Distinct roles of estrone and estradiol in endothelial colony ‐forming cells
This study provides evidence that estrone signaling is distinct from that of estradiol and that further investigation of estrone's mechanism of action and the biological effect may provide important insight into understandi ng the dysfunction and decreased number of hECFCs, and the resulting cardiovascular disease risk observed clinically in menopausal women and women undergoing hormone replacement therapy. (Source: Physiological Reports)
Source: Physiological Reports - October 5, 2023 Category: Physiology Authors: Alicia Ivory,
Andrew S. Greene Tags: ORIGINAL ARTICLE Source Type: research
Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight
This study demonstrates that leptin deficiency significantly impacts tib ia and vertebral body trabecular and cortical bone 3D architecture independent of changes in body weight. (Source: Physiological Reports)
Source: Physiological Reports - October 4, 2023 Category: Physiology Authors: Alexander Williamson,
Alexandre da Silva,
Jussara M. do Carmo,
Christine L. Le Maitre,
John E. Hall,
Nicola Aberdein Tags: ORIGINAL ARTICLE Source Type: research
Electrophysiology ‐aided DBS targeting the ventral intermediate nucleus in an essential tremor patient with MRI‐incompatible lead: A case report
We present a case of an ET patient with a non-MR-compatible cardiac orphaned leads who was a candidate for DBS surgery. Due to the lead constraints of MR use, we used a head computed tomography (CT) with contrast media as the reference exam to define the AC, PC, and midline, and to register and indirectly target the Vim. For target validation, we used intraoperative electrophysiological recordings and intraoperative CT. We implanted bilateral directional leads at the target location. We used the-essential-tremor-rating-assessment-scale (TETRAS) pre and postoperatively to clinically evaluate tremor. Intraoperative micro-ele...
Source: Physiological Reports - October 3, 2023 Category: Physiology Authors: Stefanie Glowinsky,
Hagai Bergman,
Omer Zarchi,
Shlomo Fireman,
Johnathan Reiner,
Idit Tamir Tags: ORIGINAL ARTICLE Source Type: research
Treatment of rheumatoid arthritis with baricitinib or upadacitinib is associated with reduced scaffold protein NEDD9 levels in CD4+ T cells
This study reveals previously unknown associations between JAK inhibitor treatment and NEDD9 expression and indicates that JAK inhibitors could reduce effector T-cell migration. (Source: Physiological Reports)
Source: Physiological Reports - October 2, 2023 Category: Physiology Authors: Viktoria Golumba ‐Nagy,
Shuaifeng Yan,
Eva Steinbach‐Knödgen,
Jan Thiele,
Ruth L. Esser,
Thomas H. Haak,
Anastasia Nikiforov,
Anja Meyer,
Tamina Seeger‐Nukpezah,
David M. Kofler Tags: ORIGINAL ARTICLE Source Type: research
Anserine is expressed in human cardiac and skeletal muscles
AbstractWe evaluated whether anserine, a methylated analog of the dipeptide carnosine, is present in the cardiac and skeletal muscles of humans and whether theCARNMT1 gene, which encodes the anserine synthesizing enzyme carnosine-N-methyltransferase, is expressed in human skeletal muscle. We found that anserine is present at low concentrations (low micromolar range) in both cardiac and skeletal muscles, and that anserine content in skeletal muscle is ~15 times higher than in cardiac muscle (cardiac muscle: 10.1 ± 13.4 μmol·kg−1 of dry muscle,n = 12; skeletal muscle: 158.1 ± 68.5 μmol·kg−1 of dry ...
Source: Physiological Reports - September 29, 2023 Category: Physiology Authors: L ívia de Souza Gonçalves,
Wagner Ribeiro Pereira,
Rafael Pires da Silva,
Guilherme Carvalho Yamaguchi,
Victor Henrique Carvalho,
Bianca Scigliano Vargas,
Leonardo Jensen,
Marisa Helena Gennari de Medeiros,
Hamilton Roschel,
Guilherme Giannini Tags: ORIGINAL ARTICLE Source Type: research
Genetic background influences arterial vasomotor function in male and female mice
AbstractThe purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)-mediated vasomotor function in arteries from different vascular territories. Vasomotor function was assessed in thoracic aorta, abdominal aorta, carotid arteries, and femoral arteries from the following mouse strains: SJL/J, DBA/2J, NZW/LacJ, and C57BL/6J. Contractile responses were assessed using the α1-adrenergic receptor agonist phenylephrine (PE, 10−9–10−5 M). Vasorelaxation responses were assessed by examining relaxation to an endothelium-dependent vasodilator acetylcholine (ACh, 10−9–10−5 ...
Source: Physiological Reports - September 29, 2023 Category: Physiology Authors: Dylan Holly,
Hyoseon Kim,
Christopher R. Woodman,
Michael P. Massett Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Physiological Reports)
Source: Physiological Reports - September 28, 2023 Category: Physiology Tags: ISSUE INFORMATION Source Type: research
