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Condition: Hypothermia
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Total 450 results found since Jan 2013.
Longitudinal MRI evaluation of neuroprotective effects of pharmacologically induced hypothermia in experimental ischemic stroke
Pharmacologically induced hypothermia (PIH) shows promising neuroprotective effects after stroke insult. However, the dynamic evolution of stroke infarct during the hypothermic therapy has not been understood very well. In the present study, MRI was utilized to longitudinally characterize the infarct evolution in a mouse model of ischemic stroke treated by PIH using the neurotensin agonist HPI201. Adult male C57BL/6 mice underwent permanent occlusion of the right middle cerebra artery (MCA). Each animal received a vehicle or HPI201 intraperitoneal injection.
Source: Magnetic Resonance Imaging - April 1, 2017 Category: Radiology Authors: Silun Wang, Xiaohuan Gu, Ramesh Paudyal, Ling Wei, Thomas A. Dix, Shan P. Yu, Xiaodong Zhang Tags: Original contribution Source Type: research
Diagnostic and treatment standards for cerebral sinus venous thrombosis : Results of an online survey of German stroke units.
CONCLUSION: The survey revealed substantial homogeneity between RSUs and SRSUs and standards are mostly in line with the guidelines. Non-established procedures, such as invasive therapeutic procedures and the administration of new oral anticoagulants were used significantly more often in SRSUs.
PMID: 28695244 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - July 10, 2017 Category: Neurology Authors: Geisbüsch C, Ringleb PA, Busse O, Hamann GF, Nagel S Tags: Nervenarzt Source Type: research
Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke
It has been suggested that medications can increase heat stroke (HS) susceptibility/severity. We investigated whether the nonsteroidal anti-inflammatory drug (NSAID) indomethacin (INDO) increases HS severity in a rodent model. Core temperature (Tc) of male, C57BL/6J mice (n = 45) was monitored continuously, and mice were given a dose of INDO [low dose (LO) 1 mg/kg or high dose (HI) 5 mg/kg in flavored treat] or vehicle (flavored treat) before heating. HS animals were heated to 42.4°C and euthanized at three time points for histological, molecular, and metabolic analysis: onset of HS [maximal core temperature (Tc,Max)],...
Source: Journal of Applied Physiology - September 6, 2017 Category: Physiology Authors: Audet, G. N., Dineen, S. M., Stewart, D. A., Plamper, M. L., Pathmasiri, W. W., McRitchie, S. L., Sumner, S. J., Leon, L. R. Tags: RESEARCH ARTICLE Source Type: research
Therapeutic Hypothermia in Acute Ischemic Stroke —a Systematic Review and Meta-Analysis
AbstractPurpose of ReviewTherapeutic hypothermia (TH) in stroke demonstrates robust neuroprotection in animals but clinical applications remain controversial. We assessed current literature on the efficacy of TH in ischemic stroke.Recent FindingsWe conducted a meta-analysis comparing TH versus controls in studies published until June 2019. Controlled studies reporting on ≥ 10 adults with acute ischemic stroke were included. Primary outcome was functional independence (modified Rankin Scale [mRS] ≤ 2). Twelve studies (n = 351 TH,n = 427 controls) were included. Functional independence did not differ between ...
Source: Current Neurology and Neuroscience Reports - May 4, 2020 Category: Neuroscience Source Type: research
Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke
AbstractEarly reperfusion is increasingly prioritized in ischemic stroke care, but outcomes remain suboptimal. Therefore, there is an urgent need to find neuroprotective approaches that can be combined with reperfusion to maximize efficacy. Here, the neuroprotective mechanisms behind therapeutic hypothermia were evaluated in a monkey model of ischemic stroke. Focal ischemia was induced in adult rhesus monkeys by placing autologous clots in the middle cerebral artery. Monkeys were treated with tissue plasminogen activator (t-PA) alone or t-PA plus selective intra-arterial cooling (SI-AC). Serial MRI scans and functional def...
Source: Neurotherapeutics - July 23, 2020 Category: Neurology Source Type: research
A Systematic Review and Meta-Analysis of Animal Studies Testing Intra-Arterial Chilled Infusates After Ischemic Stroke
Conclusion: Despite convincing evidence of benefit in ischemic stroke models, additional studies are required to determine the scope of benefit, especially when considering additional elements (e.g., dosing characteristics). As there is interest in using this treatment alongside current ischemic stroke therapies, more relevant animal studies will be critical to inform patient studies.
Source: Frontiers in Neurology - January 6, 2021 Category: Neurology Source Type: research
An Inhibitory and Beneficial Effect of Chlorpromazine and Promethazine (C+P) on Hyperglycolysis through HIF-1 α Regulation in Ischemic Stroke
CONCLUSION: C+P, partially depending on hypothermia, attenuates hyperglycolysis and NOX activation through HIF-1α regulation.PMID:33811844 | DOI:10.1016/j.brainres.2021.147463
Source: Brain Research - April 3, 2021 Category: Neurology Authors: Sichao Guo Eric Cosky Fengwu Li Longfei Guan Yu Ji Wenjing Wei Changya Peng Xiaokun Geng Yuchuan Ding Source Type: research
Association between cooling temperature and outcomes of patients with heat stroke
This study explored the relationship between body temperature and adverse outcomes in patients with heat stroke to identify the optimal target body temperature within the first 24 h. This retrospective, multicentre study enrolled 143 patients admitted to the emergency department and diagnosed with heat stroke. The primary outcome was the in-hospital mortality rate, while secondary outcomes included the presence and number of damaged organs and neurological sequelae at disch arge. A body temperature curve was built using a generalized additive mixed model, and the association between body temperatures and outcomes was est...
Source: Internal and Emergency Medicine - May 3, 2023 Category: Emergency Medicine Source Type: research
LB-007 Selective brain cooling is possible via CSF exchange with double lumen EVD-proof of concept in porcine stroke model
ConclusionWe are first to describe that selective brain cooling is possible via CSF exchange with double lumen EVD to achieve significant temperature difference between body core and brain. The timing and rate of selective cooling needs to be established as cause of arrhythmias before starting human trials.DisclosuresB. Rezai Jahromi: 1; C; IRRAS. 2; C; Neurovascular Innovations. 4; C; Neurovascular Innovations. 6; C; Helsinki Surgical Instruments. N. Järveläinen: None. J. Kauhanen: None. V. Zamotin: None. N. Brandmeir: 1; C; IRRAS. 2; C; IRRAS. M. Niemelä: None. S. Ylä-Herttuala: None.
Source: Journal of NeuroInterventional Surgery - August 3, 2023 Category: Neurosurgery Authors: Rezai Jahromi, B., Järveläinen, N., Kauhanen, J., Zamotin, V., Brandmeir, N., Niemelä, M., Ylä-Herttuala, S. Tags: SNIS 20th annual meeting late-breaking oral abstracts Source Type: research
Increased cytokine and chemokine gene expression in the CNS of mice during heat stroke recovery.
Abstract
Heat stroke (HS) is characterized by a systemic inflammatory response syndrome (SIRS) consisting of profound core temperature (Tc) changes in mice. Encephalopathy is common at HS collapse, but inflammatory changes occurring in the brain during the SIRS remain unidentified. We determined the association between inflammatory gene expression changes in the brain with Tc disturbances during HS recovery in mice. Gene expression changes of heat shock protein (HSP)72, heme-oxygenase (hmox1), cytokines (IL-1β, IL-6, TNFα), cyclooxygenase enzymes (COX-1, COX-2), chemokines (MCP-1, MIP-1α, MIP-1β, CX3CR1), and ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 11, 2013 Category: Physiology Authors: Biedenkapp JC, Leon LR Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
113. Neurophysiology in neonatal stroke undergoing therapeutic hypotermia: An illustrative case
We report EEG monitoring and EP in a neonate with stroke due to internal carotid thrombosis who underwent TH. Case Report: A female infant born at 38 GA, BW 2730 gr (10°ile), was recruited for TH at 3h of life, because of Sarnat 2 plus pH
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: E. Toffoli, D. De Carlo, A. Cappellari, E. Cainelli, D. Trevisanuto, A. Suppiej Tags: Society Proceedings Source Type: research
Pharmacologically-induced hypothermia by TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 minutes after reperfusion.
We examined effectiveness and specificity of pharmacological hypothermia by transient receptor potential vanilloid 1 (TRPV1) channel agonism in the treatment of focal cerebral I/R. Core temperature (Tcore) was measured after subcutaneous infusion of TRPV1 agonist, dihydrocapsaicin (DHC), in conscious C57BL/6 WT and TRPV1 KO mice. Acute measurements of heart rate (HR), mean arterial pressure (MAP), and cerebral perfusion were measured before and after DHC treatment. Focal cerebral I/R (one hour ischemia + 24 hours reperfusion) was induced by distal middle cerebral artery occlusion. Hypothermia (> 8 hours) was initiated 9...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2013 Category: Physiology Authors: Cao Z, Balasubramanian A, Marrelli SP Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
Awake Surface Cooling Feasible in Stroke PatientsAwake Surface Cooling Feasible in Stroke Patients
Surface cooling to induce mild hypothermia in awake stroke patients after IV thrombolysis is safe and feasible, a small study suggests. Reuters Health Information
Source: Medscape Nephrology Headlines - February 11, 2014 Category: Urology & Nephrology Tags: Nephrology News Source Type: news
Hibernation-like neuroprotection in stroke by attenuating brain metabolic dysfunction
Publication date: Available online 7 March 2016 Source:Progress in Neurobiology Author(s): Brian Forreider, David Pozivilko, Qingwen Kawaji, Xiaokun Geng, Yuchuan Ding Many mammalian species naturally undergo hibernation, a process that is associated with drastic changes in metabolism and systemic physiology. Their ability to retain an undamaged central nervous system during severely reduced cerebral blood flow has been studied for possible therapeutic application in human ischemic stroke. By inducing a less extreme ‘hibernation-like’ state, it has been hypothesized that similar neuroprotective effects reduce is...
Source: Progress in Neurobiology - March 8, 2016 Category: Neuroscience Source Type: research
