular system and the histaminergic system. The purpose of this review is to document how the histaminergic system interferes with normal and pathological vestibular function. In particular, we will discuss neurobiological mechanisms such as neuroinflammati...
Source: Current Neuropharmacology - March 20, 2024 Category: Drugs & Pharmacology Authors: Brahim Tighilet Jessica Trico Emna Marouane Andreas Zwergal Christian Chabbert Source Type: research
Boltzmann's Theorem Revisited: Inaccurate Time-to-Action Clocks in Affective Disorders
Curr Neuropharmacol. 2024 Mar 18. doi: 10.2174/1570159X22666240315100326. Online ahead of print.ABSTRACTTimely goal-oriented behavior is essential for survival and is shaped by experience. In this paper, a multileveled approach was employed, ranging from the polymorphic level through thermodynamic molecular, cellular, intracellular, extracellular, non-neuronal organelles and electrophysiological waves, attesting for signal variability. By adopting Boltzmann's theorem as a thermodynamic conceptualization of brain work, we found deviations from excitation-inhibition balance and wave decoupling, leading to wider signal variab...
Source: Current Neuropharmacology - March 19, 2024 Category: Drugs & Pharmacology Authors: Sari Goldstein Ferber Aron Weller Hermona Soreq Source Type: research
Boltzmann's Theorem Revisited: Inaccurate Time-to-Action Clocks in Affective Disorders
Curr Neuropharmacol. 2024 Mar 18. doi: 10.2174/1570159X22666240315100326. Online ahead of print.ABSTRACTTimely goal-oriented behavior is essential for survival and is shaped by experience. In this paper, a multileveled approach was employed, ranging from the polymorphic level through thermodynamic molecular, cellular, intracellular, extracellular, non-neuronal organelles and electrophysiological waves, attesting for signal variability. By adopting Boltzmann's theorem as a thermodynamic conceptualization of brain work, we found deviations from excitation-inhibition balance and wave decoupling, leading to wider signal variab...
Source: Current Neuropharmacology - March 19, 2024 Category: Drugs & Pharmacology Authors: Sari Goldstein Ferber Aron Weller Hermona Soreq Source Type: research
A Mechanistic Review on Protective Effects of Mangosteen and its Xanthones Against Hazardous Materials and Toxins
Curr Neuropharmacol. 2024 Mar 14. doi: 10.2174/1570159X22666240212142655. Online ahead of print.ABSTRACTDue to its pharmacological properties, α-Mangostin, mainly found in Garcinia mangostana (G. mangostana) L. (Mangosteen, queen of fruits), treats wounds, skin infections, and many other disorders. In fact, α-Mangostin and other xanthonoid, including β-Mangostin and γ-Mangostin, are found in G. mangostana, which have various advantages, namely neuroprotective, anti-proliferative, antinociceptive, antioxidant, pro-apoptotic, anti-obesity, anti-inflammatory, and hypoglycemic through multiple signaling mechanisms, for ins...
Source: Current Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Roghayeh Yahyazadeh Vafa Baradaran Rahimi Ahmad Yahyazadeh Vahid Reza Askari Source Type: research
Armodafinil as a Potential Pharmacological Treatment for Attention Deficit Hyperactivity Disorder in Adults: A Review
CONCLUSION: Armodafinil could be useful for the treatment of ADHD in adults, according to the review of the literature from both pre-clinical and clinical studies.PMID:38486390 | DOI:10.2174/1570159X22666240131121642 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Reyna Lamas-Aguilar Araceli Diaz-Ruiz Luz Navarro Ra úl Miranda-Ojeda Mar ía de Los Ángeles Martínez-Cárdenas Alfonso Mata-Bermudez Camilo Rios Source Type: research
A Mechanistic Review on Protective Effects of Mangosteen and its Xanthones Against Hazardous Materials and Toxins
Curr Neuropharmacol. 2024 Mar 14. doi: 10.2174/1570159X22666240212142655. Online ahead of print.ABSTRACTDue to its pharmacological properties, α-Mangostin, mainly found in Garcinia mangostana (G. mangostana) L. (Mangosteen, queen of fruits), treats wounds, skin infections, and many other disorders. In fact, α-Mangostin and other xanthonoid, including β-Mangostin and γ-Mangostin, are found in G. mangostana, which have various advantages, namely neuroprotective, anti-proliferative, antinociceptive, antioxidant, pro-apoptotic, anti-obesity, anti-inflammatory, and hypoglycemic through multiple signaling mechanisms, for ins...
Source: Current Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Roghayeh Yahyazadeh Vafa Baradaran Rahimi Ahmad Yahyazadeh Vahid Reza Askari Source Type: research
Armodafinil as a Potential Pharmacological Treatment for Attention Deficit Hyperactivity Disorder in Adults: A Review
CONCLUSION: Armodafinil could be useful for the treatment of ADHD in adults, according to the review of the literature from both pre-clinical and clinical studies.PMID:38486390 | DOI:10.2174/1570159X22666240131121642 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Reyna Lamas-Aguilar Araceli Diaz-Ruiz Luz Navarro Ra úl Miranda-Ojeda Mar ía de Los Ángeles Martínez-Cárdenas Alfonso Mata-Bermudez Camilo Rios Source Type: research
A Mechanistic Review on Protective Effects of Mangosteen and its Xanthones Against Hazardous Materials and Toxins
Curr Neuropharmacol. 2024 Mar 14. doi: 10.2174/1570159X22666240212142655. Online ahead of print.ABSTRACTDue to its pharmacological properties, α-Mangostin, mainly found in Garcinia mangostana (G. mangostana) L. (Mangosteen, queen of fruits), treats wounds, skin infections, and many other disorders. In fact, α-Mangostin and other xanthonoid, including β-Mangostin and γ-Mangostin, are found in G. mangostana, which have various advantages, namely neuroprotective, anti-proliferative, antinociceptive, antioxidant, pro-apoptotic, anti-obesity, anti-inflammatory, and hypoglycemic through multiple signaling mechanisms, for ins...
Source: Current Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Roghayeh Yahyazadeh Vafa Baradaran Rahimi Ahmad Yahyazadeh Vahid Reza Askari Source Type: research
Armodafinil as a Potential Pharmacological Treatment for Attention Deficit Hyperactivity Disorder in Adults: A Review
CONCLUSION: Armodafinil could be useful for the treatment of ADHD in adults, according to the review of the literature from both pre-clinical and clinical studies.PMID:38486390 | DOI:10.2174/1570159X22666240131121642 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - March 15, 2024 Category: Drugs & Pharmacology Authors: Reyna Lamas-Aguilar Araceli Diaz-Ruiz Luz Navarro Ra úl Miranda-Ojeda Mar ía de Los Ángeles Martínez-Cárdenas Alfonso Mata-Bermudez Camilo Rios Source Type: research
The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons
CONCLUSION: This study provides in vivo evidence that the multiphasic ChI response may require both top-down and bottom-up inputs. The findings suggest that the firing pattern of ChIs correlated to the iLFP might be a useful tool for estimating the degree of contribution of top-down and bottom-up inputs in regulating the firing activity of ChIs.PMID:38420787 | DOI:10.2174/1570159X22666231115151403 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Yan-Feng Zhang John N J Reynolds Source Type: research
The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons
CONCLUSION: This study provides in vivo evidence that the multiphasic ChI response may require both top-down and bottom-up inputs. The findings suggest that the firing pattern of ChIs correlated to the iLFP might be a useful tool for estimating the degree of contribution of top-down and bottom-up inputs in regulating the firing activity of ChIs.PMID:38420787 | DOI:10.2174/1570159X22666231115151403 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Yan-Feng Zhang John N J Reynolds Source Type: research
The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons
CONCLUSION: This study provides in vivo evidence that the multiphasic ChI response may require both top-down and bottom-up inputs. The findings suggest that the firing pattern of ChIs correlated to the iLFP might be a useful tool for estimating the degree of contribution of top-down and bottom-up inputs in regulating the firing activity of ChIs.PMID:38420787 | DOI:10.2174/1570159X22666231115151403 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Yan-Feng Zhang John N J Reynolds Source Type: research
The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons
CONCLUSION: This study provides in vivo evidence that the multiphasic ChI response may require both top-down and bottom-up inputs. The findings suggest that the firing pattern of ChIs correlated to the iLFP might be a useful tool for estimating the degree of contribution of top-down and bottom-up inputs in regulating the firing activity of ChIs.PMID:38420787 | DOI:10.2174/1570159X22666231115151403 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Yan-Feng Zhang John N J Reynolds Source Type: research
The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons
CONCLUSION: This study provides in vivo evidence that the multiphasic ChI response may require both top-down and bottom-up inputs. The findings suggest that the firing pattern of ChIs correlated to the iLFP might be a useful tool for estimating the degree of contribution of top-down and bottom-up inputs in regulating the firing activity of ChIs.PMID:38420787 | DOI:10.2174/1570159X22666231115151403 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - February 29, 2024 Category: Drugs & Pharmacology Authors: Yan-Feng Zhang John N J Reynolds Source Type: research
