Rethinking 'Innovation' in Psychiatry with Older and Newer Treatments: From Bench to Benchside
Curr Neuropharmacol. 2023;21(11):2176-2177. doi: 10.2174/1570159X2111230804161745.NO ABSTRACTPMID:37681661 | DOI:10.2174/1570159X2111230804161745 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 8, 2023 Category: Drugs & Pharmacology Authors: Domenico De Berardis Giovanni Martinotti Source Type: research

Rethinking 'Innovation' in Psychiatry with Older and Newer Treatments: From Bench to Benchside
Curr Neuropharmacol. 2023;21(11):2176-2177. doi: 10.2174/1570159X2111230804161745.NO ABSTRACTPMID:37681661 | DOI:10.2174/1570159X2111230804161745 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 8, 2023 Category: Drugs & Pharmacology Authors: Domenico De Berardis Giovanni Martinotti Source Type: research

Rethinking 'Innovation' in Psychiatry with Older and Newer Treatments: From Bench to Benchside
Curr Neuropharmacol. 2023;21(11):2176-2177. doi: 10.2174/1570159X2111230804161745.NO ABSTRACTPMID:37681661 | DOI:10.2174/1570159X2111230804161745 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - September 8, 2023 Category: Drugs & Pharmacology Authors: Domenico De Berardis Giovanni Martinotti Source Type: research

Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System
Curr Neuropharmacol. 2023 Aug 31. doi: 10.2174/1570159X21666230831163052. Online ahead of print.ABSTRACTThe ability of the brain to recognize and orient attention to relevant stimuli appearing in the visual field is highlighted by a tuning process, which involves modulating the early visual system by both cortical and subcortical brain areas. Selective attention is coordinated not only by the output of stimulus-based saliency maps but is also influenced by top-down cognitive factors, such as internal states, goals, or previous experiences. The basal ganglia system plays a key role in implicitly modulating the underlying me...
Source: Current Neuropharmacology - September 1, 2023 Category: Drugs & Pharmacology Authors: Matteo Esposito Sara Palermo Ylenia Camassa Nahi Marco Tamietto Alessia Celeghin Source Type: research

Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System
Curr Neuropharmacol. 2023 Aug 31. doi: 10.2174/1570159X21666230831163052. Online ahead of print.ABSTRACTThe ability of the brain to recognize and orient attention to relevant stimuli appearing in the visual field is highlighted by a tuning process, which involves modulating the early visual system by both cortical and subcortical brain areas. Selective attention is coordinated not only by the output of stimulus-based saliency maps but is also influenced by top-down cognitive factors, such as internal states, goals, or previous experiences. The basal ganglia system plays a key role in implicitly modulating the underlying me...
Source: Current Neuropharmacology - September 1, 2023 Category: Drugs & Pharmacology Authors: Matteo Esposito Sara Palermo Ylenia Camassa Nahi Marco Tamietto Alessia Celeghin Source Type: research

Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System
Curr Neuropharmacol. 2023 Aug 31. doi: 10.2174/1570159X21666230831163052. Online ahead of print.ABSTRACTThe ability of the brain to recognize and orient attention to relevant stimuli appearing in the visual field is highlighted by a tuning process, which involves modulating the early visual system by both cortical and subcortical brain areas. Selective attention is coordinated not only by the output of stimulus-based saliency maps but is also influenced by top-down cognitive factors, such as internal states, goals, or previous experiences. The basal ganglia system plays a key role in implicitly modulating the underlying me...
Source: Current Neuropharmacology - September 1, 2023 Category: Drugs & Pharmacology Authors: Matteo Esposito Sara Palermo Ylenia Camassa Nahi Marco Tamietto Alessia Celeghin Source Type: research

Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System
Curr Neuropharmacol. 2023 Aug 31. doi: 10.2174/1570159X21666230831163052. Online ahead of print.ABSTRACTThe ability of the brain to recognize and orient attention to relevant stimuli appearing in the visual field is highlighted by a tuning process, which involves modulating the early visual system by both cortical and subcortical brain areas. Selective attention is coordinated not only by the output of stimulus-based saliency maps but is also influenced by top-down cognitive factors, such as internal states, goals, or previous experiences. The basal ganglia system plays a key role in implicitly modulating the underlying me...
Source: Current Neuropharmacology - September 1, 2023 Category: Drugs & Pharmacology Authors: Matteo Esposito Sara Palermo Ylenia Camassa Nahi Marco Tamietto Alessia Celeghin Source Type: research

Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System
Curr Neuropharmacol. 2023 Aug 31. doi: 10.2174/1570159X21666230831163052. Online ahead of print.ABSTRACTThe ability of the brain to recognize and orient attention to relevant stimuli appearing in the visual field is highlighted by a tuning process, which involves modulating the early visual system by both cortical and subcortical brain areas. Selective attention is coordinated not only by the output of stimulus-based saliency maps but is also influenced by top-down cognitive factors, such as internal states, goals, or previous experiences. The basal ganglia system plays a key role in implicitly modulating the underlying me...
Source: Current Neuropharmacology - September 1, 2023 Category: Drugs & Pharmacology Authors: Matteo Esposito Sara Palermo Ylenia Camassa Nahi Marco Tamietto Alessia Celeghin Source Type: research

Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System
Curr Neuropharmacol. 2023 Aug 31. doi: 10.2174/1570159X21666230831163052. Online ahead of print.ABSTRACTThe ability of the brain to recognize and orient attention to relevant stimuli appearing in the visual field is highlighted by a tuning process, which involves modulating the early visual system by both cortical and subcortical brain areas. Selective attention is coordinated not only by the output of stimulus-based saliency maps but is also influenced by top-down cognitive factors, such as internal states, goals, or previous experiences. The basal ganglia system plays a key role in implicitly modulating the underlying me...
Source: Current Neuropharmacology - September 1, 2023 Category: Drugs & Pharmacology Authors: Matteo Esposito Sara Palermo Ylenia Camassa Nahi Marco Tamietto Alessia Celeghin Source Type: research

Use of Post-mortem Brain Tissue in Investigations of Obsessive- Compulsive Disorder: A Systematic Review
CONCLUSION: Included studies highlight the potential value of post-mortem brains from well-characterized individuals with OCD and suggest the need for additional work in this area.PMID:37644747 | DOI:10.2174/1570159X21666230829145425 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 30, 2023 Category: Drugs & Pharmacology Authors: Christine Lochner Petrus J W Naud é Dan J Stein Source Type: research

Recombinant Antibody Fragments for Neurological Disorders: An Update
Curr Neuropharmacol. 2023 Aug 30. doi: 10.2174/1570159X21666230830142554. Online ahead of print.ABSTRACTRecombinant antibody fragments are promising alternatives to full-length immunoglobulins, creating big opportunities for the pharmaceutical industry. Nowadays, antibody fragments such as antigen-binding fragments (Fab), single-chain fragment variable (scFv), single-domain antibodies (sdAbs), and bispecific antibodies (bsAbs) are being evaluated as diagnostics or therapeutics in pre-clinical models and in clinical trials. Immunotherapy approaches, including passive transfer of protective antibodies, have shown therapeutic...
Source: Current Neuropharmacology - August 30, 2023 Category: Drugs & Pharmacology Authors: Karen Manoutcharian Goar Gevorkian Source Type: research

Use of Post-mortem Brain Tissue in Investigations of Obsessive- Compulsive Disorder: A Systematic Review
CONCLUSION: Included studies highlight the potential value of post-mortem brains from well-characterized individuals with OCD and suggest the need for additional work in this area.PMID:37644747 | DOI:10.2174/1570159X21666230829145425 (Source: Current Neuropharmacology)
Source: Current Neuropharmacology - August 30, 2023 Category: Drugs & Pharmacology Authors: Christine Lochner Petrus J W Naud é Dan J Stein Source Type: research

Recombinant Antibody Fragments for Neurological Disorders: An Update
Curr Neuropharmacol. 2023 Aug 30. doi: 10.2174/1570159X21666230830142554. Online ahead of print.ABSTRACTRecombinant antibody fragments are promising alternatives to full-length immunoglobulins, creating big opportunities for the pharmaceutical industry. Nowadays, antibody fragments such as antigen-binding fragments (Fab), single-chain fragment variable (scFv), single-domain antibodies (sdAbs), and bispecific antibodies (bsAbs) are being evaluated as diagnostics or therapeutics in pre-clinical models and in clinical trials. Immunotherapy approaches, including passive transfer of protective antibodies, have shown therapeutic...
Source: Current Neuropharmacology - August 30, 2023 Category: Drugs & Pharmacology Authors: Karen Manoutcharian Goar Gevorkian Source Type: research

Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis
Curr Neuropharmacol. 2023 Aug 24. doi: 10.2174/1570159X21666230824091601. Online ahead of print.ABSTRACTAmyotrophic Lateral Sclerosis (ALS) is the most common, adult-onset, progressive motor neurodegenerative disorder that results in death within 3 years of the clinical diagnosis. Due to the clinicopathological heterogeneity, any reliable biomarkers for diagnosis or prognosis of ALS have not been identified till date. Moreover, the only three clinically approved treatments are not uniformly effective in slowing the disease progression. Over the last 15 years, there has been a rapid advancement in research on the complex pa...
Source: Current Neuropharmacology - August 25, 2023 Category: Drugs & Pharmacology Authors: Bedaballi Dey Arvind Kumar Anant Bahadur Patel Source Type: research

Pathomechanistic Networks of Motor System Injury in Amyotrophic Lateral Sclerosis
Curr Neuropharmacol. 2023 Aug 24. doi: 10.2174/1570159X21666230824091601. Online ahead of print.ABSTRACTAmyotrophic Lateral Sclerosis (ALS) is the most common, adult-onset, progressive motor neurodegenerative disorder that results in death within 3 years of the clinical diagnosis. Due to the clinicopathological heterogeneity, any reliable biomarkers for diagnosis or prognosis of ALS have not been identified till date. Moreover, the only three clinically approved treatments are not uniformly effective in slowing the disease progression. Over the last 15 years, there has been a rapid advancement in research on the complex pa...
Source: Current Neuropharmacology - August 25, 2023 Category: Drugs & Pharmacology Authors: Bedaballi Dey Arvind Kumar Anant Bahadur Patel Source Type: research