Cellular and extracellular vaginal changes following murine ovarian removal
Murine ovariectomy resulted in decreased circulating estrogen as evidence by smaller uterine: BW ratio. The hypoestrogenic vaginal state displayed altered estrogen signaling, hyaluron localization, collagen turn over, and inflammatory profile. AbstractLoss of estrogen as a result of aging, pelvic cancer therapy, genetics, or eating disorders affects numerous body systems including the reproductive tract. Specifically, a chronic hypoestrogenic state fosters debilitating vaginal symptoms like atrophy, dryness, and dyspareunia. Current treatment options, including vaginal estrogen and hyaluronan (HA), anecdotally improve symp...
Source: Physiological Reports - August 8, 2023 Category: Physiology Authors: Jennifer M. McCracken,
Gisele A. Calderon,
Quynh N. Le,
Natasha M. Faruqui,
Swathi Balaji,
Julie C. E. Hakim Tags: ORIGINAL ARTICLE Source Type: research
Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model
AbstractHypoxic ischemic encephalopathy (HIE) occurs in 2 –5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on cytochrome c oxidase, are potential treatments for AKI. To examine effects of caffeine and PBM on AKI in rats , Day 7 pups underwent a HIE intervention (Modified Rice–Vannucci model) replicating pathology observed in humans. Caffeine was administered for 3 days and/or PBM for 5 days following HIE. Weights and urine for biomarkers (NGAL, albumin, KIM-1, osteopontin) were co...
Source: Physiological Reports - August 8, 2023 Category: Physiology Authors: A. M. Groves,
C. J. Johnston,
G. Beutner,
J. E. Dahlstrom,
M. Koina,
M. O'Reilly,
B. Marples,
G. Porter,
P. D. Brophy,
A. L. Kent Tags: ORIGINAL ARTICLE Source Type: research
Cold water immersion in recovery following a single bout resistance exercise suppresses mechanisms of miRNA nuclear export and maturation
AbstractCold water immersion (CWI) following intense exercise is a common athletic recovery practice. However, CWI impacts muscle adaptations to exercise training, with attenuated muscle hypertrophy and increased angiogenesis. Tissue temperature modulates the abundance of specific miRNA species and thus CWI may affect muscle adaptations via modulating miRNA expression following a bout of exercise. The current study focused on the regulatory mechanisms involved in cleavage and nuclear export of mature miRNA, includingDROSHA,EXPORTIN-5, andDICER. Muscle biopsies were obtained from thevastus lateralis of young males (n = ...
Source: Physiological Reports - August 8, 2023 Category: Physiology Authors: Randall F. D'Souza,
Vandre C. Figueiredo,
James F. Markworth,
Nina Zeng,
Christopher P. Hedges,
Llion A. Roberts,
Truls Raastad,
Jeff S. Coombes,
Jonathan M. Peake,
Cameron J. Mitchell,
David Cameron ‐Smith Tags: ORIGINAL ARTICLE Source Type: research
Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model
AbstractHypoxic ischemic encephalopathy (HIE) occurs in 2 –5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on cytochrome c oxidase, are potential treatments for AKI. To examine effects of caffeine and PBM on AKI in rats , Day 7 pups underwent a HIE intervention (Modified Rice–Vannucci model) replicating pathology observed in humans. Caffeine was administered for 3 days and/or PBM for 5 days following HIE. Weights and urine for biomarkers (NGAL, albumin, KIM-1, osteopontin) were co...
Source: Physiological Reports - August 8, 2023 Category: Physiology Authors: A. M. Groves,
C. J. Johnston,
G. Beutner,
J. E. Dahlstrom,
M. Koina,
M. O'Reilly,
B. Marples,
G. Porter,
P. D. Brophy,
A. L. Kent Tags: ORIGINAL ARTICLE Source Type: research
