Partial sleep deprivation after an acute exercise session does not augment hepcidin levels the following day
In conclusion, the present study demonstrated that a single night of PSD after an exercise session in the evening did not affect baseline serum hepcidin level the following morning. Moreover, a 60 min run the following morning increased serum hepcidin and plasma IL‐6 levels significantly, but the exercise‐induced elevations were not affected by PSD. (Source: Physiological Reports)
Source: Physiological Reports - May 26, 2020 Category: Physiology Authors: Kazushige Goto, Aoi Mamiya, Hiroto Ito, Tatsuhiro Maruyama, Nanako Hayashi, Claire E. Badenhorst Tags: ORIGINAL RESEARCH Source Type: research

High ‐intensity training in normobaric hypoxia enhances exercise performance and aerobic capacity in Thoroughbred horses: A randomized crossover study
We examined the effects of high ‐intensity training in normobaric hypoxia on aerobic capacity and exercise performance in horses and the individual response to normoxic and hypoxic training. Eight untrained horses were studied in a randomized, crossover design after training in hypoxia (HYP; 15.0% inspired O2) or normoxia (NOR; 20.9% inspired O2) 3  days/week for 4 weeks separated by a 4‐month washout period. Before and after each training period, incremental treadmill exercise tests were performed in normoxia. Each training session consisted of 1 min cantering at 7 m/s and 2 min galloping at t...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Kazutaka Mukai, Hajime Ohmura, Akira Matsui, Hiroko Aida, Toshiyuki Takahashi, James H. Jones Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Physiological Reports, Volume 8, Issue 10, May 2020. (Source: Physiological Reports)
Source: Physiological Reports - May 22, 2020 Category: Physiology Tags: ISSUE INFORMATION Source Type: research

Associations of cardiorespiratory fitness, physical activity, and BMI with arterial health in middle ‐aged men and women
In conclusion, exercise may decrease PWV and AIx. Our results suggest that positive arterial responses to exercise could be slightly improved in fit and normal weight individuals. (Source: Physiological Reports)
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Eero A. Haapala, Earric Lee, Jari A. Laukkanen Tags: ORIGINAL RESEARCH Source Type: research

Two neuronal groups for NaCl with differential taste response properties and topographical distributions in the rat parabrachial nucleus
We examined relations between taste response properties (spike counts, response duration, and coefficient of variation [CV]) and location of taste ‐sensitive neurons in the pontine parabrachial nucleus (PBN). Extracellular single units’ activity in the PBN of Wistar rats was recorded using multibarrel glass micropipettes under urethane anesthesia. Forty taste‐sensitive neurons were classified as NaCl (N)‐best (n = 15), NaCl/HCl (NH)‐best (n = 14), HCl (H)‐best (n = 8), and sucrose (S)‐best (n = 3) neurons. The net response to NaCl (15.2 ± 2.3 s...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Tatsuko Yokota, Nubuo Katakura, Takumi Morita, Tomoko Matsunaga, Katsunari Hiraba Tags: ORIGINAL RESEARCH Source Type: research

Upper ‐airway collapsibility and compensatory responses under moderate sedation with ketamine, dexmedetomidine, and propofol in healthy volunteers
ConclusionOur findings demonstrate that ketamine sedation may have an advantage of both maintained passive upper ‐airway collapsibility and a compensatory respiratory response, due to both increase in neuromuscular activity and the increased duty cycle, to acute partial upper‐airway obstruction. (Source: Physiological Reports)
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Gaku Mishima, Takuro Sanuki, Shuntaro Sato, Masato Kobayashi, Shinji Kurata, Takao Ayuse Tags: ORIGINAL RESEARCH Source Type: research

A novel murine model of reversible bile duct obstruction demonstrates rapid improvement of cholestatic liver injury
We have established a novel surgical murine model of reversible bile duct ligation that is more physiologic than prior models of bile duct ligation reversal. Our model demonstrates acute hepatic injury from 7 ‐day bile duct ligation with rapid improvement after restoration of bile flow, including changes in immune, bile acid, and fibrotic pathways during this response. Further studies with this model may identify novel therapeutic targets for pediatric and adult cholestatic liver disease. AbstractThere are limited murine models of cholestatic liver diseases characterized by chronic biliary obstruction and resumption of b...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Sarah A. Taylor, Xin ‐Yi Yeap, Jiao‐Jing Wang, Kyle D. Gromer, Alyssa Kriegermeier, Richard M. Green, Zheng J. Zhang Tags: ORIGINAL RESEARCH Source Type: research

Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat
This study aimed to investigate whether treatment with a MRA commenced following the establishment of hypertension, a situation more accurately representing the clinical setting, modified the progression of renal fibrosis. Using male Cyp1a1Ren2 rats (n = 28), hypertension was established by addition of 0.167% indole‐3‐carbinol (w/w) to the rat chow, for 2 weeks prior to treatment. Rats were then divided into normotensive, hypertensive (H), or hypertensive with daily oral spironolactone treatment (H + SP) (human equivalent dose 50 mg/day ). Physiological data and tissue were collected after...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Catherine J. Leader, Darren J. Kelly, Ivan A. Sammut, Gerard T. Wilkins, Robert J. Walker Tags: ORIGINAL RESEARCH Source Type: research

High ‐intensity training in normobaric hypoxia enhances exercise performance and aerobic capacity in Thoroughbred horses: A randomized crossover study
We examined the effects of high ‐intensity training in normobaric hypoxia on aerobic capacity and exercise performance in horses and the individual response to normoxic and hypoxic training. Eight untrained horses were studied in a randomized, crossover design after training in hypoxia (HYP; 15.0% inspired O2) or normoxia (NOR; 20.9% inspired O2) 3  days/week for 4 weeks separated by a 4‐month washout period. Before and after each training period, incremental treadmill exercise tests were performed in normoxia. Each training session consisted of 1 min cantering at 7 m/s and 2 min galloping at t...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Kazutaka Mukai, Hajime Ohmura, Akira Matsui, Hiroko Aida, Toshiyuki Takahashi, James H. Jones Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Physiological Reports, Volume 8, Issue 10, May 2020. (Source: Physiological Reports)
Source: Physiological Reports - May 22, 2020 Category: Physiology Tags: ISSUE INFORMATION Source Type: research

Associations of cardiorespiratory fitness, physical activity, and BMI with arterial health in middle ‐aged men and women
In conclusion, exercise may decrease PWV and AIx. Our results suggest that positive arterial responses to exercise could be slightly improved in fit and normal weight individuals. (Source: Physiological Reports)
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Eero A. Haapala, Earric Lee, Jari A. Laukkanen Tags: ORIGINAL RESEARCH Source Type: research

Two neuronal groups for NaCl with differential taste response properties and topographical distributions in the rat parabrachial nucleus
We examined relations between taste response properties (spike counts, response duration, and coefficient of variation [CV]) and location of taste ‐sensitive neurons in the pontine parabrachial nucleus (PBN). Extracellular single units’ activity in the PBN of Wistar rats was recorded using multibarrel glass micropipettes under urethane anesthesia. Forty taste‐sensitive neurons were classified as NaCl (N)‐best (n = 15), NaCl/HCl (NH)‐best (n = 14), HCl (H)‐best (n = 8), and sucrose (S)‐best (n = 3) neurons. The net response to NaCl (15.2 ± 2.3 s...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Tatsuko Yokota, Nubuo Katakura, Takumi Morita, Tomoko Matsunaga, Katsunari Hiraba Tags: ORIGINAL RESEARCH Source Type: research

Upper ‐airway collapsibility and compensatory responses under moderate sedation with ketamine, dexmedetomidine, and propofol in healthy volunteers
ConclusionOur findings demonstrate that ketamine sedation may have an advantage of both maintained passive upper ‐airway collapsibility and a compensatory respiratory response, due to both increase in neuromuscular activity and the increased duty cycle, to acute partial upper‐airway obstruction. (Source: Physiological Reports)
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Gaku Mishima, Takuro Sanuki, Shuntaro Sato, Masato Kobayashi, Shinji Kurata, Takao Ayuse Tags: ORIGINAL RESEARCH Source Type: research

A novel murine model of reversible bile duct obstruction demonstrates rapid improvement of cholestatic liver injury
We have established a novel surgical murine model of reversible bile duct ligation that is more physiologic than prior models of bile duct ligation reversal. Our model demonstrates acute hepatic injury from 7 ‐day bile duct ligation with rapid improvement after restoration of bile flow, including changes in immune, bile acid, and fibrotic pathways during this response. Further studies with this model may identify novel therapeutic targets for pediatric and adult cholestatic liver disease. AbstractThere are limited murine models of cholestatic liver diseases characterized by chronic biliary obstruction and resumption of b...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Sarah A. Taylor, Xin ‐Yi Yeap, Jiao‐Jing Wang, Kyle D. Gromer, Alyssa Kriegermeier, Richard M. Green, Zheng J. Zhang Tags: ORIGINAL RESEARCH Source Type: research

Spironolactone mitigates, but does not reverse, the progression of renal fibrosis in a transgenic hypertensive rat
This study aimed to investigate whether treatment with a MRA commenced following the establishment of hypertension, a situation more accurately representing the clinical setting, modified the progression of renal fibrosis. Using male Cyp1a1Ren2 rats (n = 28), hypertension was established by addition of 0.167% indole‐3‐carbinol (w/w) to the rat chow, for 2 weeks prior to treatment. Rats were then divided into normotensive, hypertensive (H), or hypertensive with daily oral spironolactone treatment (H + SP) (human equivalent dose 50 mg/day ). Physiological data and tissue were collected after...
Source: Physiological Reports - May 22, 2020 Category: Physiology Authors: Catherine J. Leader, Darren J. Kelly, Ivan A. Sammut, Gerard T. Wilkins, Robert J. Walker Tags: ORIGINAL RESEARCH Source Type: research

Cutaneous sensory nerve ‐mediated microvascular vasodilation in normotensive and prehypertensive non‐Hispanic Blacks and Whites
Cutaneous sensory nerve activation is shifted to a higher temperature threshold in non ‐Hispanic Blacks relative to non‐Hispanic Whites. Administration of exogenous nitric oxide via nitroprusside lowered the temperature threshold in non‐Hispanic Blacks but not in non‐Hispanic Whites. AbstractRelative to non ‐Hispanic Whites, non‐Hispanic Blacks are disproportionately affected by elevated blood pressure (BP). It is unknown whether race or subclinical increases in BP affect the ability of cutaneous sensory nerves to induce cutaneous microvascular vasodilation. Sixteen participants who self‐identifi ed as non‐...
Source: Physiological Reports - May 13, 2020 Category: Physiology Authors: Casey G. Turner, James T. Miller, Jeffrey S. Otis, Matthew J. Hayat, Arshed A. Quyyumi, Brett J. Wong Tags: ORIGINAL RESEARCH Source Type: research

Ion currents, action potentials, and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes
Effects of noradrenaline on action potential (AP) repolarisation in PV cardiomyocytes. A Representative AP recording from a PV cardiomyocyte in control solution and in the presence of 1  μM noradrenaline (NA). B Representative AP recording from another PV cardiomyocyte in control solution and in the presence of 1 μM NA showing lack of AP prolongation. C Before‐and‐after plot of APD30 in PV cardiomyocytes in control solution and after superfusion with 1  μM NA. D Noradrenaline‐induced fold‐changes in APD30 in LA and PV cardiomyocytes. AbstractThe electrophysiological properties of pulmonary v...
Source: Physiological Reports - May 13, 2020 Category: Physiology Authors: Richard C. Bond, St éphanie C. Choisy, Simon M. Bryant, Jules C. Hancox, Andrew F. James Tags: ORIGINAL RESEARCH Source Type: research

Cutaneous sensory nerve ‐mediated microvascular vasodilation in normotensive and prehypertensive non‐Hispanic Blacks and Whites
Cutaneous sensory nerve activation is shifted to a higher temperature threshold in non ‐Hispanic Blacks relative to non‐Hispanic Whites. Administration of exogenous nitric oxide via nitroprusside lowered the temperature threshold in non‐Hispanic Blacks but not in non‐Hispanic Whites. AbstractRelative to non ‐Hispanic Whites, non‐Hispanic Blacks are disproportionately affected by elevated blood pressure (BP). It is unknown whether race or subclinical increases in BP affect the ability of cutaneous sensory nerves to induce cutaneous microvascular vasodilation. Sixteen participants who self‐identifi ed as non‐...
Source: Physiological Reports - May 13, 2020 Category: Physiology Authors: Casey G. Turner, James T. Miller, Jeffrey S. Otis, Matthew J. Hayat, Arshed A. Quyyumi, Brett J. Wong Tags: ORIGINAL RESEARCH Source Type: research

Ion currents, action potentials, and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes
Effects of noradrenaline on action potential (AP) repolarisation in PV cardiomyocytes. A Representative AP recording from a PV cardiomyocyte in control solution and in the presence of 1  μM noradrenaline (NA). B Representative AP recording from another PV cardiomyocyte in control solution and in the presence of 1 μM NA showing lack of AP prolongation. C Before‐and‐after plot of APD30 in PV cardiomyocytes in control solution and after superfusion with 1  μM NA. D Noradrenaline‐induced fold‐changes in APD30 in LA and PV cardiomyocytes. AbstractThe electrophysiological properties of pulmonary v...
Source: Physiological Reports - May 13, 2020 Category: Physiology Authors: Richard C. Bond, St éphanie C. Choisy, Simon M. Bryant, Jules C. Hancox, Andrew F. James Tags: ORIGINAL RESEARCH Source Type: research

Comprehensive assessment of coronary pulse wave velocity in anesthetized pigs
Four methods for measuring coronary pulse wave velocity (CoPWV) were compared in animal (n = 10) using two regular pressure guidewires. During decompression phase a trend exists for higher CoPWV and repeatability is better than during compression phase. When coronary blood flow is reduced, known methods assessing CoPWV are not applicable and only the template matching and a new “back ward wave” method yields reliable results. AbstractBackgroundCoronary stiffness represents a new paradigm for interventional cardiology and can be assessed by coronary pulse wave velocity (CoPWV). Assessing CoPWV is compl...
Source: Physiological Reports - May 12, 2020 Category: Physiology Authors: Andrei Cividjian, Brahim Harbaoui, Carole Chambonnet, Jeanne ‐Marie Bonnet, Christian Paquet, Pierre‐Yves Courand, Pierre Lantelme Tags: ORIGINAL RESEARCH Source Type: research

Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains
In conclusion, this study underscores that iron homeostasis is distinct between BL6 and Balb/c strains under both physiologic and inflammatory conditions. (Source: Physiological Reports)
Source: Physiological Reports - May 8, 2020 Category: Physiology Authors: Piu Saha, Xia Xiao, Yaqi Li, Rachel M. Golonka, Ahmed A. Abokor, Beng San Yeoh, Matam Vijay ‐Kumar Tags: ORIGINAL RESEARCH Source Type: research

Effect of somatic maturity on the aerobic and anaerobic adaptations to sprint interval training
AbstractThe purpose of this study was to assess the maturity ‐related differences in the aerobic and anaerobic adaptations to sprint interval training (SIT) among youth male athletes. Twenty‐seven youth male athletes were assessed for years from peak height velocity (PHV) and classified into prepubescent (PRE,n = 7, years from PHV = −2.21 ± 0.47 years), peripubescent (PERI,n = 10, years from PHV = 0.25 ± 0.88 years), and postpubescent (POST,n = 10, years from PHV = 2.81 ± 0.50 years) group...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Kyle S. Beyer, Jeffrey R. Stout, Michael J. Redd, Kayla M. Baker, David D. Church, Haley C. Bergstrom, Jay R. Hoffman, David H. Fukuda Tags: ORIGINAL RESEARCH Source Type: research

The effects of clothing layers on the thermoregulatory responses to short duration babywearing in babies under 12  months old
Carrying a baby in a sling, that is, babywearing, is a popular practice due to its benefits for skin-to-skin care. Babies are thermally vulnerable and public health bodies advise to dress them in one extra layer than the adult. However, these guidelines do not consider babywearing and it is unclear whether babies ’ clothing insulation should be modified during babywearing. We show that 15-min babywearing increase babies’ skin, but not tympanic, temperature by up to 1.1°C on certain body regions, and that this effect is not exacerbated by adding 1 layer of light clothing to the baby. AbstractCarrying babies ...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Davide Filingeri, Helena Cowley, Charlotte Merrick, Parenting Science Gang, Victoria L. Filingeri Tags: ORIGINAL RESEARCH Source Type: research

Cardiac surgery does not lead to loss of oscillatory components in circulatory signals
We present a case where noise is misclassified as an oscillation, raising questions about the robustness of such analyses. (Source: Physiological Reports)
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Kathrine Knai, Petter Aadahl, Nils K. Skjaervold Tags: ORIGINAL RESEARCH Source Type: research

Changes in strength and power performance and serum hormone concentrations during 12 weeks of task ‐specific or strength training in conscripts
Successful strength and conditioning program for conscripts cannot be built without taking into account the fracture nature of training caused by military specific training requirements. It is important in the future that the leadership prioritizes quality ‐controlled physical training and supports necessary changes. Strength and task‐specific training can lead to improvements in the battlefield, reduce the risk of overtraining, and prevent injuries caused by excessive running and loaded marching during the traditional military training. AbstractThe purpose of this study was to investigate the effects of two different ...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Tommi Ojanen, Heikki Kyr öläinen, Elena Kozharskaya, Keijo Häkkinen Tags: ORIGINAL RESEARCH Source Type: research

The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions
This study aimed to compare the blood pressure and cerebral blood flow responses to both repeated and sustained stand ‐to‐sit transitions in young and older adults, and to assess the relationship with cerebrovascular reactivity.MethodsIn 20 young (age: 24  ± 4 years) and 20 older (age: 71 ± 7 years) adults we compared middle cerebral artery flow velocity (MCAv), end‐tidal partial pressure of carbon dioxide (PETCO2), and blood pressure (mean arterial blood pressure [MAP]) during repeated stand ‐to‐sit (10 s standing and 10 s sitting) and sustained stand‐to‐...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Timo Klein, Tom G. Bailey, Petra Wollseiffen, Stefan Schneider, Christopher D. Askew Tags: ORIGINAL RESEARCH Source Type: research

High ‐intensity exercise training improves perioperative risk stratification in the high‐risk patient
In conclusion, preoperative HIIT training can confer a marked improvement in CRF in an elderly surgical patient and is associated with a corresponding reduction in perioperative risk . (Source: Physiological Reports)
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: George A. Rose, Michael J. Adamson, Richard G. Davies, Ian R. Appadurai, Damian M. Bailey Tags: CASE REPORT Source Type: research

Metabolic changes during pregnancy in glucose ‐intolerant NZO mice: A polygenic model with prediabetic metabolism
The aim of this work was to evaluate metabolic changes during pregnancy within the polygenic NZO mouse model and if it is a suitable one for the human disease. NZO mice showed early alterations in glucose homeostasis and insulin secretion, but no overt diabetes. Interestingly, the preconceptionally impaired glucose tolerance did not deteriorate during gestation despite a proliferation defect of Langerhans islets. AbstractGestational diabetes mellitus (GDM) is a complex metabolic disease involving genetic and environmental factors. Recent studies have underlined its heterogeneity, so it is reasonable to divide patients into...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Katharina Grupe, Melissa Asuaje Pfeifer, Franziska Dannehl, Moritz Liebmann, Ingo Rustenbeck, Annette Sch ürmann, Stephan Scherneck Tags: ORIGINAL ARTICLE Source Type: research

The time course of calf muscle fluid volume during prolonged running
We provide evidence that muscle fluid volumes undergo significant changes during 75  min of moderate‐intensity (2.7 ± 0.4 m/s) running. Using MRI measurements, we found that the volumes of calf muscles (quantified through average cross‐sectional area) in 18 young recreational runners increase (up to 9% in the gastrocnemii) at the beginning and decrease (below baseline leve ls) at later stages of running. These findings highlight the complex nature of muscle fluid shifts during prolonged running exercise. AbstractMuscle fluid is essential for the biochemistry and the biomechanics of muscle con...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Steffen Willwacher, David A. Sleboda, Daniela M ählich, Gert‐Peter Brüggemann, Thomas J. Roberts, Grischa Bratke Tags: ORIGINAL RESEARCH Source Type: research

High ‐intensity exercise training improves perioperative risk stratification in the high‐risk patient
In conclusion, preoperative HIIT training can confer a marked improvement in CRF in an elderly surgical patient and is associated with a corresponding reduction in perioperative risk . (Source: Physiological Reports)
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: George A. Rose, Michael J. Adamson, Richard G. Davies, Ian R. Appadurai, Damian M. Bailey Tags: CASE REPORT Source Type: research

The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions
This study aimed to compare the blood pressure and cerebral blood flow responses to both repeated and sustained stand ‐to‐sit transitions in young and older adults, and to assess the relationship with cerebrovascular reactivity.MethodsIn 20 young (age: 24  ± 4 years) and 20 older (age: 71 ± 7 years) adults we compared middle cerebral artery flow velocity (MCAv), end‐tidal partial pressure of carbon dioxide (PETCO2), and blood pressure (mean arterial blood pressure [MAP]) during repeated stand ‐to‐sit (10 s standing and 10 s sitting) and sustained stand‐to‐...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Timo Klein, Tom G. Bailey, Petra Wollseiffen, Stefan Schneider, Christopher D. Askew Tags: ORIGINAL RESEARCH Source Type: research

The time course of calf muscle fluid volume during prolonged running
We provide evidence that muscle fluid volumes undergo significant changes during 75  min of moderate‐intensity (2.7 ± 0.4 m/s) running. Using MRI measurements, we found that the volumes of calf muscles (quantified through average cross‐sectional area) in 18 young recreational runners increase (up to 9% in the gastrocnemii) at the beginning and decrease (below baseline leve ls) at later stages of running. These findings highlight the complex nature of muscle fluid shifts during prolonged running exercise. AbstractMuscle fluid is essential for the biochemistry and the biomechanics of muscle con...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Steffen Willwacher, David A. Sleboda, Daniela M ählich, Gert‐Peter Brüggemann, Thomas J. Roberts, Grischa Bratke Tags: ORIGINAL RESEARCH Source Type: research

Effect of somatic maturity on the aerobic and anaerobic adaptations to sprint interval training
AbstractThe purpose of this study was to assess the maturity ‐related differences in the aerobic and anaerobic adaptations to sprint interval training (SIT) among youth male athletes. Twenty‐seven youth male athletes were assessed for years from peak height velocity (PHV) and classified into prepubescent (PRE,n = 7, years from PHV = −2.21 ± 0.47 years), peripubescent (PERI,n = 10, years from PHV = 0.25 ± 0.88 years), and postpubescent (POST,n = 10, years from PHV = 2.81 ± 0.50 years) group...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Kyle S. Beyer, Jeffrey R. Stout, Michael J. Redd, Kayla M. Baker, David D. Church, Haley C. Bergstrom, Jay R. Hoffman, David H. Fukuda Tags: ORIGINAL RESEARCH Source Type: research

Changes in strength and power performance and serum hormone concentrations during 12 weeks of task ‐specific or strength training in conscripts
Successful strength and conditioning program for conscripts cannot be built without taking into account the fracture nature of training caused by military specific training requirements. It is important in the future that the leadership prioritizes quality ‐controlled physical training and supports necessary changes. Strength and task‐specific training can lead to improvements in the battlefield, reduce the risk of overtraining, and prevent injuries caused by excessive running and loaded marching during the traditional military training. AbstractThe purpose of this study was to investigate the effects of two different ...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Tommi Ojanen, Heikki Kyr öläinen, Elena Kozharskaya, Keijo Häkkinen Tags: ORIGINAL RESEARCH Source Type: research

Cardiac surgery does not lead to loss of oscillatory components in circulatory signals
We present a case where noise is misclassified as an oscillation, raising questions about the robustness of such analyses. (Source: Physiological Reports)
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Kathrine Knai, Petter Aadahl, Nils K. Skjaervold Tags: ORIGINAL RESEARCH Source Type: research

The effects of clothing layers on the thermoregulatory responses to short duration babywearing in babies under 12  months old
Carrying a baby in a sling, that is, babywearing, is a popular practice due to its benefits for skin-to-skin care. Babies are thermally vulnerable and public health bodies advise to dress them in one extra layer than the adult. However, these guidelines do not consider babywearing and it is unclear whether babies ’ clothing insulation should be modified during babywearing. We show that 15-min babywearing increase babies’ skin, but not tympanic, temperature by up to 1.1°C on certain body regions, and that this effect is not exacerbated by adding 1 layer of light clothing to the baby. AbstractCarrying babies ...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Davide Filingeri, Helena Cowley, Charlotte Merrick, Parenting Science Gang, Victoria L. Filingeri Tags: ORIGINAL RESEARCH Source Type: research

Metabolic changes during pregnancy in glucose ‐intolerant NZO mice: A polygenic model with prediabetic metabolism
The aim of this work was to evaluate metabolic changes during pregnancy within the polygenic NZO mouse model and if it is a suitable one for the human disease. NZO mice showed early alterations in glucose homeostasis and insulin secretion, but no overt diabetes. Interestingly, the preconceptionally impaired glucose tolerance did not deteriorate during gestation despite a proliferation defect of Langerhans islets. AbstractGestational diabetes mellitus (GDM) is a complex metabolic disease involving genetic and environmental factors. Recent studies have underlined its heterogeneity, so it is reasonable to divide patients into...
Source: Physiological Reports - May 6, 2020 Category: Physiology Authors: Katharina Grupe, Melissa Asuaje Pfeifer, Franziska Dannehl, Moritz Liebmann, Ingo Rustenbeck, Annette Sch ürmann, Stephan Scherneck Tags: ORIGINAL ARTICLE Source Type: research

The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload
In conclusion, a purely biomechanical insult of RV pressure overload resulted in biomechanical and transcriptional changes in both the RV and LV. Give n that the RV relies on the LV for contractile energy assistance, considering the LV could provide prognostic and therapeutic targets for treating RV failure in PH. (Source: Physiological Reports)
Source: Physiological Reports - May 5, 2020 Category: Physiology Authors: Vitaly O. Kheyfets, Melanie J. Dufva, Mario Boehm, Xuefeit Tian, Xulei Qin, Jennifer E. Tabakh, Uyen Truong, Dunbar Ivy, Edda Spiekerkoetter Tags: ORIGINAL RESEARCH Source Type: research

Effect of a 12 ‐week endurance training program on force transfer and membrane integrity proteins in lean, obese, and type 2 diabetic subjects
A 12 ‐week endurance training regimen has a relatively small effect on the levels of force transfer and membrane integrity proteins of lean, obese and type 2 diabetic individuals. Only dystrophin and muscle ankyrin repeat protein were decreased after training in lean and obese individuals, respectively . AbstractThe mechanisms accounting for the loss of muscle function with obesity and type 2 diabetes are likely the result of a combination of neural and muscular factors. One muscular factor that is important, yet has received little attention, is the protein machinery involved in longitudinal and lateral force transmissi...
Source: Physiological Reports - May 1, 2020 Category: Physiology Authors: Sebastian Jannas ‐Vela, Henning T. Langer, Hugo Marambio, Keith Baar, Hermann Zbinden‐Foncea Tags: ORIGINAL RESEARCH Source Type: research

Changes in circulating microRNA and arterial stiffness following high ‐intensity interval and moderate intensity continuous exercise
We identified a reduction in central artery stiffness and an increase in carotid arterial compliance one hour after acute high intensity interval (HII) cycling exercise, that was not seen after moderate intensity continuous cycling (MOD). HII and MOD elicited distinct increases in the concentrations of circulating microRNAs (ci ‐miRs) with potential regulatory roles in arterial stiffness. Significant correlations between some of the changes in ci‐miRs and measures of arterial stiffness suggest potential mechanistic roles for ci‐miRs. AbstractHigh ‐intensity interval (HII) exercise elicits distinct vascular response...
Source: Physiological Reports - May 1, 2020 Category: Physiology Authors: Ryan M. Sapp, Catalina A. Chesney, Lauren E. Eagan, William S. Evans, Evelyn M. Zietowski, Steven J. Prior, James M. Hagberg, Sushant M. Ranadive Tags: ORIGINAL RESEARCH Source Type: research

Actions of Rab27B ‐GTPase on mammalian central excitatory synaptic transmission
Members of the Rab3 gene family are considered central to membrane trafficking of synaptic vesicles at mammalian central excitatory synapses. While functional roles of Rab3A have been well ‐established, little functional information exists on the role of Rab27B in synaptic transmission. Our results provide a novel perspective in suggesting that Rab27B and Rab3A act synergistically, perhaps via sequential effector recruitment or signaling for presynaptic LTP expression in this hippoc ampal synaptic region. AbstractMembers of the Rab3 gene family are considered central to membrane trafficking of synaptic vesicles at mammal...
Source: Physiological Reports - May 1, 2020 Category: Physiology Authors: Erwin R. Arias ‐Hervert, Nicole Xu, Meredith Njus, Geoff G. Murphy, Yanan Hou, John A. Williams, Stephen I. Lentz, Stephen A. Ernst, Edward L. Stuenkel Tags: ORIGINAL RESEARCH Source Type: research

Effect of a 12 ‐week endurance training program on force transfer and membrane integrity proteins in lean, obese, and type 2 diabetic subjects
A 12 ‐week endurance training regimen has a relatively small effect on the levels of force transfer and membrane integrity proteins of lean, obese and type 2 diabetic individuals. Only dystrophin and muscle ankyrin repeat protein were decreased after training in lean and obese individuals, respectively . AbstractThe mechanisms accounting for the loss of muscle function with obesity and type 2 diabetes are likely the result of a combination of neural and muscular factors. One muscular factor that is important, yet has received little attention, is the protein machinery involved in longitudinal and lateral force transmissi...
Source: Physiological Reports - May 1, 2020 Category: Physiology Authors: Sebastian Jannas ‐Vela, Henning T. Langer, Hugo Marambio, Keith Baar, Hermann Zbinden‐Foncea Tags: ORIGINAL RESEARCH Source Type: research

Changes in circulating microRNA and arterial stiffness following high ‐intensity interval and moderate intensity continuous exercise
We identified a reduction in central artery stiffness and an increase in carotid arterial compliance one hour after acute high intensity interval (HII) cycling exercise, that was not seen after moderate intensity continuous cycling (MOD). HII and MOD elicited distinct increases in the concentrations of circulating microRNAs (ci ‐miRs) with potential regulatory roles in arterial stiffness. Significant correlations between some of the changes in ci‐miRs and measures of arterial stiffness suggest potential mechanistic roles for ci‐miRs. AbstractHigh ‐intensity interval (HII) exercise elicits distinct vascular response...
Source: Physiological Reports - May 1, 2020 Category: Physiology Authors: Ryan M. Sapp, Catalina A. Chesney, Lauren E. Eagan, William S. Evans, Evelyn M. Zietowski, Steven J. Prior, James M. Hagberg, Sushant M. Ranadive Tags: ORIGINAL RESEARCH Source Type: research

Actions of Rab27B ‐GTPase on mammalian central excitatory synaptic transmission
Members of the Rab3 gene family are considered central to membrane trafficking of synaptic vesicles at mammalian central excitatory synapses. While functional roles of Rab3A have been well ‐established, little functional information exists on the role of Rab27B in synaptic transmission. Our results provide a novel perspective in suggesting that Rab27B and Rab3A act synergistically, perhaps via sequential effector recruitment or signaling for presynaptic LTP expression in this hippoc ampal synaptic region. AbstractMembers of the Rab3 gene family are considered central to membrane trafficking of synaptic vesicles at mammal...
Source: Physiological Reports - May 1, 2020 Category: Physiology Authors: Erwin R. Arias ‐Hervert, Nicole Xu, Meredith Njus, Geoff G. Murphy, Yanan Hou, John A. Williams, Stephen I. Lentz, Stephen A. Ernst, Edward L. Stuenkel Tags: ORIGINAL RESEARCH Source Type: research

Resting metabolic rate and skeletal muscle SERCA and Na+/K+ ATPase activities are not affected by fish oil supplementation in healthy older adults
In conclusion, these results suggest that FO supplementation is not effective in altering RMR, substrate oxidation, and skeletal muscle SERCA and NKA prote in levels and activities, in healthy older men and women. (Source: Physiological Reports)
Source: Physiological Reports - April 27, 2020 Category: Physiology Authors: Sebastian Jannas ‐Vela, Shannon L. Klingel, Daniel T. Cervone, Kate A. Wickham, George J. F. Heigenhauser, David M. Mutch, Graham P. Holloway, Lawrence L. Spriet Tags: ORIGINAL RESEARCH Source Type: research

Do the anatomical and physiological properties of a muscle determine its adaptive response to different loading protocols?
ConclusionsThe triceps surae muscles respond robustly to regimented exercise and measures of muscle hypertrophy and isometric strength appear independent of muscle fiber type composition. Moreover, the study provides further evidence that low ‐load training is a viable strategy to increase hypertrophy in different human muscles, with hypertrophic increases similar to that observed using heavy loads. (Source: Physiological Reports)
Source: Physiological Reports - April 27, 2020 Category: Physiology Authors: Brad J. Schoenfeld, Andrew D. Vigotsky, Jozo Grgic, Cody Haun, Bret Contreras, Kenneth Delcastillo, Aston Francis, Gilda Cote, Andrew Alto Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Physiological Reports, Volume 8, Issue 9, May 2020. (Source: Physiological Reports)
Source: Physiological Reports - April 27, 2020 Category: Physiology Tags: ISSUE INFORMATION Source Type: research