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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats Basic Sciences
Conclusions— The centrally acting hypothermic drug HPI-201 greatly enhanced the efficiency and efficacy of conventional PC; this combined cooling therapy may facilitate clinical translation of hypothermic treatment for stroke.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Lee, J. H., Wei, L., Gu, X., Won, S., Wei, Z. Z., Dix, T. A., Yu, S. P. Tags: Ischemic Stroke, Neuroprotectants Basic Sciences Source Type: research

Motor and sensory effects of ipsilesional upper extremity hypothermia and contralesional sensory training for chronic stroke patients.
CONCLUSIONS: The use of immersion hypothermia on the ipsilesional UE in association with sensory training of the contralesional UE improved motor function and sensitivity in the contralesional UE of individuals with chronic stroke. Immersion hypothermia of the ipsilesional UE in chronic stroke patients is a safe, practical, inexpensive, and easily applied technique. PMID: 25776120 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - February 1, 2015 Category: Neurology Authors: Lima NM, Menegatti KC, Yu É, Sacomoto NY, Oberg TD, Honorato DC Tags: Top Stroke Rehabil Source Type: research

Therapeutic Hypothermia After Recanalization in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— In patients with ischemic stroke, after successful recanalization, therapeutic hypothermia may reduce risk of cerebral edema and hemorrhagic transformation, and lead to improved clinical outcomes.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Hong, J. M., Lee, J. S., Song, H.-J., Jeong, H. S., Choi, H. A., Lee, K. Tags: Neuroprotectors, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Mild Hypothermia After Intravenous Thrombolysis in Patients With Acute Stroke: A Randomized Controlled Trial Clinical Sciences
Conclusions— Mild hypothermia with a surface-cooling device in an acute stroke unit is safe and feasible in thrombolyzed, spontaneously breathing patients with stroke, despite the adverse events. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00987922.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Piironen, K., Tiainen, M., Mustanoja, S., Kaukonen, K.-M., Meretoja, A., Tatlisumak, T., Kaste, M. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke Clinical Sciences Source Type: research

Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2) Major Clinical Trial
Conclusions—Intravascular therapeutic hypothermia was confirmed to be safe and feasible in recombinant tissue-type plasminogen activator–treated acute ischemic stroke patients. Protocol changes designed to reduce pneumonia risk appeared to fail, although the sample is small.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01123161.
Source: Stroke - November 27, 2016 Category: Neurology Authors: Patrick Lyden, Thomas Hemmen, James Grotta, Karen Rapp, Karin Ernstrom, Teresa Rzesiewicz, Stephanie Parker, Mauricio Concha, Syed Hussain, Sachin Agarwal, Brett Meyer, Julie Jurf, Irfan Altafullah, Rema Raman Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Major Clinical Trials Source Type: research

CCR6 (CC Chemokine Receptor 6) Is Essential for the Migration of Detrimental Natural Interleukin-17-Producing {gamma}{delta} T Cells in Stroke Basic Sciences
Conclusions—Brain-infiltrating IL-17–producing γδ T cells belong to the subset of natural IL-17–producing γδ T cells. In stroke, these previously unrecognized innate lymphocytes trigger a highly conserved immune reaction, which is known from host responses toward pathogens. We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Priyadharshini Arunachalam, Peter Ludewig, Patrick Melich, Thiruma Valavan Arumugam, Christian Gerloff, Immo Prinz, Tim Magnus, Mathias Gelderblom Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Induction of Cooling With a Passive Head and Neck Cooling Device: Effects on Brain Temperature After Stroke Clinical Sciences
Conclusions— Although the decrease of brain temperature after Sovika cooling device application was statistically significant, we doubt clinical relevance of this rather limited effect (–0.36°C). Moreover, the transient increases of blood pressure and ICP warrant caution.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Poli, S., Purrucker, J., Priglinger, M., Diedler, J., Sykora, M., Popp, E., Steiner, T., Veltkamp, R., Bosel, J., Rupp, A., Hacke, W., Hametner, C. Tags: Cerebrovascular disease/stroke, CPR and emergency cardiac care, Other Treatment, Emergency treatment of Stroke Clinical Sciences Source Type: research

Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion Brief Reports
Conclusions— Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Chen, J., Liu, L., Zhang, H., Geng, X., Jiao, L., Li, G., Coutinho, J. M., Ding, Y., Liebeskind, D. S., Ji, X. Tags: Revascularization, Ischemic Stroke Brief Reports Source Type: research

Survivor gives us a lens into regional systems of care for acute ischemic stroke in North Dakota
I just got back from the North Dakota Mission: Lifeline STEMI and Acute Stroke Conference in Bismark, ND. I had a great time and I learned a lot. I often get asked to speak in various venues about acute STEMI and 12-lead ECG interpretation, but for this conference they wanted me to talk mostly about stroke. That turned out to be a good thing because it forced me to read the 2013 AHA / ASA Guildelines for the Early Management of Patients With Acute Ischemic Stroke to make sure I was asking intelligent questions during the panel discussion (which I moderated) and also giving accurate information for the class I taught about ...
Source: EMS 12-Lead - May 31, 2013 Category: Cardiology Authors: Tom Bouthillet Tags: ems-topics patient-management North Dakota Mission Lifeline Stroke Source Type: research

European Stroke Organisation (ESO) guidelines for the management of temperature in patients with acute ischemic stroke
ConclusionsThe currently available data about the management of temperature in patients with acute ischemic stroke are limited, and the strengths of the recommendations are therefore weak. We call for new randomized controlled trials as well as recruitment of eligible patients to ongoing randomized controlled trials to allow for better‐informed recommendations in the future.
Source: International Journal of Stroke - July 1, 2015 Category: Neurology Authors: George Ntaios, Tomasz Dziedzic, Patrik Michel, Vasileios Papavasileiou, Jesper Petersson, Dimitre Staykov, Brenda Thomas, Thorsten Steiner, Tags: Guidelines Source Type: research

Short‐duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise
ConclusionsWe saw major intracranial pressure elevation 24 h after stroke in two rat strains, even after small strokes. Short‐duration hypothermia prevented the intracranial pressure rise, an effect sustained for at least 18 h after rewarming. The findings have potentially important implications for design of future clinical trials.
Source: International Journal of Stroke - September 12, 2013 Category: Neurology Authors: L. A. Murtha, D. D. McLeod, S. K. McCann, D. Pepperall, S. Chung, C. R. Levi, M. B. Calford, N. J. Spratt Tags: Research Source Type: research

EuroHYP‐1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke
DiscussionWith 750 patients per intervention group, this trial has 90% power to detect 7% absolute improvement at the 5% significance level. The full trial protocol is available at http://www.eurohyp1.eu. ClinicalTrials.gov Identifier: NCT01833312.
Source: International Journal of Stroke - May 15, 2014 Category: Neurology Authors: H. Bart Worp, Malcolm R. Macleod, Philip M. W. Bath, Jacques Demotes, Isabelle Durand‐Zaleski, Bernd Gebhardt, Christian Gluud, Rainer Kollmar, Derk W. Krieger, Kennedy R. Lees, Carlos Molina, Joan Montaner, Risto O. Roine, Jesper Petersson, Dimitre Sta Tags: Protocols Source Type: research

Targeted Temperature Management at 36  °C Shows Therapeutic Effectiveness via Alteration of Microglial Activation and Polarization After Ischemic Stroke
AbstractIschemic injury leads to cell death and inflammatory responses after stroke. Microglia especially play a crucial role in this brain inflammation. Targeted temperature management (TTM) at 33  °C has shown neuroprotective effects against many acute ischemic injuries. However, it has also shown some adverse effects in preclinical studies. Therefore, we explored the neuroprotective effect of TTM at 36 °C in the ischemic brain. To confirm the neuroprotective effects of hypothermia, mice were subjected to a permanent stroke and then treated with one of the TTM paradigms at 33 and 36 °C. For comparison of TTM at 33 ...
Source: Translational Stroke Research - April 24, 2021 Category: Neurology Source Type: research

Endovascular therapeutic hypothermia for acute ischemic stroke: ICTuS 2/3 protocol
Therapeutic hypothermia improves neurological outcome after out‐of‐hospital cardiac arrest or neonatal hypoxic–ischemic injury. Although supported by preclinical evidence, therapeutic hypothermia for acute stroke remains under study. In the Intravascular Cooling in the Treatment of Stroke (ICTuS) trial, awake stroke patients were successfully cooled using an endovascular cooling catheter and a novel antishivering regimen. In the ICTuS‐L study, the combination of endovascular hypothermia and thrombolysis proved feasible; while hypothermia was associated with no increased risk of bleeding complications, there was an ...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Patrick D. Lyden, Thomas M. Hemmen, James Grotta, Karen Rapp, Rema Raman Tags: Protocols Source Type: research

Impact of immediate post-reperfusion cooling on outcome in patients with acute stroke and substantial ischemic changes
Conclusions The use of post-reperfusion cooling as a rescue treatment in patients with substantial ischemia at baseline might improve clinical outcome.
Source: Journal of NeuroInterventional Surgery - December 13, 2016 Category: Neurosurgery Authors: Hwang, Y.-H., Jeon, J.-S., Kim, Y.-W., Kang, D.-H., Kim, Y.-S., Liebeskind, D. S. Tags: Ischemic stroke Source Type: research