Electrophysiology ‐aided DBS targeting the ventral intermediate nucleus in an essential tremor patient with MRI‐incompatible lead: A case report
We present a case of an ET patient with a non-MR-compatible cardiac orphaned leads who was a candidate for DBS surgery. Due to the lead constraints of MR use, we used a head computed tomography (CT) with contrast media as the reference exam to define the AC, PC, and midline, and to register and indirectly target the Vim. For target validation, we used intraoperative electrophysiological recordings and intraoperative CT. We implanted bilateral directional leads at the target location. We used the-essential-tremor-rating-assessment-scale (TETRAS) pre and postoperatively to clinically evaluate tremor. Intraoperative micro-ele...
Source: Physiological Reports - October 3, 2023 Category: Physiology Authors: Stefanie Glowinsky,
Hagai Bergman,
Omer Zarchi,
Shlomo Fireman,
Johnathan Reiner,
Idit Tamir Tags: ORIGINAL ARTICLE Source Type: research
Treatment of rheumatoid arthritis with baricitinib or upadacitinib is associated with reduced scaffold protein NEDD9 levels in CD4+ T cells
This study reveals previously unknown associations between JAK inhibitor treatment and NEDD9 expression and indicates that JAK inhibitors could reduce effector T-cell migration. (Source: Physiological Reports)
Source: Physiological Reports - October 2, 2023 Category: Physiology Authors: Viktoria Golumba ‐Nagy,
Shuaifeng Yan,
Eva Steinbach‐Knödgen,
Jan Thiele,
Ruth L. Esser,
Thomas H. Haak,
Anastasia Nikiforov,
Anja Meyer,
Tamina Seeger‐Nukpezah,
David M. Kofler Tags: ORIGINAL ARTICLE Source Type: research
Anserine is expressed in human cardiac and skeletal muscles
AbstractWe evaluated whether anserine, a methylated analog of the dipeptide carnosine, is present in the cardiac and skeletal muscles of humans and whether theCARNMT1 gene, which encodes the anserine synthesizing enzyme carnosine-N-methyltransferase, is expressed in human skeletal muscle. We found that anserine is present at low concentrations (low micromolar range) in both cardiac and skeletal muscles, and that anserine content in skeletal muscle is ~15 times higher than in cardiac muscle (cardiac muscle: 10.1 ± 13.4 μmol·kg−1 of dry muscle,n = 12; skeletal muscle: 158.1 ± 68.5 μmol·kg−1 of dry ...
Source: Physiological Reports - September 29, 2023 Category: Physiology Authors: L ívia de Souza Gonçalves,
Wagner Ribeiro Pereira,
Rafael Pires da Silva,
Guilherme Carvalho Yamaguchi,
Victor Henrique Carvalho,
Bianca Scigliano Vargas,
Leonardo Jensen,
Marisa Helena Gennari de Medeiros,
Hamilton Roschel,
Guilherme Giannini Tags: ORIGINAL ARTICLE Source Type: research
Genetic background influences arterial vasomotor function in male and female mice
AbstractThe purpose of this study was to assess the influence of genetic background and sex on nitric oxide (NO)-mediated vasomotor function in arteries from different vascular territories. Vasomotor function was assessed in thoracic aorta, abdominal aorta, carotid arteries, and femoral arteries from the following mouse strains: SJL/J, DBA/2J, NZW/LacJ, and C57BL/6J. Contractile responses were assessed using the α1-adrenergic receptor agonist phenylephrine (PE, 10−9–10−5 M). Vasorelaxation responses were assessed by examining relaxation to an endothelium-dependent vasodilator acetylcholine (ACh, 10−9–10−5 ...
Source: Physiological Reports - September 29, 2023 Category: Physiology Authors: Dylan Holly,
Hyoseon Kim,
Christopher R. Woodman,
Michael P. Massett Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Physiological Reports)
Source: Physiological Reports - September 28, 2023 Category: Physiology Tags: ISSUE INFORMATION Source Type: research
Retraction statement: Hanyu, Y., Hoshino, M., Usui, E., Sugiyama, T., Kanaji, Y., Hada, M., Nagamine, T., Nogami, K., Ueno, H., Sayama, K., Matsuda, K., Sakamoto, T., Yonetsu, T., Sasano, T., & Kakuta, T. (2023). Microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization. Physiological Reports, 11, e15627
https://doi.org/10.14814/phy2.15627The above article, published online on 10 March 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Josephine C. Adams, The Physiological Society and American Physiological Society, and John Wiley and Sons Ltd. The retraction has been agreed at the authors' request. Since publication, the authors have identified that the calculation of microcirculatory resistance does not require a correction factor. This invalidates several figures in the paper and the overall conclusions. The editors have no ethical con...
Source: Physiological Reports - September 28, 2023 Category: Physiology Tags: RETRACTION Source Type: research
LTE: Scientific basis for retraction of article “microvascular resistance reserve in the presence of functionally significant epicardial stenosis and changes after revascularization”
(Source: Physiological Reports)
Source: Physiological Reports - September 27, 2023 Category: Physiology Authors: Yoshihiro Hanyu,
Masahiro Hoshino,
Eisuke Usui,
Tomoyo Sugiyama,
Yoshihisa Kanaji,
Masahiro Hada,
Tatsuhiro Nagamine,
Kai Nogami,
Hiroki Ueno,
Kodai Sayama,
Kazuki Matsuda,
Tatsuya Sakamoto,
Taishi Yonetsu,
Tetsuo Sasano,
Tsunekazu Kakuta Tags: LETTER TO THE EDITOR Source Type: research
Modulation of pain perceptions following treadmill running with different intensities in females
AbstractWe aimed to compare the effects of three intensities of treadmill running on exercise-induced hypoalgesia (EIH) in healthy individuals. We anticipated that the primary and secondary changes in pain perception and modulation may differ between running intensities. Sixty-six women were randomly assigned to one of three treadmill running intensities for 35 min: 40% reserved heart rate (HRR), 55% HRR, or 70% HRR. The effects of EIH were assessed using pressure pain thresholds (PPT) and tolerance thresholds (PPTol). We measured conditional pain modulation (CPM). Compared with baseline, PPT and PPTol significantly inc...
Source: Physiological Reports - September 26, 2023 Category: Physiology Authors: Xu Zi ‐Han,
An Nan,
Chang Jeremy Rui,
Yang Yong‐Long Tags: ORIGINAL ARTICLE Source Type: research
Heart rate variability in male rats
AbstractThe cardiovascular system is primarily controlled by the autonomic nervous system, and any changes in sympathetic or parasympathetic activity also have an impact on myocardial activity. Heart rate variability (HRV) is a readily available metric used to assess heart rate control by the autonomic nervous system. HRV can provide information about neural (parasympathetic, sympathetic, reflex) and humoral (hormones, thermoregulation) control of myocardial activity. Because there are no relevant reference values for HRV parameters in rats in the scientific literature, all experimental results are only interpreted on the ...
Source: Physiological Reports - September 22, 2023 Category: Physiology Authors: Pavol Švorc,
Soňa Grešová,
Pavol Švorc Tags: REVIEW Source Type: research
