[Placebo effects in pain therapy].
Abstract In the past few decades, research on pain and placebo analgesia has gained importance both scientifically and clinically. In this article, the current findings and focus of research as well as the significance of placebo research for assessing the effectiveness of pain medication are illustrated. The underlying mechanisms of placebo analgesia not only have implications for theoretical models but also offer clinically relevant guidelines for everyday interventions in pain treatment. However, many placebo phenomena are not fully understood and have to be investigated further in order to exploit the full pot...
Source: Der Nervenarzt - July 8, 2020 Category: Neurology Authors: Klinger R, Schwartz M, Bingel U Tags: Nervenarzt Source Type: research

[The learned placebo response in the immune system].
emann L Abstract The learned placebo response of the immune system is based on the mutual interaction between the brain and the immune system; both systems continually exchange information via humoral and neural communication pathways. This communication network enables the modification, i.e. suppression or stimulation, of peripheral immune functions by classical or Pavlov's conditioning. The present article provides an overview of the results of recent experimental animal studies, which also document the potential clinical relevance of learned immune responses. Learned immunological responses mediated by classica...
Source: Der Nervenarzt - July 8, 2020 Category: Neurology Authors: Hörbelt T, Hetze S, Schedlowski M, Lückemann L Tags: Nervenarzt Source Type: research

[The effect of medical and psychotherapeutic treatment models for schizophrenia on stigma and recovery expectations].
CONCLUSION: There appear to be no negative side effects of (biogenetic) models when presented in a context emphasizing recovery. Moreover, medication and CBT treatment information showed additive positive effects on the rating of treatment strategies. A combined treatment model integrating various evidence-based methods appears to be most useful in clinical practice. PMID: 32642947 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 8, 2020 Category: Neurology Authors: Schlier B, Kubera FR, Lincoln TM Tags: Nervenarzt Source Type: research

[Importance of electroconvulsive therapy (ECT) in forensic psychiatry].
CONCLUSION: The use of ECT in German forensic psychiatry is currently very limited. It is striking that the number of applied ECT treatments is eight times lower in comparison to the frequency of indications. Nevertheless, approximately two thirds of the forensic hospitals stated a medium or high need for ECT, which seems to suggest a shortage of ECT in the treatment of forensic psychiatry patients. PMID: 32642948 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 8, 2020 Category: Neurology Authors: Besse M, Schomburg AK, Simon A, Hesse D, Müller J, Zilles-Wegner D Tags: Nervenarzt Source Type: research

[Proteinase  3 (cANCA)-associated ulcerative colitis with possible inflammatory leukoencephalopathic CNS involvement].
[Proteinase 3 (cANCA)-associated ulcerative colitis with possible inflammatory leukoencephalopathic CNS involvement]. Nervenarzt. 2020 Jul 08;: Authors: Pompsch M, Veltkamp C, Veltkamp R, Weber R PMID: 32642949 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 8, 2020 Category: Neurology Authors: Pompsch M, Veltkamp C, Veltkamp R, Weber R Tags: Nervenarzt Source Type: research

[Placebos and placeboids in clinical practice: conceptual and ethical considerations].
t B Abstract Reflecting on results of recent placebo research, this article analyzes relevant key concepts and ethical positions. "Placeboids" and possibly open-label placebo treatments should replace any deceptive use of sham medication. Their use should give rise to a critical consideration of the modern patient-physician relationship. PMID: 32617632 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 2, 2020 Category: Neurology Authors: Schöne-Seifert B Tags: Nervenarzt Source Type: research

[The role of placebo and nocebo mechanisms in depressive diseases and their treatment].
CONCLUSION: The success of treatment in the use of antidepressants can be increased and the probability of side effects can be reduced by the effective use of placebo mechanisms and reduction of nocebo effects. The results emphasize the influence of clinician-patient interactions, the role of the treatment context and previous experiences with other treatments of the patient. Simultaneously, the results of this research field stimulate a new understanding of mental disorders, in particular depression and also provide points of reference for optimization of psychotherapeutic treatment. PMID: 32607602 [PubMed - as suppl...
Source: Der Nervenarzt - June 30, 2020 Category: Neurology Authors: Rief W Tags: Nervenarzt Source Type: research

[Quality psychiatry and destigmatization : Can quality psychiatry and psychotherapy contribute to destigmatization of mental illnesses?]
CONCLUSION: The components of quality psychiatry that can contribute to the destigmatization of persons with mental illnesses include the implementation of regularly updated evidence-based treatment guidelines, the individualization of psychiatric treatment (precision psychiatry) and the application of quality indicators within the framework of comprehensive quality management. The postulated relationships must be empirically verified, further analyzed and communicated to the public to be made systematically useful for the destigmatization of mental illnesses. PMID: 32607603 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 30, 2020 Category: Neurology Authors: Gaebel W, Stricker J Tags: Nervenarzt Source Type: research

[Rolf Hassler: from leucotomy to stereotaxy].
Abstract Rolf Hassler is one of the most renowned German specialists in psychiatry, neurology and neuroanatomy. Hassler's career exemplifies medicine as scientific endeavor. Relaying on an expertise in neuroanatomy gained at Oscar and Cecile Vogt's Kaiser Wilhelm Institute, especially regarding the structure of the thalamus, Hassler enabled Freiburg University's neurosurgery clinic the invention of stereotactic "stepped leucotomy" and established thalamotomy internationally in a leading way. While directing the Neuroanatomical/Neurobiological department of the Max Planck Institute for Brain Research from...
Source: Der Nervenarzt - June 16, 2020 Category: Neurology Authors: Rzesnitzek L Tags: Nervenarzt Source Type: research

[New insights into diagnostics and therapy of personality disorders-Changes in ICD-11].
Abstract Personality disorders (PD) occur frequently and show high remission rates in the long term, while psychosocial recovery remains unsuccessful in a substantial proportion of cases. In ICD-11 the traditional view that PDs have a high stability is abandoned. Instead, the minimum duration is 2 years. The diagnostic process differentiates between three degrees of severity (mild, moderate, severe) and five prominent personality trait domains. Optionally, a borderline qualifying factor can be additionally codified. There is sufficient empirical evidence only for the treatment of borderline PD (BPD). Disorder...
Source: Der Nervenarzt - June 15, 2020 Category: Neurology Authors: Jeung-Maarse H, Herpertz SC Tags: Nervenarzt Source Type: research

[The introduction of antipsychotics in the neurological psychiatric hospital of the University of Leipzig and their effects on other forms of therapy, the length of stay and transferrals].
CONCLUSION: Evidence of facilitation of mental rehabilitation through the use of antipsychotics cannot be directly confirmed; however, it appears that the administration beyond a time-limited treatment has contributed to this development and also to the establishment of outpatient facilities. Thus, both a watershed in the psychiatric treatment and a change for the patients themselves could be identified. PMID: 32542433 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 15, 2020 Category: Neurology Authors: Oeser C, Steinberg H Tags: Nervenarzt Source Type: research

[Ocrelizumab for treatment of multiple sclerosis].
Abstract Ocrelizumab is a monoclonal antibody directed against the differentiation antigen CD20, which leads to an effective long-term depletion of lymphocytes, in particular B cells. Recently published phase 3 studies confirmed that ocrelizumab is effective in the treatment of both relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). Based on these results, ocrelizumab was the first drug to be approved for primary chronic progressive MS. To place this therapeutic breakthrough in the context of the current MS therapeutic landscape, it is worthwhile taking a look...
Source: Der Nervenarzt - June 10, 2020 Category: Neurology Authors: Graf J, Albrecht P, Goebels N, Aktas O, Hartung HP Tags: Nervenarzt Source Type: research

[Therese Neumann between passion experience and trauma sequelae disorder-an informative example for the present?]
PMID: 32504249 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 5, 2020 Category: Neurology Authors: Braun B, Demling J, Loew T Tags: Nervenarzt Source Type: research

[Neuropsychological disorders of memory].
This article provides an introduction to the neuropsychology of human memory. The terms short-term memory, working memory, episodic memory, semantic and procedural memory are defined and the anatomical correlates of these various memory systems are presented. Additionally, a brief introduction to the methods for neuropsychological research on human memory is given together with advice on the neuropsychological diagnostics and therapy. PMID: 32504250 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 5, 2020 Category: Neurology Authors: Bormann T, Weiller C Tags: Nervenarzt Source Type: research

[Psychopharmacotherapy during the COVID-19 pandemic].
Abstract In view of the current coronavirus disease 2019 (COVID-19) pandemic, patient care, including that of psychiatric patients, is facing unprecedented challenges. Treatment strategies for mental illness include psychotherapy and psychopharmacological interventions. The latter are associated with a multitude of adverse drug reactions (ADR); however, they may currently represent the preferred treatment due to restrictions regarding patient care (i.e. social distancing). Direct contact to patients may have to be reduced in favor of telephone calls or video conferences, so that new techniques in diagnosing a...
Source: Der Nervenarzt - June 2, 2020 Category: Neurology Authors: Seifert J, Heck J, Eckermann G, Singer M, Bleich S, Grohmann R, Toto S Tags: Nervenarzt Source Type: research

[Risk factors for risky cannabis use : A  retrospective cohort study of 7671 cannabis users].
CONCLUSION: Potentially influenceable risk factors for risky cannabis use are relationship quality in the parental home and early onset of cannabis use. PMID: 32488414 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 2, 2020 Category: Neurology Authors: Seidel AK, Morgenstern M, Hanewinkel R Tags: Nervenarzt Source Type: research

[Confusion, grand mal series and lactic acidosis in a  46-year-old woman].
[Confusion, grand mal series and lactic acidosis in a 46-year-old woman]. Nervenarzt. 2020 Jun 02;: Authors: Friedrich M, Herrmann R, Klötzsch C PMID: 32488415 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 2, 2020 Category: Neurology Authors: Friedrich M, Herrmann R, Klötzsch C Tags: Nervenarzt Source Type: research

[Effectiveness of short-term therapy: the concept of the crisis day clinic].
PMID: 32488416 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 2, 2020 Category: Neurology Authors: Illner SC, Ueberberg B, Assion HJ Tags: Nervenarzt Source Type: research

[Social milieu: A  relevant concept for a better understanding of stigma and help-seeking?]
CONCLUSION: The concept of the social milieu constitutes a potentially important and so far barely used intersection between sociology and medicine. Against the backdrop of rising public polarization and social inequality, the concept could contribute to achieving a better understanding of the stigma of mental illness. It appears to be of relevance in a number of ways for secondary and tertiary preventive considerations regarding the treatment gap in mental healthcare. PMID: 32458012 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 26, 2020 Category: Neurology Authors: Speerforck S, Schomerus G Tags: Nervenarzt Source Type: research

[Chronic pain syndromes and other persistent functional somatic symptoms].
Abstract Somatic symptoms including pain are everyday human experiences. They usually result from a complex interaction of stimuli, interpretation and reaction, and are not necessarily proportional to structural damage. Persistent functional somatic symptoms can be associated with a significant impairment of quality of life and functioning, even without mental or somatic comorbidity. Dysfunctional experiences, expectancies and behavior, not only by patients but also by physicians, can increase the risk of chronification. From the outset, management should be graded with respect to the severity and biopsychoso...
Source: Der Nervenarzt - May 20, 2020 Category: Neurology Authors: Roenneberg C, Henningsen P, Hausteiner-Wiehle C Tags: Nervenarzt Source Type: research

[Dystextia as a  sign of acute stroke].
[Dystextia as a sign of acute stroke]. Nervenarzt. 2020 May 19;: Authors: Hörmanseder B, Heitzeneder T, Hödl G, Topakian R PMID: 32430551 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 19, 2020 Category: Neurology Authors: Hörmanseder B, Heitzeneder T, Hödl G, Topakian R Tags: Nervenarzt Source Type: research

[LATE: not every dementia is Alzheimer's disease-Discussion of a  new disease entity based on a case example : Current status of limbic-predominant age-related TDP-43 encephalopathy (LATE)].
This article presents the current state of the discussion on LATE and illustrates the concept and the clinical considerations with a case study. PMID: 32409844 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 14, 2020 Category: Neurology Authors: Görß D, Kilimann I, Dyrba M, Nitsch S, Krause B, Teipel S Tags: Nervenarzt Source Type: research

[Therese Neumann between spirituality and religious pathology-an illuminating paradigm for the present?]
PMID: 32409845 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 14, 2020 Category: Neurology Authors: Seidl O Tags: Nervenarzt Source Type: research

[Info-Telefon Depression-An exploratory analysis of data from callers to a  German information hotline for depression].
[Info-Telefon Depression-An exploratory analysis of data from callers to a German information hotline for depression]. Nervenarzt. 2020 May 13;: Authors: Görges F, Gravert C, Rummel-Kluge C, Hegerl U PMID: 32405691 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 13, 2020 Category: Neurology Authors: Görges F, Gravert C, Rummel-Kluge C, Hegerl U Tags: Nervenarzt Source Type: research

[Nonpharmacological treatment options for attention deficit hyperactivity disorder in adulthood: an update].
Abstract Attention deficit hyperactivity disorder (ADHD) in adulthood is a frequent disorder with a prevalence of 2.5%, which can successfully be treated by pharmacotherapy in 50-70% of cases, depending on the response criteria. Therefore, besides medication nonpharmacological interventions are an important component of the treatment. The essential nonpharmacological interventions are presented and described with respect to the evidence for treatment. According to the S3 guidelines an extensive psychoeducation (PE) functions as the basis of the treatment. If there is still a need for treatment after...
Source: Der Nervenarzt - May 12, 2020 Category: Neurology Authors: Lux S, Rosen H, Aslan B, Philipsen A Tags: Nervenarzt Source Type: research

[The prevalence of people with dementia in Germany-A  nationwide analysis at the district level].
[The prevalence of people with dementia in Germany-A nationwide analysis at the district level]. Nervenarzt. 2020 May 12;: Authors: Thyrian JR, Boekholt M, Hoffmann W, Leiz M, Monsees J, Schmachtenberg T, Schumacher-Schönert F, Stentzel U PMID: 32399609 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 12, 2020 Category: Neurology Authors: Thyrian JR, Boekholt M, Hoffmann W, Leiz M, Monsees J, Schmachtenberg T, Schumacher-Schönert F, Stentzel U Tags: Nervenarzt Source Type: research

[Recommendations for gene therapy of spinal muscular atrophy with onasemnogene abeparvovec-AVXS-101 : Consensus paper of the German representatives of the Society for Pediatric Neurology (GNP) and the German treatment centers with collaboration of the medical scientific advisory board of the German Society for Muscular Diseases (DGM)].
CONCLUSION: Gene replacement therapy with onasemnogene abeparvovec has the potential to significantly influence the course of SMA. Long-term data on sustainability of effects and possible adverse effects of gene replacement therapy are not yet available. The application of this innovative therapy must be carried out in specialized and appropriately qualified treatment centers under strict safety conditions. This article makes suggestions for the necessary framework conditions and gives recommendations for a systematic pretreatment and posttreatment assessment schedule under gene therapy. The effectiveness and safety o...
Source: Der Nervenarzt - May 11, 2020 Category: Neurology Authors: Ziegler A, Wilichowski E, Schara U, Hahn A, Müller-Felber W, Johannsen J, von der Hagen M, von Moers A, Stoltenburg C, Saffari A, Walter MC, Husain RA, Pechmann A, Köhler C, Horber V, Schwartz O, Kirschner J Tags: Nervenarzt Source Type: research

[Interrater reliability of the criteria-based assessment of criminal responsibility in paraphilic disorders].
CONCLUSION: The interrater reliability (IRR) with reference to the criteria of Briken and Müller was higher than the previously established criteria of Boetticher et al. The evaluation of the subjective importance of the criteria of both assessment scales showed that all criteria were rated as at least of average importance. It could thus be useful to initially include both sets of criteria for a greater transparency in the assessment process and to investigate this procedure in further studies. PMID: 32394005 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 11, 2020 Category: Neurology Authors: Dobbrunz S, Brunner F, Müller JL, Briken P Tags: Nervenarzt Source Type: research

[CANVAS: case report on a  novel repeat expansion disorder with late-onset ataxia].
This article presents the case of a 74-year-old female patient who first developed a progressive disease with sensory neuropathy, cerebellar ataxia and bilateral vestibulopathy at the age of 60 years. The family history was unremarkable. Magnetic resonance imaging (MRI) showed atrophy of the cerebellum predominantly in the vermis and atrophy of the spinal cord. The patient was given the syndromic diagnosis of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS). In 2019 the underlying genetic cause of CANVAS was discovered to be an intronic repeat expansion in the RFC1 gene with autosomal recessive inherit...
Source: Der Nervenarzt - May 4, 2020 Category: Neurology Authors: Meindl T, Cordts I, Scherzer AL, Lingor P, Maegerlein C, Galassi Deforie V, Dominik N, Houlden H, Cortese A, Deschauer M Tags: Nervenarzt Source Type: research

[Stroke aftercare : Treatment reality, challenges and future perspectives].
CONCLUSION: Ischemic stroke should be considered as a complex chronic disease and should be treated accordingly after discharge from acute inpatient treatment. Emphasis should be placed on the optimization of interdisciplinary and cross-sectoral cooperation and support for general practitioners in the outpatient post-stroke care. New concepts of post-stroke care have the potential for improvement of the current healthcare structures. PMID: 32361775 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 2, 2020 Category: Neurology Authors: Schwarzbach CJ, Eichner FA, Pankert A, Schutzmeier M, Heuschmann PU, Grau AJ Tags: Nervenarzt Source Type: research

[Palliative medicine and psychiatry-a contraintuitive relationship?]
PMID: 32356194 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 1, 2020 Category: Neurology Authors: Heinz A, Perrar KM, Voltz R Tags: Nervenarzt Source Type: research

Mitteilungen der DGPPN 5/2020.
Authors: PMID: 32356195 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 1, 2020 Category: Neurology Tags: Nervenarzt Source Type: research

[Quality of care of acute ischemic stroke in Germany 2018].
Abstract In this overview the current quality of acute in-hospital care of stroke patients in Germany in 2018 is described based on standardized and evidence-based quality indicators. For this purpose the reports of the regional quality assurance projects for stroke care, which collaborated within the German-speaking Stroke Registers Study Group (ADSR) were analyzed. Overall, more than 280,000 acute admissions of stroke patients were documented in the included quality assurance projects. The results regarding the defined 16 quality indicators comprising diagnostics, acute treatment, rehabilitation and secondary pr...
Source: Der Nervenarzt - April 30, 2020 Category: Neurology Authors: Misselwitz B, Grau A, Berger K, Bruder I, Burmeister C, Hermanek P, Hohnhold R, Koennecke HC, Matthis C, Heuschmann PU Tags: Nervenarzt Source Type: research

[Uncomplicated thrombolysis treatment with rt-PA via an intraosseous access after acute ischemic stroke].
PMID: 32347326 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 28, 2020 Category: Neurology Authors: Myftiu A, Hedtmann G, Kollmar R Tags: Nervenarzt Source Type: research

[Development of a  decision aid for participative advance planning for people with dementia and their relatives].
[Development of a decision aid for participative advance planning for people with dementia and their relatives]. Nervenarzt. 2020 Apr 28;: Authors: Bronner K, Bodner L, Jox RJ, Marckmann G, Diehl-Schmid J, Hamann J Abstract BACKGROUND: Patients with a diagnosis of dementia face various important social and health-related decisions. Due to the progression of the disease it seems crucial that patients try to deal with these decisions early in the course of the disease to have the opportunity to make decisions autonomously. Professional support can help to plan in advance according to the wishe...
Source: Der Nervenarzt - April 28, 2020 Category: Neurology Authors: Bronner K, Bodner L, Jox RJ, Marckmann G, Diehl-Schmid J, Hamann J Tags: Nervenarzt Source Type: research

[Parainfectious CNS small vessel vasculitis and autoimmune encephalitis after herpes simplex type  1 encephalitis].
[Parainfectious CNS small vessel vasculitis and autoimmune encephalitis after herpes simplex type 1 encephalitis]. Nervenarzt. 2020 Apr 28;: Authors: Lübke-Detring S, Schwabe J, Friese M, Mager AK, Franz J, Seidel G PMID: 32347328 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 28, 2020 Category: Neurology Authors: Lübke-Detring S, Schwabe J, Friese M, Mager AK, Franz J, Seidel G Tags: Nervenarzt Source Type: research

[Core aspects of a needs-conform care of patients with multiple sclerosis : Utilization of outpatient services and shared decision making].
CONCLUSION: Differences in the utilization of outpatient resources by MS patients in Germany can be explained by methodological differences and limitations of the individual studies. The use of shared decision making by MS patients is demanded by various parties but so far there is little evidence for a positive effect on the disease. PMID: 32333050 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 24, 2020 Category: Neurology Authors: Kraft AK, Berger K Tags: Nervenarzt Source Type: research

[Autism spectrum disorder in childhood and adults: diagnosis and differential diagnoses].
Abstract Autistic disorders are summarized in DSM‑5 under the term autism spectrum disorder (ASD) and are severe, lifelong, pervasive neurodevelopmental disorders. Core features manifested even in childhood are impairments in social interaction and communication as well as restricted and repetitive behavior. The intensity of symptoms, language and cognitive impairments vary but the majority of affected individuals have below average intelligence and 80% have at least one comorbid disorder. The diverse pathology and heterogeneity in phenotypes are caused by a complex genetic etiology, which is associated wit...
Source: Der Nervenarzt - April 17, 2020 Category: Neurology Authors: Kamp-Becker I, Stroth S, Stehr T Tags: Nervenarzt Source Type: research

[Early detection of Alzheimer's disease and dementia prediction in patients with mild cognitive impairment : Summary of current recommendations].
This article summarizes the current recommendations of a European expert consensus publication and a multidisciplinary working group of the Alzheimer's Association on the clinical application of cerebrospinal fluid (CSF) biomarkers for the diagnostics of AD in patients with MCI. If the clinical diagnostic criteria for MCI are fulfilled according to the medical history and neuropsychological testing, it is recommended to carry out further diagnostics (blood test, brain imaging) in order to more precisely define the differential diagnostic classification. Counseling on the potential benefits, limits and risks of bi...
Source: Der Nervenarzt - April 16, 2020 Category: Neurology Authors: Rostamzadeh A, Jessen F Tags: Nervenarzt Source Type: research

[Attention deficit hyperactivity disorder in childhood and adolescence : Current state of research].
CONCLUSION: The epidemiological prevalence of ADHD in children is estimated to be 5.3%. The etiology is complex and heterogeneous and a high percentage of the phenotypic variance can be explained by genetic influences. The challenge of ADHD diagnostics is to exclude differential diagnoses while simultaneously identifying common coexisting psychiatric conditions. Treatment recommendations depend on the severity of symptoms. In severe ADHD pharmacotherapy should be considered as the first line intervention. Psychostimulants (various methylphenidate and amphetamine preparations) and the non-stimulants atomoxetine and gua...
Source: Der Nervenarzt - April 8, 2020 Category: Neurology Authors: Häge A, Hohmann S, Millenet S, Banaschewski T Tags: Nervenarzt Source Type: research

[Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors].
Abstract All large population-based administrative studies currently indicate a significant comorbidity of adult attention deficit hyperactivity disorder (ADHD) with addictive, anxiety and in particular affective disorders. In these investigations the risk for one of these comorbid disorders increased with increasing age of the ADHD patients. The most recent genome-wide association and correlation studies also revealed indications for joint genetic risk factors of ADHD with, in particular unipolar depression, bipolar disorder, autism spectrum disorders, Tourette's syndrome and to a lesser extent schizophrenia...
Source: Der Nervenarzt - April 7, 2020 Category: Neurology Authors: Kittel-Schneider S, Reif A Tags: Nervenarzt Source Type: research

[Digital phenotyping. Pro].
PMID: 32266440 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 7, 2020 Category: Neurology Authors: Opel N, Hahn T Tags: Nervenarzt Source Type: research

[Depression, anxiety, delirium and desire to die in palliative care : Recommendations of the S3 guideline on palliative care for patients with incurable cancer].
CONCLUSION: The guideline on palliative care deals with important mental issues that should be considered by all disciplines and professions. The need for research in palliative care remains high. PMID: 32246170 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 3, 2020 Category: Neurology Authors: Pralong A, Perrar KM, Kremeike K, Rosendahl C, Voltz R Tags: Nervenarzt Source Type: research

[Digital phenotyping. Contra].
r G PMID: 32236664 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 31, 2020 Category: Neurology Authors: Gründer G Tags: Nervenarzt Source Type: research

[Pharmacotherapy of attention deficit hyperactivity disorder in adults].
r M Abstract Pharmacotherapy is a central component in the context of an overall therapeutic concept in the treatment of adults with attention deficit hyperactivity disorder (ADHD). In this concept psychosocial interventions with psychoeducation or specific psychotherapy measures also play an important role. In adults three compounds are currently approved for the pharmacological treatment of ADHD in Germany. The long-acting stimulants retarded methylphenidate preparations and lisdexamfetamine can be prescribed. Alternatively, the adrenergic uptake inhibitor atomoxetine can be used. In several meta-analyses g...
Source: Der Nervenarzt - March 30, 2020 Category: Neurology Authors: Retz W, Retz-Junginger P, Davydenko S, Rösler M Tags: Nervenarzt Source Type: research

[Psychiatrists in palliative care of people with severe psychiatric illnesses and an oncological comorbidity].
This article outlines the epidemiological data as well as the particularities in the experience of this group of people. Following selected case studies from a psychological perspective, thoughts on the tasks of the psychiatrist in the palliative setting are presented. PMID: 32232534 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 30, 2020 Category: Neurology Authors: Westermair AL, Schreiber W, Dümchen J, Perrar KM Tags: Nervenarzt Source Type: research

[Psychiatric aspects of terrorism].
CONCLUSION: The manifold manifestations of terrorism are caused by complex patterns of interacting biographic, sociological, ideological and psychopathological components that differ between lone acting and group terrorists. The real causes for acts of terrorism are not various ideologies permitting violence but consist more of a pre-existing violence-oriented mentality of the perpetrators looking for such ideologies to justify their acts. The possibilities of psychiatry in prevention and early recognition are limited. Some recently developed scales for risk assessment of extreme violence are mentioned. PMID: 322...
Source: Der Nervenarzt - March 27, 2020 Category: Neurology Authors: Seidenbecher S, Steinmetz C, Möller-Leimkühler AM, Bogerts B Tags: Nervenarzt Source Type: research

[Past and future of the ESUS concept].
Abstract Stroke has traditionally been classified according to the trial of ORG 10172 in acute stroke treatment (TOAST) criteria; however, the concept of cryptogenic stroke did not meet the operational criteria necessary to define patient populations eligible for randomized studies. Therefore, the concept of embolic stroke of undetermined etiology (ESUS) was developed. An underlying hypothesis was that most strokes in patients with ESUS are caused by embolic events, hence, anticoagulation may prevent secondary events. Therefore, two large randomized trials were conducted comparing dabigatran or rivaroxaban with ac...
Source: Der Nervenarzt - March 27, 2020 Category: Neurology Authors: Diener HC, Endres M Tags: Nervenarzt Source Type: research

[Dealing with psychological distress by healthcare professionals during the COVID-19 pandemia].
CONCLUSION: This article presents guidelines for health professionals and team leaders in healthcare that help to maintain mental health during the COVID-19 pandemia. PMID: 32221635 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 27, 2020 Category: Neurology Authors: Petzold MB, Plag J, Ströhle A Tags: Nervenarzt Source Type: research

[Care of patients with Parkinson's disease in Germany].
n J Abstract In Germany various concepts for treating patients with Parkinson's disease (PD) are available, e.g. oral medication with levodopa or deep brain stimulation (DBS), depending on the stage and severity of symptoms and also multidisciplinary management up to intersectoral treatment approaches (e.g. complex PD treatment and integrative care concepts). Nevertheless, in the treatment of patients with PD a comprehensive provision of services and a nationwide standardized collation of treatment quality are so far lacking. This is particularly true for technically complicated procedures, which necessitate ...
Source: Der Nervenarzt - March 18, 2020 Category: Neurology Authors: Stangl S, Haas K, Eggers C, Reese JP, Tönges L, Volkmann J Tags: Nervenarzt Source Type: research