Low hospitalization rate without severe arrhythmias: a prospective survey on 350 patients early home treated with hydroxychloroquine during COVID-19 pandemic
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research letters Source Type: research

Efficacy and safety of repeated infusion of levosimendan in outpatients with advanced heart failure: a real-world experience
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research letters Source Type: research

Early prenatal diagnosis of right ventricular myocardial sinusoidal-coronary artery connections in pulmonary atresia with intact septum
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

Aortic dissection during heart transplant: when a nightmare comes true
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Case reports Source Type: research

A curious ST-segment elevation case in a young man: a challenging diagnosis
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Case reports Source Type: research

Low vitamin D levels affect left ventricular wall thickness in severe aortic stenosis
Conclusion Among patients with severe degenerative aortic stenosis, vitamin D deficiency is common. We found a significant association between left ventricular wall thickness and vitamin D levels, suggesting a potential role of this hormone in modulating hypertrophic remodelling in these patients. However, future larger studies are certainly needed to confirm our findings and to define their prognostic implications. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis
Conclusion Patients with asymptomatic aortic valve stenosis have lower odds of all-cause and cardiovascular mortality when managed with early-AVR compared with conservative management. However, because of significant heterogeneity in the classification of asymptomatic patients, large scale studies are required. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Predictors of infection-related rehospitalization in heart failure patients and its impact on long-term survival
Conclusion IRRHs in patients discharged for acute decompensated heart fail independently predicted worse long-term survival. We further identified independent predictors of IRRHs. These findings warrant future studies for tackling IRRH. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Sacubitril/valsartan use in a real-world population of patients with heart failure and reduced ejection fraction
Conclusion In our experience, more than one-third of the patients were able to tolerate the higher dose of sacubitril/valsartan, and these patients were younger, had higher Hb, and better BP and renal function. MECKI score stratification was useful to discriminate patients who continued treatment from those who did not. Future prospective studies should test if these clinical variables can guide the up-titration of sacubitril/valsartan. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Impact of COVID-2019 outbreak on prevalence, clinical presentation and outcomes of ST-elevation myocardial infarction
Aims The aim of this study was to report the prevalence, clinical features and outcomes of patients with ST-elevation myocardial infarction (STEMI) hospitalized during the Corona-Virus Disease 2019 (COVID-19) outbreak compared with those admitted in a previous equivalent period. Methods and results Eighty-five patients admitted for STEMI at a high-volume Italian centre were included. Patients hospitalized during the COVID-19 outbreak (21 February–10 April 2020) (40%) were compared with those admitted in pre-COVID-19 period (3 January–20 February 2020) (60%). A 43% reduction in STEMI admissions was observed...
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Impact of the COVID-19 pandemic on coronary invasive procedures at two Italian high-volume referral centers
Conclusion During the early phase, the COVID-19 outbreak was associated with a lower rate of admissions for ACS, with a substantial impact on the time delay presentation of STEMI patients, but apparently without affecting the in-hospital outcomes. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Beyond plaque stenosis, into plaque composition, the answer comes from optical coherence tomography
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Optical coherence tomography assessment of macrophages accumulation in non-ST-segment elevation acute coronary syndromes
Aims To investigate in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) the prevalence and the features of optical coherence tomography (OCT)-detected macrophages accumulation in culprit plaques as compared with nonculprit plaques (NCP). Methods The study is a post-hoc analysis of a prospective study aimed at evaluating the relationship between aortic inflammation as assessed by 18F-fluorodeoxyglucose-PET and features of coronary plaque vulnerability as assessed by OCT. We enrolled 32 patients with first NSTE-ACS who successfully underwent three-vessel OCT. Results The median age was 65 (54...
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research

Lipid-lowering nutraceuticals update on scientific evidence
Cardiovascular diseases (CVDs) are the main cause of mortality worldwide. Risk factors of CVD can be classified into modifiable (smoking, hypertension, diabetes, hypercholesterolemia) through lifestyle changes or taking drug therapy and not modifiable (age, ethnicity, sex and family history). Elevated total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels have a lead role in the development of coronary heart disease (CHD), while high levels of high-density lipoprotein-cholesterol (HDL-C) seem to have a protective role. The current treatment for dyslipidemia consists of lifestyle modification or drug...
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Review Source Type: research

Trials and tribulations of coronavirus disease-2019 research: with a few bright lights in the fog
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - October 6, 2020 Category: Cardiology Tags: Viewpoint Source Type: research

An expression of concern on research during the Covid-19 pandemic
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Letters to the editor Source Type: research

Alternative metrics to assess the quality and impact at the level of the individual article: how to go beyond the conventional criteria of judgment without citing a given article, but simply by ‘clicking’ on it
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Letters to the editor Source Type: research

Coronavirus disease 2019 in Rome: was it circulating before December?
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research letter Source Type: research

The right parasternal window: when Doppler-beam alignment may be life-saving in patients with aortic valve stenosis
The need for multiple transducer positions, especially from right parasternal windows, is consistently mentioned in the recommendations for the accurate measurement of peak velocities across a stenotic aortic valve, but yet poorly adopted. We performed a subanalysis of the largest prospective series on the right parasternal acoustic windows in patients with aortic stenosis (330 consecutive) to calculate the degree of misalignment and estimate the potential outcome implication of this often-forgotten approach. The right parasternal view was highly feasible with an average estimated misalignment from the apical view of 14...
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research letter Source Type: research

Mitral valve prolapse and partial saw-tooth cardiomyopathy: an unusual combination
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

Intracoronary cangrelor administration-assisted primary percutaneous coronary intervention in a patient with essential thrombocythemia and recurrent ST-segment elevation myocardial infarction
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Case reports Source Type: research

A case of combined aortic bioprosthetic valve degeneration and patient–prosthesis mismatch during pregnancy: decision-making and implications after pregnancy
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Case reports Source Type: research

Rationale and design of the EPLURIBUS Study (Evidence for a comPrehensive evaLUation of left ventRicle dysfnctIon By a whole-heart coverage cardiac compUted tomography Scanner)
Background Cardiac magnetic resonance (CMR) is the standard of reference for myocardial fibrosis detection by late gadolinium enhancement. Cardiac computed tomography (CCT) is emerging as a promising alternative. The Evidence for a comPrehensive evaLUation of left ventRicle dysfnctIon By a whole-heart coverage cardiac compUted tomography Scanner study will assess the feasibility and diagnostic accuracy of a comprehensive functional and anatomical cardiac evaluation with CCT as compared with CMR and invasive coronary angiography as standard of reference. Methods Consecutive patients with a newly diagnosed left ventricl...
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Study design Source Type: research

Routine minimalist transcatheter aortic valve implantation with local anesthesia only
Conclusion Transfemoral TAVR can be safely performed with local anesthesia alone and without an on-site anesthesiologist in the vast majority of patients. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Algorithm for diagnosis of infective endocarditis after transcatheter aortic valve replacement
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Epidemiology of infective endocarditis in transcatheter aortic valve replacement: systemic review and meta-analysis
Conclusion The current study demonstrates the incidence of overall, early, and late infective endocarditis following TAVR, ranging from 2 to 8 per 1000 patients. Although it remains a rare event, infective endocarditis following TAVR is associated with high mortality. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Sarcopenia: only one of the domains of frailty in patients undergoing transcatheter aortic valve implantation
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Morphometric and traditional frailty assessment in transcatheter aortic valve implantation
Conclusion We demonstrate TPMA to be a poor measure of patient frailty when compared with traditional methods of assessment which failed to predict postintervention outcomes. Furthermore, morphometric sarcopaenia correlated poorly with established measures of frailty. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Valvular heart disease Source Type: research

Impact of exercise addiction on attitude to preparticipation evaluation and adherence to medical prescription
Aims Identification of silent cardiovascular diseases by preparticipation evaluation (PPE) and disqualification from competitive sports have the potential to prevent sudden death but may induce adverse psychological consequences, particularly for exercise addicted athletes. We investigated the relationship between exercise addiction, attitude towards PPE and reaction to cardiovascular disease diagnosis. Methods We invited Italian competitive athletes to participate in an online questionnaire investigating exercise addiction, opinion about mandatory PPE and potential reaction to both sports disqualification and hypothe...
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Sports medicine Source Type: research

Coronavirus disease 2019 infection in patients with recent cardiac surgery: does chronic anticoagulant therapy have a protective effect?
Conclusion Our study suggests that COVID-19 patients on chronic anticoagulant therapy may have a more favorable and less complicated clinical course. Further prospective studies are warranted to confirm this preliminary observation. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Incidence and mortality risk in coronavirus disease 2019 patients complicated by acute cardiac injury: systematic review and meta-analysis
Background The prevalence and prognostic implications of acute cardiac injury (ACI), as a complication of coronavirus disease 2019 (COVID-19), remain unclear. Objectives We conducted a systematic review and meta-analysis to investigate the relationship between ACI and mortality risk in COVID-19 patients. Methods Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed in abstracting data and assessing validity. We searched MEDLINE, Scopus and Web of Science to locate all articles published up to 10 April 2020 reporting data of COVID-19 survivors and nonsurvivors developing ACI as ...
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: COVID-19 Source Type: research

Inappropriate dose of nonvitamin-K antagonist oral anticoagulants: prevalence and impact on clinical outcome in patients with nonvalvular atrial fibrillation
Conclusion Nearly 13% of patients were treated with an inappropriate dose of NOACs, in this single-center study. A trend for higher numbers of thromboembolic events was observed in these patients. The results should be considered as hypothesis generating. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Atrial fibrillation ablation in real life: is there room for improvements?
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Editorial Source Type: research

Atrial fibrillation ablation long-term ESC-EHRA EORP AFA LT registry: in-hospital and 1-year follow-up findings in Italy
Aim To report the Italian data deriving from the European Society of Cardiology-EURObservational Research Program atrial fibrillation ablation long-term registry. Methods and results Ten Italian centers enrolled up to 50 consecutive patients undergoing atrial fibrillation ablation. Of the 318 patients included, 5 (1.6%) did not undergo catheter ablation, 1 had ablation partially done and 62 were lost at 1-year follow-up. Women were less represented (23.6%) and the median age was 60.0 years. A total of 195 patients (62.3%) suffered paroxysmal atrial fibrillation, whereas only 9 (2.9%) had long-standing persistent atria...
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Research articles: Arrhythmias Source Type: research

The automated external defibrillator, an underused simple life-saving device: a review of the literature. A joint document from the Italian Resuscitation Council (IRC) and Associazione Italiana di Aritmologia e Cardiostimolazione (AIAC)
The role of early defibrillation has been well established as a pivotal ring of the chain of survival since the nineties. In the following years, the scientific evidences about the beneficial role of early defibrillation have grown, and most of all, it has been demonstrated that the main determinant of survival is the time of defibrillation more than the type of rescuer. Early lay defibrillation was shown to be more effective than delayed defibrillation by healthcare providers. Moreover, because of the ease of use of automated external defibrillators (AEDs), it has been shown that also untrained lay rescuers can safely use...
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Review articles Source Type: research

Coronavirus disease 2019 and cardiovascular implications
This article is a review of the most updated literature. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - September 12, 2020 Category: Cardiology Tags: Review articles Source Type: research

Impact on hospital admission of ST-elevation myocardial infarction patients during coronavirus disease 2019 pandemic in an Italian Hospital
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research letters Source Type: research

Relationship between socioeconomic status and asymptomatic peripheral arterial disease: a retrospective study
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research letters Source Type: research

Pentacuspid aortic valve associated with bilateral renal artery dysplasia
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research

First use of Stentys XPosition S self-apposing sirolimus-eluting stent for intrapetrous carotid stenosis
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Case reports Source Type: research

Undiagnosed Fabry disease: the importance of screening for Fabry disease before transcutaneous patent foramen ovale closure in a young patient with cryptogenic stroke
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Case reports Source Type: research

The atrial FibriLlatiOn real World management registry in the Middle East and Africa: design and rationale
Conclusion The FLOW-AF registry will provide information on the uptake of oral anticoagulants, treatment patterns, clinical outcomes, and healthcare utilization and costs among newly diagnosed nonvalvular atrial fibrillation patients in the Middle Eastern region. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Study design Source Type: research

Electrocardiographic voltage criteria in patients with hypertrophic cardiomyopathy
Conclusions In our study, only a few ECG voltage criteria used for the detection of LVH in clinical practice showed an acceptable performance in the HCM population. Further studies are needed to clarify the role of ECG for LVH detection in HCM patients. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Cardiac involvement, morbidity and mortality in hereditary transthyretin amyloidosis because of p.Glu89Gln mutation
Conclusion Cardiac involvement is common and has significant prognostic implications in the evaluated patients with p.Glu89Gln mutation. Heart failure and rhythm disturbances are the main causes of death. An earlier identification of the disease is crucial to improve prognosis. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Do the remodeling effects of sacubitril/valsartan treatment depend upon heart failure duration?
We examined the effects of sacubitril/valsartan on cardiac remodeling and their correlation with heart failure duration in patients enrolled in our heart failure clinic from March 2017 to December 2019. Methods Echocardiographic and clinical/laboratory data were collected at baseline and at 6-month and 12-month follow-up visits in 69 patients (age 67 ± 12 years, disease duration 8.4 ± 5.8 years, 93% men). Results At both time points, mean NYHA class, NT-proBNP level, LVEF, LV end-systolic volume, and estimated systolic pulmonary pressure significantly (P  (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Heart failure Source Type: research

Characterization of inflammatory profile by breath analysis in chronic coronary syndromes
Conclusion CCS patients have a distinctive fingerprint of exhaled breath, and analysis by BIONOTE-V has the potential for identifying these patients. Moreover, it seems that this technique can correctly identify patients according to anatomical disease severity at ICA. If the preliminary data of this proof of concept study will be confirmed, this rapid and noninvasive diagnostic tool able to identify CCS might have an impact in routine clinical practice. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research

Impact of the metal-to-artery ratio on clinical outcomes in left main and nonleft main bifurcation: insights the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life)
Introduction The impact on clinical outcomes of the metal coverage on the coronary surface (namely the metal-to-artery ratio) of currently used drug-eluting stents (DESs) has not been defined. Methods All patients with a left main or bifurcation stenosis treated with percutaneous coronary intervention (PCI) using ultrathin stents (struts thinner than 81 μm) were enrolled with a prospective multicentre fashion. The rate of device-oriented endpoint [DOE, defined as a composite of target lesion revascularization (TLR) and stent thrombosis] was the primary endpoint, while its single components were the secondary ones...
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research

Focusing on kidneys and platelets in acute coronary syndromes: pre hoc and post hoc risk profiling
No abstract available (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research

Impact of chronic kidney disease on platelet aggregation in patients with acute coronary syndrome
Aims Chronic kidney disease (CKD) is associated with increased thrombotic events and seems to influence platelet reactivity. Conflicting results have been published on platelet response in CKD patients with stable coronary artery disease. The aim of our study was to investigate the impact of CKD on platelet aggregation in acute coronary syndrome (ACS) patients receiving dual antiplatelet therapy, included the more potent P2Y12 inhibitors. Methods We enrolled 206 patients with ACS, divided in two groups, according to the presence or the absence of moderate/severe CKD. Platelet aggregation was performed with light trans...
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research

Lombardy regional urgent reorganization for congenital cardiac patients following the Covid-19 pandemic
Conclusion Our preliminary data suggest that the model adopted met the immediate needs with a good outcome without increased mortality, nor COVID-19 exposure for the patients who underwent procedures. (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - August 4, 2020 Category: Cardiology Tags: Research articles: Congenital heart disease Source Type: research