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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Effect and feasibility of therapeutic hypothermia in patients with hemorrhagic stroke: a systematic review and meta-analysis
Therapeutic hypothermia (TH) has shown a good performance in the experimental hemorrhagic stroke. But the clinical application of TH remains controversial since reports regarding its therapeutic effect are inconsistent.
Source: World Neurosurgery - January 8, 2018 Category: Neurosurgery Authors: Zhong Yao, Chao You, Min He Tags: Literature Reviews Source Type: research

Effect and Feasibility of Therapeutic Hypothermia in Patients with Hemorrhagic Stroke: A  Systematic Review and Meta-Analysis
Therapeutic hypothermia (TH) has shown good results in experimental models of hemorrhagic stroke. The clinical application of TH, however, remains controversial, since reports regarding its therapeutic effect are inconsistent.
Source: World Neurosurgery - January 8, 2018 Category: Neurosurgery Authors: Zhong Yao, Chao You, Min He Tags: Literature Reviews Source Type: research

Magnesium as a Neuroprotective Agent: A Review of Its Use in the Fetus, Term Infant with Neonatal Encephalopathy, and the Adult Stroke Patient
This article explores the current status of magnesium being used as an adjunct to hypothermia in term neonatal encephalopathy (NE) against a background of its use in other populations. There is some evidence for magnesium sulfate as a neuroprotective agent, however animal studies of NE at term equivalent age have been confounded by concomitant hypothermia induced by magnesium itself. Nevertheless, the combination of magnesium and cooling has been shown to be more effective than either treatment alone in adult rodents. In the preterm baby, magnesium sulfate given antenatally in threatened preterm labor has demonstrated a si...
Source: Developmental Neuroscience - February 7, 2018 Category: Neuroscience Source Type: research

Influence of selective cerebral hypothermia on resting energy expenditure in patients in acute period of ischemic stroke
Rationale: Therapeutic hypothermia has a universally recognized neuroprotective potential, but clinical trials around the world are continuing to prove efficacy. To optimize nutritional support for patients with ischemic stroke who undergo selective cerebral hypothermia with systemic normothermia (SCH), we began the study.
Source: Clinical Nutrition - August 22, 2018 Category: Nutrition Authors: B.J. Torosyan, A.V. Butrov, O.A. Shevelev, D.V. Cheboxarov Source Type: research

Hypothermia in Addition to Decompressive Hemicraniectomy in Malignant Middle Cerebral Artery Stroke
This randomized clinical trial assesses whether moderate hypothermia after early hemicraniectomy reduces mortality in patients with malignant MCA stroke, compared with standard treatment.
Source: JAMA Neurology - January 18, 2019 Category: Neurology Source Type: research

Roles Played by the Na+/Ca2+ Exchanger and Hypothermia in the Prevention of Ischemia-Induced Carrier-Mediated Efflux of Catecholamines into the Extracellular Space: Implications for Stroke Therapy.
Abstract The release of [3H]dopamine ([3H]DA) and [3H]noradrenaline ([3H]NA) in acutely perfused rat striatal and cortical slice preparations was measured at 37 °C and 17 °C under ischemic conditions. The ischemia was simulated by the removal of oxygen and glucose from the Krebs solution. At 37 °C, resting release rates in response to ischemia were increased; in contrast, at 17 °C, resting release rates were significantly reduced, or resting release was completely prevented. The removal of extracellular Ca2+ further increased the release rates of [3H]DA and [3H]NA induced by ischemic conditions. This findi...
Source: Neurochemical Research - July 24, 2019 Category: Neuroscience Authors: Lakatos M, Baranyi M, Erőss L, Nardai S, Török TL, Sperlágh B, Vizi ES Tags: Neurochem Res Source Type: research

Neuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy
Publication date: Available online 17 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Julius Griauzde, Vijay M. Ravindra, Neeraj Chaudhary, Joseph J. Gemmete, Aditya S. PandeyAbstractMechanical thrombectomy is now at the forefront of the treatment of large vessel acute ischemic stroke (AIS). Selective intra-arterial (IA) access has opened a new avenue for neuroprotection in AIS that has the potential to maximize local benefit while minimizing systemic effects. On a cellular level, neuroprotective strategies are aimed at reducing inflammation and free-radical formation, maintaining blood-brain barrier fidelity...
Source: Journal of Clinical Neuroscience - August 18, 2019 Category: Neuroscience Source Type: research

Triple Neuroprotection With Targeted Hypothermia, Controlled Induced Hypertension and Barbiturate Infusion During Emergency Carotid Endarterectomy for Acute Stroke
This study aims to establish the initial safety of Triple Neuroprotection (TN) in surgical management of acute stroke.
Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Sherif Sultan, Makinderjit Dulai, John Laffey, Kevin Clarkson, Abdelaly Ma Abedi, Nora Barrett, Wael Tawfick, Niamh Hynes Source Type: research

Safety of Triple Neuroprotection with targeted hypothermia, controlled induced hypertension and barbiturate infusion during emergency carotid endarterectomy for acute stroke after missing the 24 hours window opportunity.
and Purpose: Our study aims to establish the initial safety of triple neuroprotection (TNP) in an acute stroke setting in patients presenting outside the window for systemic tissue plasminogen activator (tPA).
Source: Annals of Vascular Surgery - May 26, 2020 Category: Surgery Authors: Sherif Sultan, Makinderjit Dulai, John Laffey, Kevin Clarkson, Abdelaly MA. Abedi, Nora Barrett, Mohamed Elsherif, Wael Tawfick, Niamh Hynes Tags: Clinical Research, Basic Science Source Type: research

Safety of Triple Neuroprotection with Targeted Hypothermia, Controlled Induced Hypertension, and Barbiturate Infusion during Emergency Carotid Endarterectomy for Acute Stroke after Missing the 24  Hours Window Opportunity
The aim of this study is to establish the initial safety of triple neuroprotection (TNP) in an acute stroke setting in patients presenting outside the window for systemic tissue plasminogen activator (tPA).
Source: Annals of Vascular Surgery - May 26, 2020 Category: Surgery Authors: Sherif Sultan, Makinderjit Dulai, John Laffey, Kevin Clarkson, Abdelaly M.A. Abedi, Nora Barrett, Mohamed Elsherif, Wael Tawfick, Niamh Hynes Tags: Clinical Research Source Type: research

Selective Brain Hypothermia for Ischemic MCA-M1 Stroke: Influence of Cerebral Arterial Circulation in a 3D Brain Temperature Model
Acute ischemic stroke is a major health problem with a high mortality rate and a high risk for permanent disabilities. Selective brain hypothermia has the neuroprotective potential to possibly lower cerebral harm. A recently developed catheter system enables to combine endovascular blood cooling and thrombectomy using the same endovascular access. By using the penumbral perfusion via leptomeningeal collaterals, the catheter aims at enabling a cold reperfusion, which mitigates the risk of a reperfusion injury. However, cerebral circulation is highly patient-specific and can vary greatly. Since direct measurement of remainin...
Source: IEEE Transactions on Biomedical Engineering - January 22, 2021 Category: Biomedical Engineering Source Type: research

Mild hypothermia combined with dexmedetomidine reduced brain, lung, and kidney damage in experimental acute focal ischemic stroke
Sedatives and mild hypothermia alone may yield neuroprotective effects in acute ischemic stroke (AIS). However, the impact of this combination is still under investigation. We compared the effects of the combi...
Source: Intensive Care Medicine Experimental - December 19, 2022 Category: Surgery Authors: Denise Battaglini, Adriana Lopes da Silva, Nathane Santanna Felix, Gisele Rodrigues, Mariana Alves Antunes, Nazareth Novaes Rocha, Vera Luiza Capelozzi, Marcelo Marcos Morales, Fernanda Ferreira Cruz, Chiara Robba, Pedro Leme Silva, Paolo Pelosi and Patri Tags: Research Articles Source Type: research

Adjuvant therapies using normobaric oxygen with hypothermia or ethanol for reducing hyperglycolysis in thromboembolic cerebral ischemia
Conclusions: In a rat thromboembolic stroke model, both EtOH and TH used individually offer neuroprotection after the administration of rt-PA. While NBO monotherapy does not appear to be effective, it significantly potentiates the efficacy of EtOH and TH. The similar neuroprotection and underlying mechanisms pertaining to the attenuation of hyperglycolysis provided by EtOH or TH in combination with NBO suggest a possibility of substituting EtOH for TH. Thus a combination of NBO and EtOH, which are widely available and easily used, could become a novel and effective neuroprotective strategy in the clinical setting.
Source: Neuroscience - January 24, 2016 Category: Neuroscience Source Type: research

Innovations, new strategies and surprising twists in Neurology: captured in new journal Neurological Research and Practice
What are the current hot topics in neurology, what do you anticipate will be the challenges and trends in the future within the field? Neurology is such a rapidly moving field that it is impossible to anticipate what the new trends will be. We were frequently proven wrong with our predictions in the past, while completely unexpected developments happened and new avenues were opened. One thing however is for sure: There will be numerous innovations, new strategies, surprising twists and turns, and within the new journal Neurological Research and Practice we try to capture some of them. What are your research interests and w...
Source: BioMed Central Blog - October 1, 2018 Category: General Medicine Authors: Victoria Hentschke Tags: Biology Medicine Open Access Publishing Neurological Research and Practice Source Type: blogs

The impact of unilateral versus bilateral antegrade cerebral perfusion on surgical outcomes after aortic arch replacement: A propensity-matched analysis
Conclusions: Using unilateral antegrade cerebral perfusion in a pressure-controlled manner during mild systemic hypothermia is a safe protection strategy in elective aortic arch surgery, associated with similar morbidity and mortality in comparison with bilateral antegrade cerebral perfusion, even if total arch replacement is required. Bilateral antegrade cerebral perfusion reveals a trend of higher incidence of stroke, probably due to manipulation on the arch vessels.
Source: The Journal of Thoracic and Cardiovascular Surgery - January 6, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Andreas Zierer, Petar Risteski, Ali El-Sayed Ahmad, Anton Moritz, Anno Diegeler, Paul P. Urbanski Tags: Acquired Cardiovascular Disease Source Type: research