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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Acute Injection of Omega-3 Triglyceride Emulsion Provides Very Similar Protection as Hypothermia in a Neonatal Mouse Model of Hypoxic-Ischemic Brain Injury
Therapeutic hypothermia (HT) is a currently accepted treatment for neonatal asphyxia and is a promising strategy in adult stroke therapy. We previously reported that acute administration of docosahexaenoic acid (DHA) triglyceride emulsion (tri-DHA) protects against hypoxic-ischemic (HI) injury in neonatal mice. We questioned if co-treatment with HT and tri-DHA would achieve synergic effects in protecting the brain from HI injury. Neonatal mice (10-day old) subjected to HI injury were placed in temperature-controlled chambers for 4 h of either HT (rectal temperature 31–32°C) or normothermia (NT, rectal temperature 37°C)...
Source: Frontiers in Neurology - January 15, 2021 Category: Neurology Source Type: research

A Systematic Review and Meta-Analysis of Animal Studies Testing Intra-Arterial Chilled Infusates After Ischemic Stroke
Conclusion: Despite convincing evidence of benefit in ischemic stroke models, additional studies are required to determine the scope of benefit, especially when considering additional elements (e.g., dosing characteristics). As there is interest in using this treatment alongside current ischemic stroke therapies, more relevant animal studies will be critical to inform patient studies.
Source: Frontiers in Neurology - January 6, 2021 Category: Neurology Source Type: research

Approaches in Prehospital Sepsis Screening
Discussion In the United States, sepsis is one of the leading causes of death, which requires timely identification and proper treatment (CDC, 2019; Guerra et al., 2020; Polito et al., 2015). Based upon a review of literature conducted from 2014 to 2018, the primary investigators could locate five prehospital EMS screening tools to assist EMS providers in identifying at-risk sepsis patients. The researchers explored how the modified SIRS and qSOFA scoring systems were used in hospital settings in addition to these five prehospital EMS screening tools. The Bas 90-30-90, Guerra, PRESEP, PRESS, and Robson tools have ove...
Source: JEMS Operations - January 5, 2021 Category: Emergency Medicine Authors: JEMS Staff Tags: Exclusives Patient Care EMS EMT Paramedic Prehospital Sepsis Source Type: news

Selective Brain Hypothermia in Acute Ischemic Stroke: Reperfusion Without Reperfusion Injury
In acute ischemic stroke, early recanalization of the occluded artery is crucial for best outcome to be achieved. Recanalization aims at restoring blood flow to the ischemic tissue (reperfusion) and is achieved with pharmacological thrombolytic drugs, endovascular thrombectomy (EVT) devices, or both. The introduction of modern endovascular devices has led to tremendous anatomical and clinical success with rates of substantial reperfusion exceeding 80% and proven clinical benefit in patients with anterior circulation large vessel occlusions (LVOs). However, not every successful reperfusion procedure leads to the desired cli...
Source: Frontiers in Neurology - November 13, 2020 Category: Neurology Source Type: research

Minimally Invasive Aortic Arch Repair: Technical Considerations and Mid-Term Outcomes.
CONCLUSION: Minimal invasive aortic arch repair through an upper mini-sternotomy can be safely performed, with early and mid-term outcomes well comparable to series performed through a standard median sternotomy. PMID: 33234206 [PubMed - in process]
Source: The Heart Surgery Forum - October 27, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Risteski P, Radwan M, Boshkoski G, Salem R, Iavazzo A, Walther T, Esposito G Tags: Heart Surg Forum Source Type: research

Continuous cerebral and myocardial selective perfusion in neonatal aortic arch surgery
ConclusionCCMSP is a safe and reproducible strategy for cerebral, myocardial and visceral protection in neonatal aortic arch repair, with or without VSD closure, resulting in low complication and mortality.
Source: Journal of Cardiac Surgery - October 21, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Pierre Maminirina, Carine Pavy, Pierre Bourgoin, Olivier Baron Tags: ORIGINAL ARTICLE Source Type: research

Acute basilar artery occlusion with recurrent shivering: A case report
Rationale: Shivering is an important physiological response of the body that causes muscle tremors to maintain temperature homeostasis. Traumatic brain injuries that affect the hypothalamus cause hypothermia, and physical removal of suprasellar tumors causes thermoregulation imbalance. However, no study has reported shivering due to ischemic stroke. Patient concerns: A 58-year-old male patient was admitted to our emergency department to evaluate severe stenosis of the basilar artery. While waiting for further examination, he exhibited coarse shivering and severe dysarthria. Diagnosis: Brain computed tomography angi...
Source: Medicine - September 25, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

The expression of the cold shock protein RNA binding motif protein 3 is transcriptionally responsive to organ temperature in mice.
CONCLUSION: The study may present the possibility that organ temperature-induced alterations in gene expression are organ specific in homeotherms and the possibility that organ temperature-induced alterations in gene expression are transcriptionally regulated in some organs of homeotherms. PMID: 32972335 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - September 23, 2020 Category: Biochemistry Authors: Ushio A, Eto K Tags: Protein Pept Lett Source Type: research

Mild Systemic Hypothermic Circulatory Arrest Using a Frozen Elephant Trunk Graft with Endo-Balloon Occlusion for Total Arch Replacement.
CONCLUSION: FET using an endo-balloon occlusion with mild hypothermia is a safe and an effective approach in TAR. PMID: 32990573 [PubMed - as supplied by publisher]
Source: The Heart Surgery Forum - September 22, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Goto Y, Hosoba S, Fukumoto Y, Takagi S, Yanagisawa J Tags: Heart Surg Forum Source Type: research

Intraoperative factors contributory to myocardial injury in high-risk patients undergoing abdominal surgery in a South Indian population
Conclusions: Female patients with CAD undergoing abdominal surgery, needing vasopressors and transfusion of plasma are at high risk for MINS with higher hospital mortality and merit vigilant monitoring postoperatively.
Source: Indian Journal of Anaesthesia - August 31, 2020 Category: Anesthesiology Authors: G Gopan Lakshmi Kumar Anjana Rajan Babu Abish Sudhakar Rubin George Vidya P Menon Source Type: research