Brain age of rhesus macaques over the lifespan
In this study, we present the methodology of constructing a rhesus macaque brain age model using a machine learning algorithm and discuss the key predictive brain regions in comparison to the human brain, to shed light on cross-species primate similarities and differences. Structural information of the brain (e.g., parcellated volumes) from brain magnetic resonance imaging of 43 rhesus macaques were used to develop brain atlas-based features to build a brain age model that predicts biological age. The best-performing model used 22 selected features and achieved an R2 of 0.72. We also identified interpretable predictive bra...
Source: Neurobiology of Aging - April 21, 2024 Category: Geriatrics Authors: Yang S Liu Madhura Baxi Christopher R Madan Kevin Zhan Nikolaos Makris Douglas L Rosene Ronald J Killiany Suheyla Cetin-Karayumak Ofer Pasternak Marek Kubicki Bo Cao Source Type: research
Brain oscillatory processes related to sequence memory in healthy older adults
Neurobiol Aging. 2024 Apr 6;139:64-72. doi: 10.1016/j.neurobiolaging.2024.04.001. Online ahead of print.ABSTRACTSequence memory is subject to age-related decline, but the underlying processes are not yet fully understood. We analyzed electroencephalography (EEG) in 21 healthy older (60-80 years) and 26 young participants (20-30 years) and compared time-frequency spectra and theta-gamma phase-amplitude-coupling (PAC) during encoding of the order of visually presented items. In older adults, desynchronization in theta (4-8 Hz) and synchronization in gamma (30-45 Hz) power did not distinguish between subsequently correctly an...
Source: Neurobiology of Aging - April 16, 2024 Category: Geriatrics Authors: Nina M Ehrhardt Agnes Fl öel Shu-Chen Li Guglielmo Lucchese Daria Antonenko Source Type: research
Brain oscillatory processes related to sequence memory in healthy older adults
Neurobiol Aging. 2024 Apr 6;139:64-72. doi: 10.1016/j.neurobiolaging.2024.04.001. Online ahead of print.ABSTRACTSequence memory is subject to age-related decline, but the underlying processes are not yet fully understood. We analyzed electroencephalography (EEG) in 21 healthy older (60-80 years) and 26 young participants (20-30 years) and compared time-frequency spectra and theta-gamma phase-amplitude-coupling (PAC) during encoding of the order of visually presented items. In older adults, desynchronization in theta (4-8 Hz) and synchronization in gamma (30-45 Hz) power did not distinguish between subsequently correctly an...
Source: Neurobiology of Aging - April 16, 2024 Category: Geriatrics Authors: Nina M Ehrhardt Agnes Fl öel Shu-Chen Li Guglielmo Lucchese Daria Antonenko Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression
Neurobiol Aging. 2024 Mar 15;139:54-63. doi: 10.1016/j.neurobiolaging.2024.03.003. Online ahead of print.ABSTRACTNucleus Basalis of Meynert (NbM), a crucial source of cholinergic projection to the entorhinal cortex (EC) and hippocampus (HC), has shown sensitivity to neurofibrillary degeneration in the early stages of Alzheimer's Disease. Using deformation-based morphometry (DBM) on up-sampled MRI scans from 1447 Alzheimer's Disease Neuroimaging Initiative participants, we aimed to quantify NbM degeneration along the disease trajectory. Results from cross-sectional analysis revealed significant differences of NbM volume bet...
Source: Neurobiology of Aging - April 12, 2024 Category: Geriatrics Authors: Neda Shafiee Vladimir Fonov Mahsa Dadar R Nathan Spreng D Louis Collins Source Type: research
Decomposing neurophysiological underpinnings of age-related decline in visual working memory
Neurobiol Aging. 2024 Mar 20;139:30-43. doi: 10.1016/j.neurobiolaging.2024.03.004. Online ahead of print.ABSTRACTExploring the neural basis of age-related decline in working memory is vital in our aging society. Previous electroencephalographic studies suggested that the contralateral delay activity (CDA) may be insensitive to age-related decline in lateralized visual working memory (VWM) performance. Instead, recent evidence indicated that task-induced alpha power lateralization decreases in older age. However, the relationship between alpha power lateralization and age-related decline of VWM performance remains unknown, ...
Source: Neurobiology of Aging - April 9, 2024 Category: Geriatrics Authors: Marius Tr öndle Nicolas Langer Source Type: research
Trajectories of amyloid beta accumulation - Unveiling the relationship with APOE genotype and cognitive decline
Neurobiol Aging. 2024 Mar 29;139:44-53. doi: 10.1016/j.neurobiolaging.2024.03.007. Online ahead of print.ABSTRACTAmyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this function, reflected by different Aβ accumulation phases, influences APOE ɛ4's association with Aβ and cognitive decline in 503 participants without dementia using Aβ-PET imaging over 5.3-years. First, Aβ load and accumulation were analyzed irrespective of phases using linear mixed regression. Generally, ɛ4 carriers displayed a higher Aβ load. Moreover, Aβ normal (Aβ-) ɛ4 carriers de...
Source: Neurobiology of Aging - April 9, 2024 Category: Geriatrics Authors: Maha Wybitul Andreas Buchmann Nicolas Langer Christoph Hock Valerie Treyer Anton Gietl Alzheimer ’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing Source Type: research
Decomposing neurophysiological underpinnings of age-related decline in visual working memory
Neurobiol Aging. 2024 Mar 20;139:30-43. doi: 10.1016/j.neurobiolaging.2024.03.004. Online ahead of print.ABSTRACTExploring the neural basis of age-related decline in working memory is vital in our aging society. Previous electroencephalographic studies suggested that the contralateral delay activity (CDA) may be insensitive to age-related decline in lateralized visual working memory (VWM) performance. Instead, recent evidence indicated that task-induced alpha power lateralization decreases in older age. However, the relationship between alpha power lateralization and age-related decline of VWM performance remains unknown, ...
Source: Neurobiology of Aging - April 9, 2024 Category: Geriatrics Authors: Marius Tr öndle Nicolas Langer Source Type: research
Trajectories of amyloid beta accumulation - Unveiling the relationship with APOE genotype and cognitive decline
Neurobiol Aging. 2024 Mar 29;139:44-53. doi: 10.1016/j.neurobiolaging.2024.03.007. Online ahead of print.ABSTRACTAmyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this function, reflected by different Aβ accumulation phases, influences APOE ɛ4's association with Aβ and cognitive decline in 503 participants without dementia using Aβ-PET imaging over 5.3-years. First, Aβ load and accumulation were analyzed irrespective of phases using linear mixed regression. Generally, ɛ4 carriers displayed a higher Aβ load. Moreover, Aβ normal (Aβ-) ɛ4 carriers de...
Source: Neurobiology of Aging - April 9, 2024 Category: Geriatrics Authors: Maha Wybitul Andreas Buchmann Nicolas Langer Christoph Hock Valerie Treyer Anton Gietl Alzheimer ’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing Source Type: research
Decomposing neurophysiological underpinnings of age-related decline in visual working memory
Neurobiol Aging. 2024 Mar 20;139:30-43. doi: 10.1016/j.neurobiolaging.2024.03.004. Online ahead of print.ABSTRACTExploring the neural basis of age-related decline in working memory is vital in our aging society. Previous electroencephalographic studies suggested that the contralateral delay activity (CDA) may be insensitive to age-related decline in lateralized visual working memory (VWM) performance. Instead, recent evidence indicated that task-induced alpha power lateralization decreases in older age. However, the relationship between alpha power lateralization and age-related decline of VWM performance remains unknown, ...
Source: Neurobiology of Aging - April 9, 2024 Category: Geriatrics Authors: Marius Tr öndle Nicolas Langer Source Type: research
Trajectories of amyloid beta accumulation - Unveiling the relationship with APOE genotype and cognitive decline
Neurobiol Aging. 2024 Mar 29;139:44-53. doi: 10.1016/j.neurobiolaging.2024.03.007. Online ahead of print.ABSTRACTAmyloid beta (Aβ) follows a sigmoidal time function with varying accumulation rates. We studied how the position on this function, reflected by different Aβ accumulation phases, influences APOE ɛ4's association with Aβ and cognitive decline in 503 participants without dementia using Aβ-PET imaging over 5.3-years. First, Aβ load and accumulation were analyzed irrespective of phases using linear mixed regression. Generally, ɛ4 carriers displayed a higher Aβ load. Moreover, Aβ normal (Aβ-) ɛ4 carriers de...
Source: Neurobiology of Aging - April 9, 2024 Category: Geriatrics Authors: Maha Wybitul Andreas Buchmann Nicolas Langer Christoph Hock Valerie Treyer Anton Gietl Alzheimer ’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing Source Type: research
Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Neurobiol Aging. 2024 Mar 13;139:20-29. doi: 10.1016/j.neurobiolaging.2024.03.002. Online ahead of print.ABSTRACTBrazilian green propolis (propolis) is a chemically complex resinous substance that is a potentially viable therapeutic agent for Alzheimer's disease. Herein, propolis induced a transient increase in intracellular Ca2+ concentration ([Ca2+]i) in Neuro-2A cells; moreover, propolis-induced [Ca2+]i elevations were suppressed prior to 24-h pretreatment with amyloid-β. To reveal the effect of [Ca2+]i elevation on impaired cognition, we performed memory-related behavioral tasks in APP-KI mice relative to WT mice at 4...
Source: Neurobiology of Aging - April 7, 2024 Category: Geriatrics Authors: Ryo Inagaki Tohru Yamakuni Takashi Saito Takaomi C Saido Shigeki Moriguchi Source Type: research
Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice
Neurobiol Aging. 2024 Mar 13;139:20-29. doi: 10.1016/j.neurobiolaging.2024.03.002. Online ahead of print.ABSTRACTBrazilian green propolis (propolis) is a chemically complex resinous substance that is a potentially viable therapeutic agent for Alzheimer's disease. Herein, propolis induced a transient increase in intracellular Ca2+ concentration ([Ca2+]i) in Neuro-2A cells; moreover, propolis-induced [Ca2+]i elevations were suppressed prior to 24-h pretreatment with amyloid-β. To reveal the effect of [Ca2+]i elevation on impaired cognition, we performed memory-related behavioral tasks in APP-KI mice relative to WT mice at 4...
Source: Neurobiology of Aging - April 7, 2024 Category: Geriatrics Authors: Ryo Inagaki Tohru Yamakuni Takashi Saito Takaomi C Saido Shigeki Moriguchi Source Type: research
