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Condition: Hypothermia
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Total 450 results found since Jan 2013.
Blood biomarker changes following therapeutic hypothermia in ischemic stroke
ConclusionAlthough the exact roles of MMP3, FABP, and IL-8 in hypothermia-treated stroke patients are not known, further exploration is needed to confirm their roles in brain ischemia.
Source: Brain and Behavior - September 18, 2023 Category: Neurology Authors: Elena Pal à,
Anna Penalba,
Alejandro Bustamante,
Teresa García‐Berrocoso,
Marcel Lamana‐Vallverdú,
Christian Meisel,
Andreas Meisel,
H. Bart van der Worp,
Malcolm R Macleod,
Bernd Kallmünzer,
Stefan Schwab,
Joan Montaner Tags: BRIEF REPORT Source Type: research
Left ventricular assist device implantation combined with hemiarch replacement for severe aortic atherosclerosis
J Thorac Dis. 2023 Jul 31;15(7):3979-3983. doi: 10.21037/jtd-23-255. Epub 2023 Jul 6.ABSTRACTImplantation of the left ventricular assist device (LVAD) has emerged as a widely employed therapeutic approach for specifically chosen individuals suffering from severe heart failure. Stroke is a well-known complication of LVAD implantation. Concomitant aortic surgeries in patients requiring LVAD implantation to avoid outflow graft anastomosis to a severe atherosclerotic aorta are unknown. We illustrate a successful LVAD implantation with hemiarch replacement for severe aortic atherosclerosis to decrease the risk of postoperative ...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: June Lee Seok Beom Hong Yong Han Kim Hwan Wook Kim Do Yeon Kim Source Type: research
LB-007 Selective brain cooling is possible via CSF exchange with double lumen EVD-proof of concept in porcine stroke model
ConclusionWe are first to describe that selective brain cooling is possible via CSF exchange with double lumen EVD to achieve significant temperature difference between body core and brain. The timing and rate of selective cooling needs to be established as cause of arrhythmias before starting human trials.DisclosuresB. Rezai Jahromi: 1; C; IRRAS. 2; C; Neurovascular Innovations. 4; C; Neurovascular Innovations. 6; C; Helsinki Surgical Instruments. N. Järveläinen: None. J. Kauhanen: None. V. Zamotin: None. N. Brandmeir: 1; C; IRRAS. 2; C; IRRAS. M. Niemelä: None. S. Ylä-Herttuala: None.
Source: Journal of NeuroInterventional Surgery - August 3, 2023 Category: Neurosurgery Authors: Rezai Jahromi, B., Järveläinen, N., Kauhanen, J., Zamotin, V., Brandmeir, N., Niemelä, M., Ylä-Herttuala, S. Tags: SNIS 20th annual meeting late-breaking oral abstracts Source Type: research
Molecular Mechanisms of Lipid-Based Metabolic Adaptation Strategies in Response to Cold
Cells. 2023 May 10;12(10):1353. doi: 10.3390/cells12101353.ABSTRACTTemperature changes and periods of detrimental cold occur frequently for many organisms in their natural habitats. Homeothermic animals have evolved metabolic adaptation strategies to increase mitochondrial-based energy expenditure and heat production, largely relying on fat as a fuel source. Alternatively, certain species are able to repress their metabolism during cold periods and enter a state of decreased physiological activity known as torpor. By contrast, poikilotherms, which are unable to maintain their internal temperature, predominantly increase me...
Source: Cancer Control - July 6, 2023 Category: Cancer & Oncology Authors: Gang Wu Ralf Baumeister Thomas Heimbucher Source Type: research
What Sub-Saharan African Nations Can Teach the U.S. About Black Maternal Health
While poor maternal outcomes among Black women in the U.S. is not new, improving it is imperative. U.S. policymakers can look to sub-Saharan Africa for guidance on reversing this trend. Credit: Ernest Ankomah/IPSBy Ifeanyi NsoforABUJA, Jun 2 2023 (IPS) New research shows that Black mothers in the United States disproportionately live in counties with higher maternal vulnerability and face greater risk of preterm death for the fetus, greater risk of low birth weight for a baby, and a higher number of maternal deaths.
While poor maternal outcomes among Black women in the U.S. is not new, improving it is imperative. U.S. poli...
Source: IPS Inter Press Service - Health - June 2, 2023 Category: International Medicine & Public Health Authors: Ifeanyi Nsofor Tags: Africa Gender Headlines Health Inequality North America Poverty & SDGs Maternal Health Source Type: news
Amino acid solution mitigates hypothermia response and intestinal damage following exertional heat stroke in male mice
Exertional heat stroke (EHS) is a debilitating and potentially fatal condition for which few prevention strategies exist. These results suggest that a 5AAS improves Tc regulation during EHS recovery through maintaining mucosal function and integrity and that protecting the GI tract during EHS may be beneficial in some of the health consequences of EHS exposure. AbstractIncreased gut permeability is implicated in the initiation and extent of the cytokine inflammatory response associated with exertional heat stroke (EHS). The primary objective of this study was to determine if a five amino acid oral rehydration solution (5AA...
Source: Physiological Reports - May 23, 2023 Category: Physiology Authors: Michelle A. King,
Astrid Grosche,
Shauna M. Ward,
Jermaine A. Ward,
Anusree Sasidharan,
Thomas A. Mayer,
Mark L. Plamper,
Xiaodong Xu,
Matthew D. Ward,
Thomas L. Clanton,
Sadasivan Vidyasagar Tags: ORIGINAL ARTICLE Source Type: research
Association between cooling temperature and outcomes of patients with heat stroke
This study explored the relationship between body temperature and adverse outcomes in patients with heat stroke to identify the optimal target body temperature within the first 24 h. This retrospective, multicentre study enrolled 143 patients admitted to the emergency department and diagnosed with heat stroke. The primary outcome was the in-hospital mortality rate, while secondary outcomes included the presence and number of damaged organs and neurological sequelae at disch arge. A body temperature curve was built using a generalized additive mixed model, and the association between body temperatures and outcomes was est...
Source: Internal and Emergency Medicine - May 3, 2023 Category: Emergency Medicine Source Type: research
What Are the Classifications of Perinatal Stroke?
Discussion
Perinatal stroke occurs in about 1:1000 live births and is a “focal vascular injury from the fetal period to 28 days postnatal age.” Perinatal stroke is the most common cause of hemiparetic cerebral palsy and causes other significant morbidity including cognitive deficits, learning disabilities, motor problems, sensory problems including visual and hearing disorders, epilepsy, and behavioral and psychological problems. Family members are also affected because of the potential anxiety and guilt feelings that having a child with a stroke presents, along with the care that may be needed over the child&#...
Source: PediatricEducation.org - May 1, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Errors in Secondary Outcomes
This article was corrected online.
Source: JAMA - April 11, 2023 Category: General Medicine Source Type: research
Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest
Transl Stroke Res. 2023 Apr 4. doi: 10.1007/s12975-023-01150-8. Online ahead of print.ABSTRACTGlobal ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and neuroprotective agents are two strategies partially improve neurological outcomes following resuscitation. However, the therapeutic effects of these treatments are inconsistently reported. Stem cell therapy has emerged as a promising protective strategy due to its potential for proliferation and differentiation into functional neural cells. This editorial reviews the current status o...
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Xiao Liu Xiaofeng Jia Source Type: research
Effects of Δ < sup > 9 < /sup > -Tetrahydrocannabinol and the Aminoalkylindole K2/Spice Constituent JWH-073 on Cardiac Tissue and Mesenteric Vascular Reactivity
This study used in vitro, in vivo, and ex vivo approaches to investigate potential differences on cardiac tissue and vascular effects betweenJWH-073 and Δ9-THC. Male C57BL/6 mice were treated with JWH-073 or Δ9-THC and cardiac injury was assessed by histology. Effects of JWH-073 and Δ9-THC on H9C2 cell viability and ex vivo mesenteric vascular reactivity were also determined. Results: JWH-073 or Δ9-THC induced typical cannabinoid effects of antinociception and hypothermia but did not promote death of cardiac myocytes. No differences in cell viability were observed in cultured H9C2 cardiac myocytes after 24 h of treatme...
Source: Cell Research - April 3, 2023 Category: Cytology Authors: Chris S Breivogel Bonnie M Brenseke Khalil Eldeeb Katlyn Nichols Amreen Jonas Artik H Mistry Laura Barbalato Nicholas Luibil Allyn C Howlett Sandra Leone-Kabler Rob P H Hilgers Victor M Pulgar Source Type: research
Selective intraarterial hypothermia combined with mechanical thrombectomy for acute cerebral infarction based on microcatheter technology: A single-center, randomized, single-blind controlled study
ConclusionMechanical thrombectomy combined with intraarterial cold saline perfusion is a safe and effective measure for the treatment of acute cerebral infarction. Postoperative NIHSS scores and infarct volumes were significantly improved with this strategy compared with simple mechanical thrombectomy, and the 90-day good prognosis rate was improved. The mechanism by which this treatment exerts its cerebral protective effect may be by inhibiting the transformation of the ischaemic penumbra of the infarct core area, scavenging some oxygen free radicals, reducing inflammatory injury to cells after acute infarction and ischae...
Source: Frontiers in Neurology - February 16, 2023 Category: Neurology Source Type: research
Protecting the injured central nervous system: Do anesthesia or hypothermia ameliorate secondary injury?
Exp Neurol. 2023 Feb 10:114349. doi: 10.1016/j.expneurol.2023.114349. Online ahead of print.ABSTRACTTraumatic injury to the central nervous system (CNS) and stroke initiate a cascade of processes that expand the area of tissue loss. The current review considers recent studies demonstrating that the induction of an anesthetic state or cooling the affected tissue (hypothermia) soon after injury can have a therapeutic effect. We first provide an overview of the neurobiological processes that fuel tissue loss after traumatic brain injury (TBI), spinal cord injury (SCI) and stroke. We then examine the rehabilitative effectivene...
Source: Experimental Neurology - February 12, 2023 Category: Neurology Authors: Jacob A Davis James W Grau Source Type: research
