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Condition: Hypothermia

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Total 450 results found since Jan 2013.

Twenty-four hours hypothermia has temporary efficacy in reducing brain infarction and inflammation in aged rats.
Abstract Stroke is a major cause of disability for which no neuroprotective measures are available. Age is the principal nonmodifiable risk factor for this disease. Previously, we reported that exposure to hydrogen sulfide for 48 hours after stroke lowers whole body temperature and confers neuroprotection in aged animals. Because the duration of hypothermia in most clinical trials is between 24 and 48 hours, we questioned whether 24 hours exposure to gaseous hypothermia confers the same neuroprotective efficacy as 48 hours exposure. We found that a shorter exposure to hypothermia transiently reduced both infla...
Source: Neurobiology of Aging - February 1, 2016 Category: Geriatrics Authors: Sandu RE, Buga AM, Balseanu AT, Moldovan M, Popa-Wagner A Tags: Neurobiol Aging Source Type: research

Hypothermia followed by rapid rewarming exacerbates ischemia-induced brain injury and augments inflammatory response in rats.
Abstract Hypothermia followed by slow rewarming is neuroprotective for ischemic stroke. However, slow rewarming causes patients' longer stay in intensive care unit and increases the risk of hypothermic complications. Hypothermia followed by rapid rewarming (HTRR) is more convenient; but it exacerbates intracranial hypertension for patients with massive hemispheric infarcts. The present study aims to investigate in detail how HTRR exacerbates ischemic brain injury and what are underlying mechanisms. Rats subjected to transient focal ischemia by middle cerebral artery occlusion were treated with normothermia or hypo...
Source: Biochemical and Biophysical Research communications - April 19, 2016 Category: Biochemistry Authors: Zhu SZ, Gu Y, Wu Z, Hu YF, Pan SY Tags: Biochem Biophys Res Commun Source Type: research

Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance INTERVENTIONAL
CONCLUSIONS: Sheep proved a feasible animal model for the intracarotid cooling catheter. Fast induction of selective mild hypothermia was achieved within the cooled cerebral hemisphere, with stable temperature gradients in the contralateral brain and systemic blood. Further studies are required to demonstrate any therapeutic benefit of selective cerebral cooling in a stroke model.
Source: American Journal of Neuroradiology - May 12, 2016 Category: Radiology Authors: Cattaneo, G., Schumacher, M., Maurer, C., Wolfertz, J., Jost, T., Büchert, M., Keuler, A., Boos, L., Shah, M. J., Foerster, K., Niesen, W.- D., Ihorst, G., Urbach, H., Meckel, S. Tags: INTERVENTIONAL Source Type: research

Local cerebral hypothermia induced by selective infusion of cold lactated ringer's: a feasibility study in rhesus monkeys.
CONCLUSION: Local infusion of ice-cold lactated Ringer's solution via micro-catheter is a safe and effective method for selective cerebral hypothermia. This cooling method could potentially be developed as a new treatment in acute ischemic stroke. PMID: 27320250 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1
Acute ischemic stroke causes significant chronic disability worldwide. We designed this study to clarify the mechanism by which hypothermia helps alleviate acute ischemic stroke. In a middle cerebral artery oc...
Source: Molecular Brain - August 20, 2016 Category: Neuroscience Authors: Jung Ho Lee, Eun Jang Yoon, Jeho Seo, Adriana Kavoussi, Yong Eun Chung, Sung Phil Chung, Incheol Park, Chul Hoon Kim and Je Sung You Source Type: research

Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion.
In conclusion, we demonstrated the neuroprotective effects of transarterial regional hypothermia in an ischemic model of pMCAO with tCHP. Even though MCAO is persistent, cold infusion via the ICA is neuroprotective for the penumbra, suggesting the wider therapeutic application of this therapy. PMID: 27663968 [PubMed - as supplied by publisher]
Source: Brain Research - September 19, 2016 Category: Neurology Authors: Kurisu K, Abumiya T, Ito M, Gekka M, Osanai T, Shichinohe H, Nakayama N, Kazumata K, Houkin K Tags: Brain Res Source Type: research

Useful Computed Tomography Score for Estimation of Early Neurologic Outcome in Post-Cardiac Arrest Patients With Therapeutic Hypothermia.
CONCLUSIONS: These findings suggest that an initial CT score (ASPECTS-b) could help estimate early neurologic outcomes in post-cardiac arrest patients treated with therapeutic hypothermia. PMID: 28592725 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 6, 2017 Category: Cardiology Authors: Lee KS, Lee SE, Choi JY, Gho YR, Chae MK, Park EJ, Choi MH, Hong JM Tags: Circ J Source Type: research

Revelation of the circumstances of the accident vascular arterial ischemic brain in at term or near-term and referral.
Abstract The neonatal arterial ischemic stroke is an emergency. Recurrent focal seizures, generally occurring in the first 24-72 hours after birth, are the commonest first clinical signs. When neonatal arterial ischemic stroke is suspected, optimal initial management involves careful supportive care including treatment of clinical and frequent or prolonged subclinical seizures, correction of the possible metabolic disorders and their prevention. Contrary to hypoxic ischemic encephalopathy, therapeutic hypothermia is not indicated. This newborn requires emergent transfer to a neonatal intensive care unit for the co...
Source: Archives de Pediatrie - September 1, 2017 Category: Pediatrics Authors: Cneude F, Diependaele JF, Chabernaud JL Tags: Arch Pediatr Source Type: research

A model based on the Pennes bioheat transfer equation is valid in normal brain tissue but not brain tissue suffering focal ischaemia
AbstractIschaemic stroke is a major public health issue in both developed and developing nations. Hypothermia is believed to be neuroprotective in cerebral ischaemia. Conversely, elevated brain temperature is associated with poor outcome after ischaemic stroke. Mechanisms of heat exchange in normally-perfused brain are relatively well understood, but these mechanisms have not been studied as extensively during focal cerebral ischaemia. A finite element model (FEM) of heat exchange during focal ischaemia in the human brain was developed, based on the Pennes bioheat equation. This model incorporated healthy (normally-perfuse...
Source: Australasian Physical and Engineering Sciences in Medicine - November 2, 2017 Category: Biomedical Engineering Source Type: research

Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies
ABSTRACTPURPOSE OF REVIEWNeonatal encephalopathy is the most common condition in neonates encountered by child neurologists. The etiology is most often global hypoxia-ischemia due to failure of cerebral perfusion to the fetus caused by uterine, placental, or umbilical cord compromise prior to or during delivery. Other etiologies of neonatal encephalopathy include ischemic stroke and intracranial hemorrhage, infection, developmental anomalies, and inborn errors of metabolism.RECENT FINDINGSTherapeutic hypothermia is standard of care for the treatment of neonatal encephalopathy presumed to be caused by hypoxia-ischemia. The ...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2018 Category: Neurology Tags: Review Articles Source Type: research

Neurologic Complications in the Pediatric Intensive Care Unit
This article discusses an approach to the recognition and management of seizures, stroke, and cardiac arrest as complications of other critical illnesses in the pediatric intensive care unit.RECENT FINDINGSConvulsive and nonconvulsive seizures occur frequently in children after cardiac arrest or traumatic brain injury and during extracorporeal membrane oxygenation. Seizures may add to neurologic morbidity, and continuous EEG monitoring is needed for up to 24 hours for detection. Hypothermia has not been shown to improve outcome after cardiac arrest in children, but targeted temperature management with controlled normotherm...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2018 Category: Neurology Tags: Review Articles Source Type: research

Comparison of three haemodynamic monitoring methods in comatose post cardiac arrest patients.
CONCLUSION: We found low bias, but relatively wide limits of agreement in SV with PiCCO, FloTrac/Vigileo and TTE during TTM treatment. The methods are not interchangeable. Precision was not improved by transpulmonary thermodilution calibration during hypothermia. PMID: 29544369 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - March 20, 2018 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Role of Moderate Hypothermia and Antegrade Cerebral Perfusion during Repair of Type A Aortic Dissection
Int J Angiol DOI: 10.1055/s-0038-1675204The goal of this study was to compare early postoperative outcomes and actuarial survival between patients who underwent repair of acute type A aortic dissection with deep or moderate hypothermia.A total of 132 consecutive patients from a single academic medical center underwent repair of acute type A aortic dissection between January 2000 and June 2014. Of those, 105 patients were repaired under deep hypothermia (< 24 C°), while 27 patients were repaired under moderate hypothermia (≥24 C°). Median ages were 62 years (range: 27–86) and 59 years (range: 35–83) for patients ...
Source: International Journal of Angiology - October 29, 2018 Category: Cardiology Authors: Stamou, Sotiris C. McHugh, Michael A. Conway, Brian D. Nores, Marcos Tags: Original Article Source Type: research

Intracranial atherosclerotic disease.
Abstract Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensiv...
Source: Neurobiology of Disease - November 12, 2018 Category: Neurology Authors: Wang Y, Meng R, Liu G, Cao C, Chen F, Jin K, Ji X, Cao G Tags: Neurobiol Dis Source Type: research

Early Prophylactic Hypothermia for Patients With Severe Traumatic Injury: Premature to Close the Case
This study demonstrates that there is no role for the initiation of hypothermia during the acute phase of TBI (1, 2). However, it would be damaging to abandon the concept prematurely. Inflammation Also Paves the Way to Tissue Repair As soon as trauma occurs, the inflammatory cascade begins to take place. The deleterious role of inflammation in the secondary injury response is well-documented, hence the rationale to attempt early prophylactic hypothermia in TBI. However, inflammation also initiates tissue repair and regeneration (3–6). We now know that the secondary injury response accompanies the regenerating and...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research