New psychoactive substances in emergency medicine
Nervenarzt. 2024 Jan 8. doi: 10.1007/s00115-023-01602-4. Online ahead of print.ABSTRACTNew psychoactive substances (NPS) are a heterogeneous group of synthetic intoxicating substances. What they have in common is their "new" appearance as a narcotic drug. Many of them imitate known drugs; some of them are derivatives of substances developed as drugs many years ago. Changed or completely newly developed chemical structures often give the NPS a massively increased effect. This includes not only the effects desired by the consumer, but also the undesirable effects with sometimes fatal consequences. The use of NPS has been an ...
Source: Der Nervenarzt - January 8, 2024 Category: Neurology Authors: R Marinowitz J Strube A Schaper Source Type: research
Additional functional symptoms in Parkinson's disease and tremor syndromes
Nervenarzt. 2024 Jan 5. doi: 10.1007/s00115-023-01594-1. Online ahead of print.ABSTRACTPatients with Parkinson's Disease or a tremor syndrome may present with additional functional movement disorders. The differential diagnosis is particularly difficult. In some cases, functional symptoms occur either before the manifestation of the organic disease or can emerge as an additional symptom after Parkinson's disease or tremor became apparent. In patients with Parkinson's disease the prevalence for additional functional symptoms is 7 %. In the case that patients with Parkinson's diseases have one side that is more severely affe...
Source: Der Nervenarzt - January 5, 2024 Category: Neurology Authors: Kirsten E Zeuner Petra Schwingenschuh Source Type: research
Tumor-host cell interaction in the microenvironment: new target points for treatment?
CONCLUSION: A deeper understanding of the complex immune landscape and the microenvironment of metastases of the CNS and intracerebral tumors is essential to optimize future treatment strategies.PMID:38180512 | DOI:10.1007/s00115-023-01604-2 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 5, 2024 Category: Neurology Authors: Lisa Sevenich Dieter Henrik Heiland Source Type: research
Additional functional symptoms in Parkinson's disease and tremor syndromes
Nervenarzt. 2024 Jan 5. doi: 10.1007/s00115-023-01594-1. Online ahead of print.ABSTRACTPatients with Parkinson's Disease or a tremor syndrome may present with additional functional movement disorders. The differential diagnosis is particularly difficult. In some cases, functional symptoms occur either before the manifestation of the organic disease or can emerge as an additional symptom after Parkinson's disease or tremor became apparent. In patients with Parkinson's disease the prevalence for additional functional symptoms is 7 %. In the case that patients with Parkinson's diseases have one side that is more severely affe...
Source: Der Nervenarzt - January 5, 2024 Category: Neurology Authors: Kirsten E Zeuner Petra Schwingenschuh Source Type: research
Tumor-host cell interaction in the microenvironment: new target points for treatment?
CONCLUSION: A deeper understanding of the complex immune landscape and the microenvironment of metastases of the CNS and intracerebral tumors is essential to optimize future treatment strategies.PMID:38180512 | DOI:10.1007/s00115-023-01604-2 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 5, 2024 Category: Neurology Authors: Lisa Sevenich Dieter Henrik Heiland Source Type: research
Additional functional symptoms in Parkinson's disease and tremor syndromes
Nervenarzt. 2024 Jan 5. doi: 10.1007/s00115-023-01594-1. Online ahead of print.ABSTRACTPatients with Parkinson's Disease or a tremor syndrome may present with additional functional movement disorders. The differential diagnosis is particularly difficult. In some cases, functional symptoms occur either before the manifestation of the organic disease or can emerge as an additional symptom after Parkinson's disease or tremor became apparent. In patients with Parkinson's disease the prevalence for additional functional symptoms is 7 %. In the case that patients with Parkinson's diseases have one side that is more severely affe...
Source: Der Nervenarzt - January 5, 2024 Category: Neurology Authors: Kirsten E Zeuner Petra Schwingenschuh Source Type: research
Tumor-host cell interaction in the microenvironment: new target points for treatment?
CONCLUSION: A deeper understanding of the complex immune landscape and the microenvironment of metastases of the CNS and intracerebral tumors is essential to optimize future treatment strategies.PMID:38180512 | DOI:10.1007/s00115-023-01604-2 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 5, 2024 Category: Neurology Authors: Lisa Sevenich Dieter Henrik Heiland Source Type: research
Transcranial direct current stimulation to enhance training effectiveness in chronic poststroke aphasia-A challenge for recruiting participants
DISCUSSION: The multicenter study DC_TRAIN_APHASIA aims to provide evidence on tDCS as an adjuvant application to increase the effect size of intensive speech-language therapy in chronic post-stroke aphasia. The present review may guide future studies in recruiting samples that involve people with impaired communicative abilities.PMID:38175228 | DOI:10.1007/s00115-023-01572-7 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 4, 2024 Category: Neurology Authors: Nina Unger Benjamin Stahl Robert Darkow Veronika Scholz Isabel Weinmar Johanna Schmidt Caterina Breitenstein Marcus Meinzer Tanja Grewe Agnes Fl öel Source Type: research
Erratum zu: Die Situation des deutschen Ma ßregelvollzugs – Ergebnisse einer Umfrage der DGPPN
Nervenarzt. 2024 Jan 4. doi: 10.1007/s00115-023-01582-5. Online ahead of print.NO ABSTRACTPMID:38175229 | DOI:10.1007/s00115-023-01582-5 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 4, 2024 Category: Neurology Authors: Robert Zeidler Manuela Dudeck Udo Frank Gabriel Gerlinger Dirk Hesse Jutta Muysers Thomas Pollm ächer Christian Riedemann Julia Sander Birgit V öllm J ürgen L Müller Source Type: research
Transcranial direct current stimulation to enhance training effectiveness in chronic poststroke aphasia-A challenge for recruiting participants
DISCUSSION: The multicenter study DC_TRAIN_APHASIA aims to provide evidence on tDCS as an adjuvant application to increase the effect size of intensive speech-language therapy in chronic post-stroke aphasia. The present review may guide future studies in recruiting samples that involve people with impaired communicative abilities.PMID:38175228 | DOI:10.1007/s00115-023-01572-7 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 4, 2024 Category: Neurology Authors: Nina Unger Benjamin Stahl Robert Darkow Veronika Scholz Isabel Weinmar Johanna Schmidt Caterina Breitenstein Marcus Meinzer Tanja Grewe Agnes Fl öel Source Type: research
Erratum zu: Die Situation des deutschen Ma ßregelvollzugs – Ergebnisse einer Umfrage der DGPPN
Nervenarzt. 2024 Jan 4. doi: 10.1007/s00115-023-01582-5. Online ahead of print.NO ABSTRACTPMID:38175229 | DOI:10.1007/s00115-023-01582-5 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 4, 2024 Category: Neurology Authors: Robert Zeidler Manuela Dudeck Udo Frank Gabriel Gerlinger Dirk Hesse Jutta Muysers Thomas Pollm ächer Christian Riedemann Julia Sander Birgit V öllm J ürgen L Müller Source Type: research
Immunotherapy against gliomas
This article provides an overview of the current status of different immunotherapeutic concepts against gliomas, highlighting the advantages, disadvantages, and challenges. Additionally, it provides an overview of currently ongoing immunotherapeutic clinical trials in Germany and neighboring countries.RESULTS: Previous randomized studies on antibodies against programmed cell death protein 1 (anti-PD1) immune checkpoint inhibition, viral treatment and peptide vaccination targeting the variant III of the epidermal growth factor receptor (EGFRvIII) in glioblastomas were negative with respect to survival benefits. Conversely, ...
Source: Der Nervenarzt - January 3, 2024 Category: Neurology Authors: Katharina Sahm Tobias Weiss Source Type: research
Assisted suicide-What remains from §216 of the German Criminal Code (StGB)?
Nervenarzt. 2024 Jan 3. doi: 10.1007/s00115-023-01593-2. Online ahead of print.NO ABSTRACTPMID:38170206 | DOI:10.1007/s00115-023-01593-2 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 3, 2024 Category: Neurology Authors: Thomas Pollm ächer Source Type: research
Sweet cannabis intoxication at the airport
Nervenarzt. 2024 Jan 3. doi: 10.1007/s00115-023-01591-4. Online ahead of print.NO ABSTRACTPMID:38172264 | DOI:10.1007/s00115-023-01591-4 (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 3, 2024 Category: Neurology Authors: Marian Sujak Julia Neuhauser Karl Matz Source Type: research
Glioblastomas exploit neuronal properties: a key to new forms of treatment?
Nervenarzt. 2023 Dec 29. doi: 10.1007/s00115-023-01589-y. Online ahead of print.ABSTRACTRecent research indicates that glioblastomas exhibit different neural properties that successfully promote tumor growth, colonize the brain and resist standard treatment. This opens up opportunities for new therapeutic strategies giving rise to the new research field of cancer neuroscience at the interface between oncology and neuroscience. It has been observed that glioblastomas as well as other incurable brain tumor entities, form multicellular tumor networks through long cell projections called tumor microtubes that are molecularly c...
Source: Der Nervenarzt - December 29, 2023 Category: Neurology Authors: Varun Venkataramani Frank Winkler Source Type: research
