Repeated infusion of levosimendan in outpatients with advanced heart failure: to cure sometimes, to relieve often, and to comfort always
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Letters to the editor Source Type: research

Repetitive levosimendan in outpatients affected by advanced heart failure: the need for a uniform approach
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Letters to the editor Source Type: research

Feasibility of effective atomic number assessment in coronary intervention for chronic total occlusion
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research letter Source Type: research

Ischemic dilated cardiomyopathy complicating Tetralogy of Fallot
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

Takotsubo syndrome and electrical storm following electrical cardioversion of atrial fibrillation: cause, consequence or both?
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Case report Source Type: research

Pacemaker need after sutureless aortic valve replacement: the role of the learning curve
Aim Aortic valve replacement (AVR) using sutureless prosthesis is a reasonable alternative in those patients with aortic stenosis who would benefit from reduced cross clamp time, such as elderly and high-risk patients. Actually, excellent performances have been demonstrated in hemodynamic outcomes and safety, but some questions remain open regarding long-term durability and the need for postoperative pacemaker implantation. Methods Between January 2014 and August 2019, all 436 patients [male 40.6%, median age 78 years interquartile range (73–82)] treated with sutureless AVR with a Perceval prosthesis were ...
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

A cohort study examining urgent and emergency treatment for decompensated severe aortic stenosis
Aims We compared strategies in the treatment of decompensated severe aortic stenosis. The hypothesis was that undertaking urgent or emergency transcatheter aortic valve implantation (TAVI) directly in such patients is safer and more effective than urgent or emergency balloon aortic valvuloplasty (BAV) followed by elective TAVI or surgical aortic valve replacement (SAVR). Methods This was a single-centre retrospective study including all consecutive patients who underwent urgent or emergency BAV or TAVI for decompensated severe aortic stenosis between September 2014 and February 2018. Primary endpoints were 30-da...
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Frequency, predictors and prognostic impact of implantable cardioverter defibrillator shocks in a primary prevention population with heart failure and reduced ejection fraction
Aims The role of the implantable cardioverter defibrillator (ICD) in primary prevention real-world population is debated. We sought to evaluate the incidence, predictors and prognostic impact of ICD shocks in consecutive heart failure patients implanted for primary prevention at our tertiary institution. Methods and results We retrospectively selected a sample of 497 patients (mean age 64.8 years, 82.1% men, average left ventricular ejection fraction, LVEF, 27.1%). At long-term follow-up (median time 70.4 months), total mortality was 40.8%, and 16.5% of patients had received at least one appropriate shock (3.12%...
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Arrhythmic event prediction in patients with heart failure and reduced ejection fraction
Aims Implantable cardioverter defibrillator (ICD) is an effective treatment to reduce mortality in patients with symptomatic heart failure and left ventricular ejection fraction (LVEF) 35% or less. LVEF presents a low sensitivity for predicting arrhythmic events. Aim of this study was to identify predictors of sustained ventricular arrhythmias (SVAs), overall and according to the cause of heart failure. Methods Single-center, retrospective, cohort study of 193 patients (51 nonischemic and 142 ischemic) with chronic heart failure and LVEF less than 35% who had received ICD for primary prevention of sudden cardiac...
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Clinical and electrocardiographic features of patients with myocardial infarction with non-obstructive coronary artery disease (MINOCA)
This study aimed to evaluate clinical and ECG characteristics of MINOCA in a large cohort of patients admitted for acute coronary syndrome. Methods All coronary angiograms performed at the University Heart Center in Zurich (Switzerland) between 2012 and 2016 were investigated. MINOCA was defined according to European Society of Cardiology guidelines and patients were divided into two groups, based on the presence or absence of coronary sclerosis at angiogram[nonobstructive coronary artery disease (noCAD) and normal coronary arteries (NCA)]), after exclusion of myocarditis and Takotsubo syndrome. Results Out o...
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research articles: Editorial comment Source Type: research

Sirolimus-coated balloons: ready for primetime in real world patients?
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research articles: Editorial comment Source Type: research

Clinical performance of a novel sirolimus-coated balloon in coronary artery disease: EASTBOURNE registry
Conclusion The current interim analysis of 12-month follow-up of the EASTBOURNE registry shows good immediate performance and an adequate and encouraging safety profile through 12 months for this novel SCB. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research

Cardiac resynchronization therapy: variations across Europe in implant rates and types of implanted devices
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Editorial comment Source Type: research

Pathophysiology and management of recreational drug-related acute coronary syndrome: ANMCO position statement
Recreational drug use may cause coronary artery disease through several mechanisms. An increasing number of young patients with drug-related acute coronary syndrome have been reported over recent years. The present position statement reports the most recent epidemiological data on acute coronary syndrome in the setting of drug abuse, describes the main pathophysiological mechanisms underlying coronary artery disease and acute events in these patients, and provides practical recommendations on management and an overview of prognosis. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Position paper Source Type: research

Are women really more affected by vasovagal syncope than men?
It is commonly reported that vasovagal syncope (VVS) is more frequent in women. Presently, this issue has never been investigated. The purpose of this review was to evaluate, through an extensive review of the literature, whether women are really more affected by VVS than men. The gender distribution was investigated in individuals with classical and nonclassical VVS. The database PubMed was searched using the terms ‘syncope’, ‘vasovagal syncope’, ‘neurally mediated syncope’ and ‘tilt testing’. Twelve studies dealing with classical and 75 with nonclassical VVS were eligible. ...
Source: Journal of Cardiovascular Medicine - January 7, 2021 Category: Cardiology Tags: Review article Source Type: research

Left ventricular wall stress is associated with myocardial functional recovery in patients with severe aortic stenosis and systolic dysfunction undergoing transcatheter aortic valve replacement
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research letter Source Type: research

Infundibular ventricular septal defect: a dangerous ‘hole’ for the aortic valve
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

A novel missense mutation for Fabry disease detected by echocardiographic screening in left ventricular hypertrophy patients
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Case report Source Type: research

A very long-term observation of a family with dilated cardiomyopathy and overlapping phenotype from lamin A/C mutation
Conclusion In lamin A/C gene mutation carriers, a strict, multidisciplinary follow-up allows the opportunity to monitor the progress of the disease and to intervene precociously with the best available treatments. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Phenotypic clustering of heart failure with preserved ejection fraction reveals different rates of hospitalization
Conclusion This study demonstrated that clustering can be used to characterize subgroups of patients with newly identified HFpEF, assess differences in heart failure related hospitalization rates at 1 year and suggest patient subtypes may respond differently to treatments or interventions. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Sex-related differences in chronic heart failure: a community-based study
Conclusion In a community-based heart failure cohort, females were differently distributed within heart failure phenotypes and they presented some different characteristics across ejection fraction categories. Although in an unadjusted model there was no significant difference for adverse outcomes, in an adjusted model females showed a lower risk of mortality in HFpEF and HFmrEF. Concerning sex-related prognostic risk factors, noncardiac comorbidities significantly affected adverse prognosis in females with HFpEF. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Characteristics and hospital course of patients admitted for acute cardiovascular diseases during the coronavirus disease-19 outbreak
Introduction During the coronavirus disease-19 (COVID-19) outbreak in spring 2020, people may have been reluctant to seek medical care fearing infection. We aimed to assess the number, characteristics and in-hospital course of patients admitted for acute cardiovascular diseases during the COVID-19 outbreak. Methods We enrolled all consecutive patients admitted urgently for acute myocardial infarction, heart failure or arrhythmias from 1 March to 31 May 2020 (outbreak period) and 2019 (control period). We evaluated the time from symptoms onset to presentation, clinical conditions at admission, length of hospitali...
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Coronary stent thickness: thinner is (always) better for all lesions?
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study
Conclusion In this real-world population, patients being treated for small vessels lesions with thinner strut stents had lower rates of TLF, MI and ST. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research articles: Coronary disease Source Type: research

Clinical characteristics and treatment of Spontaneous Coronary Artery Dissection in Young Women Undergoing Percutaneous Coronary Intervention
Conclusion SCAD was not uncommon among young Japanese women requiring percutaneous coronary intervention. Patients with SCAD exhibited fewer coronary risk factors and more precipitating factors than those without SCAD, and long-term clinical outcomes after an early period appeared to be favorable. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Research articles: Coronary disease Source Type: research

Resilience and response of the congenital cardiac network in Italy during the COVID-19 pandemic
The worldwide response to the current COVID-19 pandemic has been focused on how to prevent the disease and to protect the high-risk patient from a potentially lethal infection. Several consensus and guidelines articles have been published dealing with the cardiac patient with systemic hypertension, heart transplant or heart failure. Very little is known about the patients, both in the pediatric as well as in the adult age, with congenital heart disease. The peculiar physiology of the heart with a native, repaired or palliated congenital heart defect deserves a specialized care. Hereby we describe the early recommendations ...
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Position paper Source Type: research

Colchicine for the treatment of cardiovascular diseases: old drug, new targets
Well known in past centuries as a herbal remedy for osteoarticular pain and commonly used in the treatment of gout and familial Mediterranean fever, colchicine has an emerging role in the setting of cardiovascular diseases. Its unique properties not only target the key mechanisms of recurrent inflammation underlying pericardial syndromes but also inflammation within atherosclerotic plaques, atrial fibrillation recurrence and adverse ventricular remodelling leading to heart failure. The effect of colchicine in the treatment of cardiovascular diseases along with essential pharmacology will be discussed, reviewing the most...
Source: Journal of Cardiovascular Medicine - December 16, 2020 Category: Cardiology Tags: Review Source Type: research

Impact of complete revascularization on mortality in patients with ST-segment elevation myocardial infarction and multivessel disease: an updated meta-analysis
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Research letter Source Type: research

Immediate failure of a valve-sparing procedure: repair with a Perceval sutureless prosthesis
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Case report Source Type: research

Prevalence and prognostic impact of nonischemic late gadolinium enhancement in stress cardiac magnetic resonance
Conclusion NI-LGE can be detected in 11% of patients during stress-CMR providing a diagnosis of nonischemic cardiac disease. Patients with NI-LGE have worse prognosis than those with no-LGE. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Research articles: Imaging Source Type: research

Fast-track ruling in/out SARS-CoV-2 infection with rapid 0/1.5 h molecular test in patients with acute coronary syndromes
Conclusion This study demonstrates that 0–1.5 h fast-track triage for coronavirus disease 2019 (COVID 19) is feasible in patients with ACS. The execution of nasopharyngeal swab in the cath lab and its analysis with a rapid molecular test allows rapid stratification of SARS-CoV-2 infection. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Transcatheter therapies for tricuspid valve regurgitation
Tricuspid regurgitation, either isolated or associated with left-valve disease, has a strong impact on outcome. Surgical treatment of tricuspid regurgitation has increased in recent years, but in-hospital mortality remains high probably due to the risk profile of the recipients. As a consequence, most of the patients with severe tricuspid regurgitation, especially if isolated, remain untreated. Transcatheter tricuspid valve interventions are rapidly spreading as alternative options to open-heart procedures fulfilling this important unmet need. Although patient selection and timing of intervention are unclear, many devices ...
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Reviews Source Type: research

The combined measurement of high-sensitivity cardiac troponins and natriuretic peptides: a useful tool for clinicians?
An enormous amount of experimental and clinical evidence has clearly shown that the measurement of cardio-specific biomarkers is able to significantly and independently improve the diagnostic accuracy and risk stratification in cardiovascular diseases. Furthermore, many recent studies have reported that the measurement of cardio-specific biomarkers has a positive impact also on the management and outcome of patients with cardiovascular diseases. Considering the significant and independent information associated with cardio-specific biomarkers, several studies have recently reported that the combined dosage of natriuretic p...
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Reviews Source Type: research

Acute coronary syndromes in cancer patients
Cardiovascular disease and cancer are responsible for the majority of deaths in the Western world. These two entities share common risk factors and their intersection will be more and more frequent in future due to general population aging and long-term cancer control. Clinical presentation, management and outcome of acute coronary syndromes (ACS) in cancer patients could differ from noncancer ones. Cancer patients were frequently excluded from clinical trials and so the paucity of data further complicates the scenario. The management of ACS in cancer patients represents a unique setting in which the risk/benefit ratio of ...
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Reviews Source Type: research

Management of nonischemic-dilated cardiomyopathies in clinical practice: a position paper of the working group on myocardial and pericardial diseases of Italian Society of Cardiology
Nonischemic-dilated cardiomyopathy (NIDCM) is an entity that gathers extremely heterogeneous diseases. This awareness, although leading to continuous improvement in survival, has increased the complexity of NIDCM patients’ management. Even though the endorsed ‘red-flags’ approach helps clinicians in pursuing an accurate etiological definition in clinical practice, it is not clear when and how peripheral centers should interact with referral centers with specific expertise in challenging scenarios (e.g. postmyocarditis and genetically determined dilated cardiomyopathy) and with easier access to second-line...
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Position paper Source Type: research

Highlights in valvular heart diseases
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - November 13, 2020 Category: Cardiology Tags: Viewpoint Source Type: research

Low hospitalization rate without severe arrhythmias: a prospective survey on 350 patients early home treated with hydroxychloroquine during COVID-19 pandemic
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research letters Source Type: research

Efficacy and safety of repeated infusion of levosimendan in outpatients with advanced heart failure: a real-world experience
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research letters Source Type: research

Early prenatal diagnosis of right ventricular myocardial sinusoidal-coronary artery connections in pulmonary atresia with intact septum
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

Aortic dissection during heart transplant: when a nightmare comes true
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Case reports Source Type: research

A curious ST-segment elevation case in a young man: a challenging diagnosis
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Case reports Source Type: research

Low vitamin D levels affect left ventricular wall thickness in severe aortic stenosis
Conclusion Among patients with severe degenerative aortic stenosis, vitamin D deficiency is common. We found a significant association between left ventricular wall thickness and vitamin D levels, suggesting a potential role of this hormone in modulating hypertrophic remodelling in these patients. However, future larger studies are certainly needed to confirm our findings and to define their prognostic implications. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis
Conclusion Patients with asymptomatic aortic valve stenosis have lower odds of all-cause and cardiovascular mortality when managed with early-AVR compared with conservative management. However, because of significant heterogeneity in the classification of asymptomatic patients, large scale studies are required. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Predictors of infection-related rehospitalization in heart failure patients and its impact on long-term survival
Conclusion IRRHs in patients discharged for acute decompensated heart fail independently predicted worse long-term survival. We further identified independent predictors of IRRHs. These findings warrant future studies for tackling IRRH. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Sacubitril/valsartan use in a real-world population of patients with heart failure and reduced ejection fraction
Conclusion In our experience, more than one-third of the patients were able to tolerate the higher dose of sacubitril/valsartan, and these patients were younger, had higher Hb, and better BP and renal function. MECKI score stratification was useful to discriminate patients who continued treatment from those who did not. Future prospective studies should test if these clinical variables can guide the up-titration of sacubitril/valsartan. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Impact of COVID-2019 outbreak on prevalence, clinical presentation and outcomes of ST-elevation myocardial infarction
Aims The aim of this study was to report the prevalence, clinical features and outcomes of patients with ST-elevation myocardial infarction (STEMI) hospitalized during the Corona-Virus Disease 2019 (COVID-19) outbreak compared with those admitted in a previous equivalent period. Methods and results Eighty-five patients admitted for STEMI at a high-volume Italian centre were included. Patients hospitalized during the COVID-19 outbreak (21 February–10 April 2020) (40%) were compared with those admitted in pre-COVID-19 period (3 January–20 February 2020) (60%). A 43% reduction in STEMI admissions was observed...
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Impact of the COVID-19 pandemic on coronary invasive procedures at two Italian high-volume referral centers
Conclusion During the early phase, the COVID-19 outbreak was associated with a lower rate of admissions for ACS, with a substantial impact on the time delay presentation of STEMI patients, but apparently without affecting the in-hospital outcomes. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Beyond plaque stenosis, into plaque composition, the answer comes from optical coherence tomography
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Optical coherence tomography assessment of macrophages accumulation in non-ST-segment elevation acute coronary syndromes
Aims To investigate in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) the prevalence and the features of optical coherence tomography (OCT)-detected macrophages accumulation in culprit plaques as compared with nonculprit plaques (NCP). Methods The study is a post-hoc analysis of a prospective study aimed at evaluating the relationship between aortic inflammation as assessed by 18F-fluorodeoxyglucose-PET and features of coronary plaque vulnerability as assessed by OCT. We enrolled 32 patients with first NSTE-ACS who successfully underwent three-vessel OCT. Results The median age was 65 (54...
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research

Lipid-lowering nutraceuticals update on scientific evidence
Cardiovascular diseases (CVDs) are the main cause of mortality worldwide. Risk factors of CVD can be classified into modifiable (smoking, hypertension, diabetes, hypercholesterolemia) through lifestyle changes or taking drug therapy and not modifiable (age, ethnicity, sex and family history). Elevated total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels have a lead role in the development of coronary heart disease (CHD), while high levels of high-density lipoprotein-cholesterol (HDL-C) seem to have a protective role. The current treatment for dyslipidemia consists of lifestyle modification or drug...
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Review Source Type: research