[Erratum to: Oxidative stress in bipolar affective disorder.]
PMID: 25676925 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 14, 2015 Category: Neurology Authors: Reininghaus EZ, Zelzer S, Reininghaus B, Lackner N, Birner A, Bengesser SA, Fellendorf FT, Kapfhammer HP, Mangge H Tags: Nervenarzt Source Type: research

[Predictors of mental and physical quality of life in Huntington's disease].
This study underlines the relationship between function capacity and depressive symptoms with mental and physical QoL. This is the first time that hrQoL has been investigated in a German speaking cohort. The results are in accordance with previous studies of hrQoL in HD. PMID: 25659843 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 1, 2015 Category: Neurology Authors: Brugger F, Hepperger C, Hametner EM, Holl AK, Painold A, Schusterschitz C, Bonelli R, Holas C, Wenning GK, Poewe W, Seppi K Tags: Nervenarzt Source Type: research

[Postherpetic neuralgia].
au G Abstract Postherpetic neuralgia is considered to be a neuropathic pain syndrome. Typically, patients experience pain in the dermatomes of skin lesions persisting for more than 3 months after skin restitution. About 10 % of patients with herpes zoster develop postherpetic neuralgia. Its prevalence increases with age. Common clinical symptoms include continuous burning pain, sharp pain attacks, and allodynia. Additionally, sensory hyperactivation or loss in the affected skin area is present. Pathophysiology includes mechanisms of peripheral and central sensitization, based on damaged nerve fibers as...
Source: Der Nervenarzt - February 1, 2015 Category: Neurology Authors: Goßrau G Tags: Nervenarzt Source Type: research

[Optic neuropathy after retrobulbar neuritis in multiple sclerosis : Are optical coherence tomography and magnetic resonance imaging useful and necessary follow-up parameters?]
This study evaluated whether progressive optic neuropathy (ON) is commonly found after retrobulbar neuritis and whether optical coherence tomography (OCT) is a useful tool for follow-up of patients with multiple sclerosis (MS). METHODS: An observational study of 86 MS patients (currently treated with immunomodulation) with a past medical history of ON was carried out. Patients were assessed in 2010 and 2012 using the expanded disability status scale (EDSS), visual acuity, visual evoked potentials (VEP) and OCT but magnetic resonance imaging (MRI) was performed only in 2012. RESULTS: In this study 16 men and 70 wo...
Source: Der Nervenarzt - February 1, 2015 Category: Neurology Authors: Dachsel RM, Dachsel R, Domke S, Groß T, Schubert O, Kotrini L, Ladegast K, Vogel J, Jordan T, Zawade S Tags: Nervenarzt Source Type: research

[Rheumatoid vasculitis of the central nervous system.]
RA PMID: 25637081 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 1, 2015 Category: Neurology Authors: Lee DH, Blinzler C, Stöckl T, Engelhorn T, Buslei R, Schwab S, Linker RA Tags: Nervenarzt Source Type: research

[The catastrophic antiphospholipid antibody syndrome : Case report and review of the literature.]
mann GF PMID: 25637082 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - February 1, 2015 Category: Neurology Authors: Hüwel J, Zühlke C, Kostopoulos P, Mann C, Hamann GF Tags: Nervenarzt Source Type: research

[Peripheral neurology: not a fringe area in routine clinical treatment!]
PMID: 25631119 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 30, 2015 Category: Neurology Authors: Straube A, Dengler R Tags: Nervenarzt Source Type: research

[Neonaticide : A classification of female perpetrators in an east-west comparison.]
CONCLUSION: The presented categorization of female perpetrators into two groups, where the features only show a small degree of overlap, should be taken into consideration in the assessment of the reasons for neonaticide. The typology of female perpetrators is more heterogeneous than previously assumed. The presented typologies and knowledge of conditional constellations involved in neonaticide achieve better prerequisites to be able to recognize persons at risk earlier and to instigate preventive measures. PMID: 25631120 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 30, 2015 Category: Neurology Authors: Schöne M, Peter E, Dobrowolny H, Bogerts B Tags: Nervenarzt Source Type: research

[Inception of institutionalization of clinical neurology in Munich (1913-1933) : With particular focus on Eugen von Malaisé]
[Inception of institutionalization of clinical neurology in Munich (1913-1933) : With particular focus on Eugen von Malaisé] Nervenarzt. 2015 Jan 30; Authors: Voss H Abstract At the University of Munich the teaching and treatment of neurological diseases had been covered by internists since the last quarter of the nineteenth century. Under the direction of Bumke the psychiatric clinic also laid claim to the representation of neurology starting in 1924. However, the military departments for nerve- and brain-injured soldiers, which were founded during WWI, developed into non-academic neurological...
Source: Der Nervenarzt - January 30, 2015 Category: Neurology Authors: Voss H Tags: Nervenarzt Source Type: research

[Traumatic nerve damage : Causes, approaches and prognosis.]
l H Abstract  Whereas minor injuries to peripheral nerves merely lead to a circumscribed damage of the myelin sheath which is completely healed within 3 months, penetrating injuries lead to degeneration of the distal axonal fragment (Waller degeneration) and simultaneously to time-dependent alterations in the effector organs, in the perikarya in the medulla and spinal ganglia as well as in the brain. Animal experimental studies and also findings in humans confirm that the conditions for regeneration of nerve fibers are most favorable in the first days and weeks following injury. Therefore, for optimal therapy it...
Source: Der Nervenarzt - January 29, 2015 Category: Neurology Authors: Müller-Vahl H Tags: Nervenarzt Source Type: research

[Painful ischemic neuropathy.]
Abstract Chronic ischemia in patients with peripheral arterial disease (PAD) represents a common medical problem. Neuropathic changes and pain caused by chronic ischemia are often found in the lower extremities of these patients. Pain in patients with chronic critical limb ischemia fulfill the criteria of neuropathic pain. Diagnostic tools besides medical history and examination are questionnaires, quantitative sensory testing (QST) and measuring intraepidermal nerve fiber density (IENFD) when indicated. A pharmacological approach with non-opioids and opioids as well as antidepressive and anticonvulsive drugs (acc...
Source: Der Nervenarzt - January 28, 2015 Category: Neurology Authors: Lang PM Tags: Nervenarzt Source Type: research

[Reality of treatment in psychotherapy : Results of a survey of German psychiatric hospitals.]
Abstract OBJECTIVES: Since the introduction of the qualification as specialist for psychiatry and psychotherapy, in addition to psychopharmacotherapy psychotherapy is an integral component of the treatment of mentally ill people. A survey was carried out to evaluate the reality of clinical routine use of psychotherapy in German psychiatric hospitals. METHODS: Between October 2011 and March 2012 German hospitals of psychiatry and psychotherapy were contacted by the head organization, the conference of national directors (Bundesdirektorenkonferenz), to participate in a survey regarding the application of psycho...
Source: Der Nervenarzt - January 28, 2015 Category: Neurology Authors: Laux G, Sander K, Artmann S, Dreher J, Lenz J, Hauth I Tags: Nervenarzt Source Type: research

[Diabetic neuropathy : Do not only consider distal symmetrical neuropathy.]
This article gives an overview of the less frequent forms of diabetic neuropathy and discusses their impact, diagnostic and therapeutic implications. RESULTS: Autonomic diabetic neuropathy, diabetic small fiber neuropathy and less frequent forms of diabetic neuropathy, such as diabetic radiculoplexopathy, diabetic neuropathy of cranial nerves, therapy-induced neuropathy and alternative causes of peripheral neuropathy in patients with diabetes are described. DISCUSSION: Diagnosis of less frequent subtypes of diabetic neuropathy and differentiation towards alternative causes of peripheral neuropathy are often diffi...
Source: Der Nervenarzt - January 23, 2015 Category: Neurology Authors: Doppler K, Reiners K Tags: Nervenarzt Source Type: research

[University professors in the Soviet Occupation Zone and the German Democratic Republic up to 1961 : Academic alternation of generations at university psychiatric hospitals.]
Abstract After WWII a politically guided staffing policy foresaw an exchange program for professors from the Soviet Occupation Zone and the German Democratic Republic (GDR). In the field of medicine this initiative was not successful. With respect to university psychiatric/neurological hospitals this experiment failed as a result of a shortage of personnel due to the consequences of war, denazification and people migrating into western occupation zones. Criteria for politically selecting promising young talent which had been propagated by the Socialist Unity Party of Germany (Sozialistische Einheitspartei Deutschl...
Source: Der Nervenarzt - January 23, 2015 Category: Neurology Authors: Kumbier E, Haack K Tags: Nervenarzt Source Type: research

[Tryptophan immunoadsorption for multiple sclerosis and neuromyelitis optica : Therapy option for acute relapses during pregnancy and breastfeeding.]
CONCLUSION: Tryptophan IA was found to be safe, well-tolerated and effective in the treatment of MS and NMO relapses during pregnancy and breastfeeding, sometimes without preceding glucocorticoid pulse therapy. A binding recommendation is limited without prospective clinical studies. PMID: 25604838 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 23, 2015 Category: Neurology Authors: Hoffmann F, Kraft A, Heigl F, Mauch E, Koehler J, Harms L, Kümpfel T, Köhler W, Klingel R, Fassbender C, Schimrigk S Tags: Nervenarzt Source Type: research

[Cardiac and metabolic risk factors in severe mental disorders : Task of a prevention manager.]
This article presents new organizational structures to overcome this deficit with a prevention manager playing a central role in organizing and applying preventive and therapeutic care. Results from cardiology and diabetic medicine have shown the effectiveness of pooling this responsibility. The measure has the potential to reduce the increased mortality of people with severe mental disorders. PMID: 25591753 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 17, 2015 Category: Neurology Authors: Lederbogen F, Schwarz P, Häfner S, Schweiger U, Bohus M, Deuschle M Tags: Nervenarzt Source Type: research

[Chemotherapy-induced neuropathy.]
CONCLUSION: The CINs are an unsolved medical problem. Knowledge of symptoms as well as preventive, diagnostic and therapeutic strategies is important when patients present in clinical practice with neurological symptoms following chemotherapy. PMID: 25586233 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 15, 2015 Category: Neurology Authors: Boehmerle W, Huehnchen P, Endres M Tags: Nervenarzt Source Type: research

[The contribution of neuroscience to the concept of mental disorder.]
DISCUSSION: Psychiatric nosology is confronted by similar challenges as every general nosology. Among these are the role of dysfunction versus "normal" function, the fuzzy boundary of health and disorder, the role of subjective suffering and the role of causal mechanisms. In the case of mental disorders, a further issue is that every nosology has to take a stance about what mental processes actually are. In this article, the disorder concepts of the fifth edition of the diagnostic and statistical manual of mental disorders (DSM-5) and of the research domain criteria (RDoC) approach of the National Institute of Me...
Source: Der Nervenarzt - January 11, 2015 Category: Neurology Authors: Walter H, Müller J Tags: Nervenarzt Source Type: research

[Intraneural hemangioma of the ulnar nerve.]
PMID: 25575631 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - January 11, 2015 Category: Neurology Authors: Brand C, Pedro MT, Schick M, Scheuerle A, Scheglmann K, Wirtz CR, Antoniadis G Tags: Nervenarzt Source Type: research

[Hippocampal stroke.]
Abstract Unilateral cerebral ischemia of the hippocampus is very rare. This paper reviews the literature and presents the case of a 59-year-old woman with an amnestic syndrome due to a left hippocampal stroke. The patient suffered from retrograde amnesia which was most severe over the 2 days prior to presenting and a slight anterograde amnesia. In addition, a verbal memory disorder was confirmed 1 week after admission by neurological tests. As risk factors, arterial hypertension and a relative hyper-beta lipoproteinemia were found. This case shows that unilateral amnestic stroke, e.g. in the hippocampus region, ma...
Source: Der Nervenarzt - January 11, 2015 Category: Neurology Authors: Rollnik JD, Traitel B, Dietrich B, Lenz O Tags: Nervenarzt Source Type: research

[Disease and disability : The ICF model.]
Abstract Diagnoses alone, e.g. according to the international classification of diseases 10 (ICD-10), do not give information on the illness severity, treatment needs and consequences. This depends on the functional health status, e.g. according to the international classification of functioning, disability and health (ICF) which discriminates between impairment of functions, limitations in activity and capacity and participation restrictions. The German social law (SGB IX) defines disability as a chronic health status which lasts longer than 6 months and which results in participation restrictions. Participation ...
Source: Der Nervenarzt - January 10, 2015 Category: Neurology Authors: Linden M Tags: Nervenarzt Source Type: research

[Common and not so common nerve entrapment syndromes : Diagnostics, clinical aspects and therapy.]
Abstract Altogether, nerve entrapment syndromes have a very high incidence. Neurological deficits attributable to a focal peripheral nerve lesion lead to the clinical diagnosis. Frequently, pain is the dominant symptom but is often not confined to the nerve supply area. Electroneurography, electromyography, and more recently also neurosonography are the most important diagnostic tools. In most patients surgical therapy is necessary, which should be carried out in a timely manner. The entrapment syndromes discussed are suprascapular nerve entrapment, carpal tunnel syndrome, cubital tunnel syndrome, meralgia paraest...
Source: Der Nervenarzt - December 21, 2014 Category: Neurology Authors: Schulte-Mattler WJ, Grimm T Tags: Nervenarzt Source Type: research

[The term mental disease in psychiatry and psychotherapy.]
PMID: 25515335 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 18, 2014 Category: Neurology Authors: Heinz A Tags: Nervenarzt Source Type: research

[Medical and vocational rehabilitation in rehabilitation facilities for people with mental illnesses in Germany : Analysis of admission and discharge data.]
CONCLUSION: For people with severe mental illnesses, RPKs can be a place of successful rehabilitative measures facilitating participation in community life. Future studies need to investigate predictors of outcome. PMID: 25515336 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 18, 2014 Category: Neurology Authors: Stengler K, Kauffeldt S, Theißing A, Bräuning-Edelmann M, Becker T Tags: Nervenarzt Source Type: research

[Takotsubo cardiomyopathy after electroconvulsive therapy : A case report.]
PMID: 25511627 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 17, 2014 Category: Neurology Authors: Krause TJ, Said SM, Braun-Dullaeus RC, Bogerts B, Genz A Tags: Nervenarzt Source Type: research

[Estimation of prevalence and treatment needs of mental disorders : The problem of diagnostic thresholds.]
DISCUSSION: Despite fuzzy boundaries, threshold-based diagnoses (DSM-IV) represent a satisfactory and reproducible disease classification (in terms of illness and sickness) for estimation of prevalence. There is a lack of definitions and instruments to assess treatment needs. It is still debated whether diagnostic symptom criteria always represent pathological disorders (i. e. disease). PMID: 25503066 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 14, 2014 Category: Neurology Authors: Jacobi F, Barnikol UB Tags: Nervenarzt Source Type: research

[The function of a general concept of disease from an historical perspective.]
This article questions why medicine fails to provide a general concept of disease for use by doctors, patients and society because the lack of such a unified concept inhibits any definitive distinction between "deviant" and "disease". By providing an historical overview of the particularities related to this question the authors demonstrate that the ever-changing concepts of disease were not driven by the process through which medicine became a science. In contrast to naturalistic concepts of disease, anthropological, sociocultural and psychosomatic concepts are grounded in an understanding of disease t...
Source: Der Nervenarzt - December 14, 2014 Category: Neurology Authors: Hess V, Herrn R Tags: Nervenarzt Source Type: research

[Erratum to: Obituary for Christian Müller (1921-2013).]
[Erratum to: Obituary for Christian Müller (1921-2013).] Nervenarzt. 2014 Dec 13; Authors: Ciompi L, Baumann P PMID: 25502892 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 13, 2014 Category: Neurology Authors: Ciompi L, Baumann P Tags: Nervenarzt Source Type: research

[Organic personality disorder : Conceptual principles, clinical symptoms and treatment.]
r M Abstract The organic personality disorder is primarily characterized by a change of premorbid behavior due to an organic impairment or disease of the central nervous system. German psychopathological preliminary work had a determining influence on the current diagnostic concepts in the international classification of diseases 10 (ICD-10) and the diagnostic and statistical manual of mental disorders 5 (DSM-5). An analysis of the literature in the MEDLINE database shows that most studies can be found for traumatic brain injury and epilepsy. The most common symptoms described were symptoms of depression, emotiona...
Source: Der Nervenarzt - December 11, 2014 Category: Neurology Authors: Lang FU, Dudeck M, Becker T, Jäger M Tags: Nervenarzt Source Type: research

[Effectiveness of aftercare treatment after release from prison : A first evaluation of the forensic therapeutic outpatient clinic for serious violent and sexual offenders in Berlin.]
CONCLUSION: Individually adapted measures should be maintained after finishing aftercare treatment; however, because prisoners released from prison are frequently less prepared than patients from forensic psychiatric hospitals, the therapeutic work often reaches its limits in these cases. Therefore, social work should be taken into account right from the start. PMID: 25476037 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 6, 2014 Category: Neurology Authors: Sauter J, Voss T, Dahle KP Tags: Nervenarzt Source Type: research

[Lifestyle].
PMID: 25476185 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 1, 2014 Category: Neurology Authors: Schneider F, Weiller C Tags: Nervenarzt Source Type: research

[Psychotherapy for everyone? : On the indications for psychotherapeutic treatment].
CONCLUSION: The indications for psychotherapy should always be made with a sense of proportion, taking into consideration the currently available scientific evidence and clinical experience. In the future, the training of psychotherapists, scientific investigations of psychotherapies and clinical service provision should increasingly concentrate on patients with severe mental disorders and/or with psychological and physical comorbidities. PMID: 25476186 [PubMed - in process] (Source: Der Nervenarzt)
Source: Der Nervenarzt - December 1, 2014 Category: Neurology Authors: Schnyder U, McShine RM, Kurmann J, Rufer M Tags: Nervenarzt Source Type: research

[Secretion scale by Murray et al. for FEES(®) : Comparison of reliability and validity of the German long and short version].
This study aimed at the validation of the German translation of the long version of the secretion scale by Murray et al. and at a comparison of reliability and validity of the short and long versions. MATERIAL AND METHODS: A total of 40 videos of fiberoptic endoscopic evaluation of swallowing (FEES(®)), 10 for each severity level, were rated by 4 otorhinolaryngologists (ENT specialists) independently and with different randomizations for examination of the reliability and validity. Two rating sessions for each of the scale versions were conducted. Intrarater and interrater reliability as well as the agreement of t...
Source: Der Nervenarzt - December 1, 2014 Category: Neurology Authors: Pluschinski P, Zaretsky Y, Almahameed A, Koseki JC, Leinung M, Girth L, Wagenblast J, Sader R, Stöver T, Hey C Tags: Nervenarzt Source Type: research

[Guidelines on "pharmacotherapy of neurodegenerative dementia" : An update].
This article presents the evidence-based pharmacotherapeutic options for the most common forms of neurodegenerative dementia. The aim is to present the recommendations derived from the relevant studies on the neurological, psychiatric and geriatric practice of treatment for dementia patients. The text is derived from the 2009 guidelines of the German Society of Neurology (DGN, lead management: K. Fassbinder), the S3 guidelines of the DGN/German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN, lead management: G. Deuschl and W. Maier) and the latest amendments of the European Federation of Neurological S...
Source: Der Nervenarzt - December 1, 2014 Category: Neurology Authors: Fassbender K, Frölich L Tags: Nervenarzt Source Type: research

[On the history of the German Democratic Republic Journal Psychiatry, Neurology and Medical Psychology (1949-1990).]
Abstract Scientific journals were established in the Soviet occupied zone following WWII in order to distinguish themselves from the other occupying powers. Starting in 1949 a journal with the title "Psychiatry, Neurology and Medical Psychology" was founded as no publishing house existed in the field of psychiatry and neurology and it became necessary to establish a new journal that was competitive. The journal was primarily distributed in the German Democratic Republic (GDR) until 1990 but the interest internationally was very limited. State affairs had a great influence from the very beginning so that ...
Source: Der Nervenarzt - November 30, 2014 Category: Neurology Authors: Teitge M, Kumbier E Tags: Nervenarzt Source Type: research

[Deep brain stimulation using simultaneous stereotactic electrode placement : An alternative to conventional functional stereotaxy?]
CONCLUSION: In summary, both stereotactic procedures are reliable and safe procedures for the placement of stimulating electrodes as well as the stimulation effect achieved. The logistical uncoupling of presurgical planning from surgical therapy emphasizes the benefits of the individualized stereotactic procedure. PMID: 25431126 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 29, 2014 Category: Neurology Authors: Matzke C, Hammer N, Weise D, Lindner D, Fritzsch D, Classen J, Meixensberger J, Winkler D Tags: Nervenarzt Source Type: research

[Low dose naltrexone in the treatment of dissociative symptoms.]
CONCLUSION: Treatment with low-dose naltrexone may be a helpful element in the treatment of patients with complex posttraumatic stress disorder. However, it has to be realized that the decrease of dissociation may lead patients to a not yet resolvable challenge, in as much as dissociation had previously been a necessary mechanism of self-protection. PMID: 25421416 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 26, 2014 Category: Neurology Authors: Pape W, Wöller W Tags: Nervenarzt Source Type: research

[Long-term effects of deep brain stimulation for movement disorders : A literature-based analysis.]
CONCLUSION: Deep brain stimulation remains a relatively safe and effective therapy in carefully selected patients after long-term follow-up according to published data, although disease progression and other disease-specific factors seem to modify its effectiveness over time. PMID: 25421418 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 26, 2014 Category: Neurology Authors: Eberhardt O, Reithmeier T, Topka H Tags: Nervenarzt Source Type: research

[Nutrition and dietary supplements in psychiatric diseases.]
Abstract Nutrition and specific nutritional supplements can have prophylactic or therapeutic properties with respect to certain psychiatric disorders. A traditional Mediterranean diet, for example, seems to have prophylactic benefits against depression and dementia, whereas overeating and obesity increase the risk for both.Although evidence for nutritional supplements in the treatment of psychiatric disorders is not sufficient for general recommendations, data from observational studies and randomized controlled trials (RCT) seem to point to their use for specific indications. Folate, S-adenosylmethionine (SAM) an...
Source: Der Nervenarzt - November 19, 2014 Category: Neurology Authors: Himmerich H, Erbguth F Tags: Nervenarzt Source Type: research

[Nutrition and dietary supplements in neurological diseases.]
Abstract "Healthy" diets and supplements are widely used for prevention and disease modification in vascular, inflammatory and degenerative neurological diseases. Apart from a large number of cross-sectional and prospective cohort studies, there are only few interventional studies on individual dietary measures. A recent study confirmed the stroke preventive effect of a Mediterranean diet rich in olive oil and nuts; a ketogenic diet reduces seizure frequency in epilepsy. Supplementation of riboflavin, magnesium and coenzyme Q10 are probably effective in migraine prophylaxis. Creatine can improve muscle s...
Source: Der Nervenarzt - November 19, 2014 Category: Neurology Authors: Erbguth F, Himmerich H Tags: Nervenarzt Source Type: research

[Neuroenhancement.]
This article discusses the potential of pharmacological cognitive enhancement with some of the most common drugs. METHODS: A selective literature search was performed taking into account the most important groups of substances (i.e. caffeine, nicotine, stimulants including modafinil, and acetylcholine esterase inhibitors) for which studies on the pharmacological elevation of cognitive performance in healthy subjects are available. RESULTS: The extent of the effects that can be pharmacologically achieved is essentially genetically determined. Some of the best-characterized polymorphisms are described here. Pharmac...
Source: Der Nervenarzt - November 19, 2014 Category: Neurology Authors: Gründer G, Bartsch T Tags: Nervenarzt Source Type: research

[Coping and depression in underage children of cancer patients : Data on the course.]
CONCLUSION: Children and adolescents are particularly psychologically distressed after cancer treatment of parents. This distress was connected with not helpful coping strategies. The extended adjustment of children/adolescents of cancer patients has to be considered in the clinical and psychosocial care of the families. PMID: 25403290 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 19, 2014 Category: Neurology Authors: Ernst J, von Klitzing K, Brähler E, Romer G, Götze H Tags: Nervenarzt Source Type: research

[Moebius syndrome and narcolepsy.]
We report on a patient with Moebius syndrome and the clinical presentation of a narcolepsy cataplexy syndrome. With the hypoplasia of the brainstem in the cranial magnetic resonance imaging, we were able to show the morphological correlate of Moebius syndrome. Comorbidity was detected by cognitive tests, polysomnography and detection of hypocretin in the cerebrospinal fluid. Despite normal sleep onset latency and only one episode of sleep onset rapid eye movement (REM) in the multiple sleep latency test, where expressiveness is significantly reduced in cases of paralysis of horizontal eye movement, the diagnosis of parasom...
Source: Der Nervenarzt - November 13, 2014 Category: Neurology Authors: Krämer S, Goldammer U, Sindern E Tags: Nervenarzt Source Type: research

[Physical training for neurological and mental diseases.]
CONCLUSION: The concerted integration of physical exercise into prophylactic and therapeutic interventions can lower the burden of neurological and mental diseases; however, scientific evidence is still lacking concerning the optimal duration, type, and intensity as well as potential risks of physical exercise. PMID: 25380564 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 9, 2014 Category: Neurology Authors: Henkel K, Reimers CD, Knapp G, Schneider F Tags: Nervenarzt Source Type: research

[Fumaric acid or dimethyl fumarate?]
PMID: 25374116 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 7, 2014 Category: Neurology Authors: - Tags: Nervenarzt Source Type: research

[Check-ups and screening for young people : What is reasonable with respect to psychiatric disorders?]
CONCLUSIONS: The adolescence healthcare examinations can be a useful element for early detection of mental disorders and damaging behavior if the utilization rate is high and actions taken in case of suspected beginning disorder/damaging behavior are evaluated. To date, screening instruments for psychiatric disorders should not be used in wide population classes without group-specific targets and without direct contact between therapists and patients. Already established preventive services and initiatives should be interlinked. The health effects of the actions have to be analyzed. PMID: 25367230 [PubMed - as supplie...
Source: Der Nervenarzt - November 2, 2014 Category: Neurology Authors: Pfennig A, Klosterkötter J Tags: Nervenarzt Source Type: research

[Sinus thrombosis in a 15-year-old girl : An interdisciplinary case.]
u M PMID: 25367231 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - November 2, 2014 Category: Neurology Authors: Graf S, Prothmann S, Lehmberg J, Ilg R, Wunderlich S, Schneider J, Mühlau M Tags: Nervenarzt Source Type: research

[Clinically validated molecular biomarkers of neurodegenerative dementia.]
Abstract As cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) has now been validated at the S3 evidence level, the German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN) and the German Society for Neurology (DGN) recommend CSF-NDD in the recent joint dementia guidelines for improved early and differential diagnostics of multigenic (sporadic) Alzheimer's dementia (AD). The CSF-NDD also provides a predictive diagnosis of incipient AD for high-risk patients when they are still in the prodromal stage of mild cognitive impairment (MCI) but as no (secondary) preventive therapy o...
Source: Der Nervenarzt - October 22, 2014 Category: Neurology Authors: Wiltfang J Tags: Nervenarzt Source Type: research

[Physicians conscience and Zeitgeist.]
This article aims at a sensitization for questions of formation and vulnerability of the conscience. PMID: 25331215 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - October 19, 2014 Category: Neurology Authors: Helmchen H Tags: Nervenarzt Source Type: research

[Psychotherapeutic work with older patients.]
Abstract Despite the high prevalence of mental illness in Germany, elderly people are significantly under-represented in psychotherapeutic treatment. This is not only due to their own reservations about psychotherapy but also to a greater extent a reflection of the models of old age in our society. Deficit-oriented theories dating back to the origins of psychotherapy in the last century are still widespread leading to fear of contact with consultants and therapists.The specific methods of psychotherapeutic work with older patients are presented. Methodologically, the treatment of elderly patients with depressive d...
Source: Der Nervenarzt - October 18, 2014 Category: Neurology Authors: Koethe D, Mattern M, Herpertz SC Tags: Nervenarzt Source Type: research