Treatment of rheumatoid arthritis with baricitinib or upadacitinib is associated with reduced scaffold protein NEDD9 levels in CD4+ T cells

This study reveals previously unknown associations between JAK inhibitor treatment and NEDD9 expression and indicates that JAK inhibitors could reduce effector T-cell migration.

Source: Physiological Reports - October 2, 2023 Category: Physiology Authors: Viktoria Golumba ‐Nagy, Shuaifeng Yan, Eva Steinbach‐Knödgen, Jan Thiele, Ruth L. Esser, Thomas H. Haak, Anastasia Nikiforov, Anja Meyer, Tamina Seeger‐Nukpezah, David M. Kofler Tags: ORIGINAL ARTICLE Source Type: research