Exercise intensities modulate ACE2/MasR/eNOS pathway in male Wistar rat's lung
In conclusion, high-intensity exercise may induce NO synthesis in the lung by increasing mRNA expression of ACE2, MasR, and eNOS without decreasing the medial wall thickness of the muscular artery. Thus, high-intensity exercise may be the optimal intensity to improve NO synthesis and vascular fun ction in the lung. (Source: Physiological Reports)
Source: Physiological Reports - September 5, 2023 Category: Physiology Authors: Yani Medina Lestari,
Vita Murniati Tarawan,
Achadiyani Achadiyani,
Putri Teesa Radhiyanti,
Hamidie Ronald Daniel Ray,
Ronny Lesmana,
Hanna Goenawan Tags: ORIGINAL ARTICLE Source Type: research
Lactate thresholds and role of nitric oxide in male rats performing a test with forced swimming to exhaustion
AbstractThe present study assessed a complex of biochemical parameters at the anaerobic threshold (AT) in untrained male Wistar rats with different times to exhaustion (Tex) from swimming. The first group of rats was randomly divided into six subgroups and subjected to a swimming test to exhaustion without a load or with a load of 2% –10% of body weight (BW). In the first group, we established that for untrained rats, the load of 4% BW in the swimming to exhaustion test was optimal for endurance assessment in comparison with other loads. The second group of rats went through a preliminary test with swimming to exhaustion...
Source: Physiological Reports - September 5, 2023 Category: Physiology Authors: Natalya Potolitsyna,
Olga Parshukova,
Nadezhda Vakhnina,
Nadezhda Alisultanova,
Lubov Kalikova,
Anastasia Tretyakova,
Alexey Chernykh,
Vera Shadrina,
Arina Duryagina,
Evgeny Bojko Tags: ORIGINAL ARTICLE Source Type: research
LTE: Does caffeine truly raise muscle carnitine in humans?
(Source: Physiological Reports)
Source: Physiological Reports - September 1, 2023 Category: Physiology Authors: Dumitru Constantin ‐Teodosiu Tags: LETTER TO THE EDITOR Source Type: research
Reply to LTE: Does caffeine truly raise muscle carnitine in humans?
(Source: Physiological Reports)
Source: Physiological Reports - September 1, 2023 Category: Physiology Authors: Benjamin T. Wall,
Francis B. Stephens Tags: LETTER TO THE EDITOR Source Type: research
No impact of a high ‐fat meal coupled with intermittent hypoxemia on acute kidney injury biomarkers in adults with and without obstructive sleep apnea
AbstractObstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxemia, which is associated with progressive loss of kidney function, where postprandial fluctuations in renal physiology may further compromise oxygen supply and kidney function. Therefore, we measured biomarkers of acute kidney injury (AKI) following a high-fat meal with and without intermittent hypoxemia. Eighteen healthy young men (mean age [SD]: 22.7 years [3.1]) and seven middle-aged to older individuals with OSA (54.4 years [6.4]) consumed a high-fat meal during normoxia or intermittent hypoxemia (~15 hypoxic cycles per hour, ~85%...
Source: Physiological Reports - September 1, 2023 Category: Physiology Authors: Nicholas Goulet,
Emily J. Tetzlaff,
Ren ée Morin,
Jean‐François Mauger,
Ruwan Amaratunga,
Glen P. Kenny,
Pascal Imbeault Tags: ORIGINAL ARTICLE Source Type: research
Physiological Reports begins a new manuscript category, the Methods article
(Source: Physiological Reports)
Source: Physiological Reports - September 1, 2023 Category: Physiology Authors: Josephine C. Adams Tags: EDITORIAL Source Type: research
The dependence of maximum oxygen uptake and utilization (V ̇O2max) on hemoglobin‐oxygen affinity and altitude
AbstractOxygen transport from the lungs to peripheral tissue is dependent on the affinity of hemoglobin for oxygen. Recent experimental data have suggested that the maximum human capacity for oxygen uptake and utilization (V ̇O2max) at sea level and altitude (~3000 m) is sensitive to alterations in hemoglobin-oxygen affinity. However, the effect of such alterations onV ̇O2max at extreme altitudes remains largely unknown due to the rarity of mutations affecting hemoglobin-oxygen affinity. This work uses a mathematical model that couples pulmonary oxygen uptake with systemic oxygen utilization under conditions of high m...
Source: Physiological Reports - September 1, 2023 Category: Physiology Authors: Kevin L. Webb,
Michael J. Joyner,
Chad C. Wiggins,
Timothy W. Secomb,
Tuhin K. Roy Tags: ORIGINAL ARTICLE Source Type: research
