[Medical students' attitude towards electroconvulsive therapy : Impact of patient-oriented training.]
CONCLUSION: Reservations to touch on the controversial issue of ECT during the clinical training do not seem to be justified. Even a single hands-on or video experience can have a relevant impact on knowledge and attitude towards ECT in medical students. This opportunity should be used more intensively. PMID: 24943362 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 20, 2014 Category: Neurology Authors: Paheenthararajah K, Ladas T, Gauggel S, Prinz S, Grözinger M Tags: Nervenarzt Source Type: research

[Non-ketotic hyperglycemia-induced hemichorea athetosis.]
PMID: 24943363 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 20, 2014 Category: Neurology Authors: Hiesgen J Tags: Nervenarzt Source Type: research

[Is controlled drinking a reasonable therapy target for alcohol dependence? For.]
PMID: 24939081 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 19, 2014 Category: Neurology Authors: Zimmermann US Tags: Nervenarzt Source Type: research

[Driving ability with mental and neurological diseases.]
PMID: 24906533 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - June 8, 2014 Category: Neurology Authors: Laux G, Widder B Tags: Nervenarzt Source Type: research

[Driving ability with alcohol and drug dependence and schizophrenia.]
Abstract Alcohol and drugs use are of great relevance for driving ability. The number of alcohol-related accidents with injuries in Germany showed a 40 % decline over the past decade (2011: 15,898 including 400 deaths, other drugs 1400). Road surveys indicate the risk of accidents to be high in psychostimulant users but only medium in opioid users. Guidelines for medical and psychological examinations of drunken drivers are given. Alcohol-related questions are the most commonly encountered in medical psychological expert opinions with 51 % followed by drugs and medications with 21 %. The fundament...
Source: Der Nervenarzt - June 8, 2014 Category: Neurology Authors: Soyka M, Dittert S, Kagerer-Volk S, Soyka M Tags: Nervenarzt Source Type: research

[Driving ability with affective disorders and under psychotropic drugs.]
Abstract There are only few data available regarding the effects of depressive disorders on road safety due to methodological shortcomings. Patients with acute severe depression or manias are unqualified for driving but after clinical remission driving ability can be attested under psychiatric supervision in most cases. So far there are only few data available about a patient's fitness to drive under psychotropic medication. Regarding the effects of antidepressants on road safety depressed patients obviously benefit from treatment with newer antidepressants; however, at least some subgroups of patients do not reac...
Source: Der Nervenarzt - June 8, 2014 Category: Neurology Authors: Laux G, Brunnauer A Tags: Nervenarzt Source Type: research

[Driving ability with multiple sclerosis.]
s C Abstract Driving is an important issue for young patients, especially for those whose walking capacity is impaired. Driving might support the patient's social and vocational participation. The question as to whether a patient with multiple sclerosis (MS) is restricted in the ability to drive a car depends on neurological and neuropsychological deficits, self-awareness, insight into deficits and ability to compensate for loss of function. Because of the enormous variability of symptoms in MS the question is highly individualized. A practical driving test under supervision of a driving instructor (possibly accom...
Source: Der Nervenarzt - June 8, 2014 Category: Neurology Authors: Küst J, Dettmers C Tags: Nervenarzt Source Type: research

[Assessment of driving in patients with vertigo and dizziness.]
Abstract The driving performance of patients with dizziness and vertigo has gained only minor attention so far. Patients with permanent vestibular loss or with episodic vestibular symptoms can experience difficulties in driving a motor vehicle. The presence of a chronic or episodic syndrome presenting with dizziness and/or vertigo does not automatically exclude the ability to drive. Assessment of driving performance should consider the degree of the deficits and compensation in chronic dysfunction and the severity and frequency of attacks, prodromes and triggers of symptoms in episodic disorders. PMID: 249065...
Source: Der Nervenarzt - June 8, 2014 Category: Neurology Authors: von Brevern M, von Stuckrad-Barre S, Fetter M Tags: Nervenarzt Source Type: research

[Principles of evaluating driving ability for neurological and psychiatric diseases.]
Abstract If attending physicians and psychologists recognize restricted or a lack of driving ability they are obliged to inform their patients appropriately. In Germany the legal basis for assessing driving ability is the "Fahrerlaubnis-Verordnung" (FeV, driving licence act), supplemented by guidelines for evaluating driving ability. In each individual case it has to be clarified whether and to what extent permanent or paroxysmally occurring disorders affect driving ability and whether lack of insight ability or personality defects are a threat to driving safety. In addition, it has to be considered whet...
Source: Der Nervenarzt - June 8, 2014 Category: Neurology Authors: Brunnauer A, Widder B, Laux G Tags: Nervenarzt Source Type: research

[Gait disorders in the elderly.]
r T Abstract Gait disorders are one of the most common gerontoneurological symptoms. Falls that occasionally cause severe injuries are highly relevant consequences. A clinical neurological examination and inspectoral gait analysis are the core investigations of the diagnostic process, which yields hypotheses with respect to the impaired structures as well as to specific diagnostic measures. The supplemental motor assessment quantifies the resulting impairment of mobility and risk of falling with the help of well-established instruments. Characteristic of gait disorders in the elderly are the multifactorial causes ...
Source: Der Nervenarzt - May 29, 2014 Category: Neurology Authors: Amadori K, Püllen R, Steiner T Tags: Nervenarzt Source Type: research

[Quality guidelines for presurgical epilepsy diagnosis and operative epilepsy therapy : 1st revised version.]
herapie Abstract In patients with pharmacorefractory epilepsy, preoperative epilepsy evaluation and subsequent epilepsy surgery lead to a significant improvement of seizure control, proportion of seizure-free patients, quality of life and social participation. The aims of preoperative epilepsy evaluation are to define the chance of complete seizure freedom and the likelihood of inducing new neurological deficits in a given patient. As epilepsy surgery is an elective procedure quality standards are particularly high. As detailed in the first edition of these practice guidelines, quality control relates to seven dif...
Source: Der Nervenarzt - May 28, 2014 Category: Neurology Authors: Rosenow F, Bast T, Czech T, Hans V, Helmstaedter C, Huppertz HJ, Seeck M, Trinka E, Wagner K, Vorstand der Arbeitsgemeinschaft für prächirurgische Epilepsiediagnostik und operative Epilepsietherapie Tags: Nervenarzt Source Type: research

[Antiepileptics in women of childbearing age and during pregnancy : Comparison of specialized information with the current state of knowledge in Germany and Switzerland.]
DISCUSSION: The information regarding use in women of childbearing age and during pregnancy provided by the SmPCs is heterogeneous and poorly reflects the current state of knowledge. Regular updates of SmPCs are warranted in order for these documents to be of reliable use for health care professionals. PMID: 24861194 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 28, 2014 Category: Neurology Authors: Winterfeld U, Gotta V, Rothuizen LE, Panchaud A, Rossetti AO, Buclin T Tags: Nervenarzt Source Type: research

[Frontal brain volume reduction due to antipsychotic drugs?]
This article reviews the results of longitudinal studies on frontal brain volume reduction in patients with schizophrenia spectrum disorders and focuses on the relationship with antipsychotic treatment. Based on a systematic literature search all studies were included in which results on changes of brain volumes over a longer period of time were correlated with antipsychotic treatment dose and disease severity. The findings indicate that there is evidence for grey and white matter volume changes of the frontal brain, which cannot be explained by the severity of the disease alone but are also very likely a manifestation of ...
Source: Der Nervenarzt - May 25, 2014 Category: Neurology Authors: Aderhold V, Weinmann S, Hägele C, Heinz A Tags: Nervenarzt Source Type: research

[Combination of TMS and MRT to understand neurological diseases.]
Abstract Modern neuroimaging techniques, such as structural and functional magnetic resonance imaging (MRI) and non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) are increasingly used in the neuroscientific research of neurological disorders, such as stroke, tinnitus and movement disorders. These methods offer a non-invasive approach and especially in combination, not only the opportunity to add to the pathophysiological understanding of these disorders but also to provide information about the functional recovery and the natural course of the disease in a predictive way. B...
Source: Der Nervenarzt - May 23, 2014 Category: Neurology Authors: Hummel FC Tags: Nervenarzt Source Type: research

[Resting state functional MRI of the brain.]
Abstract The article presents an introduction to studies of the brain using functional magnetic resonance imaging during rest (rsfMRI). These studies are based on the fact that the resting brain exhibits a certain level of constant background activity. These spontaneous rsfMRT activities are characterized by fluctuations of the blood oxygenation level-dependent (BOLD) signal (typically in the low frequency part of the power spectrum
Source: Der Nervenarzt - May 23, 2014 Category: Neurology Authors: Grodd W, Beckmann CF Tags: Nervenarzt Source Type: research

[Neuroimaging in psychiatry : Multivariate analysis techniques for diagnosis and prognosis.]
CONCLUSION: The results of the studies are heterogeneous although some studies report promising findings. Further multicentre studies are needed with clearly specified patient populations to systematically investigate the potential utility of neuroimaging for the clinical routine. PMID: 24849118 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 23, 2014 Category: Neurology Authors: Kambeitz J, Koutsouleris N Tags: Nervenarzt Source Type: research

[Vertebral artery dissection in a female patient with Turner's syndrome : Unusual cause of a radicular lesion.]
PMID: 24849119 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 23, 2014 Category: Neurology Authors: Barg N, Kapp B, Isenhardt K Tags: Nervenarzt Source Type: research

[Erratum to: Treatment of asymptomatic carotid artery stenosis.]
PMID: 24849120 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 23, 2014 Category: Neurology Authors: Reiff T, Amiri H, Fraedrich G, Jansen O, Mudra H, Mansmann U, Hacke W, Ringleb PA, Eckstein HH, SPACE-2 Steering Committee Tags: Nervenarzt Source Type: research

[Functional imaging of physiological and pathological speech production.]
This article summarizes the insights from neuroimaging on physiological speech production and also on the pathomechanisms underlying Parkinson's disease and developmental stuttering. PMID: 24832012 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 17, 2014 Category: Neurology Authors: Kell CA Tags: Nervenarzt Source Type: research

[Professor Brandt retires as Editor : Characterized Der Nervenarzt over 25 years.]
PMID: 24832013 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 17, 2014 Category: Neurology Authors: Hacke W, Maier W, Braun C Tags: Nervenarzt Source Type: research

[Karl Jaspers: 100 years "Allgemeine Psychopathologie"]
[Karl Jaspers: 100 years "Allgemeine Psychopathologie"] Nervenarzt. 2014 May 14; Authors: - PMID: 24821291 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 14, 2014 Category: Neurology Authors: - Tags: Nervenarzt Source Type: research

[Simultaneous EEG-fMRI measurements : Insights in applications and challenges.]
CONCLUSIONS: Current developments in multimodal imaging focus on the combination of electrophysiological and MRI parameters within ultra-high field MRI as well as on positron emission tomography (PET) in a trimodal approach. PMID: 24817636 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 11, 2014 Category: Neurology Authors: Reese B, Habel U, Neuner I Tags: Nervenarzt Source Type: research

[Coping with multiple sclerosis in partnerships : A systematic review of the literature.]
CONCLUSION: Targeted support for dyadic coping can lead to stress reduction and higher relationship satisfaction of couples living with MS. PMID: 24817637 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 11, 2014 Category: Neurology Authors: Busch AK, Spirig R, Schnepp W Tags: Nervenarzt Source Type: research

[Psychiatric psychotherapeutic interventions in breast cancer inpatients : A contribution to liaison-consultation psychiatry.]
CONCLUSION: Despite methodological limitations this investigation contributes to describing relevant psychopathological syndromes in a group of breast cancer patients without pre-existing mental disorders and the goodness of fit of the different psychiatric and psychotherapeutic interventions. Finally the study confirmed the assumption that stabilization of the mental state may help to avoid treatment interruptions in an oncological inpatient setting and therefore decrease the likelihood that reduced psychological well-being can negatively impact the biological course of tumor development. PMID: 24796707 [PubMed - as ...
Source: Der Nervenarzt - May 7, 2014 Category: Neurology Authors: Grube M, Weigand-Tomiuk H Tags: Nervenarzt Source Type: research

[Bipolar disorders in DSM-5].
CONCLUSIONS: While some of the novelties are clearly useful, e.g. addition of increased goal-directed activity/energy as obligatory symptom for (hypo)manic episodes, this remains to be demonstrated for others, such as the definition of various subthreshold bipolar disorders. PMID: 24796943 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - May 1, 2014 Category: Neurology Authors: Severus E, Bauer M Tags: Nervenarzt Source Type: research

[Mild neurocognitive disorder - a disease? For.]
PMID: 24777656 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 30, 2014 Category: Neurology Authors: Jessen F Tags: Nervenarzt Source Type: research

[Treatment after first seizure? Against.]
PMID: 24763810 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 26, 2014 Category: Neurology Authors: Steinhoff B Tags: Nervenarzt Source Type: research

[Mild neurocognitive disorder - a disease? Against.]
h L PMID: 24763811 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 26, 2014 Category: Neurology Authors: Frölich L Tags: Nervenarzt Source Type: research

[Neurocognitive disorders in DSM-5 : Pervasive changes in the diagnostics of dementia.]
Abstract The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposes an innovative chapter on neurocognitive disorders (NCD) as a substitute for the dementia, delirium and amnestic disorders chapter in DSM-IV. This NCD chapter promotes a most innovative change compared to DSM-IV. While the term delirium is preserved, the commonly used term dementia does not occur as a diagnostic entity. Neurocognitive disorders are more inclusive than dementias; they also cover early prodromal stages of dementias below the DSM-IV threshold. The diagnosis of NCDs requires essentially neuropsychological testing prefer...
Source: Der Nervenarzt - April 19, 2014 Category: Neurology Authors: Maier W, Barnikol UB Tags: Nervenarzt Source Type: research

[The new DSM 5 classification system : Essential amendments in the psychiatric classification.]
PMID: 24740352 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 18, 2014 Category: Neurology Authors: Bauer M, Maier W, Schneider F, Kapfhammer HP Tags: Nervenarzt Source Type: research

[Schizophrenia and other psychotic disorders in DSM-5 : Summary of the changes compared to DSM-IV.]
This article gives an overview of the changes that have been made within the revision process from DSM-IV to DSM-5. PMID: 24740353 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 18, 2014 Category: Neurology Authors: Paulzen M, Schneider F Tags: Nervenarzt Source Type: research

[Anxiety disorders in DSM-5 : An overview on changes in structure and content.]
Abstract The Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) "anxiety, obsessive-compulsive spectrum, posttraumatic, and dissociative disorders" work group addressed reconceptualization issues regarding all anxiety-related disorders. Based on systematic literature reviews, reanalyses of available data and evaluation of results following the DSM-5 principles it was decided to rearrange the disorder spectrum into separate groupings for the classical anxiety disorders, trauma- and stressor-related disorders, obsessive-compulsive and related disorders, and dissociative disorders. Among the cl...
Source: Der Nervenarzt - April 17, 2014 Category: Neurology Authors: Wittchen HU, Heinig I, Beesdo-Baum K Tags: Nervenarzt Source Type: research

[DSM-5: important changes in the field of addictive diseases.]
Abstract There are two major changes in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) concerning the field of addiction. Firstly, the previous distinction between abuse and dependence has been abolished and both disorders are now subsumed under the category addiction and related disorders. Secondly, pathological gambling has now been included in the section of addiction with slight changes in diagnostic criteria. Both changes have major implications for the definition and conceptualization of what we call a psychiatric "disease" or "disorder", which have also been addressed ...
Source: Der Nervenarzt - April 17, 2014 Category: Neurology Authors: Heinz A, Friedel E Tags: Nervenarzt Source Type: research

[Trauma and stressor-related disorders : Diagnostic conceptualization in DSM-5.]
Abstract The Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5) includes a distinct diagnostic group of trauma and stressor-related disorders that has been set apart from anxiety disorders. From a perspective of adult psychiatry this new disorder category includes posttraumatic stress disorder (PTSD), acute stress disorder (ASD), and adjustment disorders. The PTSD is based on narrower trauma criteria that focus on acute life-threatening situations, serious injury, or sexual violence by way of direct confrontation, witnessing or indirect confrontation. Indirect confrontation, however, is reserved only ...
Source: Der Nervenarzt - April 13, 2014 Category: Neurology Authors: Kapfhammer HP Tags: Nervenarzt Source Type: research

[Social phobia.]
Abstract With a lifetime prevalence of 13 % social phobia (social anxiety disorder) is a common and serious condition that should not be played down because of the burden associated with the disorder, an increased suicide rate and the frequent comorbidity with substance abuse disorders. Social phobia is characterized by the excessive and unrealistic fear of being scrutinized or criticized by others. The disorder often begins in adolescence.Symptoms of social phobia can be effectively treated with evidence-based treatment, including cognitive behavior therapy (CBT) and psychopharmacological medications. In t...
Source: Der Nervenarzt - April 11, 2014 Category: Neurology Authors: Bandelow B, Wedekind D Tags: Nervenarzt Source Type: research

[Multimorbidity: concept, epidemiology and treatment].
Abstract Multimorbidity is defined as the simultaneous presence of several diseases or health conditions (at least two or more) in one person. In contrast, comorbidity indicates the occurrence of additional diseases to a main or index disease. The probability for the occurrence of multimorbidity increases with advancing age and is a growing problem for affected patients, relatives, and also for the healthcare system, as multimorbid patients have a decreased quality of life, often requiring high levels of care and may increase the resource use at all levels of healthcare. The prevalence of multimorbidity is difficu...
Source: Der Nervenarzt - April 1, 2014 Category: Neurology Authors: Dodel R Tags: Nervenarzt Source Type: research

[Hereditary diffuse leukencephalopathy with spheroids : A microgliopathy due to CSF1 receptor impairment].
We report three patients with HDLS who carried missense mutations in the CSF1R gene, two of them novel (p.L582P and p.V383L). Particularly in younger patients with rapid cognitive decline and/or leukencephalopathy of unknown origin, HDLS appears to be more common than previously thought. Various compounds acting on the CSF1 receptor are available from the treatment of hemato-oncological malignancies, so novel therapeutic approaches could be developed for this devastating condition. PMID: 24706185 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 1, 2014 Category: Neurology Authors: Schuberth M, Levin J, Sawalhe D, Schwarzkopf R, von Baumgarten L, Ertl-Wagner B, Rominger A, Arzberger T, Kretzschmar HA, Froböse T, Diehl-Schmid J, Biskup S, Danek A Tags: Nervenarzt Source Type: research

[Lumbar puncture for diagnosis of dementia: liquor puncture is indispensable. For].
PMID: 24706186 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 1, 2014 Category: Neurology Authors: Schulz JB Tags: Nervenarzt Source Type: research

[Erratum to: Treatment of asymptomatic carotid artery stenosis. Improvement of evidence with new SPACE-2 design necessary].
PMID: 24706187 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 1, 2014 Category: Neurology Authors: Reiff T, Amiri H, Ringleb PA, Jansen O, Hacke W, Eckstein HH Tags: Nervenarzt Source Type: research

[Lumbar puncture for diagnosis of dementia: liquor puncture is indispensable. Against].
PMID: 24706188 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - April 1, 2014 Category: Neurology Authors: Schmidtke K Tags: Nervenarzt Source Type: research

[Fiber optic endoscopic evaluation of swallowing on the stroke unit.]
PMID: 24682089 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 30, 2014 Category: Neurology Authors: - Tags: Nervenarzt Source Type: research

[Multimorbidity of neurological patients in palliative care units.]
This article gives a retrospective review of data and presentation of own results together with a discussion on basic knowledge and expert recommendations. RESULTS: Multimorbidity of patients with neurological diseases depends on the underlying disease and age. Multimorbidity is often associated with polypharmacy which should be critically evaluated during palliative care treatment. Long-term pharmacological treatment often needs to be terminated as the side effects outweigh the benefits. Our own data show that patients leaving the palliative care unit often have a reduced amount of drugs compared to those who have di...
Source: Der Nervenarzt - March 30, 2014 Category: Neurology Authors: Lorenzl S Tags: Nervenarzt Source Type: research

[CXCL13: a biomarker for acute Lyme neuroborreliosis : Investigation of the predictive value in the clinical routine.]
CONCLUSIONS: The biomarker CXCL13 has a higher sensitivity (100 % vs. 87 %) with a specificity (99 %) comparable with the established diagnostic markers for LNB, e.g. CSF pleocytosis and Borrelia-AI in the investigated patient population. The negative predictive value of CXCL13 is 100 %. Therefore, a normal CXCL13 level virtually excludes LNB. In the clinical routine CXCL13 is a valuable and practical diagnostic marker for LNB and can even detect an acute LNB in patients without CSF pleocytosis. PMID: 24682168 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 30, 2014 Category: Neurology Authors: Rupprecht TA, Lechner C, Tumani H, Fingerle V Tags: Nervenarzt Source Type: research

[Cluster-like headache due to dissection of the internal carotid artery after Pilates training.]
PMID: 24682169 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 30, 2014 Category: Neurology Authors: Weber R, Grab J, Berlit P, Gaul C Tags: Nervenarzt Source Type: research

[Development of neurology in Germany after 1960.]
PMID: 24682170 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 30, 2014 Category: Neurology Authors: Haensch CA Tags: Nervenarzt Source Type: research

[Schema therapy for personality disorders : A critical review.]
Abstract In the 10 years since schema therapy was first recognized in Germany it has become widespread among practitioners and has taken a place among the so-called third wave therapies. The overall goal of schema therapy is conceptualizing and treating personality disorders or traits reinforcing axis I disorders. Early maladaptive schemas result from a child's unmet emotional core needs. In a limited reparenting therapy relationship these interpersonal situations are re-experienced and rescripted under the therapist's control. Schema therapy integrates elements of existing models and techniques into a consistent ...
Source: Der Nervenarzt - March 29, 2014 Category: Neurology Authors: Roediger E, Zarbock G Tags: Nervenarzt Source Type: research

[Fumaric acid as therapeutic agent for multiple sclerosis.]
Abstract After the approval of fumaric acid in February 2014 another first line agent is now available for the treatment of multiple sclerosis (MS). Along with the various beta interferon preparations, glatiramer acetate, teriflunomide and fumaric acid add to the repertoire of oral therapeutics for the initial treatment of relapsing remitting MS in daily practice. In order to employ these drugs in an individualized and precise medical manner and considering their efficacy and side effects, it seems worthwhile to learn the so far known mode of action and background history. Fumaric acid, as one of the newest drugs ...
Source: Der Nervenarzt - March 27, 2014 Category: Neurology Authors: Haghikia A, Linker R, Gold R Tags: Nervenarzt Source Type: research

[The new financial compensation system PEPP : An ethical analysis.]
CONCLUSION: The ethical analysis of PEPP reveals that apart from the limited opportunities to improve efficiency, there is a considerable ethical risk of loss of quality in psychiatric inpatient care in particular for severely and chronically mentally ill patients. PMID: 24668401 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 27, 2014 Category: Neurology Authors: Vollmann J Tags: Nervenarzt Source Type: research

[Paraneoplastic neurological syndromes and autoimmune encephalitis.]
Abstract Paraneoplastic neurological syndromes (PNS) are defined as remote effects on the central and peripheral nervous system that are not caused directly by the tumor, its metastases and treatment, or metabolic disorders. The most probable cause is a falsely initiated immune reaction. Well-defined classical PNSs are associated with distinct tumors and occur with onconeural antibodies directed against intracellular neuronal antigens. However, response to therapy is limited. Recently, new antibodies directed against neuronal surface antigens were described in encephalitic syndromes of autoimmune origin. These pro...
Source: Der Nervenarzt - March 27, 2014 Category: Neurology Authors: Stich O, Rauer S Tags: Nervenarzt Source Type: research

[Delirium in patients with neurological diseases : Diagnosis, management and prognosis.]
r B Abstract Delirium is a common acute neuropsychiatric syndrome. It is characterized by concurrent disturbances of consciousness and attention, perception, reasoning, memory, emotionality, the sleep-wake cycle as well as psychomotor symptoms. Delirium caused by alcohol or medication withdrawal is not the subject of the current review. Specific predisposing and precipitating factors have been identified in delirium which converge in a common final pathway of global brain dysfunction. The major predisposing factors are older age, cognitive impairment or dementia, sensory deficits, multimorbidity and polypharmacy. ...
Source: Der Nervenarzt - March 26, 2014 Category: Neurology Authors: Hüfner K, Sperner-Unterweger B Tags: Nervenarzt Source Type: research