[Update on stroke].
PMID: 31588975 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 1, 2019 Category: Neurology Authors: Dichgans M Tags: Nervenarzt Source Type: research

Mitteilungen der DGPPN 10/2019.
Authors: PMID: 31588976 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 1, 2019 Category: Neurology Tags: Nervenarzt Source Type: research

Mitteilungen der DGN.
Authors: PMID: 31588977 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 1, 2019 Category: Neurology Tags: Nervenarzt Source Type: research

[Update on antithrombotic secondary prevention of ischemic stroke].
z C Abstract Over the past decade innovations regarding antithrombotic treatment for secondary stroke prevention have been particularly dominated by the non-vitamin K dependent anticoagulants in patients with cardioembolic stroke; however, several studies investigating other important aspects have also recently been published. This update focuses on new trials on intensified antiplatelet therapy in the early phase of (mild) stroke and transient ischemic attacks (TIA) as well as studies on secondary prevention in patients with embolic stroke of undetermined source (ESUS). Data from these studies are critically...
Source: Der Nervenarzt - September 27, 2019 Category: Neurology Authors: Köhrmann M, Kleinschnitz C Tags: Nervenarzt Source Type: research

[Cognitive disorders in schizophrenia].
Abstract Cognitive disorders in schizophrenia are highly correlated with the psychosocial level (e.g. relationships, quality of life and work). It has been shown that healthy relatives and people at ultrahigh risk also display cognitive dysfunctions albeit to a lesser degree. The cognitive impairment increases simultaneously with an acute phase and then reverts back to baseline levels. At the psychopathological level, negative symptoms and the disorganization syndrome show the strongest associations with cognitive deficits, whereby the extent of manifestation of deficits increases with increasing symptomatolo...
Source: Der Nervenarzt - September 26, 2019 Category: Neurology Authors: Krug A, Stein F, Kircher T Tags: Nervenarzt Source Type: research

[Poverty, migration and mental health].
This article provides a review and discussion on the relationship between mental health, poverty and related constructs, such as social cohesion, social capital and social exclusion in general as well as in specific risk groups, such as migrant and refugee populations. PMID: 31559479 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 26, 2019 Category: Neurology Authors: Kluge U, Rapp MA, Mehran N, Jumaa J, Aichberger MC Tags: Nervenarzt Source Type: research

[Myasthenia gravis].
This article reviews the basic and advanced treatment options of the different disease subtypes including plasma exchange and immunoglobulins for treatment in a myasthenic crisis. Recently, clinical approval of eculizumab, a complement inhibitor, enriched the pharmacological armamentarium for AChR antibody-positive MG patients not appropriately responding to immunosuppression alone. PMID: 31538208 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 19, 2019 Category: Neurology Authors: Müllges W, Stoll G Tags: Nervenarzt Source Type: research

[Computational psychiatry : Data-driven vs. mechanistic approaches].
This article presents this field of research using selected examples based on the distinction between data-driven and theory-driven approaches. Exemplary for a data-driven approach are studies to predict clinical outcome, for example, in persons with a high-risk state for psychosis or on the response to pharmacological treatment for depression. Theory-driven approaches attempt to describe the mechanisms of altered information processing as the cause of psychiatric symptoms at the behavioral and neuronal level. In computational models possible mechanisms can be described that may have produced the measured behavioral o...
Source: Der Nervenarzt - September 19, 2019 Category: Neurology Authors: Kaminski J, Katthagen T, Schlagenhauf F Tags: Nervenarzt Source Type: research

[Brain stimulation for treating stroke-related motor deficits].
Abstract Functional recovery of stroke-related deficits is mainly achieved through neural reorganization. Neurorehabilitative approaches, therefore, aim at supporting positive processes while suppressing maladaptive neuronal processes. This review summarizes the main findings of studies using non-invasive and invasive brain stimulation with respect to the benefits of the treatment for motor deficits after stroke. In addition, the article discusses possible approaches to enhance the effectiveness of neuromodulatory approaches and thus improve the outcome of patients. PMID: 31538210 [PubMed - as supplied by pub...
Source: Der Nervenarzt - September 19, 2019 Category: Neurology Authors: Tscherpel C, Grefkes C Tags: Nervenarzt Source Type: research

[Autoimmune encephalitis-Diagnostic and therapeutic decision tree from a psychiatric, neurological and ethico-legal point of view : Approach in cases of lack of ability to give consent and permissibility of compulsory treatment].
S, Müller S Abstract Patients with severe mental illnesses who are unable to give consent often need a rapid diagnosis and treatment but due to the psychiatric symptoms they often reject such measures. In the routine practice, the question arises to what extent the patient's expressed will should dictate the treatment steps and whether a decision against the patient's will is medically reasonable, ethically justifiable or even demanded and legally permissible. Autoimmune encephalitides, such as N‑methyl-D-aspartate receptor (NMDAR) encephalitis, have recently become important differential diagnoses due...
Source: Der Nervenarzt - September 19, 2019 Category: Neurology Authors: Prüß H, Köhler S, Müller S Tags: Nervenarzt Source Type: research

[Seronegative myasthenic syndrome?]
ilich P PMID: 31535177 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 18, 2019 Category: Neurology Authors: Selge C, Kümpfel T, Havla J, Schöberl F, Danek A, Reilich P Tags: Nervenarzt Source Type: research

[Indications for varicella zoster and herpes zoster vaccination in multiple sclerosis: current situation].
UK Abstract In patients with multiple sclerosis (MS) primary varicella zoster virus (VZV) infections (chickenpox) or reactivation (shingles, herpes zoster) pose a particular challenge for neurologists and physicians in everyday clinical practice. On the one hand the various immunotherapeutic agents for treatment of MS have differently expressed risks for VZV-associated infections and on the other hand the currently available vaccination strategies (dead vs. live vaccines, single vs. combination vaccines) require an individualized approach. Moreover, in addition to the optimal timing of vaccination during the...
Source: Der Nervenarzt - September 17, 2019 Category: Neurology Authors: Winkelmann A, Löbermann M, Zettl UK Tags: Nervenarzt Source Type: research

[New classification of epileptic seizures : A critical evaluation of the changes].
r G Abstract In the new classification of epileptic seizures by the International League Against Epilepsy (ILAE), a multitude of changes are recommended particularly for seizures of focal origin. In addition to aspects of the nomenclature, this involves the introduction of different levels of classification with respect to the state of consciousness and the evolution to a bilateral tonic-clonic seizure, the inclusion of the first semiological seizure element in the classification and a new operationalization of the state of consciousness. This leads partly to specification in the description but in some areas also...
Source: Der Nervenarzt - September 10, 2019 Category: Neurology Authors: Schulze-Bonhage A, Hamer H, Krämer G Tags: Nervenarzt Source Type: research

[Psychiatric polypharmacy and electroconvulsive therapy in treatment-resistant depression].
CONCLUSION: The data possibly indicate that patients with TRD who receive ECT during inpatient treatment already have a more extensive psychiatric medication at admission. Also, psychiatric medication appears to be increased less prominently when ECT is performed. These findings and the possibly associated long-term benefits should be addressed in future research. PMID: 31489462 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 5, 2019 Category: Neurology Authors: Zöllner R, Huber MT, Mangelsdorf C, Konrad C, Zavorotnyy M Tags: Nervenarzt Source Type: research

[Healthcare research in the living environment].
Abstract BACKGROUND: Healthcare research in the living environment is focused on the scientific investigation of care, which is delivered in the personal environment of those affected by diseases. OBJECTIVE: Presentation of the healthcare policy starting position, content and evidence of forms of care by which treatment focuses on the living environment of affected persons. Presentation of the RECOVER model, by which these forms of care are integrated and coordinated in a care model. MATERIAL AND METHODS: Literature search on "care or treatment models" and "psychiatric disease" over t...
Source: Der Nervenarzt - September 3, 2019 Category: Neurology Authors: Lambert M, Karow A, Gallinat J Tags: Nervenarzt Source Type: research

[The importance of social neurosciences for psychiatry].
CONCLUSION: Social stress affects subnetworks also compromised in psychiatric disorders. Therefore, it is plausible that the social brain might mediate the association between social stress and psychiatric disorders. To advance ecological validity in social neuroscience, recent research has highlighted the role of hyperscanning and virtual reality as means by which a more naturalistic assessment of social interactions might be feasible. PMID: 31482185 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - September 3, 2019 Category: Neurology Authors: Holz NE, Meyer-Lindenberg A Tags: Nervenarzt Source Type: research

[German S3 guidelines on avoidance of coercion: prevention and therapy of aggressive behavior in adults].
This article reports on the developmental process, significance and scope of clinical practice guidelines and presents changes to the former S2 guidelines on therapeutic interventions for aggressive behavior (2010). Aggressive behavior is understood both in the context of risk characteristics on the patient side and as a result of escalating conflicts between patients and staff. If coercive measures are unavoidable, they must be carried out in the most bearable and humane way possible for all participants. For the first time these guidelines provide clear evidence-based and consensus-based recommendations for these is...
Source: Der Nervenarzt - August 31, 2019 Category: Neurology Authors: Steinert T, Hirsch S Tags: Nervenarzt Source Type: research

[Rare causes of stroke-a frequent stroke etiology].
Abstract As a whole, rare stroke causes represent a frequent stroke etiology. Since rare stroke causes affect primarily young patients, early diagnosis and treatment are of high socioeconomic relevance. In our everyday clinical practice, cervical artery dissection, which is the most common stroke etiology among patients
Source: Der Nervenarzt - August 30, 2019 Category: Neurology Authors: Schmidt-Pogoda A, Minnerup J Tags: Nervenarzt Source Type: research

[Internet-based cognitive behavioral therapy of insomnia and nightmare disorder].
This article presents the current situation in the treatment of insomnia and nightmare disorders as particularly well-suited fields of application. For insomnia there are several English language and also recently German language options, which for example were also evaluated for the application to work-related stress and sleep disorders. In this respect, procedures with and without contact to a therapist or multicomponent procedures and single interventions can be differentiated. For nightmare disorders imagery rehearsal therapy provides a structure, which can also easily be transferred to an internet-based therapy p...
Source: Der Nervenarzt - August 30, 2019 Category: Neurology Authors: Frase L, Duss SB, Gieselmann A, Penzel T, Wetter TC, Pollmächer T Tags: Nervenarzt Source Type: research

[Some further thoughts on Zeitgeist and human rights in the context of psychiatric care].
PMID: 31468091 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 29, 2019 Category: Neurology Authors: Kronenberg G, Hellweg R Tags: Nervenarzt Source Type: research

[Weather and suicide : Association between meteorological variables and suicidal behavior-a  systematic qualitative review article].
CONCLUSION: A total of 99 studies were included and grouped according to the research analysis based on daily, weekly, monthly and annual data. The majority of the studies reported a statistical association with at least one meteorological variable. The most consistent positive correlation was shown between temperature and suicidal behavior. However, the results are not conclusive and in part contradictory. The reported studies differed distinctively in terms of study design. Meteorological parameters may be associated with suicidal behavior. Future research in this area is needed to provide further clarity. Desp...
Source: Der Nervenarzt - August 29, 2019 Category: Neurology Authors: Pervilhac C, Schoilew K, Znoj H, Müller TJ Tags: Nervenarzt Source Type: research

[Video presentations for examination questions in psychiatry : A  pilot study].
CONCLUSION: Due to the versatile applicability and high efficiency, MC questions will continue to play an important role in medical examinations. In accordance with the aims of MM2020, it could be shown that psychiatric knowledge can be examined in a competence-oriented manner and with a practical orientation by means of video presentations in an e‑examination. A broader application of video presentations could complement electronically supported examinations in the discipline of psychiatry. PMID: 31468093 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 29, 2019 Category: Neurology Authors: Trost S, Dieterle J, Herrmann M, Signerski-Krieger J Tags: Nervenarzt Source Type: research

[Implementation of exercise therapy in daily clinical practice in psychiatric clinics in Germany].
l;hle A Abstract Exercise therapy has proven to be effective in the treatment of multiple mental illnesses. As mental disorders result in tremendous costs for the healthcare system as well as a huge burden for the affected individuals, improving treatment strategies according to latest scientific evidence should be of highest priority. In 2016 a first study provided indications that only a minority of patients are treated with exercise therapy during their stay in hospital. Hence, the aim of this study was to assess the actual extent of exercise therapy usage in psychiatric inpatients in Germany, th...
Source: Der Nervenarzt - August 28, 2019 Category: Neurology Authors: Brehm K, Dallmann P, Freyer T, Winter K, Malchow B, Wedekind D, Diller IM, Henkel K, Sieberer M, Bär KJ, Schneider F, Ströhle A Tags: Nervenarzt Source Type: research

[Work-related medical rehabilitation in neurology : Effective on the basis of individualized rehabilitant identification].
CONCLUSION: The applied neurological WMR concept accomplished a comparable RTW rate between rehabilitants with SRWA by a WMR and those without SRWA and conventional rehabilitation. The SIMBO-C should only be used in combination with the individualized anamnesis to identify SRWA. PMID: 31451849 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 26, 2019 Category: Neurology Authors: Leniger T, Ghadimi A Tags: Nervenarzt Source Type: research

[The report on Ludwig  II by Gudden and his colleagues in relation to the state of knowledge at that time].
[The report on Ludwig II by Gudden and his colleagues in relation to the state of knowledge at that time]. Nervenarzt. 2019 Aug 23;: Authors: Hippius H, Steinberg R Abstract Bernhard von Gudden and his prominent co-experts Grashey, Hagen and Hubrich wrote an expert opinion on Ludwig II that was based on statements of sworn witnesses of the 41-year-old monarch's pathological behavior. With the contemporary material available today it can be understood why Gudden reached the diagnosis of "paranoia (madness)", which was in accordance with the state of psychiatric knowledge at that tim...
Source: Der Nervenarzt - August 23, 2019 Category: Neurology Authors: Hippius H, Steinberg R Tags: Nervenarzt Source Type: research

[Psychotherapy in psychiatry via digital media? For].
PMID: 31444519 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 23, 2019 Category: Neurology Authors: Juckel G, Hegerl U Tags: Nervenarzt Source Type: research

[Prevention of cognitive decline and dementia by treatment of risk factors].
CONCLUSION: The treatment of modifiable risk factors can have a preventive effects on cognitive decline and dementia. More research is needed to identify subgroups with the greatest likelihood of benefits. PMID: 31440769 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 22, 2019 Category: Neurology Authors: Escher C, Jessen F Tags: Nervenarzt Source Type: research

[Psychotherapy in psychiatry via digital media? Against].
a H PMID: 31440770 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 22, 2019 Category: Neurology Authors: Löffler-Stastka H Tags: Nervenarzt Source Type: research

[Neuroinflammation as motor of Alzheimer's disease].
This article reviews and discusses the function of the cerebral innate immune system, the newly discovered genes associated with the disease development and the experimental evidence around the role of microglia in the onset and progression of Alzheimer's disease. The discovery of different microglia phenotypes associated with the pathology as well as new molecular players will enable the development of new preventive and therapeutic strategies by modulating neuroinflammation in neurodegenerative diseases. PMID: 31428829 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 19, 2019 Category: Neurology Authors: Castro-Gomez S, Binder J, Heneka MT Tags: Nervenarzt Source Type: research

[Innovation in diagnostics-mobile technologies].
CONCLUSION: Mobile app-based technologies can help to improve the cognitive assessment of patients with the main symptom of memory complaints. They can reduce overuse and underuse of diagnostic and therapeutic pathways and enable a targeted and meaningful use of advanced diagnostics. In addition, they can structure risk-modifying preventive measures, identify iatrogenic impairment of cognition and in this respect also strengthen patient competence. PMID: 31420690 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 16, 2019 Category: Neurology Authors: Düzel E, Thyrian JR, Berron D Tags: Nervenarzt Source Type: research

[First conclusions from the register for coercive measures in Baden-W ürttemberg].
[First conclusions from the register for coercive measures in Baden-Württemberg]. Nervenarzt. 2019 Aug 16;: Authors: Steinert T PMID: 31420691 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 16, 2019 Category: Neurology Authors: Steinert T Tags: Nervenarzt Source Type: research

[ADHD in adult patients with substance use disorders].
CONCLUSION: In recent years new findings on the comorbidity of ADHD in patients with SUD have emerged. A series of screening and diagnostic instruments have meanwhile been evaluated in this patient group. The consensus paper and various guidelines therefore provide clinicians with specific help in detecting ADHD in patients with SUD and in conducting further diagnostics and treatment of both disorders. For example, the importance of stimulants in the treatment of patients with SUD and ADHD has significantly changed and first studies on psychotherapeutic interventions specific to this comorbidity are now available. ...
Source: Der Nervenarzt - August 12, 2019 Category: Neurology Authors: Luderer M, Kiefer F, Reif A, Moggi F Tags: Nervenarzt Source Type: research

[Intracerebral hemorrhage: hot topics].
This article addresses these most relevant topics in acute and long-term treatment of ICH patients and provides an overview of current debates in these areas of treatment. PMID: 31407044 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 12, 2019 Category: Neurology Authors: Sprügel MI, Huttner HB Tags: Nervenarzt Source Type: research

[New biomarkers for Alzheimer's disease in cerebrospinal fluid and blood].
Abstract In accordance with the current German dementia guidelines, the dementia biomarkers amyloid beta 42, the tau peptides total tau and phosphorylated tau 181 are recommended for cerebrospinal fluid (CSF)-based diagnostics of dementia. Several studies have clearly shown that determination of the amyloid beta 42 to amyloid beta 40 peptide ratio is superior to the interpretation of amyloid beta 42 alone and should be implemented in the clinical work-up; however, in recent years different studies have presented many other innovative CSF and blood-based biomarkers. Besides CSF-based neurochemical diagnostics of de...
Source: Der Nervenarzt - August 12, 2019 Category: Neurology Authors: Vogelgsang J, Wiltfang J Tags: Nervenarzt Source Type: research

[Acute treatment of ischemic stroke : Current standards].
Abstract Important milestones of acute ischemic stroke (AIS) treatment were achieved in recent years. The results of two randomized controlled trials revealed that intravenous thrombolysis is efficacious for treatment of AIS patients with a symptom onset
Source: Der Nervenarzt - August 12, 2019 Category: Neurology Authors: Barow E, Thomalla G Tags: Nervenarzt Source Type: research

[Coercive measures in psychiatric clinics-one among other indicators of treatment quality].
PMID: 31399812 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 9, 2019 Category: Neurology Authors: Weinmann S, Aderhold V, Kleinschmidt M, Zinkler M, von Peter S Tags: Nervenarzt Source Type: research

[New slow-release buprenorphine formulations for optimization of opioid substitution].
Abstract Opioid maintenance treatment with methadone or buprenorphine is an established first-line treatment for opioid dependence. In addition to the novel weekly and monthly subcutaneously injectable buprenorphine depot CAM 2038 (Buvidal®), which is already available in Germany, two other long-acting buprenorphine formulations may be introduced in the near future: the monthly depot formulation RBP-6000 (Sublocade™) and a 6-month buprenorphine depot implant (Probuphine™). Basic pharmacological and clinical data of these three medications are given and possible clinical applications are discus...
Source: Der Nervenarzt - August 9, 2019 Category: Neurology Authors: Soyka M, Pogarell O Tags: Nervenarzt Source Type: research

[Obituary for Prof. Dr. Werner Janzarik (1920-2019)].
g; H PMID: 31388692 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - August 6, 2019 Category: Neurology Authors: Herpertz SC, Mundt C, Saß H Tags: Nervenarzt Source Type: research

[Aspects of nutrition for prevention and treatment of chronic neurological diseases].
Abstract Chronic neurodegenerative and neuroinflammatory diseases, such as idiopathic Parkinson's syndrome, amyotrophic lateral sclerosis and multiple sclerosis, represent a therapeutic challenge. Their pathophysiology is not well understood and a cure for any of these diseases is not possible. Over the past decades lifestyle and nutritional habits in modern industrial nations have changed and evidence is increasing that the prevalence of chronic diseases as well their clinical presentation are also changing. Epidemiological investigations indicate that nutritional components might have an impact on the ...
Source: Der Nervenarzt - August 2, 2019 Category: Neurology Authors: Leussink VI Tags: Nervenarzt Source Type: research

[Bernhard von Gudden's psychiatric assessment and the deposition of King Ludwig  II of Bavaria in 1886 : Comments on the article by R. Steinberg in Der Nervenarzt 01/2019].
[Bernhard von Gudden's psychiatric assessment and the deposition of King Ludwig II of Bavaria in 1886 : Comments on the article by R. Steinberg in Der Nervenarzt 01/2019]. Nervenarzt. 2019 Aug 01;: Authors: Häfner H Abstract King Ludwig II of Bavaria drowned himself in Lake Starnberg on 13 June 1886 after subduing and drowning Bernhard von Gudden, a Munich-based psychiatrist who had tried to hold him back. Commissioned by Prince Luitpold, Ludwig's successor to the throne, von Gudden had provided a psychiatric assessment on the king. Finding him to be suffering from a ...
Source: Der Nervenarzt - August 1, 2019 Category: Neurology Authors: Häfner H Tags: Nervenarzt Source Type: research

[In memory of Professor Dr. med. Klaus Weise (1929-2019)].
PMID: 31346647 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 25, 2019 Category: Neurology Authors: Steinberg H, Uhle M Tags: Nervenarzt Source Type: research

[Anti-tau therapies-what can be expected?]
This article summarizes recent progress in anti-tau therapies, especially therapies based on anti-tau immunization and antisense oligonucleotides (ASO). PMID: 31332452 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 22, 2019 Category: Neurology Authors: Fließbach K, McCormick C, Kaulen B, Schneider A Tags: Nervenarzt Source Type: research

[Unappropriate recommendation grades for carbamazepine and valproate].
PMID: 31324933 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 19, 2019 Category: Neurology Authors: Greil W Tags: Nervenarzt Source Type: research

[Diagnosis of irreversible loss of brain function ("brain death")-what is new?]
This article provides an assessment of the current situation including an international comparison. International case reports with allegedly incorrect ICBF diagnosis are reviewed from the point of view of the German guideline. These case reports underpin the validity of the German guideline, especially its following provisions: (1) in patients with known or suspected adaptation to chronic hypercapnia, apnea cannot be diagnosed as usual; therefore in such a case the proof of cerebral circulatory arrest is mandatory; (2) if perfusion scintigraphy is used for proof of cerebral circulatory arrest, only validated lip...
Source: Der Nervenarzt - July 16, 2019 Category: Neurology Authors: Walter U, Brandt SA Tags: Nervenarzt Source Type: research

[Wearables in the treatment of neurological diseases-where do we stand today?]
This article presents the general understanding of the technical application for the most relevant functional impairments in neurology. While wearables used for sleep assessment have already reached a high level of technological readiness due to the defined test environment (bed, sleep), other wearable applications, e.g. for gait and mobility during home monitoring require further research in order to transfer the technical capabilities into real-life patient care. PMID: 31309270 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 15, 2019 Category: Neurology Authors: Klucken J, Gladow T, Hilgert JG, Stamminger M, Weigand C, Eskofier B Tags: Nervenarzt Source Type: research

[Erratum to: Therapeutic drug monitoring in neuropsychopharmacology : Summary of the consensus guidelines 2017 of the TDM task force of the AGNP].
l;ller MJ, Paulzen M, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Schoretsanitis G, Schwarz M, Gracia MS, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Waschgler R, Zernig G, Zurek G, Hiemke C PMID: 31309271 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 15, 2019 Category: Neurology Authors: Unterecker S, Hefner G, Baumann P, Gründer G, Bergemann N, Clement HW, Conca A, Deckert J, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Haen E, Havemann-Reinecke U, Helmer R, Janssen G, Jaquenoud E, Laux G, Messer T, Mössner R, Müller MJ, Tags: Nervenarzt Source Type: research

[Day care/inpatient psychiatric treatment of minors and adults with hyperkinetic disorder in German psychiatric hospitals : Basic conditions, diagnoses and comorbidities].
CONCLUSION: Due to greater distances from their residence to a psychiatric hospital for minors, extension of capacities with a focus on child and youth psychiatry seems to be a reasonable conclusion. Simultaneously, the intensity of treatment seems to be lower for adult patients, despite a greatly increased number of secondary diagnoses and thus anticipated psychological stress. Transition difficulties from child and youth psychiatry to adult psychiatry may be a possible explanation for this discrepancy. PMID: 31297572 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 11, 2019 Category: Neurology Authors: Büchsel R, Belz M, Wiltfang J, Wolff-Menzler C, Kis B Tags: Nervenarzt Source Type: research

[Correction of the level of recommendation for TDM].
PMID: 31297573 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 11, 2019 Category: Neurology Authors: Unterecker S, Hefner G, TDM-Arbeitsgruppe der AGNP Tags: Nervenarzt Source Type: research

[Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : Current status and recommendations in Germany].
This article summarizes specific recommendations for the diagnostics and treatment of TB under MS immunotherapies with a focus on the situation in Germany. Due to low case numbers and little experience with the risk of TB under the new immunotherapies, the clinical competence network for MS (KKNMS) consensus recommendations have a low grade of evidence. PMID: 31297574 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 11, 2019 Category: Neurology Authors: Bittner S, Engel S, Lange C, Weber MS, Haghikia A, Luessi F, Korn T, Klotz L, Bayas A, Paul F, Heesen C, Stangel M, Wildemann B, Bergh FT, Tackenberg B, Trebst C, Warnke C, Linker R, Kerschensteiner M, Zettl U, Tumani H, Brück W, Meuth SG, Kümpfel T, He Tags: Nervenarzt Source Type: research

[Gene therapies for neuromuscular diseases].
CONCLUSION: Gene therapies have the potential to significantly influence the course of neuromuscular diseases. First positive intermediate results have been published and the first treatment has recently been approved in the USA. Long-term data on sustained effects and toxicity of gene therapies are not yet available. These novel treatment options will present new challenges for the healthcare systems concerning diagnosis, treatment and reimbursement. PMID: 31286145 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - July 8, 2019 Category: Neurology Authors: Saffari A, Weiler M, Hoffmann GF, Ziegler A Tags: Nervenarzt Source Type: research