[New aspects of immunotherapy in multiple sclerosis].
Abstract The spectrum of therapeutic options for immunotherapy of multiple sclerosis is continuously broadening. After the approval of cladribine and ocrelizumab in Europe, two new drugs are now available with ocrelizumab being the first approved option for treatment of primary progressive multiple sclerosis; however, the increased use of highly effective therapies is accompanied by a rise in severe side effects. During recent months, special attention was paid to the new progressive multifocal leukoencephalopathy (PML) risk assessment in natalizumab-treated patients, cardiac side effects of fingolimod, cases...
Source: Der Nervenarzt - June 7, 2018 Category: Neurology Authors: Pape K, Zipp F, Bittner S Tags: Nervenarzt Source Type: research

[The Indian Ayurveda medicine-a meaningful supplement to psychiatric treatment?]
Abstract Ayurveda is a traditional Indian system of medicine that is more than 3000 years old, consisting mostly of a specific diet, oily infusions mainly in the area of the head, enemas, medicinal plants and yoga. It is based on a naturopathic and anthropological belief in association with the hinduistic religion. Ayurveda has been practiced very successfully in India but so far it has only been insufficiently appreciated by western medicine, especially psychiatry. An exception is Scharfetter from Zürich who wrote a review article on this topic in 1976. Nevertheless, it is probable that particularl...
Source: Der Nervenarzt - June 6, 2018 Category: Neurology Authors: Juckel G, Hoffmann K Tags: Nervenarzt Source Type: research

[Resilience trajectories-examples from longitudinal studies].
This study was based on a qualitative literature review of published prospective studies investigating resilience listed in PubMed and study protocols of the four longitudinal studies. RESULTS: The exemplarily described studies have shown that resilience processes are changeable in all age groups and subject to a variety of influencing factors. The specific and potentially age-associated types of alterations have so far been difficult to determine and need further clarification. DISCUSSION: In view of the dynamic course of resilience, prospective longitudinal studies are urgently needed. Prospective lon...
Source: Der Nervenarzt - June 6, 2018 Category: Neurology Authors: Lindert J, Schick A, Reif A, Kalisch R, Tüscher O Tags: Nervenarzt Source Type: research

[Diagnosis of multiple sclerosis: revision of the McDonald criteria 2017].
Abstract Multiple sclerosis (MS) is the most common chronic autoimmune disorder of the central nervous system (CNS) largely affecting young adults. The diagnosis of MS is based on two pillars: 1) detection of the spatial and temporal dissemination of focal neurological deficits and 2) exclusion of important differential diagnoses. The current revision of the diagnostic criteria (McDonald 2017) also follows these principles, takes new data on magnetic resonance imaging (MRI) into account and reintroduces the role of cerebrospinal fluid (CSF) diagnostics for relapsing-remitting forms. The main priority is ...
Source: Der Nervenarzt - June 6, 2018 Category: Neurology Authors: Aktas O, Wattjes MP, Stangel M, Hartung HP Tags: Nervenarzt Source Type: research

[Prevalence of sleep-related breathing disorders of inpatients with psychiatric disorders].
DISCUSSION: The high prevalence indicates that sleep apnea is a common sleep disorder among psychiatric patients. Although OSAS can lead to substantial disorders of the mental state and when untreated is accompanied by serious somatic health problems, screening procedures are not part of the routine work-up in psychiatric hospitals; therefore, sleep apnea is presumably underdiagnosed in psychiatric patients. In view of the results of this and previous studies, this topic complex should be the subject of further research studies. PMID: 29876601 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 6, 2018 Category: Neurology Authors: Behr M, Acker J, Cohrs S, Deuschle M, Danker-Hopfe H, Göder R, Norra C, Richter K, Riemann D, Schilling C, Weeß HG, Wetter TC, Wollenburg LM, Pollmächer T Tags: Nervenarzt Source Type: research

[Nationwide survey of postgraduate medical training in clinical neurology].
CONCLUSION: Specialist training in neurology can be improved by simple arrangements, e. g., the introduction of a binding rotation scheme, internal mentoring and structured feedback. In addition, it will be necessary to relieve medical staff of administrative duties in order to create time for training and the learning of competencies. PMID: 29872878 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 5, 2018 Category: Neurology Authors: Biesalski AS, Franke C, Sturm D, Behncke J, Schreckenbach T, Knauß S, Eisenberg H, Hillienhof A, Sand F, Zupanic M Tags: Nervenarzt Source Type: research

[Suicidal tendencies in adolescence : Dysfunctional familiar communication as risk factor].
CONCLUSION: The results of this literature search indicate that functional communication with parents seems to be protective for suicidal adolescents. From this, recommendations can be derived for preventive measures in families with adolescents who are otherwise at increased risk of suicide. Longitudinal study designs are needed to conclusively answer the research question. PMID: 29872879 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 5, 2018 Category: Neurology Authors: Radde S, Gutwinski S, Stuke F, Fuchs A, Schouler-Ocak M, Bermpohl F, Henssler J Tags: Nervenarzt Source Type: research

[Yoga for mental disorders].
CONCLUSION: There is preliminary evidence that meditation-based yoga interventions may be helpful for depression, anxiety and PTSD; however, there may also be the risk of engaging in extreme yoga practices. The value of integrating yoga into a treatment plan for patients with psychiatric disorders needs to be evaluated on an individual basis. Healthcare providers can motivate and help patients evaluate whether a given yoga class is helpful and safe for them. Methodological problems and the unclear risk-benefit ratio preclude definitive recommendations for yoga as an adjunct treatment. PMID: 29858642 [PubMed ...
Source: Der Nervenarzt - June 1, 2018 Category: Neurology Authors: Meister K, Becker S Tags: Nervenarzt Source Type: research

[Homeopathy for psychiatric patients-for and against].
Abstract The application of homeopathic treatment quickly becomes a matter of ideological confrontation; however, homeopathy is steadily gaining in sympathy in the population. Although the possible effectiveness and the modes of action are currently not scientifically elucidated and the study situation regarding homeopathic treatment in psychiatry is still manageable, there is a whole series of positive evidence for the effects of homeopathic remedies for mental disorders, such as depression, anxiety disorders and addiction. The most important studies are presented and the most important arguments are weighed...
Source: Der Nervenarzt - June 1, 2018 Category: Neurology Authors: Hock N, Juckel G Tags: Nervenarzt Source Type: research

[Herbal medicines for psychiatric disorders].
CONCLUSION: Due to the promising effects and the low side effect potential within the existing studies, further randomized controlled trials (e. g. for Passiflora incarnata, Rhodiola rosea and Lavendula officinalis) are definitely indicated. PMID: 29846749 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 30, 2018 Category: Neurology Authors: Anheyer D, Haller H, Klose P, Cramer H, Dobos G Tags: Nervenarzt Source Type: research

[Internet-based resilience training and prevention of mental disorders].
DISCUSSION: Given the heterogeneous nature of intervention contents, theoretical foundations and therapeutic methods used, the heterogeneity of the evidence is discussed. In addition, perspectives for the further development of resource-oriented resilience interventions are outlined. PMID: 29846750 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 30, 2018 Category: Neurology Authors: Lehr D, Kunzler A, Helmreich I, Behrendt D, Chmitorz A, Lieb K Tags: Nervenarzt Source Type: research

[Chameleon spondylodiscitis : Challenge for geriatricians].
Abstract The incidence of spondylodiscitis is increasing and attributable to an aging population with multimorbidities. Spondylodiscitis represents a life-threatening disease. Typical clinical manifestations often involve nonspecific symptoms with back pain; however, due to the frequent absence of fever the disease is often overlooked. Pathogen detection and spinal imaging with magnetic resonance imaging (MRI) are essential for the diagnosis. Identification of the causative pathogen is particularly important for initiating targeted antibiotic treatment. Debridement and stabilization are the mainstays of surgi...
Source: Der Nervenarzt - May 28, 2018 Category: Neurology Authors: Hofmann W Tags: Nervenarzt Source Type: research

[Resilience].
PMID: 29802417 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 25, 2018 Category: Neurology Authors: Lieb K, Kunzler AM Tags: Nervenarzt Source Type: research

[Current concepts of resilience research].
CONCLUSIONS: In the upcoming decades, further profitable findings from current prospective longitudinal studies can be expected. One challenge for future resilience research consists in the continuous dissemination and implementation of the approaches described. PMID: 29796896 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 23, 2018 Category: Neurology Authors: Kunzler AM, Gilan DA, Kalisch R, Tüscher O, Lieb K Tags: Nervenarzt Source Type: research

[Recurrence of carotodynia or TIPIC syndrome].
r J PMID: 29767816 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 16, 2018 Category: Neurology Authors: Schaumberg J, Michels P, Eckert B, Röther J Tags: Nervenarzt Source Type: research

[Motor neuron diseases : Clinical and genetic differential diagnostics].
Abstract The causes of degenerative disease of the upper and lower motor neurons are incompletely understood. In this review the current concepts in the clinical and genetic differential diagnostics of motor neuron diseases are presented. Hereditary spastic paraplegia, primary lateral sclerosis, spinal muscular atrophy and amyotrophic lateral sclerosis are explained, structured according to the affection of the upper and/or lower motor neuron. The substantial variability in the presentation and course of motor neuron diseases as well as the lack of specific laboratory tests hinder an early diagnosis. The precise d...
Source: Der Nervenarzt - May 16, 2018 Category: Neurology Authors: Regensburger M, Weidner N, Kohl Z Tags: Nervenarzt Source Type: research

[Frequent neurological diseases associated with the restless legs syndrome].
CONCLUSION: There is an increased prevalence of association with RLS for the diseases discussed. This prevalence is possibly determined by the pathophysiology of these disorders. These diseases are possibly characterized by genetic predispositions as well, which can hopefully be classified more accurately in the future. PMID: 29736677 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 7, 2018 Category: Neurology Authors: Bartl M, Winkelmann J, Högl B, Paulus W, Trenkwalder C Tags: Nervenarzt Source Type: research

[Juvenile familial vertebrobasilar brain infarctions due to adenosine deaminase 2 deficiency].
PMID: 29736678 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 7, 2018 Category: Neurology Authors: Etgen T, Kiefer T, Luther M, Haberl R Tags: Nervenarzt Source Type: research

[Structured Curricular Advanced Education in "Medical Assessment" : Combined Concept of DGNB, DGN, DGNC, and DGPPN].
[Structured Curricular Advanced Education in "Medical Assessment" : Combined Concept of DGNB, DGN, DGNC, and DGPPN]. Nervenarzt. 2018 May 04;: Authors: Gahn G, Gaidzik P, Bergmann F, Hauth I, Tronnier V, Zumkeller M, Ferbert A, Widder B PMID: 29728718 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 4, 2018 Category: Neurology Authors: Gahn G, Gaidzik P, Bergmann F, Hauth I, Tronnier V, Zumkeller M, Ferbert A, Widder B Tags: Nervenarzt Source Type: research

Mitteilungen der DGPPN 5/2018.
Authors: PMID: 29737399 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 1, 2018 Category: Neurology Tags: Nervenarzt Source Type: research

Mitteilungen der DGN.
Authors: PMID: 29737400 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 1, 2018 Category: Neurology Tags: Nervenarzt Source Type: research

[Degenerative spinal diseases].
PMID: 29679125 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 20, 2018 Category: Neurology Authors: Vajkoczy P, Weidner N Tags: Nervenarzt Source Type: research

[Surgical treatment of adult spinal deformities].
CONCLUSION: Patients for whom even conservative treatment leads to success should be identified earlier and better. The surgical treatment ranges from minimally invasive decompression to multilevel fusions. Complications in large corrective interventions can be substantial but if the indications are correctly assessed, such complex surgical treatment has excellent clinical results in terms of pain and quality of life. PMID: 29679126 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 20, 2018 Category: Neurology Authors: Krieg SM, Vajkoczy P, Eicker SO, Rohde V, Thome C, Stoffel M, Ringel F, Meyer B Tags: Nervenarzt Source Type: research

[Basic principles of diagnosis and treatment of gliomas].
DISCUSSION: To date the classical treatment modalities comprising surgery, radiotherapy and chemotherapy remain the mainstay of glioma treatment. The integration of molecular features into the classification of gliomas is a basis for personalized treatment approaches. PMID: 29679127 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 20, 2018 Category: Neurology Authors: Wirsching HG, Weiss T, Roth P, Weller M Tags: Nervenarzt Source Type: research

[Activities without patient contact : Estimate of time costs based on telephone interviews in eight psychiatric hospitals].
t T Abstract The aim of this pilot study was to estimate the share of working time that staff in psychiatric hospitals theoretically spend on obligatory activities, such as training and further education, organizational and documentation tasks as well as statutory lecturing duties without patient contact. A total of 47 physicians, 39 nurses, 34 psychologists and 35 social workers from eight psychiatric hospitals were interviewed. The results reveal that the theoretically remaining time for direct patient contact is low. The ratio of time spent with versus time spent without patient contact was ...
Source: Der Nervenarzt - April 20, 2018 Category: Neurology Authors: Blume A, Brückner-Bozetti P, Steinert T Tags: Nervenarzt Source Type: research

[Operative treatment of degenerative diseases of the lumbar spine].
CONCLUSION: The treatment of specific lower back pain due to degenerative lumbar pathologies represents an interdisciplinary challenge, requiring both conservative and surgical treatment strategies in a synergistic treatment concept in order to achieve the best results for patients. PMID: 29679129 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 20, 2018 Category: Neurology Authors: Czabanka M, Thomé C, Ringel F, Meyer B, Eicker SO, Rohde V, Stoffel M, Vajkoczy P Tags: Nervenarzt Source Type: research

[Influence of staffing levels on conflicts in inpatient psychiatric care].
r M Abstract Acute psychiatric wards are an important element in the mental healthcare of people at risk for acute harm to others or self-harm. Unfortunately, aggression, violence (conflict) and the use of coercion (containment) are still part of psychiatric care. The decisive factor for the correct handling of these situations is the quantity as well as the quality of the employees. Therefore, the present study dealt with the care situation on acute psychiatric wards. The hypothesis is that both the number of beds on the acute psychiatric ward and the number of caregivers have an impact on the occurrence of confl...
Source: Der Nervenarzt - April 17, 2018 Category: Neurology Authors: Nienaber A, Heinz A, Rapp MA, Bermpohl F, Schulz M, Behrens J, Löhr M Tags: Nervenarzt Source Type: research

[Willingness to participate in group beneficial dementia research].
This study included 85 persons and all of them gave their informed consent to participation. The mean age was 70 years, 47% were male, 61% had a university degree and 46% an independent profession. Mild cognitive impairment was diagnosed in 26%. This survey revealed a relatively high basic approval of group beneficial dementia research as well as of pharmaceutical withdrawal studies. In addition, research authorization gained a substantially positive evaluation. Only a few participants were informed about the new law in force since 2017. The present results were drawn from an explorative study with...
Source: Der Nervenarzt - April 16, 2018 Category: Neurology Authors: Haupt M, Jänner M Tags: Nervenarzt Source Type: research

[Diagnostics and conservative treatment of cervical and lumbar spinal stenosis].
CONCLUSION: Clinical neurological examination and diagnostic imaging are fundamental for the diagnosis of neurologically relevant cervical and lumbar spinal stenosis. Additional laboratory blood and cerebrospinal fluid testing might be required for a differential diagnosis. Neurophysiological testing is reserved for specific clinical problems. The clinical evidence for the efficacy of conservative therapeutic strategies is limited. PMID: 29663022 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 16, 2018 Category: Neurology Authors: Hug A, Hähnel S, Weidner N Tags: Nervenarzt Source Type: research

[Do we have the caring relatives of dementia patients in mind?]
PMID: 29654378 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 13, 2018 Category: Neurology Authors: Riedel-Heller SG Tags: Nervenarzt Source Type: research

[Low-threshold consulting services for dementia : Quality criteria from a  provider's point of view].
CONCLUSION: Increased cooperation and coordination of all involved stakeholders is necessary to improve the knowledge and utilization of the services and the qualitative orientation. PMID: 29637232 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 10, 2018 Category: Neurology Authors: Ulbrecht G, Gräßel E, Nickel F, Kolominsky-Rabas P Tags: Nervenarzt Source Type: research

[Quality of life among older informal caregivers of people with dementia].
CONCLUSION: The results of the study highlighted caregivers' need for assistance. Due to demographic changes, tailored support services should be based on older caregivers' needs. PMID: 29637233 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 10, 2018 Category: Neurology Authors: Conrad I, Alltag S, Matschinger H, Kilian R, Riedel-Heller SG Tags: Nervenarzt Source Type: research

[Informal care for dementia according to type of service].
CONCLUSION: The provision of all types of informal care services is associated with dementia. The association is pronounced for services that can be more easily integrated into the daily routines of the informal caregiver. Policy makers who plan to integrate informal care into the general care arrangements for dementia should consider this. PMID: 29637234 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 10, 2018 Category: Neurology Authors: Brettschneider C, Hajek A, Stein J, Luck T, Mamone S, Wiese B, Mösch E, Weeg D, Fuchs A, Pentzek M, Werle J, Weyerer S, Mallon T, van den Bussche H, Heser K, Wagner M, Scherer M, Maier W, Riedel-Heller SG, König HH Tags: Nervenarzt Source Type: research

[Unmet needs of family dementia caregivers of persons with dementia : Primary medical care].
DISCUSSION: The article illustrates the importance and the possibilities for general practitioners and specialists to identify caregivers' unmet needs. The question to what extent unmet needs' assessments for family caregivers of PwD could be implemented and financed in routine care is still under debate. PMID: 29619534 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 4, 2018 Category: Neurology Authors: Zwingmann I, Hoffmann W, Michalowsky B, Wucherer D, Eichler T, Teipel S, Dreier-Wolfgramm A, Kilimann I, Thyrian JR Tags: Nervenarzt Source Type: research

[Operative treatment of the degenerative cervical spine].
CONCLUSION: Depending on the cervical pathology, the most prevalent surgical options for radiculopathy include anterior cervical discectomy and fusion (ACDF), cervical arthroplasty or posterior cervical foraminotomy. Cervical myelopathy may be decompressed by ACDF, corpectomy or posterior approaches like laminectomy plus instrumented fusion or laminoplasty. The outcome depends on the cervical pathology and the type of operation. Overall, in long-term follow-up studies the results of all surgical techniques on the cervical spine are generally considered to be very good, although specific patient characteristics are more sui...
Source: Der Nervenarzt - April 4, 2018 Category: Neurology Authors: Tschugg A, Meyer B, Stoffel M, Vajkoczy P, Ringel F, Eicker SO, Rhode V, Thomé C Tags: Nervenarzt Source Type: research

[Selective mutism].
e A Abstract Selective mutism was first described in the medical literature 140 years ago. The diagnosis came into the focus of adult psychiatry with the appearance of DSM-5. Henceforth, selective mutism during infancy, adolescence and also adulthood is specified as an independent anxiety disorder. It often begins in early childhood with a kind of speechlessness in certain situations. A diagnostic clarification often only takes place after school enrolment. Very often comorbid anxiety disorders, especially social phobia and depression also occur. The course is very variable and with some affected persons...
Source: Der Nervenarzt - March 29, 2018 Category: Neurology Authors: Rogoll J, Petzold M, Ströhle A Tags: Nervenarzt Source Type: research

[Laboratory diagnostics in transient loss of consciousness : Serum lactate compared to serum creatine kinase as diagnostic indicator for generalized tonic-clonic seizures].
Abstract BACKGROUND: Laboratory parameters can help in the differential diagnostics of acute episodes of transient loss of consciousness. Especially serum lactate and serum creatine kinase (CK) levels may provide valuable hints to distinguish generalized tonic-clonic seizures (GTCS) from syncope. MATERIAL AND METHODS: Serum lactate levels at admission and CK levels 10-48 h after the episodes that led to admission were compared between patients with GTCS (n = 30) and those with syncope (n = 15). In addition, sensitivity and specificity of lactate and CK as diagnostic markers for syncope and...
Source: Der Nervenarzt - March 21, 2018 Category: Neurology Authors: Dafotakis M, Heckelmann J, Zechbauer S, Litmathe J, Brokmann J, Willmes K, Surges R, Matz O Tags: Nervenarzt Source Type: research

Pharmacological treatment for schizoaffective disorder : A comparison with schizophrenia and bipolar disorder.
CONCLUSION: Polypharmacy tends to be more the rule than the exception, especially when patients present with affective psychotic features. Bipolar and schizoaffective disorders cannot be differentiated according to their prescription patterns. PMID: 29564469 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 21, 2018 Category: Neurology Authors: Assion HJ, Schweppe A, Reinbold H, Frommberger U Tags: Nervenarzt Source Type: research

[Misdiagnosis of Wilson's disease despite positive genetics].
PMID: 29564470 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 21, 2018 Category: Neurology Authors: Hermann W, Hennig C, Hoffmann J Tags: Nervenarzt Source Type: research

[Schizophrenia and bipolar disorder : Treatment of cognitive impairments].
Abstract More than half of the patients diagnosed with schizophrenia and a subgroup of patients diagnosed with bipolar disorder show impairment in neurocognitive and social cognitive performance. The degree of impairment varies from person to person. An improvement of cognitive impairment results in increased subjective quality of life and increased psychosocial functioning, to a much greater extent than successful treatment of other symptoms. Therefore, it is reasonable to not only recognize and bear decreased cognitive functioning in mind but also to offer specific treatment of impairments. The systema...
Source: Der Nervenarzt - March 13, 2018 Category: Neurology Authors: Riedel P, Smolka MN, Bauer M Tags: Nervenarzt Source Type: research

[Principles of autoimmune and paraneoplastic encephalitis].
Abstract The paraneoplastic and autoimmune encephalitides are now well-established entities. Detection of neural autoantibodies enables specific diagnoses, provides information on the underlying disease pathophysiology, immunological treatability and the likelihood of a tumor being the underlying cause. This is true for the "high ranking" neural antibodies that have been established in the context of circumscribed clinical images and in consideration of large control groups, have been found in the same way by other laboratories and they respond to immunotherapy. The immune reaction can be triggered ...
Source: Der Nervenarzt - March 13, 2018 Category: Neurology Authors: Bien CG Tags: Nervenarzt Source Type: research

[Cladribine tablets : Oral immunotherapy of relapsing-remitting multiple sclerosis with short yearly treatment periods].
CONCLUSION: Cladribine tablets are an important addition to the therapeutic landscape in RMS. With patient-friendly short dosing periods and a favorable adverse event profile, cladribine tablets provide a sustained and strong reduction of MS disease activity. The primary target population for cladribine tablets is patients with relevant MS disease activity (highly active RMS) while on first-line treatment, e. g. with injectable disease-modifying drugs. PMID: 29523912 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 9, 2018 Category: Neurology Authors: Meuth SG, Ruck T, Aktas O, Hartung HP Tags: Nervenarzt Source Type: research

[Autoimmune encephalitis with psychotic symptoms : Diagnostics, warning signs and practical approach].
A, Falkai P Abstract Despite intensive research, a precise cause of schizophrenic and schizoaffective disorders has not yet been identified. Therefore, psychiatric diagnoses are still made based on clinical ICD-10/DSM‑5 criteria and not on any objective markers; however, various causes or pathophysiological processes may ultimately lead to similar symptoms. An important task for the future of psychiatry is to identify disease subtypes with a distinct pathophysiology to develop more specific and causally acting therapies. A new diagnostic entity has become established in clinical neurology and psychiat...
Source: Der Nervenarzt - March 9, 2018 Category: Neurology Authors: Steiner J, Prüß H, Köhler S, Hasan A, Falkai P Tags: Nervenarzt Source Type: research

[Nutrition, microbiome and multiple sclerosis : Current knowledge from basic research and clinical practice].
Abstract Epidemiological data indicate a disproportional increase in the incidence of multiple sclerosis (MS) over the last decades, particularly in industrialized countries. Although this increase is also associated with altered diagnostic criteria and improved sensitivity of imaging procedures, current data suggest that particularly alterations in our way of life play an important role. In recent years the importance of the gut and intestinal microbiome for some neurological diseases and in particular for MS was recognized. Because nutritional habits have a substantial influence on the composition of the microbi...
Source: Der Nervenarzt - March 7, 2018 Category: Neurology Authors: Haghikia A, Linker RA Tags: Nervenarzt Source Type: research

[Use of antiepileptic drugs during breastfeeding : What do we tell the mother?]
CONCLUSION: Phenobarbital, primidone, carbamazepine, valproate and levetiracetam are probably compatible with breastfeeding. Treatment with phenytoin, ethosuximide, clonazepam, oxcarbazepine, vigabatrin, topiramate, gabapentin, pregabalin, lamotrigine and zonisamide can be authorized during breastfeeding, provided breastfed infants are carefully monitored for side effects. Since data on the use of mesuximide, clobazam, rufinamide, felbamate, lacosamide, sultiame, perampanel and retigabine are insufficient to adequately assess the risk for breastfed infants, use in breastfeeding women is in principle not recommended and sho...
Source: Der Nervenarzt - February 27, 2018 Category: Neurology Authors: Crettenand M, Rossetti AO, Buclin T, Winterfeld U Tags: Nervenarzt Source Type: research

[Differential indication for psychotherapy in psychosis : Are there evidence-based criteria?]
Abstract The major objective of this paper is to discuss the available evidence on the question as to which patients benefit most from psychotherapy in psychotic disorders and the question of which kind of psychotherapy. From a methodological perspective, this task can be seen as the question of moderators of treatment success. To answer this question, the status of efficacy research on psychotherapeutic interventions in schizophrenia is summarized in a first step. Secondly, studies comparing different active psychotherapeutic approaches are discussed. There are no studies available on routine psychotherapeutic ca...
Source: Der Nervenarzt - February 26, 2018 Category: Neurology Authors: Klingberg S, Hesse K Tags: Nervenarzt Source Type: research

[The new tremor classification of the International Parkinson and Movement Disorder Society : Update on frequent tremors].
l G Abstract Tremor is one of the most frequent movement disorders. The recently published new classification of the Movement Disorder Society separates the clinical description of tremor syndromes as so-called axis 1 symptom constellations from the etiologies of tremor (axis 2). The same tremor syndromes can therefore be combined with different causes and vice versa. The terminology used in this classification is precisely defined and thereby also the necessary language for medical communication. Frequent tremor syndromes, such as enhanced physiologic tremor, dystonic and parkinsonian tremor as well as focal trem...
Source: Der Nervenarzt - February 13, 2018 Category: Neurology Authors: Gövert F, Becktepe J, Deuschl G Tags: Nervenarzt Source Type: research

[Biomarker-based diagnostics of Alzheimer's disease : Concept of suspected non-Alzheimer pathology].
This article discusses the prognostic implications of a SNAP result and the diagnostic and prognostic problems of biomarker-based diagnostic criteria are presented based on the SNAP. PMID: 29423820 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 8, 2018 Category: Neurology Authors: Fliessbach K, Schneider A Tags: Nervenarzt Source Type: research

[Which psychotherapy for whom?]
PMID: 29411051 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 6, 2018 Category: Neurology Authors: Arolt V Tags: Nervenarzt Source Type: research

[From stiff man syndrome to stiff person spectrum disorders].
Abstract The identification of new variants of the stiff man syndrome (SMS) and of new, probably pathogenic neuronal autoantibodies has led to the concept of stiff man (or person) spectrum disorders (SPSD). This is an expanding group of rare chronic autoimmune inflammatory diseases of the central nervous system (CNS) that have in common the main symptoms of fluctuating rigidity and spasms with pronounced stimulus sensitivity. These core symptoms are mandatory and can be accompanied by a wide variety of other neurological signs. The SPSDs are associated with autoantibodies directed against neuronal proteins th...
Source: Der Nervenarzt - February 5, 2018 Category: Neurology Authors: Meinck HM, Balint B Tags: Nervenarzt Source Type: research