[Neurogenetics of schizophrenia: findings from studies based on data sharing and global partnerships].
Abstract Schizophrenic psychoses are the result of a multifactorial process in which not only environmental influences but also genetic factors play an important role. These factors are based on a complex mode of inheritance that involves a large number of genetic variants. In the last three decades, biological psychiatric research has focused closely on molecular genetic aspects of the hereditary basis of schizophrenic psychoses. In particular, international consortia are combining cohorts from individual researchers, creating continuously increasing sample sizes and thus increased statistical powe...
Source: Der Nervenarzt - January 13, 2021 Category: Neurology Authors: Adorjan K, Schulze TG, Budde M, Heilbronner U, Tessema F, Mekonnen Z, Falkai P Tags: Nervenarzt Source Type: research

[Psychological stress during the COVID-19 pandemic: consequences for psychiatric patients and therapeutic implications].
DISCUSSION: People with mental illnesses are particularly vulnerable to the psychological strain of the COVID-19 pandemic. Long-term studies on the further course of disease will be necessary. Additional studies that test interventions to build resilience in this population will also be needed. PMID: 33433633 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 12, 2021 Category: Neurology Authors: Winkler JG, Jalilzadeh Masah D, Moran JK, Bretz J, Tsagkas I, Goldschmidt T, Schouler-Ocak M Tags: Nervenarzt Source Type: research

[Psychotraumatological aspects in intensive care medicine].
Abstract In the context of intensive care medicine, patients, their relatives, and more infrequently members of the ICU team can be affected by potential trauma. Acute stress disorder often results. Psychological symptoms of critically ill patients should therefore be regularly screened in a standardized manner in order to be able to identify and treat patients with a high symptom burden. Some traumatic stressors in intensive care medicine can be reduced using trauma-sensitive communication. Psychological and psychotherapeutic interventions can complement this basic care. High quality communication with ...
Source: Der Nervenarzt - January 7, 2021 Category: Neurology Authors: Deffner T, Rosendahl J, Niecke A Tags: Nervenarzt Source Type: research

[Disturbances of time experience in mental disorders].
Abstract Experience of time is a field of only little research in psychiatry which is and was often induced by philosophers interested in the human existence in time. This review article underlines the importance to differentiate between several forms of time experience. With respect to current knowledge, there are disturbances of time experience in the sense of knowledge about basal temporal relations only in organic brain disorders, while objective time perception was found to be changed in patients with schizophrenia, but less in those with depression. In contrast, the subjective time feeling seems to be d...
Source: Der Nervenarzt - January 5, 2021 Category: Neurology Authors: Juckel G, Steinfath H, Mavrogiorgou P Tags: Nervenarzt Source Type: research

[Current aspects of neurogenic dysfunctions of the lower urinary tract in multiple sclerosis].
DISCUSSION: The proposed algorithm enables the detection of NLUTD in patients with MS with the help of four statistically significant predictors: 1) the residual urine volume, 2) the number of urinary tract infections (UTI) within the last 6 months, 3) the standardized micturition frequency and 4) the presence/absence of urinary incontinence. The newly developed algorithm has proved to be efficient with the following results: approximately 75% of the patients do not need a urodynamic examination for a first-line treatment decision. In 25% of cases, urodynamic examinations are essential for an adequate t...
Source: Der Nervenarzt - January 5, 2021 Category: Neurology Authors: Domurath B, Flachenecker P, Henze T, Feneberg W, Brandt A, Kurze I, Kirschner-Hermanns R, Kaufmann A, Bremer J, Vonthien M, Ratering K, Schäfer C, Vance WN, Schmidt P Tags: Nervenarzt Source Type: research

[Prevention of anxiety disorders].
Abstract Preventive interventions, such as universal and targeted, i.e. selective and indicated, interventions can effectively reduce the incidence of anxiety disorders and thus lower the high individual and socioeconomic burden of anxiety disorders. This review article provides an overview of internationally established prevention programs for children, adolescents and adults. The efficacy and cost effectiveness of preventive interventions are discussed. Due to the large target group, universally implemented strategies are costly and organizationally complex but can prevent a large number of manifest anxiety...
Source: Der Nervenarzt - January 5, 2021 Category: Neurology Authors: Domschke K, Schiele MA, Romanos M Tags: Nervenarzt Source Type: research

[Response distortion or symptom severity? Symptom description by psychiatric patients and sociomedical assessment subjects].
CONCLUSION: The results underline the importance of further research on SVTs in sociomedical assessments, especially regarding symptom severity and response distortion. PMID: 33337503 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 18, 2020 Category: Neurology Authors: Wertz M, Mader E, Nedopil N, Schiltz K, Yundina E Tags: Nervenarzt Source Type: research

[Catatonic walks with Emil Kraepelin, Aloys Alzheimer, Henry Aloysius Cotton and others].
l H Abstract Staff outings of Emil Kraepelin's Royal Department of Psychiatry were known as "catatonic walks". A remarkable number of important German and international visitors participated in 1906, Nicolas Achucarro, Henry Cotton, Eduard Flatau, Smith Ely Jelliffe, Gaetano Perusini, Edward Scripture, Maurycy Urstein and others. Many of Kraepelin's collaborators were inspired by his ideas and driven by scientific enthusiasm which contributed to significant scientific advances, but also took them to very different ends from dental and bowel surgery to psychoanalysis and eventually evidence-based med...
Source: Der Nervenarzt - December 16, 2020 Category: Neurology Authors: Förstl H Tags: Nervenarzt Source Type: research

[Separation anxiety disorder].
Abstract In the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) separation anxiety disorder has been included in the chapter on anxiety disorders, thereby removing the age of onset restriction that previously required first onset during childhood or adolescence. Separation anxiety disorder has a lifetime prevalence of 4.8% and onset often occurs after the age of 18 years. Despite the high prevalence, separation anxiety disorder is often underdiagnosed and subsequently remains untreated. This narrative review summarizes the etiology, clinical features, diagnostic criteri...
Source: Der Nervenarzt - December 14, 2020 Category: Neurology Authors: Schiele MA, Domschke K Tags: Nervenarzt Source Type: research

[Handling of potentially critical items in acute psychiatry (a study of the Federal Directors Conference)].
DISCUSSION: The nationwide survey provided feedback from 39 psychiatric hospitals throughout Germany. The results confirmed a broad critical awareness of potentially dangerous objects; however, the handling of these objects proved to be heterogeneous. Psychiatric clinics and departments have been practicing the control and securing of these objects for decades but there is a lack of written recommendations for handling them. In everyday life, the handling of these objects is taught within the ward, through the ward rules and/or orally. This illustrates a lack of uniform nationwide regulations or guideli...
Source: Der Nervenarzt - December 12, 2020 Category: Neurology Authors: Ackermann K, Ueberberg B, Assion HJ Tags: Nervenarzt Source Type: research

[Gut and brain].
PMID: 33252745 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 1, 2020 Category: Neurology Authors: Oertel W, Rupprecht R Tags: Nervenarzt Source Type: research

Mitteilungen der DGN.
Authors: PMID: 33252746 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 1, 2020 Category: Neurology Tags: Nervenarzt Source Type: research

Mitteilungen der Schlaganfallgesellschaft.
Authors: PMID: 33252747 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 1, 2020 Category: Neurology Tags: Nervenarzt Source Type: research

[Decision support systems, assistance systems and telemedicine in epileptology].
CONCLUSION: Due to the chronic course and the complexity of the epilepsies and their sequelae, persons with epilepsy could profit from CDSS. Epilepsy-specific CDSS should be usable by medical professionals and patients themselves. Currently, medical apps for people with epilepsy are mostly used to document the clinical course, seizure frequency, medication compliance and side effects. Available seizure detection systems mainly detect generalized tonic-clonic seizures (GTCS). A clinical benefit of such devices is not yet sufficiently confirmed but appears to be likely, because these seizures are specifically associated...
Source: Der Nervenarzt - November 27, 2020 Category: Neurology Authors: Zöllner JP, Wolking S, Weber Y, Rosenow F Tags: Nervenarzt Source Type: research

[The IMAGEN cohort: perspectives and problems of longitudinal research].
CONCLUSION: Longitudinal neurobiological basic research can validate the effects of candidate genes and reveal relevant environmental factors. Relevant modifiable factors indicated by the IMAGEN study and related datasets include drug use during pregnancy, trauma and other experiences of violence, social disadvantage and exclusion. PMID: 33245403 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 27, 2020 Category: Neurology Authors: Heinz A, Mascarell Maricic L, Liu S, Walter H, Schumann G, Beck A Tags: Nervenarzt Source Type: research

[Potentials and limits of aging cohort studies for geriatric psychiatry].
Abstract The sizeable number of population-based cohort studies of aging in Germany have provided highly valuable contributions for the specification of risk factors and predictors for frequent mental disorders in old age, especially dementia and depression. The results from these cohort studies enable the specification of mechanisms for the development of and preventative interventions for common mental disorders in old age. On the other hand, there is a significant paucity of clinical cohort studies investigating disease trajectories and possible markers for specific individualized interventions of frequent...
Source: Der Nervenarzt - November 26, 2020 Category: Neurology Authors: Rapp MA, Tschorn M, Supprian T, Thomas C, Kreisel S, Benninghoff J, Schumann G, Heinz A Tags: Nervenarzt Source Type: research

[Anxiety in times of COVID-19 and other health crises].
CONCLUSION: Fears should be observed and addressed in order to reduce pathological processes, especially in vulnerable groups. It is advisable to promote resilience factors and to counteract risk factors with preventive and therapeutic measures. For this purpose, the development and empirical testing of specific interventions as well as further longitudinal studies are needed. PMID: 33219467 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 20, 2020 Category: Neurology Authors: Bendau A, Petzold MB, Wyka S, Pyrkosch L, Plag J, Ströhle A Tags: Nervenarzt Source Type: research

[Expert recommendation: treatment of nonambulatory patients with Duchenne muscular dystrophy].
CONCLUSION: Loss of ambulation is heterogeneously defined across clinical trials. Among others, the need of a wheelchair, ambulation without mobility aids or maximum walking distance can be suitable parameters for assessment. Treatment of DMD patients at any stage of the disease is based on supportive and symptomatic measures, which should be continued after loss of ambulation. In addition, disease-modifying drugs are available for the treatment of DMD and glucocorticoids are the usual standard of care treatment even beyond the loss of ambulation. Ataluren, a potentially dystrophin restorative, disease-modifying ...
Source: Der Nervenarzt - November 19, 2020 Category: Neurology Authors: Bernert G, Hahn A, Köhler C, Meyer S, Schara U, Schlachter K, Trollmann R, Walter MC Tags: Nervenarzt Source Type: research

[The interdisciplinary diagnostics and treatment of peripheral nerve lesions].
Abstract Nerve lesions are a frequent and often neglected problem in the daily routine of hospitals and clinical work and necessitate an intensive interdisciplinary treatment. In addition to correct anatomical allocation, the correct timing of the appropriate diagnostics, the timely decision for a possible intervention and the appropriate accompanying treatment are important prerequisites for a favorable prognosis. The basic diagnostics are, above all, neurography and electromyography after a sound clinical examination and documentation. In recent years both high-resolution ultrasound imaging a...
Source: Der Nervenarzt - November 17, 2020 Category: Neurology Authors: Grimm A, Winter N, Kolbenschlag J, Herlan SF, Stahl JH, Mayer J, Daigeler A, Schuhmann MU Tags: Nervenarzt Source Type: research

[Care of patients with Parkinson's disease in Germany: status quo and perspectives as reflected in the digital transition].
Abstract As a chronic neurodegenerative disease, Parkinson's disease requires a close cooperation between different specialist disciplines in order to ensure the best possible quality of life for patients. A problem that has been identified is the inadequate communication between the protagonists (e.g. caregivers, physicians and therapists), especially at the sectoral interfaces. Due to structural hurdles, the current process and supply chains for Parkinson's disease do not reflect successful cross-sectoral care. Against the background of the new Digital Care Act in Germany that refunds patient-cent...
Source: Der Nervenarzt - November 16, 2020 Category: Neurology Authors: Eggers C, Wellach I, Groppa S, Strothjohann M, Klucken J Tags: Nervenarzt Source Type: research

[Suicidality in schizophrenic psychosis: a current overview].
CONCLUSION: Clinicians must have knowledge of the specific risk factors for suicide in psychotic patients, the characteristics of suicide in terms of design and temporal connection with treatment. The exploration and assessment of suicidality is often more difficult in psychotic patients than in affective or personality disorder patients, as there are often impulsive suicide attempts that can be explained by (suddenly occurring) psychotic symptoms and are therefore difficult or even impossible to foresee. PMID: 33165624 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 9, 2020 Category: Neurology Authors: Knorr R, Hoffmann K Tags: Nervenarzt Source Type: research

[Neuropsychological impairments of episodic memory and their objectification].
PMID: 33156366 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 6, 2020 Category: Neurology Authors: Bormann T, Weiller C Tags: Nervenarzt Source Type: research

[Gut microbiota and depression : Pathophysiology of depression: hypothalamic-pituitary-adrenal axis and microbiota-gut-brain axis].
Abstract Depression is a chronic disease with a complex multifactorial and still not fully clarified etiology. Due to new insights after recent investigations of the microbiota-gut-brain (MGB) axis, a relationship between a disrupted gut microbiota composition and the probability to develop a depression can be assumed. This hypothesis is supported by evidence that there is a strong communication between gut microbiota and the central nervous system (CNS) and that this communication is mediated through the MGB axis. Apparently, this bidirectional axis can be modulated by environmental ...
Source: Der Nervenarzt - November 2, 2020 Category: Neurology Authors: Lima-Ojeda JM, Rupprecht R, Baghai TC Tags: Nervenarzt Source Type: research

[DGPPN congress 2020-Psychiatry and psychotherapy in the social environment].
PMID: 33136194 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 1, 2020 Category: Neurology Authors: Heinz A Tags: Nervenarzt Source Type: research

Mitteilungen der DGPPN 11/2020.
Authors: PMID: 33136195 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 1, 2020 Category: Neurology Tags: Nervenarzt Source Type: research

[Acute care interventions in inpatient neurorehabilitation].
Abstract Treatment in hospitals differs from treatment in rehabilitation centers from a legal perspective because German law mandates that in hospitals physicians and other qualified personnel must be on duty at all times. This is not required for inpatient rehabilitation centers. Since this Act was passed more than 30 years ago, more acute medical interventions are now carried out and the number of older people in the population has increased. As a result patients are nowadays older, more multimorbid and therefore have a greater risk for medical complications. This is especially true for postacute neurologic...
Source: Der Nervenarzt - October 30, 2020 Category: Neurology Authors: Knecht S, Jalali VK, Schmidt-Wilcke T, Studer B Tags: Nervenarzt Source Type: research

[Memory and memory disorders].
PMID: 33123770 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 29, 2020 Category: Neurology Authors: Markowitsch HJ Tags: Nervenarzt Source Type: research

[Cohort studies in child and adolescent psychiatry].
CONCLUSION: Existing cohort studies on early mental development have shown specific focal points. To identify general and specific risk and resilience factors for psychiatric disorders and to model trajectories, there is a need for multimodal integration of data sets. PMID: 33112964 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 28, 2020 Category: Neurology Authors: Holz NE, Nees F, Meyer-Lindenberg A, Tost H, Hölling H, Keil T, Brandeis D, Romanos M, Banaschewski T Tags: Nervenarzt Source Type: research

[Pronounced proximally accentuated changes in high-voltage stimulation and nerve ultrasound in long-standing therapy-naive CIDP variants].
h M Abstract The differential diagnosis of chronic demyelinating polyneuropathy particularly includes inflammatory (CIDP) and hereditary causes. Using the example of a 63-year-old patient, we show the diagnostic procedure with conventional electrophysiological diagnostics and additionally by the use of proximal nerve conduction studies with high-voltage stimulation (HVS) and the direct morphological examination by high-resolution nerve ultrasound. In the present case, the focal accentuation of the changes in HVS and the equally pronounced focal thickening of the most affected ulnar nerve in ultrasound confirm...
Source: Der Nervenarzt - October 28, 2020 Category: Neurology Authors: Gardill K, Schüpbach M Tags: Nervenarzt Source Type: research

[Fetal alcohol spectrum disorders in adults].
Abstract Fetal alcohol spectrum disorders (FASD) are a common cause of a congenital developmental disability acquired in the womb due to alcohol consumption by the mother during pregnancy. The physical and mental consequences persist into adulthood. The 4‑digit code is an evidence-based method for diagnosing the full spectrum of outcomes, i.e. the full picture of fetal alcohol syndrome (FAS), partial fetal alcohol syndrome (pFAS), alcohol-related neurodevelopmental disorder (ARND) and alcohol-related birth defects (ARBD). The four key diagnostic features are (1) growth disorder, (2) facial dy...
Source: Der Nervenarzt - October 26, 2020 Category: Neurology Authors: Wagner JC, Tergeist M, Kruse B, Sappok T Tags: Nervenarzt Source Type: research

[Debts, loans and unpaid bills among day patients and inpatients in psychiatric care in Berlin, Germany].
CONCLUSION: Financial burdens and outstanding debts among patients in psychiatric care should be inquired about and considered more intensively in practice. Suitable models of support need to be developed and evaluated. PMID: 33052424 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 14, 2020 Category: Neurology Authors: Schreiter S, Heidrich S, Heinz A, Rössler W, Krausz RM, Schouler-Ocak M, Bermpohl F, Gutwinski S Tags: Nervenarzt Source Type: research

[Microbiota and multiple sclerosis].
This article summarizes and discusses the current research efforts to characterize the microbiome of MS patients using human material. In addition, we present research studies that utilized classical or humanized animal models to determine the influence of certain microbiota species or compositions of microbiota on the immune system and disease progression and to define possible causal associations. PMID: 33044577 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 12, 2020 Category: Neurology Authors: Gerdes LA, Yoon H, Peters A Tags: Nervenarzt Source Type: research

[Innovative outpatient models].
Mönter N Abstract Innovative, multimodal, cross-professional and cross-sectoral approaches to outpatient care have been funded in Germany since 2004 when the integrated care (IV) according to § 140 ff Social Security Code V (SGB V) and selective contracts according to § 73 SGB V were introduced. As a result, almost 7000 IV contracts were established providing psychiatric care; however, most of them were short-term contracts and only 1-2% of the total number of patients were treated by means of IV contracts. Great attention has been paid to the multiprofessional care o...
Source: Der Nervenarzt - October 12, 2020 Category: Neurology Authors: Köhler S, Roth-Sackenheim C, Navarro Ureña A, Mönter N Tags: Nervenarzt Source Type: research

[Stalking and crimes of passion : Discussion of a case example on ex-partner stalking].
This article investigates the question of the extent to which empirical findings from stalking research can contribute to the assessment of crimes of passion. PMID: 33044579 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 12, 2020 Category: Neurology Authors: Dreßing H, Saß H Tags: Nervenarzt Source Type: research

[Gut microbiome and anorexia nervosa : The relationship between microbiome and gut-brain interaction in the context of anorexia nervosa].
This article gives a first insight into the underlying processes that play a role in gut-brain interaction in the context of AN and summarizes the previous empirical findings on this topic. Finally, an outlook on future research and possible implications for the therapeutic practice and treatment of AN is given. PMID: 33034670 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 9, 2020 Category: Neurology Authors: Seitz J, Keller L, Trinh S, Herpertz-Dahlmann B Tags: Nervenarzt Source Type: research

[Psychosocial support during the COVID-19 pandemic: interdisciplinary concept of care at a university hospital].
CONCLUSION: The concept integrates innovative and sustainable ideas, e.g. telemedicine-based approaches and highlights the importance of multidisciplinary collaboration to cope with challenges in the healthcare system. PMID: 33025071 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 5, 2020 Category: Neurology Authors: Reinhard MA, Burkhardt G, Grosse-Wentrup F, Eser-Valerie D, Mumm FHA, Barnikol-Oettler B, Bausewein C, von Bergwelt-Baildon M, Klein M, Falkai P, Jauch KW, Adorjan K, Padberg F, Hoch E Tags: Nervenarzt Source Type: research

[Memory clinics in Germany-structural requirements and areas of responsibility].
CONCLUSION: The MC should implement evidence-based standards in diagnostics and treatment and introduce innovations in the care of patients with cognitive disorders and at-risk and prodromal stages. Their role in the German healthcare system must be strengthened. Sufficient and sustained funding needs to be established, since current reimbursement does not cover costs. PMID: 33025072 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 5, 2020 Category: Neurology Authors: Hausner L, Frölich L, von Arnim CAF, Bohlken J, Dodel R, Otto M, Rapp M, Schulz J, Supprian T, Wollmer MA, Jessen F, Deutsches Netzwerk Gedächtnisambulanzen Tags: Nervenarzt Source Type: research

[The role of the gut microbiome in idiopathic Parkinson's disease].
CONCLUSION: Over the past 5 years there has been an enormous increase in the evidence with respect to the relevance of the microbiome for IPD. While early work in this field was mainly descriptive, new diagnostic methods provide evidence for the underlying mechanisms and the complex interactions between man as the host, the human immune system, the enteric nervous system, gut microbiota and microbial metabolites. A relatively novel and clinically relevant field of research is how the gut microbiome can influence the success of oral pharmacotherapy and whether substitution of specific microbiome components might b...
Source: Der Nervenarzt - October 5, 2020 Category: Neurology Authors: Unger MM, Becker A, Keller A, Schäfer KH, Schwiertz A, Oertel WH Tags: Nervenarzt Source Type: research

[Olga von Leonova (1851-?): a  neuroscientist vanishes].
[Olga von Leonova (1851-?): a neuroscientist vanishes]. Nervenarzt. 2020 Oct 06;: Authors: Förstl H PMID: 33025074 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 5, 2020 Category: Neurology Authors: Förstl H Tags: Nervenarzt Source Type: research

[Treatment reality of stroke in Germany].
PMID: 33006660 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 30, 2020 Category: Neurology Authors: Eyding J, Krogias C, Weber R Tags: Nervenarzt Source Type: research

Mitteilungen der DGPPN 10/2020.
Authors: PMID: 33006661 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 30, 2020 Category: Neurology Tags: Nervenarzt Source Type: research

Mitteilungen der DGN.
Authors: PMID: 33006662 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 30, 2020 Category: Neurology Tags: Nervenarzt Source Type: research

Mitteilungen der Schlaganfallgesellschaft.
Authors: PMID: 33006663 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 30, 2020 Category: Neurology Tags: Nervenarzt Source Type: research

[Neurological complications of hepatitis C infections].
NI) Abstract Chronic hepatitis C virus (HCV) infection is a highly prevalent systemic disease, which can cause a variety of neurological complications. The HCV-associated symptoms can be differentiated into central and peripheral nervous systems as well as the musculature. Important pathomechanisms are HCV-associated autoimmunity (e.g. mixed cryoglobulinemia with polyneuropathy) and direct neurotoxic effects of the virus (e.g. HCV-associated cognitive deficits). Distal symmetric polyneuropathies, small fiber neuropathies and cognitive deficits are the most prevalent neurological manifestations. Furthermo...
Source: Der Nervenarzt - September 30, 2020 Category: Neurology Authors: Kleefeld F, Arendt G, Neuen-Jacob E, Maschke M, Husstedt I, Obermann M, Schmidt H, Hahn K, Deutsche Gesellschaft für Neuro-AIDS und Neuro-Infektiologie (DGNANI) Tags: Nervenarzt Source Type: research

[Coercive measures and the SARS-CoV-2 pandemic].
This article presents and discusses in detail the legal regulations currently applicable in Germany. PMID: 33001264 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 30, 2020 Category: Neurology Authors: Adorjan K, Gaudernack D, Beer J, von Massenbach C, Falkai P, Pollmächer T, Pogarell O Tags: Nervenarzt Source Type: research

[Coercion in psychiatry: practical consequences of ethical aspects].
Abstract Within the framework of the legal and ethical requirements of the application of coercion in psychiatry, the perspective of its prevention is discussed. Coercion is permissible exclusively in cases of incapability of self-determination and immediate specific danger for the patient's physical integrity or life. Practical difficulties in assessing these criteria are illustrated by means of case examples. Preventive procedures for avoidance of coercion (advance directives, trust-building procedures, recognition of influence of context, sensitization against coercion) as well as clarification of indications a...
Source: Der Nervenarzt - September 29, 2020 Category: Neurology Authors: Helmchen H Tags: Nervenarzt Source Type: research

[Antipsychotics during pregnancy: a systematic review].
CONCLUSION: Treating mental illnesses during pregnancy requires an individual assessment of the benefits and risks. The risk of an untreated mental illness versus the benefit of a suitable treatment with antipsychotics and the potential harm to the infant must be evaluated. If certain rules are observed and a suitable antipsychotic is selected the risk to the newborn child and/or mother during pregnancy can be minimized, however, a decision about subsequent medication can only be indirectly made from the results of this study. PMID: 33000289 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 29, 2020 Category: Neurology Authors: Hillemacher T, Simen S, Rehme MK, Frieling H Tags: Nervenarzt Source Type: research

[Brivaracetam-A good alternative for the treatment of muscle cramps].
CONCLUSION: Further studies are needed to demonstrate the effect of brivaracetam on muscle cramps. PMID: 32990789 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 28, 2020 Category: Neurology Authors: Kneppe K, Czell D Tags: Nervenarzt Source Type: research

[Cenobamate-a  new perspective for epilepsy treatment].
[Cenobamate-a new perspective for epilepsy treatment]. Nervenarzt. 2020 Sep 29;: Authors: Steinhoff BJ Abstract In spite of the introduction of numerous new antiseizure drugs (ASD) over the last decades, the percentage of drug-resistant epilepsies has remained almost stable. To achieve seizure freedom in such patients with any modified ASD regimen is an exception. Cenobamate (CNB) is a new ASD that showed unusually high efficacy in the pivotal placebo controlled, randomized trials. In both studies (C013 and C017), the rate of seizure-free patients was sometimes more than 20% and thus in a&nb...
Source: Der Nervenarzt - September 28, 2020 Category: Neurology Authors: Steinhoff BJ Tags: Nervenarzt Source Type: research

[Antihypertensive drugs in psychiatry : Prescription behavior and potential drug-drug interactions].
CONCLUSION: Antihypertensive drugs are important in the treatment of psychiatric patients. An interaction test should be performed if pharmacotherapy is to be supplemented or changed. Where appropriate, measures to improve drug treatment safety should be considered. PMID: 32986155 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 22, 2020 Category: Neurology Authors: Endres K, Schiller E, Haen E Tags: Nervenarzt Source Type: research