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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Neurocritical Care of the Pregnant Patient
AbstractPurpose of reviewTo summarize recent changes in management and emerging therapies for pregnant neurocritical care patients.Recent findingsDiagnostic and treatment options for managing neurologic emergencies in pregnant patients have expanded with both greater understanding of the effects of imaging modalities and medications on pregnancy and application of standard treatments for non-pregnant patients to pregnant populations. Specifically, this includes cerebrovascular diseases (pregnancy-associated ischemic stroke, pregnancy-associated intracerebral hemorrhage, cerebral venous sinus thrombosis), post-maternal card...
Source: Current Treatment Options in Neurology - June 21, 2021 Category: Neurology Source Type: research

A System for Continuous Pre- to Post-reperfusion Intra-carotid Cold Infusion for Selective Brain Hypothermia in Rodent StrokeModels
AbstractIntra-carotid cold infusion (ICCI) appears as a promising method for hypothermia-mediated brain protection from ischemic stroke. Recent clinical pilot studies indicate easy implementation of ICCI into endovascular acute ischemic stroke treatment. Current rodent ICCI-in-stroke models limit ICCI to the post-reperfusion phase. To establish a method for continuous ICCI over the duration of intra-ischemia to post-reperfusion in rodent stroke models, a novel system was developed. Eighteen male Sprague-Dawley rats were included. Intraluminal filament method was used for transient middle cerebral artery occlusion (MCAO). N...
Source: Translational Stroke Research - June 18, 2021 Category: Neurology Source Type: research

Early and long-term results of hypothermic circulatory arrest in aortic surgery: a 20-year single-centre experience
Aims The aim of this study was to document the postoperative outcomes of patients who underwent hypothermic circulatory arrest (HCA), the evolution of HCA management over time and to identify the risks factor for early mortality and postoperative stroke. Methods Four hundred and twenty-four patients who underwent aortic surgery with HCA at our institution between January 1995 and June 2016 were consecutively included. Results The main indications were degenerative aneurysm (254; 59.9%) and acute type A aortic dissection (146; 34.4%). Interventions were performed under deep (18.4 ± 0.9°C; n = 350...
Source: Journal of Cardiovascular Medicine - June 15, 2021 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Targeted Temperature Management at 36  °C Shows Therapeutic Effectiveness via Alteration of Microglial Activation and Polarization After Ischemic Stroke
AbstractIschemic injury leads to cell death and inflammatory responses after stroke. Microglia especially play a crucial role in this brain inflammation. Targeted temperature management (TTM) at 33  °C has shown neuroprotective effects against many acute ischemic injuries. However, it has also shown some adverse effects in preclinical studies. Therefore, we explored the neuroprotective effect of TTM at 36 °C in the ischemic brain. To confirm the neuroprotective effects of hypothermia, mice were subjected to a permanent stroke and then treated with one of the TTM paradigms at 33 and 36 °C. For comparison of TTM at 33 ...
Source: Translational Stroke Research - April 24, 2021 Category: Neurology Source Type: research

Chlorpromazine and promethazine reduces Brain injury through RIP1-RIP3 regulated activation of NLRP3 inflammasome following ischemic stroke
Conclusion: These findings suggest that the anti-inflammatory effect of C + P may be dependent on drug-induced hypothermia and regulation of the NLRP3 inflammasome via the RIP1/RIP3 complex. Future investigations are needed regarding C + P as potential treatment of ischemic stroke.PMID:33829970 | DOI:10.1080/01616412.2021.1910904
Source: Neurological Research - April 8, 2021 Category: Neurology Authors: Qian Jiang M élissa Wills Xiaokun Geng Yuchuan Ding Source Type: research

Hypothermia Protects Mice Against Ischemic Stroke by Modulating Macrophage Polarization Through Upregulation of Interferon Regulatory Factor-4
Source: Journal of Inflammation Research - April 7, 2021 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research

An Inhibitory and Beneficial Effect of Chlorpromazine and Promethazine (C+P) on Hyperglycolysis through HIF-1 α Regulation in Ischemic Stroke
CONCLUSION: C+P, partially depending on hypothermia, attenuates hyperglycolysis and NOX activation through HIF-1α regulation.PMID:33811844 | DOI:10.1016/j.brainres.2021.147463
Source: Brain Research - April 3, 2021 Category: Neurology Authors: Sichao Guo Eric Cosky Fengwu Li Longfei Guan Yu Ji Wenjing Wei Changya Peng Xiaokun Geng Yuchuan Ding Source Type: research

Mild hypothermia protects rat cortical neurons against oxygen-glucose deprivation/reoxygenation injury via the PI3K/Akt pathway
Ischemic stroke is the most frequent cause of long-term morbidity and mortality in the elderly worldwide. Mild hypothermia (32–35°C) has been found to have a neuroprotective effect against ischemic stroke. However, the protective mechanisms remain unclear. In the present study, we explore the neuroprotective effect of mild hypothermia in neuron-astrocyte cocultures by oxygen-glucose deprivation/reoxygenation (OGD/R) as well as the underlying mechanisms. Thionin staining was performed and cell viability, extracellular glutamate concentration and the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) pathway-relate...
Source: NeuroReport - March 3, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Neuroprotective Effects of Early Hypothermia Induced by Phenothiazines and DHC in Ischemic Stroke.
Conclusion: Both interischemia and inter-reperfusion pharmacological hypothermia treatments play a role in neuroprotection after stroke. Interischemia hypothermia treatment may be better able to induce stronger neuroprotection after ischemic stroke. This study provides a new avenue and reference for stronger neuroprotective hypothermia before vascular recanalization in stroke patients. PMID: 33531913 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - February 4, 2021 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Selective-cerebral-hypothermia-induced neuroprotection against-focal cerebral ischemia/reperfusion injury is associated with an increase in SUMO2/3 conjugation.
In this study, we investigated the effect of selective cerebral hypothermia on SUMO2/3 conjugation during focal cerebral I/R injury. A total of 140 Sprague-Dawley rats were divided into four groups. In the sham group, only the carotid artery was exposed. The endoluminal filament technique was used to induce middle cerebral artery occlusion in the other three groups. After 2 hours of occlusion, the filaments were slowly removed to allow blood reperfusion in the I/R group. In the hypothermia (HT) group and normothermia (NT) group, normal saline at 4°C and 37°C, respectively , was perfused through the carotid artery, follow...
Source: Brain Research - February 1, 2021 Category: Neurology Authors: Sun G, Qin W, Wang Q, Sun X, Chen H, Li J, Sun L, Shi F, Zhang G, Wang M Tags: Brain Res Source Type: research

Selective Brain Hypothermia for Ischemic MCA-M1 Stroke: Influence of Cerebral Arterial Circulation in a 3D Brain Temperature Model
Acute ischemic stroke is a major health problem with a high mortality rate and a high risk for permanent disabilities. Selective brain hypothermia has the neuroprotective potential to possibly lower cerebral harm. A recently developed catheter system enables to combine endovascular blood cooling and thrombectomy using the same endovascular access. By using the penumbral perfusion via leptomeningeal collaterals, the catheter aims at enabling a cold reperfusion, which mitigates the risk of a reperfusion injury. However, cerebral circulation is highly patient-specific and can vary greatly. Since direct measurement of remainin...
Source: IEEE Transactions on Biomedical Engineering - January 22, 2021 Category: Biomedical Engineering Source Type: research